Oxt (oxytocin/neurophysin I prepropeptide) - Rat Genome Database

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Gene: Oxt (oxytocin/neurophysin I prepropeptide) Rattus norvegicus
Symbol: Oxt
Name: oxytocin/neurophysin I prepropeptide
RGD ID: 3238
Description: Enables neuropeptide hormone activity and oxytocin receptor binding activity. Involved in several processes, including positive regulation of smooth muscle contraction; regulation of secretion; and response to steroid hormone. Located in extracellular space; secretory granule; and terminal bouton. Used to study gastric ulcer and hypertension. Biomarker of hypertension. Orthologous to human OXT (oxytocin/neurophysin I prepropeptide); PARTICIPATES IN oxytocin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,4-D.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: OT-NPI; oxcytocin; oxytocin; oxytocin, prepropeptide; oxytocin-neurophysin 1; Oxytocin/neurophysin; oxytocin/neurophysin (Oxt) gene, complete gene, complete cds; oxytocin/neurophysin 1 prepropeptide; Rat oxytocin/neurophysin (Oxt) gene complete gene complete cds
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bp37
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.23117,782,650 - 117,783,490 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,782,650 - 117,783,490 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3121,677,109 - 121,677,940 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03130,274,375 - 130,275,205 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03127,933,240 - 127,934,071 (+)NCBIRnor_WKY
Rnor_6.03123,106,694 - 123,107,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,106,694 - 123,107,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03129,604,822 - 129,605,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,194,219 - 118,195,056 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,097,303 - 118,100,512 (+)NCBI
Celera3116,593,509 - 116,594,349 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
drinking behavior  (IDA)
eating behavior  (IDA)
female pregnancy  (IEP)
grooming behavior  (IDA)
heart development  (IEP)
hyperosmotic salinity response  (IEP)
lactation  (TAS)
male mating behavior  (IEP)
maternal aggressive behavior  (IEP)
maternal behavior  (IDA)
memory  (IEP)
negative regulation of blood pressure  (IMP)
negative regulation of gastric acid secretion  (IDA)
negative regulation of urine volume  (IDA)
parturition  (TAS)
positive regulation of blood pressure  (IDA)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of female receptivity  (IDA)
positive regulation of hindgut contraction  (IDA)
positive regulation of norepinephrine secretion  (IDA)
positive regulation of ossification  (IDA)
positive regulation of penile erection  (IDA)
positive regulation of prostaglandin secretion  (IDA)
positive regulation of renal sodium excretion  (IDA)
positive regulation of synapse assembly  (IDA)
positive regulation of synaptic transmission  (IDA)
positive regulation of uterine smooth muscle contraction  (IDA)
regulation of digestive system process  (IDA)
regulation of heart rate  (IDA)
regulation of sensory perception of pain  (IDA)
response to activity  (IEP)
response to amphetamine  (IEP)
response to cAMP  (IEP)
response to cocaine  (IEP)
response to electrical stimulus  (IEP)
response to estradiol  (IEP)
response to ether  (IEP)
response to external biotic stimulus  (ISS)
response to food  (IEP,ISS)
response to glucocorticoid  (IEP)
response to mechanical stimulus  (ISS)
response to organic cyclic compound  (IDA,IEP)
response to peptide hormone  (IEP)
response to progesterone  (IDA)
response to prostaglandin E  (IEP)
response to retinoic acid  (IEP)
response to steroid hormone  (IEP)
response to sucrose  (IEP)
signal transduction  (IEA)
sleep  (IDA)
social behavior  (IDA)
sperm ejaculation  (IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Relationship between gene expression and function of uterotonic systems in the rat during gestation, uterine activation and both term and preterm labour. Arthur P, etal., J Physiol. 2008 Dec 15;586(Pt 24):6063-76. Epub 2008 Oct 20.
2. Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs. Asad M, etal., Life Sci. 2001 Nov 21;70(1):17-24.
3. Phenylethanolamine N-methyltransferase gene expression in the heart and blood pressure response to oxytocin treatment in rats exposed to voluntary wheel running. Bakos J, etal., Ann N Y Acad Sci. 2008 Dec;1148:302-7.
4. CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. Bale TL, etal., J Neurosci. 2001 Apr 1;21(7):2546-52.
5. Oxytocin, water intake, and food sodium availability in male rats. Bernal A, etal., Horm Behav. 2007 Sep;52(3):289-96. Epub 2007 May 22.
6. Vasopressin and oxytocin release as influenced by thyrotropin-releasing hormone in euhydrated and dehydrated rats. Ciosek J J Physiol Pharmacol 2002 Sep;53(3):423-37.
7. Time course of c-fos, vasopressin and oxytocin mRNA expression in the hypothalamus following long-term dehydration. da Silveira LT, etal., Cell Mol Neurobiol. 2007 Aug;27(5):575-84.
8. Oxytocin alleviates hepatic ischemia-reperfusion injury in rats. Dusunceli F, etal., Peptides. 2008 Jul;29(7):1216-22. Epub 2008 Feb 26.
9. Chromosomal and comparative mapping of rat oxytocin, oxytocin receptor and vasopressin genes. Dutil J, etal., Cytogenet Cell Genet 2001;93(1-2):57-9.
10. Possible neuroendocrine role for oxytocin in bone remodeling. Elabd SK, etal., Endocr Regul. 2007 Nov;41(4):131-41.
11. Estradiol Upregulates the Expression of Oxytocin Receptor in Colon in Rats. Feng M, etal., Am J Physiol Endocrinol Metab. 2009 Mar 3.
12. Oxytocin receptor activity in the ventrocaudal periaqueductal gray modulates anxiety-related behavior in postpartum rats. Figueira RJ, etal., Behav Neurosci. 2008 Jun;122(3):618-28.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V(1A) receptors and not oxytocin receptors. Gupta J, etal., Br J Pharmacol. 2008 Sep;155(1):118-26. Epub 2008 Jun 16.
16. Microarray analysis of the transcriptome of the subfornical organ in the rat: regulation by fluid and food deprivation. Hindmarch C, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1914-20. Epub 2008 Oct 1.
17. The proximal portion of the COOH terminus of the oxytocin receptor is required for coupling to g(q), but not g(i). Independent mechanisms for elevating intracellular calcium concentrations from intracellular stores. Hoare S, etal., J Biol Chem. 1999 Oct 1;274(40):28682-9.
18. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
19. Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Huber D, etal., Science. 2005 Apr 8;308(5719):245-8.
20. Oxytocin ameliorates skin damage and oxidant gastric injury in rats with thermal trauma. Iseri SO, etal., Burns. 2008 May;34(3):361-9. Epub 2007 Sep 10.
21. Structure and comparison of the oxytocin and vasopressin genes from rat. Ivell R and Richter D, Proc Natl Acad Sci U S A 1984 Apr;81(7):2006-10.
22. Oxytocin in cardiac ontogeny. Jankowski M, etal., Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13074-9. Epub 2004 Aug 17.
23. Co-expression of vasopressin and androgen-binding protein in the rat hypothalamus. Jirikowski GF, etal., J Chem Neuroanat. 2005 Jun;29(4):233-7. Epub 2005 Mar 17.
24. Oxytocin release from the rat neurohypophysis into the blood: effects of tachykinin NK-1 and NK-2 receptors agonists and antagonists. Juszczak M and Boczek-Leszczyk E, J Physiol Pharmacol. 2008 Sep;59(3):553-62.
25. Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure. Kasahara Y, etal., Biosci Biotechnol Biochem. 2007 Dec;71(12):3122-6. doi: 10.1271/bbb.70498. Epub 2007 Dec 7.
26. Differential effect of neocuproine, a copper(I) chelator, on contractile activity in isolated ovariectomized non-pregnant rat, pregnant rat and pregnant human uterus. Kumcu EK, etal., Eur J Pharmacol. 2009 Mar 1;605(1-3):158-63.
27. Intracerebral oxytocin modulates sleep-wake behaviour in male rats. Lancel M, etal., Regul Pept. 2003 Jul 15;114(2-3):145-52.
