Fdps (farnesyl diphosphate synthase) - Rat Genome Database

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Gene: Fdps (farnesyl diphosphate synthase) Rattus norvegicus
Analyze
Symbol: Fdps (Ensembl: Rusc1)
Name: farnesyl diphosphate synthase
RGD ID: 68953
Description: Enables geranyltranstransferase activity. Involved in several processes, including farnesyl diphosphate biosynthetic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of cholesterol biosynthetic process. Located in mitochondrial matrix and peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: (2E,6E)-farnesyl diphosphate synthase; Ac2-125; cholesterol-regulated 39 kDa protein; CR 39; dimethylallyltranstransferase; farensyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; Farnesyldiphosphate synthase; FPP synthase; FPP synthetase; FPS; geranyltranstransferase; testis-specific farnesyl pyrophosphate synthetase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22174,497,402 - 174,507,031 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,486,665 - 174,507,776 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,643,561 - 181,653,177 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02179,665,921 - 179,675,537 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02174,265,880 - 174,275,498 (-)NCBIRnor_WKY
Rnor_6.02188,403,595 - 188,413,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,392,858 - 188,413,219 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,816,332 - 207,826,348 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,138,474 - 181,177,903 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,119,007 - 181,128,009 (-)NCBI
Celera2168,441,483 - 168,451,110 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
alachlor  (EXP)
alendronic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
antimony(0)  (ISO)
Archazolid B  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
azoxystrobin  (ISO)
benzatropine  (ISO)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Di-n-hexyl phthalate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (ISO)
Dicyclohexyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dinophysistoxin 1  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
Ganoderic acid A  (ISO)
glafenine  (EXP)
hexaconazole  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
iodide salt  (EXP)
isopentenyl diphosphate  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
lead nitrate  (EXP)
lovastatin  (ISO)
manganese(II) chloride  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methyltestosterone  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (EXP)
nickel dichloride  (ISO)
nitrofen  (EXP)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
pamidronate  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylpropanolamine  (ISO)
picoxystrobin  (ISO)
pinosylvin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (ISO)
Risedronate sodium  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
trans-pinosylvin  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
zoledronic acid  (EXP,ISO)

References

References - curated
# Reference Title Reference Citation
1. Identification and regulation of a rat liver cDNA encoding farnesyl pyrophosphate synthetase. Ashby MN and Edwards PA, J Biol Chem. 1989 Jan 5;264(1):635-40.
2. Alendronate lowers cholesterol synthesis in the central nervous system of rats - a preliminary study. CIBICKOVA L, etal., Physiol Res. 2009;58(3):455-8. Epub 2008 Jul 18.
3. Molecular cloning and sequence of a cholesterol-repressible enzyme related to prenyltransferase in the isoprene biosynthetic pathway. Clarke CF, etal., Mol Cell Biol 1987 Sep;7(9):3138-46.
4. An integrated genetic linkage map with 1,137 markers constructed from five F2 crosses of autoimmune disease-prone and -resistant inbred rat strains. Dracheva SV, etal., Genomics 2000 Jan 15;63(2):202-26.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism. Gupta SD, etal., J Lipid Res. 1999 Sep;40(9):1572-84.
8. Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo. Heemers H, etal., Mol Cell Endocrinol. 2003 Jul 31;205(1-2):21-31.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes. Kovacs WJ, etal., Histochem Cell Biol. 2007 Mar;127(3):273-90. Epub 2006 Dec 19.
11. Farnesyl-diphosphate synthase is localized in peroxisomes. Krisans SK, etal., J Biol Chem. 1994 May 13;269(19):14165-9.
12. Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids. Le Jossic-Corcos C, etal., Biochem J. 2005 Feb 1;385(Pt 3):787-94.
13. Peroxisome proliferator-activated receptor alpha (PPARalpha) activators induce hepatic farnesyl diphosphate synthase gene expression in rodents. Le Jossic-Corcos C, etal., J Steroid Biochem Mol Biol. 2004 Feb;88(2):203-11.
