Oxt (oxytocin/neurophysin I prepropeptide) - Rat Genome Database

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Gene: Oxt (oxytocin/neurophysin I prepropeptide) Rattus norvegicus
Analyze
Symbol: Oxt
Name: oxytocin/neurophysin I prepropeptide
RGD ID: 3238
Description: Exhibits neuropeptide hormone activity and oxytocin receptor binding activity. Involved in several processes, including mating; positive regulation of smooth muscle contraction; and regulation of secretion. Localizes to extracellular space; secretory granule; and terminal bouton. Used to study gastric ulcer and hypertension. Biomarker of hypertension. Orthologous to human OXT (oxytocin/neurophysin I prepropeptide); PARTICIPATES IN oxytocin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,4-D.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: OT-NPI; oxcytocin; oxytocin; oxytocin, prepropeptide; oxytocin-neurophysin 1; Oxytocin/neurophysin; oxytocin/neurophysin (Oxt) gene, complete gene, complete cds; oxytocin/neurophysin 1 prepropeptide; Rat oxytocin/neurophysin (Oxt) gene complete gene complete cds
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23117,782,650 - 117,783,490 (+)NCBI
Rnor_6.0 Ensembl3123,106,694 - 123,107,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03123,106,694 - 123,107,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03129,604,822 - 129,605,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,194,219 - 118,195,056 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13118,097,303 - 118,100,512 (+)NCBI
Celera3116,593,509 - 116,594,349 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
drinking behavior  (IDA)
eating behavior  (IDA)
female pregnancy  (IEP)
grooming behavior  (IDA)
heart development  (IEP)
hyperosmotic salinity response  (IEP)
lactation  (TAS)
male mating behavior  (IEP)
maternal aggressive behavior  (IEP)
maternal behavior  (IDA)
memory  (IEP)
negative regulation of blood pressure  (IMP)
negative regulation of gastric acid secretion  (IDA)
negative regulation of urine volume  (IDA)
parturition  (TAS)
positive regulation of blood pressure  (IDA)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of female receptivity  (IDA)
positive regulation of hindgut contraction  (IDA)
positive regulation of norepinephrine secretion  (IDA)
positive regulation of ossification  (IDA)
positive regulation of penile erection  (IDA)
positive regulation of prostaglandin secretion  (IDA)
positive regulation of renal sodium excretion  (IDA)
positive regulation of synapse assembly  (IDA)
positive regulation of synaptic transmission  (IDA)
positive regulation of uterine smooth muscle contraction  (IDA)
regulation of digestive system process  (IDA)
regulation of heart rate  (IDA)
regulation of sensory perception of pain  (IDA)
response to activity  (IEP)
response to amphetamine  (IEP)
response to cAMP  (IEP)
response to cocaine  (IEP)
response to electrical stimulus  (IEP)
response to estradiol  (IEP)
response to ether  (IEP)
response to external biotic stimulus  (ISS)
response to food  (IEP,ISS)
response to glucocorticoid  (IEP)
response to mechanical stimulus  (ISS)
response to organic cyclic compound  (IDA,IEP)
response to peptide hormone  (IEP)
response to progesterone  (IDA)
response to prostaglandin E  (IEP)
response to retinoic acid  (IEP)
response to steroid hormone  (IEP)
response to sucrose  (IEP)
signal transduction  (IEA)
sleep  (IDA)
social behavior  (IDA)
sperm ejaculation  (IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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6. Ciosek J J Physiol Pharmacol 2002 Sep;53(3):423-37.
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8. Dusunceli F, etal., Peptides. 2008 Jul;29(7):1216-22. Epub 2008 Feb 26.
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10. Elabd SK, etal., Endocr Regul. 2007 Nov;41(4):131-41.
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12. Figueira RJ, etal., Behav Neurosci. 2008 Jun;122(3):618-28.
13. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. GOA data from the GO Consortium
15. Gupta J, etal., Br J Pharmacol. 2008 Sep;155(1):118-26. Epub 2008 Jun 16.
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17. Hoare S, etal., J Biol Chem. 1999 Oct 1;274(40):28682-9.
18. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
19. Huber D, etal., Science. 2005 Apr 8;308(5719):245-8.
20. Iseri SO, etal., Burns. 2008 May;34(3):361-9. Epub 2007 Sep 10.
21. Ivell R and Richter D, Proc Natl Acad Sci U S A 1984 Apr;81(7):2006-10.
22. Jankowski M, etal., Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13074-9. Epub 2004 Aug 17.
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24. Juszczak M and Boczek-Leszczyk E, J Physiol Pharmacol. 2008 Sep;59(3):553-62.