28. Vaginocervical stimulation enhances social recognition memory in rats via oxytocin release in the olfactory bulb. Larrazolo-Lopez A, etal., Neuroscience. 2008 Mar 27;152(3):585-93. Epub 2008 Jan 25.
29. Prenatal stress generates deficits in rat social behavior: Reversal by oxytocin. Lee PR, etal., Brain Res. 2007 Jul 2;1156:152-67. Epub 2007 Apr 22.
30. Molecular mechanisms of antidiuretic effect of oxytocin. Li C, etal., J Am Soc Nephrol. 2008 Feb;19(2):225-32. Epub 2007 Dec 5.
31. Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites. Ludwig M, etal., Nature 2002 Jul 4;418(6893):85-9.
32. Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats. Lukas M, etal., Neuropharmacology. 2009 Jun 26.
33. Oxytocin Pretreatment Decreases Oxytocin-induced Myometrial Contractions in Pregnant Rats in a Concentration-dependent But Not Time-dependent Manner. Magalhaes J, etal., Reprod Sci. 2009 Jan 22.
34. Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior. Marroni SS, etal., Mol Psychiatry. 2007 Dec;12(12):1103-17. Epub 2007 May 15.
35. PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats. Martinez-Lorenzana G, etal., Pain. 2008 Nov 30;140(2):265-73. Epub 2008 Sep 26.
36. Hypertension and exercise training differentially affect oxytocin and oxytocin receptor expression in the brain. Martins AS, etal., Hypertension. 2005 Oct;46(4):1004-9. Epub 2005 Sep 12.
37. Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams. McMurray MS, etal., Stress. 2008;11(5):398-410.
38. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
39. Intrauterine oxytocin system. Compartmental distribution of oxytocin and oxytocin receptors in rat endometrial epithelium. Morel G, etal., Cell Tissue Res. 2001 Jun;304(3):377-82.
40. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity. Ochedalski T, etal., J Neuroendocrinol. 2007 Mar;19(3):189-97.
42. Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding: Involvement of opioids, orexin, oxytocin and NPY. Olszewski PK, etal., Peptides. 2009 Feb;30(2):226-33. Epub 2008 Oct 30.
43. Facilitative role of endogenous oxytocin in noradrenaline release in the rat supraoptic nucleus. Onaka T, etal., Eur J Neurosci. 2003 Dec;18(11):3018-26.
44. Oxytocin exerts protective effects on in vitro myocardial injury induced by ischemia and reperfusion. Ondrejcakova M, etal., Can J Physiol Pharmacol. 2009 Feb;87(2):137-42.
45. Oxytocin enhances cranial visceral afferent synaptic transmission to the solitary tract nucleus. Peters JH, etal., J Neurosci. 2008 Nov 5;28(45):11731-40.
46. Postnatal oxytocin treatment of spontaneously hypertensive male rats decreases blood pressure and body weight in adulthood. Petersson M and Uvnas-Moberg K, Neurosci Lett. 2008 Aug 1;440(2):166-9. Epub 2008 Jun 16.
47. Neonatal oxytocin treatment modulates oxytocin receptor, atrial natriuretic peptide, nitric oxide synthase and estrogen receptor mRNAs expression in rat heart. Pournajafi-Nazarloo H, etal., Peptides. 2007 Jun;28(6):1170-7. Epub 2007 May 6.
48. The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation. Rehbein M, etal., Biol Chem Hoppe Seyler 1986 Aug;367(8):695-704.
49. GOA pipeline RGD automated data pipeline
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Glucocorticoid modulation of neuronal activity and hormone secretion induced by blood volume expansion. Ruginsk SG, etal., Exp Neurol. 2007 Aug;206(2):192-200. Epub 2007 May 10.
52. Involvement of neuromedin S in the oxytocin release response to suckling stimulus. Sakamoto T, etal., Biochem Biophys Res Commun. 2008 Oct 10;375(1):49-53. Epub 2008 Aug 12.
53. Rat vasopressin and oxytocin genes are linked by a long interspersed repeated DNA element (LINE): sequence and transcriptional analysis of LINE. Schmitz E, etal., DNA Cell Biol 1991 Mar;10(2):81-91.