14. Pituitary regulation of the expression of the farnesyl pyrophosphate synthetase gene in the testes of the sexually maturing rat. Nazian SJ, etal., J Androl. 1991 Jul-Aug;12(4):264-72.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Isoprenoid biosynthesis in rat liver mitochondria. Studies on farnesyl pyrophosphate synthase and trans-prenyltransferase. Runquist M, etal., J Biol Chem. 1994 Feb 25;269(8):5804-9.
24. Molecular cloning and promoter analysis of the rat liver farnesyl diphosphate synthase gene. Spear DH, etal., J Biol Chem 1992 Jul 15;267(20):14462-9.
25. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
26. Testis-specific transcripts of rat farnesyl pyrophosphate synthetase are developmentally regulated and localized to haploid germ cells. Teruya JH, etal., Biol Reprod. 1991 Apr;44(4):663-71.
27. Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA. Teruya JH, etal., Mol Cell Biol 1990 May;10(5):2315-26.
28. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
29. Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway. Ye Y, etal., FEBS Lett. 2009 Sep 17;583(18):2997-3003. Epub 2009 Aug 28.
Additional References at PubMed
PMID:18614015   PMID:19800872   PMID:22658674   PMID:24527834   PMID:24625528   PMID:25847782  


Genomics

Comparative Map Data
Fdps
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22174,497,402 - 174,507,031 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,486,665 - 174,507,776 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,643,561 - 181,653,177 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02179,665,921 - 179,675,537 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02174,265,880 - 174,275,498 (-)NCBIRnor_WKY
Rnor_6.02188,403,595 - 188,413,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,392,858 - 188,413,219 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,816,332 - 207,826,348 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,138,474 - 181,177,903 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,119,007 - 181,128,009 (-)NCBI
Celera2168,441,483 - 168,451,110 (-)NCBICelera
Cytogenetic Map2q34NCBI
FDPS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,308,866 - 155,320,665 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1155,308,748 - 155,320,666 (+)EnsemblGRCh38hg38GRCh38
GRCh371155,278,657 - 155,290,456 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,545,374 - 153,557,080 (+)NCBINCBI36Build 36hg18NCBI36
Build 341152,092,649 - 152,103,529NCBI
Celera1128,351,680 - 128,363,599 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1126,640,838 - 126,652,759 (+)NCBIHuRef
CHM1_11156,673,976 - 156,685,898 (+)NCBICHM1_1
T2T-CHM13v2.01154,447,406 - 154,459,205 (+)NCBIT2T-CHM13v2.0
Fdps
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,000,895 - 89,009,274 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,000,895 - 89,009,266 (-)EnsemblGRCm39 Ensembl
GRCm38389,093,588 - 89,101,967 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,093,588 - 89,101,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,897,510 - 88,905,867 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,179,515 - 89,187,872 (-)NCBIMGSCv36mm8
Celera389,132,279 - 89,140,636 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.01NCBI
Fdps
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,757,418 - 1,765,028 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555451,757,090 - 1,765,028 (+)NCBIChiLan1.0ChiLan1.0
FDPS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11134,258,881 - 134,270,237 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,258,968 - 134,270,237 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01130,653,316 - 130,665,196 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FDPS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,241,086 - 42,250,373 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,241,107 - 42,250,225 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,731,911 - 41,741,200 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,110,187 - 42,119,478 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,110,191 - 42,119,346 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,890,063 - 41,899,349 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,943,839 - 41,953,128 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,227,832 - 42,237,121 (-)NCBIUU_Cfam_GSD_1.0
