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Gene: Fdps (farnesyl diphosphate synthase) Rattus norvegicus
Symbol: Fdps
Name: farnesyl diphosphate synthase
RGD ID: 68953
Description: Exhibits geranyltranstransferase activity. Involved in several processes, including farnesyl diphosphate biosynthetic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of cholesterol biosynthetic process. Localizes to mitochondrial matrix and peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
Also known as: (2E,6E)-farnesyl diphosphate synthase; Ac2-125; cholesterol-regulated 39 kDa protein; CR 39; dimethylallyltranstransferase; farensyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; Farnesyldiphosphate synthase; FPP synthase; FPP synthetase; FPS; geranyltranstransferase; testis-specific farnesyl pyrophosphate synthetase
Homo sapiens (human) : FDPS (farnesyl diphosphate synthase)  HGNC  Alliance
Mus musculus (house mouse) : Fdps (farnesyl diphosphate synthetase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fdps (farnesyl diphosphate synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : FDPS (farnesyl diphosphate synthase)
Canis lupus familiaris (dog) : FDPS (farnesyl diphosphate synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fdps (farnesyl diphosphate synthase)
Sus scrofa (pig) : FDPS (farnesyl diphosphate synthase)
Chlorocebus sabaeus (African green monkey) : FDPS (farnesyl diphosphate synthase)
Heterocephalus glaber (naked mole-rat) : Fdps (farnesyl diphosphate synthase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02188,403,595 - 188,413,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,392,858 - 188,413,219 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,816,332 - 207,826,348 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,138,474 - 181,177,903 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12181,119,007 - 181,128,009 (-)NCBI
Celera2168,441,483 - 168,451,110 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Fdps
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68953
Created: 2001-11-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.