54. cAMP stimulation of vasopressin and oxytocin release and regulation of vasopressin mRNA stability: role of auto-facilitation. Song Z, etal., J Neuroendocrinol. 2001 Feb;13(2):158-65.
55. ERK2 mediates oxytocin-stimulated PGE2 synthesis. Strakova Z, etal., Am J Physiol. 1998 Apr;274(4 Pt 1):E634-41.
56. Oxytocin induces penile erection when injected into the ventral tegmental area of male rats: role of nitric oxide and cyclic GMP. Succu S, etal., Eur J Neurosci. 2008 Aug;28(4):813-21. Epub 2008 Jul 30.
57. The effects of alprostadil on hypothalamic and amygdalar function and the central expression of oxytocin: a potential central role of alprostadil cream. Sun X, etal., J Sex Med. 2009 Jan;6(1):81-90. Epub 2008 Nov 5.
58. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
59. Oxytocin and estrogen promote rapid formation of functional GABA synapses in the adult supraoptic nucleus. Theodosis DT, etal., Mol Cell Neurosci. 2006 Apr;31(4):785-94. Epub 2006 Feb 20.
60. A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy"). Thompson MR, etal., Neuroscience. 2007 May 11;146(2):509-14. Epub 2007 Mar 23.
61. Central vasopressin and oxytocin release: regulation of complex social behaviours. Veenema AH and Neumann ID, Prog Brain Res. 2008;170:261-76.
62. Evidence for an interaction between CB1 cannabinoid and oxytocin receptors in food and water intake. Verty AN, etal., Neuropharmacology. 2004 Sep;47(4):593-603.
63. Genistein supplementation stimulates the oxytocin system in the aorta of ovariectomized rats. Wang D, etal., Cardiovasc Res. 2003 Jan;57(1):186-94.
64. Dominant role of betagamma subunits of G-proteins in oxytocin-evoked burst firing. Wang YF and Hatton GI, J Neurosci. 2007 Feb 21;27(8):1902-12.
65. Neurosteroid regulation of oxytocin and vasopressin release from the rat supraoptic nucleus. Widmer H, etal., J Physiol. 2003 Apr 1;548(Pt 1):233-44. Epub 2003 Feb 14.
66. Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats. Wu CL, etal., Naunyn Schmiedebergs Arch Pharmacol. 2003 Apr;367(4):406-13. Epub 2003 Feb 26.
67. Effect of oxytocin on acupuncture analgesia in the rat. Yang J, etal., Neuropeptides. 2007 Oct;41(5):285-92. Epub 2007 Jul 30.
68. Oxytocin administered intrathecally preferentially increases heart rate rather than arterial pressure in the rat. Yashpal K, etal., J Auton Nerv Syst. 1987 Aug;20(2):167-78.
69. Differential kinetics of oxytocin and vasopressin heteronuclear RNA expression in the rat supraoptic nucleus in response to chronic salt loading in vivo. Yue C, etal., J Neuroendocrinol. 2008 Feb;20(2):227-32. Epub 2007 Dec 14.
70. Vasopressin administration into the PVN normalizes plasma oxytocin and corticosterone levels in Brattleboro rats. Zelena D, etal., Endocrinology. 2009 Feb 26.
71. Impact of ether anesthesia on the hypophyseal content of oxytocin neurophysin I and II: a comparative study with ketamine in the rat. Zierer R Life Sci. 1991;49(19):1391-7.