Fdps
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,768,903 - 25,778,024 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365804,799,354 - 4,808,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FDPS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,500,141 - 94,518,408 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,500,140 - 94,514,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,291,797 - 103,304,940 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FDPS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,514,311 - 8,526,363 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660387,851,669 - 7,864,161 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fdps
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624885943,571 - 949,528 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624885942,998 - 949,529 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fdps
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:142
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000033917, ENSRNOT00000065065
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat

Markers in Region
D2Arb36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,507,381 - 174,507,593 (+)MAPPERmRatBN7.2
Rnor_6.02188,413,570 - 188,413,781NCBIRnor6.0
Rnor_5.02207,826,699 - 207,826,910UniSTSRnor5.0
RGSC_v3.42181,178,253 - 181,178,466RGDRGSC3.4
RGSC_v3.42181,178,254 - 181,178,466UniSTSRGSC3.4
RGSC_v3.12181,128,359 - 181,128,572RGD
Celera2168,451,461 - 168,451,672UniSTS
Cytogenetic Map2q34UniSTS
RH127967  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q34UniSTS
AA408288  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,487,951 - 174,488,122 (+)MAPPERmRatBN7.2
Rnor_6.02188,394,145 - 188,394,315NCBIRnor6.0
Rnor_5.02207,806,504 - 207,806,674UniSTSRnor5.0
RGSC_v3.42181,157,880 - 181,158,050UniSTSRGSC3.4
Celera2168,432,196 - 168,432,366UniSTS
Cytogenetic Map2q34UniSTS
AW534365  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,488,335 - 174,488,454 (+)MAPPERmRatBN7.2
Rnor_6.02188,394,529 - 188,394,647NCBIRnor6.0
Rnor_5.02207,806,888 - 207,807,006UniSTSRnor5.0
RGSC_v3.42181,158,264 - 181,158,382UniSTSRGSC3.4
Celera2168,432,580 - 168,432,698UniSTS
RH 3.4 Map21160.7UniSTS
Cytogenetic Map2q34UniSTS
RH128237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,488,052 - 174,488,233 (+)MAPPERmRatBN7.2
Rnor_6.02188,394,246 - 188,394,426NCBIRnor6.0
Rnor_5.02207,806,605 - 207,806,785UniSTSRnor5.0
RGSC_v3.42181,157,981 - 181,158,161UniSTSRGSC3.4
Celera2168,432,297 - 168,432,477UniSTS
RH 3.4 Map21156.2UniSTS
Cytogenetic Map2q34UniSTS
BQ193911  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,486,692 - 174,486,851 (+)MAPPERmRatBN7.2
Rnor_6.02188,392,886 - 188,393,044NCBIRnor6.0
Rnor_5.02207,805,245 - 207,805,403UniSTSRnor5.0
RGSC_v3.42181,156,621 - 181,156,779UniSTSRGSC3.4
Celera2168,430,937 - 168,431,095UniSTS
RH 3.4 Map21162.0UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 57 41 19 41 8 11 74 35 41 11 8
Low 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M89945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000033917   ⟹   ENSRNOP00000031191
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,486,665 - 174,506,182 (-)Ensembl
Rnor_6.0 Ensembl2188,392,858 - 188,412,329 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000065065   ⟹   ENSRNOP00000058918
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,497,399 - 174,506,141 (-)Ensembl
Rnor_6.0 Ensembl2188,403,595 - 188,413,219 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080185   ⟹   ENSRNOP00000070394
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,497,405 - 174,506,923 (-)Ensembl
Rnor_6.0 Ensembl2188,403,583 - 188,412,362 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094500   ⟹   ENSRNOP00000083196
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,487,922 - 174,493,757 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103438   ⟹   ENSRNOP00000096239
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,487,922 - 174,507,776 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118716   ⟹   ENSRNOP00000076679
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,487,922 - 174,507,362 (-)Ensembl
RefSeq Acc Id: NM_031840   ⟹   NP_114028
