Atp6v0c (ATPase H+ transporting V0 subunit C) - Rat Genome Database

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Gene: Atp6v0c (ATPase H+ transporting V0 subunit C) Rattus norvegicus
Analyze
Symbol: Atp6v0c
Name: ATPase H+ transporting V0 subunit C
RGD ID: 621394
Description: Predicted to enable ubiquitin protein ligase binding activity. Involved in negative regulation of autophagic cell death and positive regulation of ERK1 and ERK2 cascade. Located in Golgi apparatus; lysosome; and synaptic vesicle. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c); PARTICIPATES IN oxidative phosphorylation pathway; phagocytosis pathway; rheumatoid arthritis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Atp6c; Atp6l; ATPase, H transporting, lysosomal V0 subunit c; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit C; ATPase, H+ transporting, lysosomal 1; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; ATPase, H+ transporting, lysosomal V0 subunit C; ATPase, H+ transporting, V0 subunit C; V-ATPase 16 kDa proteolipid subunit; V-ATPase 16 kDa proteolipid subunit c; V-type proton ATPase 16 kDa proteolipid subunit; V-type proton ATPase 16 kDa proteolipid subunit c; vacuolar proton pump 16 kDa proteolipid subunit; vacuolar proton pump 16 kDa proteolipid subunit c
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21013,196,204 - 13,202,580 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,196,204 - 13,201,500 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,941,023 - 17,946,085 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01017,429,860 - 17,434,922 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01012,928,324 - 12,933,402 (-)NCBIRnor_WKY
Rnor_6.01013,537,031 - 13,543,407 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,537,033 - 13,542,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,352,991 - 13,359,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,415,671 - 13,420,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,415,670 - 13,420,715 (-)NCBI
Celera1012,882,252 - 12,887,296 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structure of V-ATPase from the mammalian brain. Abbas YM, etal., Science. 2020 Mar 13;367(6483):1240-1246. doi: 10.1126/science.aaz2924.
2. Protective effects of vacuolar H+ -ATPase c on hydrogen peroxide-induced cell death in C6 glioma cells. Byun YJ, etal., Neurosci Lett. 2007 Oct 2;425(3):183-7. doi: 10.1016/j.neulet.2007.08.027. Epub 2007 Aug 19.
3. PFKFB2 Promoter Hypomethylation as Recurrence Predictive Marker in Well-Differentiated Thyroid Carcinomas. Camargo Barros-Filho M, etal., Int J Mol Sci. 2019 Mar 16;20(6). pii: ijms20061334. doi: 10.3390/ijms20061334.
4. The V0 sector of the V-ATPase, synaptobrevin, and synaptophysin are associated on synaptic vesicles in a Triton X-100-resistant, freeze-thawing sensitive, complex. Galli T, etal., J Biol Chem. 1996 Jan 26;271(4):2193-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Molecular cloning of a rat liver cDNA encoding the 16 kDa subunit of vacuolar H(+)-ATPases: organellar and tissue distribution of 16 kDa proteolipids. Nezu J, etal., J Biochem (Tokyo) 1992 Aug;112(2):212-9.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:17897319   PMID:18298843   PMID:19056867   PMID:20093472   PMID:21423176   PMID:29476059   PMID:30155790  


Genomics

Comparative Map Data
Atp6v0c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21013,196,204 - 13,202,580 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,196,204 - 13,201,500 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,941,023 - 17,946,085 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01017,429,860 - 17,434,922 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01012,928,324 - 12,933,402 (-)NCBIRnor_WKY
Rnor_6.01013,537,031 - 13,543,407 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,537,033 - 13,542,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,352,991 - 13,359,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,415,671 - 13,420,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,415,670 - 13,420,715 (-)NCBI
Celera1012,882,252 - 12,887,296 (-)NCBICelera
Cytogenetic Map10q12NCBI
ATP6V0C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,513,726 - 2,520,218 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl162,513,952 - 2,520,218 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,563,727 - 2,570,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,503,954 - 2,510,220 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,503,953 - 2,510,219NCBI
Celera162,755,525 - 2,785,155 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,489,699 - 2,496,194 (+)NCBIHuRef
CHM1_1162,563,664 - 2,570,161 (+)NCBICHM1_1
T2T-CHM13v2.0162,535,856 - 2,542,340 (+)NCBIT2T-CHM13v2.0
Atp6v0c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,382,839 - 24,388,652 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,382,840 - 24,388,676 (-)EnsemblGRCm39 Ensembl
GRCm381724,163,865 - 24,169,678 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,163,866 - 24,169,702 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,300,833 - 24,306,374 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361723,891,488 - 23,897,029 (-)NCBIMGSCv36mm8
Celera1724,669,200 - 24,674,661 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
Atp6v0c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,791,795 - 14,798,066 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544214,791,795 - 14,798,066 (-)NCBIChiLan1.0ChiLan1.0
ATP6V0C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1162,613,096 - 2,619,204 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,613,096 - 2,619,204 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0161,370,460 - 1,376,775 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ATP6V0C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,519,869 - 38,525,217 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,520,765 - 38,525,062 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,758,250 - 39,763,598 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0638,829,102 - 38,834,450 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,829,102 - 38,834,443 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,514,259 - 38,519,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,486,868 - 38,492,219 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,962,951 - 38,968,303 (-)NCBIUU_Cfam_GSD_1.0
Atp6v0c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,167,247 - 105,173,070 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366941,536,393 - 1,542,218 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP6V0C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1339,532,707 - 39,538,704 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,700,733 - 42,706,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP6V0C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,387,891 - 2,394,111 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,387,812 - 2,394,180 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606828,630,936 - 28,637,307 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp6v0c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624824267,102 - 272,893 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624824267,102 - 272,893 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp6v0c
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:291
Count of miRNA genes:179
Interacting mature miRNAs:196
Transcripts:ENSRNOT00000008736
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat

Markers in Region
RH143316  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,201,346 - 13,201,620 (+)MAPPERmRatBN7.2
Rnor_6.01013,542,174 - 13,542,447NCBIRnor6.0
Rnor_5.01013,358,134 - 13,358,407UniSTSRnor5.0
RGSC_v3.41013,420,812 - 13,421,085UniSTSRGSC3.4
Celera1012,887,393 - 12,887,666UniSTS
RH 3.4 Map10192.2UniSTS
Cytogenetic Map10q12UniSTS
Atp6l  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,196,216 - 13,196,379 (+)MAPPERmRatBN7.2
Rnor_6.01013,537,044 - 13,537,206NCBIRnor6.0
Rnor_5.01013,353,004 - 13,353,166UniSTSRnor5.0
RGSC_v3.41013,415,682 - 13,415,844UniSTSRGSC3.4
Celera1012,882,263 - 12,882,425UniSTS
Cytogenetic Map10q12UniSTS
Atp6c3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,196,216 - 13,196,405 (+)MAPPERmRatBN7.2
Rnor_6.01013,537,044 - 13,537,232NCBIRnor6.0
Rnor_5.01013,353,004 - 13,353,192UniSTSRnor5.0
RGSC_v3.41013,415,682 - 13,415,870UniSTSRGSC3.4
Celera1012,882,263 - 12,882,451UniSTS
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 17
Medium 3 43 57 41 19 41 8 11 57 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_130823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000008736   ⟹   ENSRNOP00000008736
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,196,207 - 13,201,206 (-)Ensembl
Rnor_6.0 Ensembl1013,537,033 - 13,542,077 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104238   ⟹   ENSRNOP00000087132
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,196,204 - 13,201,500 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113937   ⟹   ENSRNOP00000088542
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,196,204 - 13,201,243 (-)Ensembl
RefSeq Acc Id: NM_130823   ⟹   NP_570836
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21013,196,206 - 13,201,250 (-)NCBI
Rnor_6.01013,537,033 - 13,542,077 (-)NCBI
Rnor_5.01013,352,991 - 13,359,367 (-)NCBI
RGSC_v3.41013,415,671 - 13,420,715 (-)RGD
Celera1012,882,252 - 12,887,296 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245898   ⟹   XP_006245960
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21013,196,204 - 13,202,580 (-)NCBI
Rnor_6.01013,537,031 - 13,543,407 (-)NCBI
Rnor_5.01013,352,991 - 13,359,367 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_570836   ⟸   NM_130823
- UniProtKB: P23967 (UniProtKB/Swiss-Prot),   P63081 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245960   ⟸   XM_006245898
- Peptide Label: isoform X1
- UniProtKB: P23967 (UniProtKB/Swiss-Prot),   P63081 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008736   ⟸   ENSRNOT00000008736
RefSeq Acc Id: ENSRNOP00000087132   ⟸   ENSRNOT00000104238
RefSeq Acc Id: ENSRNOP00000088542   ⟸   ENSRNOT00000113937
Protein Domains
ATP-synt_C

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63081-F1-model_v2 AlphaFold P63081 1-155 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697004
Promoter ID:EPDNEW_R7529
Type:initiation region
Name:Atp6v0c_1
Description:ATPase H+ transporting V0 subunit C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01013,542,033 - 13,542,093EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621394 AgrOrtholog
BioCyc Gene G2FUF-25873 BioCyc
BioCyc Pathway PWY-7980 [ATP biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000006542 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008736.4 UniProtKB/TrEMBL
  ENSRNOP00000087132.1 UniProtKB/TrEMBL
  ENSRNOP00000088542 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008736.7 UniProtKB/TrEMBL
  ENSRNOT00000104238.1 UniProtKB/TrEMBL
  ENSRNOT00000113937 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6918203 IMAGE-MGC_LOAD
InterPro ATPase_proteolipid_c-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_proteolipid_csu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_proteolipid_su_C_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F/V-ATP_Csub_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170667 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72710 IMAGE-MGC_LOAD
NCBI Gene 170667 ENTREZGENE
Pfam ATP-synt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp6v0c PhenoGen
PRINTS VACATPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81333 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs V_ATP_synt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A7E7_RAT UniProtKB/TrEMBL
  A0A8L2Q4M1_RAT UniProtKB/TrEMBL
  P23967 ENTREZGENE
  P63081 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P23967 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Atp6v0c  ATPase H+ transporting V0 subunit C  Atp6v0c  ATPase, H+ transporting, lysosomal V0 subunit C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Atp6v0c  ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c  Atp6v0c  ATPase, H+ transporting, lysosomal V0 subunit C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27 Atp6v0c  ATPase, H+ transporting, lysosomal V0 subunit C  Atp6v0c  ATPase, H transporting, lysosomal V0 subunit c  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Atp6v0c  ATPase, H transporting, lysosomal V0 subunit c    ATPase, H+ transporting, V0 subunit C  Name updated 1299863 APPROVED
2005-01-20 Atp6v0c  ATPase, H+ transporting, V0 subunit C  Atp6l  ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa  Symbol and Name updated 1299863 APPROVED
2002-08-07 Atp6l  ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to lysosomes and to the Golgi apparatus 631903
gene_protein 16 kDa subunit 631903
gene_protein isoelectric point is 9.5 631903