Fdps (farnesyl diphosphate synthase)

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Gene: Fdps (farnesyl diphosphate synthase) Rattus norvegicus

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Symbol:

Fdps

Name:

farnesyl diphosphate synthase

RGD ID:

68953

Description:

Exhibits geranyltranstransferase activity. Involved in several processes, including farnesyl diphosphate biosynthetic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of cholesterol biosynthetic process. Localizes to mitochondrial matrix and peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

(2E,6E)-farnesyl diphosphate synthase; Ac2-125; cholesterol-regulated 39 kDa protein; CR 39; dimethylallyltranstransferase; farensyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; Farnesyldiphosphate synthase; FPP synthase; FPP synthetase; FPS; geranyltranstransferase; testis-specific farnesyl pyrophosphate synthetase

Orthologs:

Homo sapiens (human) : FDPS (farnesyl diphosphate synthase) HGNC Alliance
Mus musculus (house mouse) : Fdps (farnesyl diphosphate synthetase) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fdps (farnesyl diphosphate synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : FDPS (farnesyl diphosphate synthase)
Canis lupus familiaris (dog) : FDPS (farnesyl diphosphate synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fdps (farnesyl diphosphate synthase)
Sus scrofa (pig) : FDPS (farnesyl diphosphate synthase)
Chlorocebus sabaeus (African green monkey) : FDPS (farnesyl diphosphate synthase)
Heterocephalus glaber (naked mole-rat) : Fdps (farnesyl diphosphate synthase)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FDPS (farnesyl diphosphate synthase)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Fdps (farnesyl diphosphate synthetase)	HGNC	Treefam, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Fdps (farnesyl diphosphate synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FDPS (farnesyl diphosphate synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FDPS (farnesyl diphosphate synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fdps (farnesyl diphosphate synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FDPS (farnesyl diphosphate synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	FDPS (farnesyl diphosphate synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fdps (farnesyl diphosphate synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RUSC1 (RUN and SH3 domain containing 1)	HGNC	EggNOG, Ensembl
Alliance orthologs ³
Homo sapiens (human):	FDPS (farnesyl diphosphate synthase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Fdps (farnesyl diphosphate synthetase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Danio rerio (zebrafish):	fdps (farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase))	Alliance	DIOPT (PhylomeDB\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	ERG20	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Fpps	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	fdps-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

NCBI Annotation Information:

Annotation category: suggests misassembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	2	188,403,595 - 188,413,219 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	188,392,858 - 188,413,219 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	207,816,332 - 207,826,348 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	181,138,474 - 181,177,903 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	181,119,007 - 181,128,009 (-)	NCBI
Celera	2	168,441,483 - 168,451,110 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

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Strain Sequence Variants (Rnor 6.0)

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Additional Information

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Nomenclature History

RGD Curation Notes

More on Fdps
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: rn5 rn6
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	68953
Created:	2001-11-06
Species:	Rattus norvegicus
Last Modified:	2020-08-20
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - ClinVar

Imported Annotations - CTD

Imported Annotations - OMIM

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Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)