25. Kasahara Y, etal., Biosci Biotechnol Biochem. 2007 Dec;71(12):3122-6. doi: 10.1271/bbb.70498. Epub 2007 Dec 7.
26. Kumcu EK, etal., Eur J Pharmacol. 2009 Mar 1;605(1-3):158-63.
27. Lancel M, etal., Regul Pept. 2003 Jul 15;114(2-3):145-52.
28. Larrazolo-Lopez A, etal., Neuroscience. 2008 Mar 27;152(3):585-93. Epub 2008 Jan 25.
29. Lee PR, etal., Brain Res. 2007 Jul 2;1156:152-67. Epub 2007 Apr 22.
30. Li C, etal., J Am Soc Nephrol. 2008 Feb;19(2):225-32. Epub 2007 Dec 5.
31. Ludwig M, etal., Nature 2002 Jul 4;418(6893):85-9.
32. Lukas M, etal., Neuropharmacology. 2009 Jun 26.
33. Magalhaes J, etal., Reprod Sci. 2009 Jan 22.
34. Marroni SS, etal., Mol Psychiatry. 2007 Dec;12(12):1103-17. Epub 2007 May 15.
35. Martinez-Lorenzana G, etal., Pain. 2008 Nov 30;140(2):265-73. Epub 2008 Sep 26.
36. Martins AS, etal., Hypertension. 2005 Oct;46(4):1004-9. Epub 2005 Sep 12.
37. McMurray MS, etal., Stress. 2008;11(5):398-410.
38. MGD data from the GO Consortium
39. Morel G, etal., Cell Tissue Res. 2001 Jun;304(3):377-82.
40. NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. Ochedalski T, etal., J Neuroendocrinol. 2007 Mar;19(3):189-97.
