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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxiconazole
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Accession:CHEBI:7825 term browser browse the term
Definition:An oxime O-ether that is the 2,4-dichlorobenzyl ether of the oxime obtained by formal condensation of hydroxylamine with the carbonyl group of acetopnenone in which the phenyl group is substituted by chlorines at positions 2 and 4, and in which one of the hydrogens of the methyl group is replaced by a 1H-imidazol-1-yl group. An antifungal agent, it is used (generally as the nitrate salt) in creams and powders for the topical treatment of fungal skin infections.
Synonyms:exact_synonym: (1Z)-N-[(2,4-dichlorobenzyl)oxy]-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanimine
 related_synonym: 2',4'-Dichloro-2-imidazol-1-ylacetophenone (Z)-[O-(2,4-dichlorobenzyl)oxime];   Formula=C18H13Cl4N3O;   InChI=1S/C18H13Cl4N3O/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22/h1-8,11H,9-10H2/b24-18+;   InChIKey=QRJJEGAJXVEBNE-HKOYGPOVSA-N;   Ro 13-8996;   SMILES=Clc1ccc(CO\\N=C(/Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1;   oxiconazol;   oxiconazolum
 xref: CAS:64211-45-6;   DrugBank:DB00239;   Drug_Central:3408;   HMDB:HMDB0014384;   KEGG:C08074;   KEGG:D08313
 xref_mesh: MESH:C022155
 xref: PMID:15797782;   PMID:2029718;   PMID:22569007;   PMID:23482479;   PMID:2793313;   PMID:7037014;   Patent:US4550175;   Reaxys:6004213;   Wikipedia:Oxiconazole
 cyclic_relationship: is_conjugate_base_of CHEBI:77698



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oxiconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO oxiconazole results in decreased activity of CYP19A1 protein CTD PMID:24496634 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO oxiconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]]; oxiconazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]
oxiconazole results in increased expression of CYP3A4 mRNA
CTD PMID:17998298 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO oxiconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO oxiconazole results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; oxiconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Rifampin inhibits the reaction [oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]] CTD PMID:17998298 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
decreases expression
decreases activity
ISO oxiconazole binds to and results in increased activity of NR1I2 protein; oxiconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]]; oxiconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; oxiconazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; oxiconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Rifampin inhibits the reaction [oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Rifampin inhibits the reaction [oxiconazole results in increased expression of NR1I2 mRNA]
oxiconazole results in decreased expression of NR1I2 mRNA
oxiconazole results in decreased activity of NR1I2 protein
CTD PMID:17438109 PMID:17998298 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO oxiconazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link

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  CHEBI ontology 20059
    role 20009
      application 19747
        pharmaceutical 19619
          drug 19619
            antiinfective agent 14200
              oxiconazole 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic molecule 19819
                              organic cyclic compound 19581
                                organic heterocyclic compound 18804
                                  heteroarene 16601
                                    monocyclic heteroarene 13600
                                      azole 12823
                                        diazole 8611
                                          imidazoles 7704
                                            imidazole antifungal agent 1303
                                              imidazole antifungal drug 830
                                                oxiconazole 7
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