Additional References at PubMed
PMID:891987   PMID:3008332   PMID:3203740   PMID:5150741   PMID:6689019   PMID:7036996   PMID:7238864   PMID:12383972   PMID:12475730   PMID:12787053   PMID:12834434   PMID:12907752  
PMID:15033917   PMID:15044184   PMID:15149956   PMID:15358676   PMID:15975651   PMID:16033890   PMID:16354922   PMID:16357095   PMID:16439458   PMID:16513365   PMID:16677710   PMID:16875693  
PMID:17170309   PMID:17332000   PMID:17524563   PMID:17568668   PMID:17593952   PMID:17615142   PMID:17925443   PMID:18006631   PMID:18039781   PMID:18048495   PMID:18293170   PMID:18510735  
PMID:18579201   PMID:18996098   PMID:19106214   PMID:19258669   PMID:19269259   PMID:19420012   PMID:19429063   PMID:19493620   PMID:19595642   PMID:19625689   PMID:19638362   PMID:19703497  
PMID:19723921   PMID:19766607   PMID:19769589   PMID:20015826   PMID:20036647   PMID:20146024   PMID:20224888   PMID:20399835   PMID:20580660   PMID:20621145   PMID:20624160   PMID:20688065  
PMID:21061153   PMID:21207221   PMID:21382355   PMID:21439337   PMID:21481539   PMID:21545817   PMID:21858088   PMID:21858181   PMID:21872599   PMID:21920364   PMID:22083216   PMID:22100184  
PMID:22197269   PMID:22245139   PMID:22266748   PMID:22326383   PMID:22363799   PMID:22464293   PMID:22872656   PMID:23102690   PMID:23136757   PMID:23142109   PMID:23225240   PMID:23474276  
PMID:23515287   PMID:23550008   PMID:23551170   PMID:23680380   PMID:23888412   PMID:23912682   PMID:24010161   PMID:24042175   PMID:24342802   PMID:24389591   PMID:24403294   PMID:24444823  
PMID:24518793   PMID:24631553   PMID:25047873   PMID:25089000   PMID:25126708   PMID:25451978   PMID:25559382   PMID:25637830   PMID:25702774   PMID:25976631   PMID:26177679   PMID:26830961  
PMID:27016581   PMID:27529669   PMID:27829122   PMID:29118105   PMID:30166555   PMID:30176320   PMID:30633838   PMID:30826070   PMID:31499086   PMID:31820102   PMID:32571836   PMID:32726160  
PMID:32914562   PMID:33201416   PMID:34006875   PMID:34210188   PMID:34530103   PMID:34713515   PMID:35007255   PMID:35301015   PMID:35870680   PMID:36064593   PMID:36064966   PMID:36130511  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.23117,782,650 - 117,783,490 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,782,650 - 117,783,490 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3121,677,109 - 121,677,940 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03130,274,375 - 130,275,205 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03127,933,240 - 127,934,071 (+)NCBIRnor_WKY
Rnor_6.03123,106,694 - 123,107,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,106,694 - 123,107,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03129,604,822 - 129,605,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,194,219 - 118,195,056 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,097,303 - 118,100,512 (+)NCBI
Celera3116,593,509 - 116,594,349 (+)NCBICelera
Cytogenetic Map3q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38203,071,620 - 3,072,517 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl203,071,620 - 3,072,517 (+)EnsemblGRCh38hg38GRCh38
GRCh37203,052,266 - 3,053,163 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,000,266 - 3,001,162 (+)NCBINCBI36Build 36hg18NCBI36
Build 34203,000,265 - 3,001,162NCBI
Celera203,114,251 - 3,115,147 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef202,998,607 - 2,999,505 (+)NCBIHuRef
CHM1_1203,046,806 - 3,047,704 (+)NCBICHM1_1
T2T-CHM13v2.0203,102,517 - 3,103,415 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392130,416,432 - 130,418,974 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2130,418,093 - 130,418,974 (+)EnsemblGRCm39 Ensembl
GRCm382130,574,519 - 130,577,054 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,576,173 - 130,577,054 (+)EnsemblGRCm38mm10GRCm38
MGSCv372130,401,909 - 130,402,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362130,267,614 - 130,268,429 (+)NCBIMGSCv36mm8
Celera2131,800,597 - 131,801,412 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.24NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
Mhudiblu_PPA_v0203,157,246 - 3,159,013 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12418,193,381 - 18,194,232 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2418,193,339 - 18,194,170 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2418,021,790 - 18,022,393 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02418,612,328 - 18,612,968 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2418,612,281 - 18,613,193 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12418,205,647 - 18,206,253 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02418,318,339 - 18,318,942 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02418,646,119 - 18,646,759 (-)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1732,605,586 - 32,606,546 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11732,605,586 - 32,606,449 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,975,726 - 36,976,589 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1233,749,520 - 33,750,981 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl233,750,108 - 33,750,968 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607110,763,922 - 10,764,819 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247414,200,478 - 4,201,580 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247414,200,594 - 4,201,416 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Oxt
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:41
Interacting mature miRNAs:42
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3115638168135181505Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23117,782,845 - 117,782,996 (+)MAPPERmRatBN7.2
Rnor_6.03123,106,890 - 123,107,040NCBIRnor6.0
Rnor_5.03129,605,018 - 129,605,168UniSTSRnor5.0
RGSC_v3.43118,194,415 - 118,194,565UniSTSRGSC3.4
Celera3116,593,705 - 116,593,855UniSTS
Cytogenetic Map3q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2
Low 25 4
Below cutoff 1 2 6 5 1 5 1 3 28 12 20 1 1


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028829   ⟹   ENSRNOP00000028829
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3117,782,650 - 117,783,490 (+)Ensembl
Rnor_6.0 Ensembl3123,106,694 - 123,107,534 (+)Ensembl
RefSeq Acc Id: NM_012996   ⟹   NP_037128
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.23117,782,650 - 117,783,490 (+)NCBI
Rnor_6.03123,106,694 - 123,107,534 (+)NCBI
Rnor_5.03129,604,822 - 129,605,662 (+)NCBI
RGSC_v3.43118,194,219 - 118,195,056 (+)RGD
Celera3116,593,509 - 116,594,349 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037128   ⟸   NM_012996
- Peptide Label: preproprotein
- UniProtKB: Q53WU2 (UniProtKB/Swiss-Prot),   P01179 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028829   ⟸   ENSRNOT00000028829

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01179-F1-model_v2 AlphaFold P01179 1-125 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692436
Promoter ID:EPDNEW_R2960
Type:single initiation site
Description:oxytocin/neurophysin 1 prepropeptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.03123,106,695 - 123,106,755EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3238 AgrOrtholog
BioCyc Gene G2FUF-47853 BioCyc
Ensembl Genes ENSRNOG00000021225 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000028829 ENTREZGENE
  ENSRNOP00000028829.3 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028829 ENTREZGENE
  ENSRNOT00000028829.6 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot
InterPro Neurhyp_horm UniProtKB/Swiss-Prot
  Neurhyp_horm_dom_sf UniProtKB/Swiss-Prot
  Neurohypophysial_hormone_CS UniProtKB/Swiss-Prot
KEGG Report rno:25504 UniProtKB/Swiss-Prot
  PTHR11681 UniProtKB/Swiss-Prot
Pfam Hormone_4 UniProtKB/Swiss-Prot
  Hormone_5 UniProtKB/Swiss-Prot
PhenoGen Oxt PhenoGen
PIRSF Nonapeptide_hormone_precursor UniProtKB/Swiss-Prot
SMART SM00003 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49606 UniProtKB/Swiss-Prot
TIGR TC207027
UniProt NEU1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q53WU2 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-04 Oxt  oxytocin/neurophysin I prepropeptide  Oxt  oxytocin/neurophysin I prepropeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-04 Oxt  oxytocin/neurophysin I prepropeptide  Oxt  oxytocin/neurophysin 1 prepropeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-11-07 Oxt  oxytocin/neurophysin 1 prepropeptide  Oxt  oxytocin, prepropeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Oxt  oxytocin, prepropeptide  Oxt  oxytocin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Oxt  oxcytocin      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression protein synthesized by magnocellular neurons of the supraoptic and paraventricular nuclei of the hypothalamus; synthesized in ovary, thymus, kidneys, heart and vasculature 631223
gene_mapping maps to the Bp37 QTL region and proposed to be a candidate gene for blood pressure regulation 631223
gene_process reduces mean arterial pressure and peripheral resistance; may play a role in body fluid hemeostasis 631223
gene_regulation biosynthesis and secretion are regulated by thyrotropin-releasing hormone (TRH) 634240