Zar1 (zygote arrest 1) - Rat Genome Database

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Gene: Zar1 (zygote arrest 1) Rattus norvegicus
Analyze
Symbol: Zar1
Name: zygote arrest 1
RGD ID: 727972
Description: Predicted to enable RNA sequestering activity; mRNA 3'-UTR binding activity; and molecular condensate scaffold activity. Predicted to be involved in several processes, including oocyte maturation; post-transcriptional regulation of gene expression; and translation. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be active in cytoplasm and intracellular non-membrane-bounded organelle. Orthologous to human ZAR1 (zygote arrest 1); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: oocyte-specific maternal effect factor; zygote arrest protein 1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81435,547,467 - 35,551,757 (-)NCBIGRCr8
mRatBN7.21435,193,446 - 35,197,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1435,193,446 - 35,197,382 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1435,557,323 - 35,561,262 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01436,862,080 - 36,866,019 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01435,350,406 - 35,354,345 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01437,757,579 - 37,764,389 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1437,759,776 - 37,763,712 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01437,570,281 - 37,574,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41437,598,421 - 37,602,357 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11437,600,855 - 37,604,792 (-)NCBI
Celera1434,448,509 - 34,452,445 (-)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries. Wu X, etal., Biol Reprod 2003 Sep;69(3):861-7. Epub 2003 May 28.
Additional References at PubMed
PMID:20014101  


Genomics

Comparative Map Data
Zar1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81435,547,467 - 35,551,757 (-)NCBIGRCr8
mRatBN7.21435,193,446 - 35,197,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1435,193,446 - 35,197,382 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1435,557,323 - 35,561,262 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01436,862,080 - 36,866,019 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01435,350,406 - 35,354,345 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01437,757,579 - 37,764,389 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1437,759,776 - 37,763,712 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01437,570,281 - 37,574,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41437,598,421 - 37,602,357 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11437,600,855 - 37,604,792 (-)NCBI
Celera1434,448,509 - 34,452,445 (-)NCBICelera
Cytogenetic Map14p11NCBI
ZAR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38448,490,252 - 48,497,635 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl448,490,252 - 48,494,389 (+)EnsemblGRCh38hg38GRCh38
GRCh37448,492,269 - 48,496,406 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36448,187,066 - 48,191,181 (+)NCBINCBI36Build 36hg18NCBI36
Build 34448,333,236 - 48,337,348NCBI
Celera448,941,100 - 48,945,109 (+)NCBICelera
Cytogenetic Map4p11NCBI
HuRef447,812,310 - 47,816,447 (+)NCBIHuRef
CHM1_1448,491,424 - 48,495,561 (+)NCBICHM1_1
T2T-CHM13v2.0448,457,286 - 48,465,127 (+)NCBIT2T-CHM13v2.0
Zar1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39572,734,457 - 72,738,427 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl572,734,149 - 72,738,597 (-)EnsemblGRCm39 Ensembl
GRCm38572,577,113 - 72,581,361 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl572,576,806 - 72,581,254 (-)EnsemblGRCm38mm10GRCm38
MGSCv37572,968,353 - 72,972,323 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36572,856,249 - 72,860,219 (-)NCBIMGSCv36mm8
Celera569,825,570 - 69,829,543 (-)NCBICelera
Cytogenetic Map5C3.2NCBI
cM Map538.44NCBI
ZAR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2379,367,224 - 79,374,553 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1479,628,838 - 79,636,039 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0473,655,842 - 73,663,037 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1484,386,344 - 84,390,005 (-)NCBIpanpan1.1PanPan1.1panPan2
ZAR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11344,301,690 - 44,307,188 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1344,252,794 - 44,257,490 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01344,903,436 - 44,907,993 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1344,904,428 - 44,907,984 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11344,577,962 - 44,582,609 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01344,114,292 - 44,117,682 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01344,993,008 - 44,997,709 (+)NCBIUU_Cfam_GSD_1.0
Zar1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528531,781,714 - 31,795,486 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648214,503,197 - 14,507,183 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648214,502,680 - 14,510,023 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZAR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl838,386,643 - 38,391,611 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1838,386,520 - 38,391,618 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2840,420,104 - 40,425,070 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZAR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1271,745,297 - 1,762,724 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl271,758,050 - 1,762,016 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604747,756,823 - 47,765,472 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zar1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476118,485,440 - 18,488,882 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476118,485,286 - 18,488,988 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zar1
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:92
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000030610
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143076702539153750Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4
Low 41 7
Below cutoff 1 3 15 2 14 2 4 4 27 4 18 7 4

Sequence


RefSeq Acc Id: ENSRNOT00000030610   ⟹   ENSRNOP00000032032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1435,193,446 - 35,197,382 (-)Ensembl
Rnor_6.0 Ensembl1437,759,776 - 37,763,712 (-)Ensembl
RefSeq Acc Id: NM_181385   ⟹   NP_852050
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81435,547,467 - 35,551,403 (-)NCBI
mRatBN7.21435,193,446 - 35,197,382 (-)NCBI
Rnor_6.01437,759,776 - 37,763,712 (-)NCBI
Rnor_5.01437,570,281 - 37,574,217 (-)NCBI
RGSC_v3.41437,598,421 - 37,602,357 (-)RGD
Celera1434,448,509 - 34,452,445 (-)RGD
Sequence:
RefSeq Acc Id: XR_010057381
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81435,548,696 - 35,551,757 (-)NCBI
Protein Sequences
Protein RefSeqs NP_852050 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP37037 (Get FASTA)   NCBI Sequence Viewer  
  EDL89977 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032032
  ENSRNOP00000032032.1
  ENSRNOP00055006017
  ENSRNOP00060031379
  ENSRNOP00065026286
GenBank Protein Q7TSX9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_852050   ⟸   NM_181385
- UniProtKB: Q7TSX9 (UniProtKB/Swiss-Prot),   A6JD55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000032032   ⟸   ENSRNOT00000030610
Protein Domains
3CxxC-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TSX9-F1-model_v2 AlphaFold Q7TSX9 1-361 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727972 AgrOrtholog
BioCyc Gene G2FUF-15861 BioCyc
Ensembl Genes ENSRNOG00000026150 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055004999 UniProtKB/Swiss-Prot
  ENSRNOG00060021984 UniProtKB/Swiss-Prot
  ENSRNOG00065019513 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000030610 ENTREZGENE
  ENSRNOT00000030610.2 UniProtKB/Swiss-Prot
  ENSRNOT00055007985 UniProtKB/Swiss-Prot
  ENSRNOT00060038071 UniProtKB/Swiss-Prot
  ENSRNOT00065032889 UniProtKB/Swiss-Prot
InterPro Zar1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZAR1/RTP1-5-like_Znf-3CxxC UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
KEGG Report rno:353228 UniProtKB/Swiss-Prot
NCBI Gene 353228 ENTREZGENE
PANTHER PTHR31054 UniProtKB/Swiss-Prot
  ZYGOTE ARREST PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZYGOTE ARREST PROTEIN 1-LIKE ISOFORM X1 UniProtKB/TrEMBL
Pfam zf-3CxxC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zar1 PhenoGen
RatGTEx ENSRNOG00000026150 RatGTEx
  ENSRNOG00055004999 RatGTEx
  ENSRNOG00060021984 RatGTEx
  ENSRNOG00065019513 RatGTEx
SMART zf-3CxxC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JD55 ENTREZGENE, UniProtKB/TrEMBL
  Q7TSX9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Zar1  zygote arrest 1      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_evolution C-terminal region evolutionarily conserved throughout vertebrates 1299617