42. Olszewski PK, etal., Peptides. 2009 Feb;30(2):226-33. Epub 2008 Oct 30.
43. Onaka T, etal., Eur J Neurosci. 2003 Dec;18(11):3018-26.
44. Ondrejcakova M, etal., Can J Physiol Pharmacol. 2009 Feb;87(2):137-42.
45. Peters JH, etal., J Neurosci. 2008 Nov 5;28(45):11731-40.
46. Petersson M and Uvnas-Moberg K, Neurosci Lett. 2008 Aug 1;440(2):166-9. Epub 2008 Jun 16.
47. Pournajafi-Nazarloo H, etal., Peptides. 2007 Jun;28(6):1170-7. Epub 2007 May 6.
48. Rehbein M, etal., Biol Chem Hoppe Seyler 1986 Aug;367(8):695-704.
49. RGD automated data pipeline
50. RGD automated import pipeline for gene-chemical interactions
51. Ruginsk SG, etal., Exp Neurol. 2007 Aug;206(2):192-200. Epub 2007 May 10.
52. Sakamoto T, etal., Biochem Biophys Res Commun. 2008 Oct 10;375(1):49-53. Epub 2008 Aug 12.
53. Schmitz E, etal., DNA Cell Biol 1991 Mar;10(2):81-91.
54. Song Z, etal., J Neuroendocrinol. 2001 Feb;13(2):158-65.
55. Strakova Z, etal., Am J Physiol. 1998 Apr;274(4 Pt 1):E634-41.
56. Succu S, etal., Eur J Neurosci. 2008 Aug;28(4):813-21. Epub 2008 Jul 30.
57. Sun X, etal., J Sex Med. 2009 Jan;6(1):81-90. Epub 2008 Nov 5.
58. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
59. Theodosis DT, etal., Mol Cell Neurosci. 2006 Apr;31(4):785-94. Epub 2006 Feb 20.
60. Thompson MR, etal., Neuroscience. 2007 May 11;146(2):509-14. Epub 2007 Mar 23.
61. Veenema AH and Neumann ID, Prog Brain Res. 2008;170:261-76.
62. Verty AN, etal., Neuropharmacology. 2004 Sep;47(4):593-603.
63. Wang D, etal., Cardiovasc Res. 2003 Jan;57(1):186-94.
64. Wang YF and Hatton GI, J Neurosci. 2007 Feb 21;27(8):1902-12.
65. Widmer H, etal., J Physiol. 2003 Apr 1;548(Pt 1):233-44. Epub 2003 Feb 14.
66. Wu CL, etal., Naunyn Schmiedebergs Arch Pharmacol. 2003 Apr;367(4):406-13. Epub 2003 Feb 26.
67. Yang J, etal., Neuropeptides. 2007 Oct;41(5):285-92. Epub 2007 Jul 30.
68. Yashpal K, etal., J Auton Nerv Syst. 1987 Aug;20(2):167-78.
69. Yue C, etal., J Neuroendocrinol. 2008 Feb;20(2):227-32. Epub 2007 Dec 14.
70. Zelena D, etal., Endocrinology. 2009 Feb 26.
71. Zierer R Life Sci. 1991;49(19):1391-7.
Additional References at PubMed
PMID:891987   PMID:3008332   PMID:3203740   PMID:5150741   PMID:6689019   PMID:7036996   PMID:7238864   PMID:12383972   PMID:12475730   PMID:12787053   PMID:12834434   PMID:12907752  
PMID:15033917   PMID:15044184   PMID:15149956   PMID:15358676   PMID:15975651   PMID:16033890   PMID:16354922   PMID:16357095   PMID:16439458   PMID:16513365   PMID:16677710   PMID:16875693  
PMID:17170309   PMID:17332000   PMID:17524563   PMID:17568668   PMID:17593952   PMID:17615142   PMID:17925443   PMID:18006631   PMID:18039781   PMID:18048495   PMID:18293170   PMID:18510735  
PMID:18579201   PMID:18996098   PMID:19106214   PMID:19258669   PMID:19269259   PMID:19420012   PMID:19429063   PMID:19493620   PMID:19595642   PMID:19625689   PMID:19638362   PMID:19703497  
PMID:19723921   PMID:19766607   PMID:19769589   PMID:20015826   PMID:20036647   PMID:20146024   PMID:20224888   PMID:20399835   PMID:20580660   PMID:20621145   PMID:20624160   PMID:20688065  
PMID:21061153   PMID:21207221   PMID:21382355   PMID:21439337   PMID:21481539   PMID:21545817   PMID:21858088   PMID:21858181   PMID:21872599   PMID:21920364   PMID:22083216   PMID:22100184  
PMID:22197269   PMID:22245139   PMID:22266748   PMID:22326383   PMID:22363799   PMID:22464293   PMID:22872656   PMID:23102690   PMID:23136757   PMID:23142109   PMID:23225240   PMID:23474276  
PMID:23515287   PMID:23550008   PMID:23551170   PMID:23680380   PMID:23888412   PMID:23912682   PMID:24010161   PMID:24042175   PMID:24342802   PMID:24389591   PMID:24403294   PMID:24444823  
PMID:24518793   PMID:24631553   PMID:25047873   PMID:25089000   PMID:25126708   PMID:25451978   PMID:25559382   PMID:25637830   PMID:25702774   PMID:25976631   PMID:26177679   PMID:26830961  
PMID:27016581   PMID:27529669   PMID:27829122   PMID:29118105   PMID:30166555   PMID:30176320   PMID:30633838   PMID:30826070   PMID:31499086   PMID:31820102   PMID:32571836   PMID:32726160  


Genomics

Candidate Gene Status
Oxt is a candidate Gene for QTL Bp37
Comparative Map Data
Oxt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23117,782,650 - 117,783,490 (+)NCBI
Rnor_6.0 Ensembl3123,106,694 - 123,107,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03123,106,694 - 123,107,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03129,604,822 - 129,605,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,194,219 - 118,195,056 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13118,097,303 - 118,100,512 (+)NCBI
Celera3116,593,509 - 116,594,349 (+)NCBICelera
Cytogenetic Map3q36NCBI
OXT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl203,071,620 - 3,072,517 (+)EnsemblGRCh38hg38GRCh38
GRCh38203,068,871 - 3,072,517 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37203,052,266 - 3,053,163 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,000,266 - 3,001,162 (+)NCBINCBI36hg18NCBI36
Build 34203,000,265 - 3,001,162NCBI
Celera203,114,251 - 3,115,147 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef202,998,607 - 2,999,505 (+)NCBIHuRef
CHM1_1203,046,806 - 3,047,704 (+)NCBICHM1_1
Oxt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,416,432 - 130,418,974 (+)NCBIGRCm39mm39
GRCm39 Ensembl2130,418,093 - 130,418,974 (+)Ensembl
GRCm382130,574,519 - 130,577,054 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,576,173 - 130,577,054 (+)EnsemblGRCm38mm10GRCm38
MGSCv372130,401,909 - 130,402,724 (+)NCBIGRCm37mm9NCBIm37
MGSCv362130,267,614 - 130,268,429 (+)NCBImm8
Celera2131,800,597 - 131,801,412 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.24NCBI
OXT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0203,157,246 - 3,159,013 (+)NCBIMhudiblu_PPA_v0panPan3
OXT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12418,193,381 - 18,194,232 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2418,193,339 - 18,194,170 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2418,021,790 - 18,022,393 (-)NCBI