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,497,402 - 174,507,031 (-)NCBI
Rnor_6.02188,403,595 - 188,413,219 (-)NCBI
Rnor_5.02207,816,332 - 207,826,348 (-)NCBI
RGSC_v3.42181,138,474 - 181,177,903 (-)RGD
Celera2168,441,483 - 168,451,110 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_114028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40960 (Get FASTA)   NCBI Sequence Viewer  
  AAA41143 (Get FASTA)   NCBI Sequence Viewer  
  AAH59125 (Get FASTA)   NCBI Sequence Viewer  
  EDM00669 (Get FASTA)   NCBI Sequence Viewer  
  P05369 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_114028   ⟸   NM_031840
- UniProtKB: P05369 (UniProtKB/Swiss-Prot),   F1LND7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031191   ⟸   ENSRNOT00000033917
RefSeq Acc Id: ENSRNOP00000070394   ⟸   ENSRNOT00000080185
RefSeq Acc Id: ENSRNOP00000058918   ⟸   ENSRNOT00000065065
RefSeq Acc Id: ENSRNOP00000076679   ⟸   ENSRNOT00000118716
RefSeq Acc Id: ENSRNOP00000083196   ⟸   ENSRNOT00000094500
RefSeq Acc Id: ENSRNOP00000096239   ⟸   ENSRNOT00000103438
Protein Domains
RUN   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05369-F1-model_v2 AlphaFold P05369 1-353 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691456
Promoter ID:EPDNEW_R1981
Type:initiation region
Name:Fdps_1
Description:farnesyl diphosphate synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02188,413,113 - 188,413,173EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68953 AgrOrtholog
BioCyc Gene G2FUF-52455 BioCyc
BioCyc Pathway PWY-5122 [geranyl diphosphate biosynthesis] BioCyc
  PWY-5123 [trans, trans-farnesyl diphosphate biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000043377 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000031191.4 UniProtKB/TrEMBL
  ENSRNOP00000058918.3 UniProtKB/TrEMBL
  ENSRNOP00000070394 ENTREZGENE
  ENSRNOP00000070394.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033917.7 UniProtKB/TrEMBL
  ENSRNOT00000065065.3 UniProtKB/TrEMBL
  ENSRNOT00000080185 ENTREZGENE
  ENSRNOT00000080185.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.600.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.900 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6919326 IMAGE-MGC_LOAD
InterPro Isoprenoid_synthase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Polyprenyl_synt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Polyprenyl_synt_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Run UniProtKB/TrEMBL
  Run_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report rno:83791 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72758 IMAGE-MGC_LOAD
NCBI Gene 83791 ENTREZGENE
Pfam polyprenyl_synt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
  SH3_9 UniProtKB/TrEMBL
PharmGKB FDPS RGD
PhenoGen Fdps PhenoGen
PROSITE POLYPRENYL_SYNTHASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLYPRENYL_SYNTHASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART RUN UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SH3 UniProtKB/TrEMBL
  SSF140741 UniProtKB/TrEMBL
  SSF48576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JXT3_RAT UniProtKB/TrEMBL
  F1LND7 ENTREZGENE, UniProtKB/TrEMBL
  FPPS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TPK0_RAT UniProtKB/TrEMBL
UniProt Secondary F1LMQ2 UniProtKB/TrEMBL
  Q6GT82 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Fdps  farnesyl diphosphate synthase  Fdps  farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Fdps  farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)  Fdps  farnesyl diphosphate synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Fdps  farnesyl diphosphate synthetase  Fdps  farnesyl diphosphate synthase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-11   farnesyl diphosphate synthase  Fdps  farensyl diphosphate synthase  Name updated 1299863 APPROVED
2002-06-10 Fdps  farensyl diphosphate synthase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the formation of geranyl- and farnesylpyrophosphate from the condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate  
gene_pathway part of isoprene biosynthetic pathway, which provides the cell with cholesterol, ubiquinone, dolichol, and other nonsterol metabolites 61515
gene_process functions in the isoprene biosynthetic pathway  
gene_regulation co-regulated with HMG-CoA synthase and HMG-CoA reductase 61515