Cr2 (complement C3d receptor 2) - Rat Genome Database

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Gene: Cr2 (complement C3d receptor 2) Rattus norvegicus
Analyze
Symbol: Cr2
Name: complement C3d receptor 2
RGD ID: 1310065
Description: Predicted to enable several functions, including complement receptor activity; immunoglobulin receptor binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including B cell activation; negative regulation of complement activation, classical pathway; and type I interferon-mediated signaling pathway. Predicted to act upstream of or within with a negative effect on complement activation, alternative pathway. Predicted to act upstream of or within several processes, including cellular response to lipopolysaccharide; immunoglobulin mediated immune response; and skeletal system development. Located in cell surface and extracellular space. Human ortholog(s) of this gene implicated in common variable immunodeficiency 7; nasopharynx carcinoma; and systemic lupus erythematosus. Orthologous to human CR2 (complement C3d receptor 2); PARTICIPATES IN B cell receptor signaling pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cd21; complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; complement receptor 2; complement receptor type 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813109,207,034 - 109,244,980 (-)NCBIGRCr8
mRatBN7.213106,678,579 - 106,716,595 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13106,685,413 - 106,716,235 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13109,202,762 - 109,233,397 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013110,586,602 - 110,617,233 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013107,811,075 - 107,841,707 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013113,890,274 - 113,927,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,890,272 - 113,927,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013118,580,480 - 118,618,039 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413111,078,338 - 111,113,667 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113111,281,069 - 111,300,233 (-)NCBI
Celera13106,107,601 - 106,138,227 (-)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of C3 receptors on cultured rat glomerular endothelial cells. Alexander JJ, etal., Kidney Int. 1997 Apr;51(4):1124-32. doi: 10.1038/ki.1997.155.
2. Mucosal type mast cells express complement receptor type 2 (CD21). Andrásfalvy M, etal., Immunol Lett. 2002 Jun 3;82(1-2):29-34. doi: 10.1016/s0165-2478(02)00015-9.
3. Functional polymorphism in the 5'-UTR of CR2 is associated with susceptibility to nasopharyngeal carcinoma. Fan Q, etal., Oncol Rep. 2013 Jul;30(1):11-6. doi: 10.3892/or.2013.2421. Epub 2013 Apr 23.
4. Complement and natural antibody are required in the long-term memory response to influenza virus. Fernandez Gonzalez S, etal., Vaccine. 2008 Dec 30;26 Suppl 8:I86-93. doi: 10.1016/j.vaccine.2008.11.057.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice. Kane SJ, etal., mSphere. 2017 Nov 22;2(6). pii: mSphere00493-17. doi: 10.1128/mSphereDirect.00493-17. eCollection 2017 Nov-Dec.
8. Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response. Lindblom RP, etal., J Neuroinflammation. 2015 Oct 26;12:192. doi: 10.1186/s12974-015-0413-6.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. In vivo decrease in the expression of complement receptor 2 on B-cells in HIV infection. Scott ME, etal., AIDS. 1993 Jan;7(1):37-41. doi: 10.1097/00002030-199301000-00006.
15. Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice. Takahashi K, etal., J Immunol. 1997 Aug 1;159(3):1557-69.
Additional References at PubMed
PMID:2995485   PMID:6363792   PMID:8041705   PMID:11034390   PMID:11435465   PMID:11728339   PMID:14662849   PMID:15909309   PMID:19414760   PMID:19828624   PMID:20458337   PMID:22885687  
PMID:23382219   PMID:36527877  


Genomics

Comparative Map Data
Cr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813109,207,034 - 109,244,980 (-)NCBIGRCr8
mRatBN7.213106,678,579 - 106,716,595 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13106,685,413 - 106,716,235 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13109,202,762 - 109,233,397 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013110,586,602 - 110,617,233 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013107,811,075 - 107,841,707 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013113,890,274 - 113,927,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,890,272 - 113,927,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013118,580,480 - 118,618,039 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413111,078,338 - 111,113,667 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113111,281,069 - 111,300,233 (-)NCBI
Celera13106,107,601 - 106,138,227 (-)NCBICelera
Cytogenetic Map13q27NCBI
CR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381207,454,328 - 207,489,892 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1207,453,024 - 207,489,895 (+)EnsemblGRCh38hg38GRCh38
GRCh371207,627,673 - 207,663,237 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,694,293 - 205,729,863 (+)NCBINCBI36Build 36hg18NCBI36
Build 341204,016,064 - 204,051,633NCBI
Celera1180,876,666 - 180,912,267 (+)NCBICelera
Cytogenetic Map1q32.2NCBI
HuRef1178,320,710 - 178,356,313 (+)NCBIHuRef
CHM1_11208,900,385 - 208,935,976 (+)NCBICHM1_1
T2T-CHM13v2.01206,719,629 - 206,755,209 (+)NCBIT2T-CHM13v2.0
Cr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,819,120 - 194,859,096 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,819,119 - 194,859,024 (-)EnsemblGRCm39 Ensembl
GRCm381195,136,811 - 195,176,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,136,811 - 195,176,716 (-)EnsemblGRCm38mm10GRCm38
MGSCv371196,963,005 - 197,002,909 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361196,840,394 - 196,877,439 (-)NCBIMGSCv36mm8
Celera1202,035,969 - 202,075,750 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map198.44NCBI
Cr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540642,876,966 - 42,911,564 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540642,877,041 - 42,910,970 (+)NCBIChiLan1.0ChiLan1.0
CR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2141,889,483 - 41,926,416 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1141,855,514 - 41,892,457 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01183,052,798 - 183,088,385 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11187,330,483 - 187,366,069 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1187,330,483 - 187,366,069 (+)Ensemblpanpan1.1panPan2
Cr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,006,478 - 68,043,276 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365575,246,770 - 5,256,608 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12521,914,690 - 21,954,244 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2521,919,393 - 21,953,659 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605522,536,015 - 22,575,130 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,152,230 - 4,179,211 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,149,472 - 4,179,269 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cr2
93 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:97
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000010910
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
AI177829  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr813109,210,548 - 109,210,668 (+)Marker Load Pipeline
mRatBN7.213106,682,093 - 106,682,214 (+)MAPPERmRatBN7.2
Rnor_6.013113,893,787 - 113,893,907NCBIRnor6.0
Rnor_5.013118,583,993 - 118,584,113UniSTSRnor5.0
RGSC_v3.413111,079,916 - 111,080,036UniSTSRGSC3.4
Celera13106,104,282 - 106,104,402UniSTS
RH 3.4 Map13760.1UniSTS
Cytogenetic Map13q27UniSTS
AI029543  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213106,685,489 - 106,685,736 (+)MAPPERmRatBN7.2
Rnor_6.013113,897,183 - 113,897,429NCBIRnor6.0
Rnor_5.013118,587,389 - 118,587,635UniSTSRnor5.0
RGSC_v3.413111,083,312 - 111,083,558UniSTSRGSC3.4
Celera13106,107,678 - 106,107,924UniSTS
RH 3.4 Map13760.9UniSTS
Cytogenetic Map13q27UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 19 76 80 79 48 25 48 6 151 66 56 20 46 31