ROS_Cfam_1.02418,612,328 - 18,612,968 (-)NCBI
UMICH_Zoey_3.12418,205,647 - 18,206,253 (-)NCBI
UNSW_CanFamBas_1.02418,318,339 - 18,318,942 (-)NCBI
UU_Cfam_GSD_1.02418,646,119 - 18,646,759 (-)NCBI
OXT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1732,605,588 - 32,606,483 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11732,605,586 - 32,606,449 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,975,726 - 36,976,589 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OXT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,749,520 - 33,750,981 (+)NCBI
ChlSab1.1 Ensembl233,750,108 - 33,750,968 (+)Ensembl
Oxt
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247414,200,594 - 4,201,416 (+)NCBI

Position Markers
RH142212  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23117,782,845 - 117,782,996 (+)MAPPER
Rnor_6.03123,106,890 - 123,107,040NCBIRnor6.0
Rnor_5.03129,605,018 - 129,605,168UniSTSRnor5.0
RGSC_v3.43118,194,415 - 118,194,565UniSTSRGSC3.4
Celera3116,593,705 - 116,593,855UniSTS
Cytogenetic Map3q36UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)330114912123700444Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)339248391140271184Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)345406058127023997Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)348561928155263151Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)351821836124513579Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)362922868127023997Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)372672290127023997Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)372973445127023997Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)378700444123700444Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)381136227154416635Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)388910015133910015Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)394788365139788365Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)397009185142009185Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)399465522168732722Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3101058963146058963Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3102152812155263151Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3102466149147466149Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3103141944170934860Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3114376250159376250Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3117303473141971336Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3119471263164471263Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3120917788141971336Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3120917788141971336Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:41
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000028829
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 25 4
Below cutoff 1 2 6 5 1 5 1 3 28 12 20 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028829   ⟹   ENSRNOP00000028829
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3123,106,694 - 123,107,534 (+)Ensembl
RefSeq Acc Id: NM_012996   ⟹   NP_037128
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23117,782,650 - 117,783,490 (+)NCBI
Rnor_6.03123,106,694 - 123,107,534 (+)NCBI
Rnor_5.03129,604,822 - 129,605,662 (+)NCBI
RGSC_v3.43118,194,219 - 118,195,056 (+)RGD
Celera3116,593,509 - 116,594,349 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037128   ⟸   NM_012996
- Peptide Label: preproprotein
- UniProtKB: P01179 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028829   ⟸   ENSRNOT00000028829

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692436
Promoter ID:EPDNEW_R2960
Type:single initiation site
Name:Oxt_1
Description:oxytocin/neurophysin 1 prepropeptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03123,106,695 - 123,106,755EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3238 AgrOrtholog
Ensembl Genes ENSRNOG00000021225 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000028829 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028829 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.9.10 UniProtKB/Swiss-Prot
InterPro Neurhyp_horm UniProtKB/Swiss-Prot
  Neurhyp_horm_dom_sf UniProtKB/Swiss-Prot
  Neurohypophysial_hormone_CS UniProtKB/Swiss-Prot
KEGG Report rno:25504 UniProtKB/Swiss-Prot
NCBI Gene 25504 ENTREZGENE
PANTHER PTHR11681 UniProtKB/Swiss-Prot
Pfam Hormone_4 UniProtKB/Swiss-Prot
  Hormone_5 UniProtKB/Swiss-Prot
PhenoGen Oxt PhenoGen
PIRSF Nonapeptide_hormone_precursor UniProtKB/Swiss-Prot
PRINTS NEUROPHYSIN UniProtKB/Swiss-Prot
PROSITE NEUROHYPOPHYS_HORM UniProtKB/Swiss-Prot
SMART SM00003 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49606 UniProtKB/Swiss-Prot
TIGR TC207027
UniProt NEU1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q53WU2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-04 Oxt  oxytocin/neurophysin I prepropeptide  Oxt  oxytocin/neurophysin I prepropeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-04 Oxt  oxytocin/neurophysin I prepropeptide  Oxt  oxytocin/neurophysin 1 prepropeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-11-07 Oxt  oxytocin/neurophysin 1 prepropeptide  Oxt  oxytocin, prepropeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Oxt  oxytocin, prepropeptide  Oxt  oxytocin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Oxt  oxcytocin      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression protein synthesized by magnocellular neurons of the supraoptic and paraventricular nuclei of the hypothalamus; synthesized in ovary, thymus, kidneys, heart and vasculature 631223
gene_mapping maps to the Bp37 QTL region and proposed to be a candidate gene for blood pressure regulation 631223
gene_process reduces mean arterial pressure and peripheral resistance; may play a role in body fluid hemeostasis 631223
gene_regulation biosynthesis and secretion are regulated by thyrotropin-releasing hormone (TRH) 634240