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Gene: Tpmt (thiopurine S-methyltransferase) Rattus norvegicus
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Symbol: Tpmt
Name: thiopurine S-methyltransferase
Description: Predicted to have S-adenosyl-L-methionine binding activity and thiopurine S-methyltransferase activity. Involved in response to testosterone. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in alopecia; leukopenia; precursor lymphoblastic lymphoma/leukemia; and thiopurine S-methyltransferase deficiency. Orthologous to human TPMT (thiopurine S-methyltransferase); PARTICIPATES IN azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; INTERACTS WITH (+)-schisandrin B; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC690050; similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase); thiopurine methyltransferase
Orthologs:
Homo sapiens (human) : TPMT (thiopurine S-methyltransferase)  HGNC  Alliance
Mus musculus (house mouse) : Tpmt (thiopurine methyltransferase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpmt (thiopurine S-methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : TPMT (thiopurine S-methyltransferase)
Canis lupus familiaris (dog) : TPMT (thiopurine S-methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpmt (thiopurine S-methyltransferase)
Sus scrofa (pig) : TPMT (thiopurine S-methyltransferase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01718,029,090 - 18,047,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1718,029,124 - 18,047,714 (+)Ensembl
Rnor_5.01719,889,509 - 19,908,063 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41723,697,900 - 23,714,173 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1717,356,338 - 17,372,611 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Tpmt
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1585162
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.