Sequence


Ensembl Acc Id: ENSRNOT00000010910   ⟹   ENSRNOP00000010910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13106,685,413 - 106,716,235 (-)Ensembl
Rnor_6.0 Ensembl13113,897,112 - 113,927,745 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080616   ⟹   ENSRNOP00000073714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13113,890,272 - 113,927,877 (-)Ensembl
RefSeq Acc Id: NM_001105989   ⟹   NP_001099459
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813109,213,867 - 109,244,506 (-)NCBI
mRatBN7.213106,685,413 - 106,716,052 (-)NCBI
Rnor_6.013113,897,106 - 113,927,745 (-)NCBI
Rnor_5.013118,580,480 - 118,618,039 (-)NCBI
RGSC_v3.413111,078,338 - 111,113,667 (-)RGD
Celera13106,107,601 - 106,138,227 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769847   ⟹   XP_008768069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813109,207,034 - 109,244,980 (-)NCBI
mRatBN7.213106,678,579 - 106,716,595 (-)NCBI
Rnor_6.013113,890,274 - 113,927,824 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272195   ⟹   XP_063128265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813109,207,034 - 109,244,976 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099459 (Get FASTA)   NCBI Sequence Viewer  
  XP_008768069 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128265 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95056 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010910.7
RefSeq Acc Id: NP_001099459   ⟸   NM_001105989
- Peptide Label: precursor
- UniProtKB: A6JH50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768069   ⟸   XM_008769847
- Peptide Label: isoform X1
- UniProtKB: D3Z9F7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073714   ⟸   ENSRNOT00000080616
Ensembl Acc Id: ENSRNOP00000010910   ⟸   ENSRNOT00000010910
RefSeq Acc Id: XP_063128265   ⟸   XM_063272195
- Peptide Label: isoform X2
- UniProtKB: A6JH50 (UniProtKB/TrEMBL)
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K684-F1-model_v2 AlphaFold A0A0G2K684 1-1406 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699134
Promoter ID:EPDNEW_R9659
Type:single initiation site
Name:Cr2_1
Description:complement C3d receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013113,927,800 - 113,927,860EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310065 AgrOrtholog
BioCyc Gene G2FUF-16728 BioCyc
Ensembl Genes ENSRNOG00000034164 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010910.7 UniProtKB/TrEMBL
Gene3D-CATH Complement Module, domain 1 UniProtKB/TrEMBL
InterPro Compl-Cell_Adhes-Reg UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP UniProtKB/TrEMBL
NCBI Gene 289395 ENTREZGENE
PANTHER C4B-BINDING PROTEIN UniProtKB/TrEMBL
  COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/TrEMBL
  LOCOMOTION-RELATED PROTEIN HIKARU GENKI UniProtKB/TrEMBL
Pfam Sushi UniProtKB/TrEMBL
PhenoGen Cr2 PhenoGen
PROSITE SUSHI UniProtKB/TrEMBL
RatGTEx ENSRNOG00000034164 RatGTEx
SMART CCP UniProtKB/TrEMBL
Superfamily-SCOP Complement_control_module UniProtKB/TrEMBL
UniProt A6JH50 ENTREZGENE, UniProtKB/TrEMBL
  D3Z9F7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 Cr2  complement C3d receptor 2  Cr2  complement component 3d receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-20 Cr2  complement component 3d receptor 2  Cr2  complement component (3d/Epstein Barr virus) receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-10 Cr2  complement component (3d/Epstein Barr virus) receptor 2  Cr2  complement receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cr2  complement receptor 2   Cr2_predicted  complement receptor 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cr2_predicted  complement receptor 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED