Polr1c (RNA polymerase I and III subunit C) - Rat Genome Database

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Gene: Polr1c (RNA polymerase I and III subunit C) Rattus norvegicus
Analyze
Symbol: Polr1c
Name: RNA polymerase I and III subunit C
RGD ID: 1309689
Description: Predicted to enable DNA binding activity and protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase I and transcription by RNA polymerase III. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Orthologous to human POLR1C (RNA polymerase I and III subunit C); PARTICIPATES IN RNA polymerase I transcription pathway; RNA polymerase III transcription pathway; purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ac2-127; DNA-directed RNA polymerases I and III subunit RPAC1; LOC301246; MGC105583; polymerase (RNA) I polypeptide C; polymerase (RNA) I subunit C; RNA polymerase 1-1; RNA polymerase I subunit; RNA polymerase I subunit C; Rpo1-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2914,735,740 - 14,739,852 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,735,714 - 14,739,852 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx923,319,979 - 23,324,091 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0928,382,463 - 28,386,575 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0926,683,367 - 26,687,479 (+)NCBIRnor_WKY
Rnor_6.0917,120,759 - 17,124,871 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,120,759 - 17,124,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0916,017,436 - 16,021,548 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4910,298,309 - 10,302,421 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1910,295,630 - 10,299,743 (+)NCBI
Celera912,483,058 - 12,487,170 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, etal., Cell Cycle. 2010 Sep 15;9(18):3687-99. Epub 2010 Sep 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. Hu P, etal., Mol Cell Biol. 2002 Nov;22(22):8044-55.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Schneider DA Gene. 2012 Feb 10;493(2):176-84. doi: 10.1016/j.gene.2011.08.006. Epub 2011 Aug 26.
11. Conservation between the RNA polymerase I, II, and III transcription initiation machineries. Vannini A and Cramer P, Mol Cell. 2012 Feb 24;45(4):439-46. doi: 10.1016/j.molcel.2012.01.023.
Additional References at PubMed
PMID:7929437   PMID:12477932   PMID:24107381  


Genomics

Comparative Map Data
Polr1c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2914,735,740 - 14,739,852 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,735,714 - 14,739,852 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx923,319,979 - 23,324,091 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0928,382,463 - 28,386,575 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0926,683,367 - 26,687,479 (+)NCBIRnor_WKY
Rnor_6.0917,120,759 - 17,124,871 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,120,759 - 17,124,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0916,017,436 - 16,021,548 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4910,298,309 - 10,302,421 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1910,295,630 - 10,299,743 (+)NCBI
Celera912,483,058 - 12,487,170 (+)NCBICelera
Cytogenetic Map9q12NCBI
POLR1C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38643,517,089 - 44,461,400 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl643,509,702 - 43,562,419 (+)EnsemblGRCh38hg38GRCh38
GRCh37643,484,827 - 44,429,137 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,592,769 - 43,605,092 (+)NCBINCBI36Build 36hg18NCBI36
Celera645,036,412 - 45,048,735 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef643,202,730 - 43,208,225 (+)NCBIHuRef
CHM1_1643,487,909 - 43,492,383 (+)NCBICHM1_1
T2T-CHM13v2.0643,345,828 - 44,296,039 (+)NCBIT2T-CHM13v2.0
Polr1c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,554,846 - 46,558,971 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1746,554,846 - 46,558,980 (-)EnsemblGRCm39 Ensembl
GRCm381746,243,920 - 46,248,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,243,920 - 46,248,054 (-)EnsemblGRCm38mm10GRCm38
MGSCv371746,380,869 - 46,384,994 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361745,707,509 - 45,711,545 (-)NCBIMGSCv36mm8
Celera1749,677,058 - 49,681,183 (-)NCBICelera
Cytogenetic Map17CNCBI
Polr1c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,346,397 - 9,350,591 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,346,397 - 9,350,591 (+)NCBIChiLan1.0ChiLan1.0
POLR1C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1644,399,936 - 44,404,420 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl644,395,787 - 44,412,257 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0643,101,771 - 43,121,460 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
POLR1C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,978,337 - 11,982,265 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,978,422 - 12,008,579 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1212,004,514 - 12,008,441 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01212,461,954 - 12,465,881 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1212,462,031 - 12,509,169 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11211,987,354 - 11,991,281 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01212,074,263 - 12,078,191 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01212,167,748 - 12,171,676 (+)NCBIUU_Cfam_GSD_1.0
Polr1c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494647,472,764 - 47,476,677 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647616,480,835 - 16,487,424 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647616,483,203 - 16,487,360 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLR1C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,507,073 - 38,537,943 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1738,511,521 - 38,531,938 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2744,092,595 - 44,111,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POLR1C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11728,637,868 - 28,649,898 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604443,572,869 - 43,577,363 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Polr1c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475416,122,935 - 16,136,395 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475416,125,322 - 16,129,339 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Polr1c
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000025787
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat

Markers in Region
RH127411  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2914,739,364 - 14,739,673 (+)MAPPERmRatBN7.2
Rnor_6.0917,124,384 - 17,124,692NCBIRnor6.0
Rnor_5.0916,021,061 - 16,021,369UniSTSRnor5.0
RGSC_v3.4910,301,934 - 10,302,242UniSTSRGSC3.4
Celera912,486,683 - 12,486,991UniSTS
RH 3.4 Map963.8UniSTS
Cytogenetic Map9q12UniSTS
BF386341  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2914,736,564 - 14,736,714 (+)MAPPERmRatBN7.2
Rnor_6.0917,121,584 - 17,121,733NCBIRnor6.0
Rnor_5.0916,018,261 - 16,018,410UniSTSRnor5.0
RGSC_v3.4910,299,134 - 10,299,283UniSTSRGSC3.4
Celera912,483,883 - 12,484,032UniSTS
RH 3.4 Map963.5UniSTS
Cytogenetic Map9q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 3 5 74 35 41 11 3
Low 5 6 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025787   ⟹   ENSRNOP00000025787
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl914,735,714 - 14,739,849 (+)Ensembl
Rnor_6.0 Ensembl917,120,759 - 17,124,871 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077749   ⟹   ENSRNOP00000073552
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl914,735,763 - 14,739,852 (+)Ensembl
Rnor_6.0 Ensembl917,122,284 - 17,124,675 (+)Ensembl
RefSeq Acc Id: NM_001008330   ⟹   NP_001008331
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2914,735,740 - 14,739,852 (+)NCBI
Rnor_6.0917,120,759 - 17,124,871 (+)NCBI
Rnor_5.0916,017,436 - 16,021,548 (+)NCBI
RGSC_v3.4910,298,309 - 10,302,421 (+)RGD
Celera912,483,058 - 12,487,170 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008331 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86597 (Get FASTA)   NCBI Sequence Viewer  
  AAP92620 (Get FASTA)   NCBI Sequence Viewer  
  EDM18804 (Get FASTA)   NCBI Sequence Viewer  
  EDM18805 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001008331   ⟸   NM_001008330
- UniProtKB: Q5RJK9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073552   ⟸   ENSRNOT00000077749
RefSeq Acc Id: ENSRNOP00000025787   ⟸   ENSRNOT00000025787
Protein Domains
RPOLD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RJK9-F1-model_v2 AlphaFold Q5RJK9 1-346 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696530
Promoter ID:EPDNEW_R7053
Type:multiple initiation site
Name:Polr1c_1
Description:RNA polymerase I subunit C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0917,120,793 - 17,120,853EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309689 AgrOrtholog
BioCyc Gene G2FUF-28210 BioCyc
Ensembl Genes ENSRNOG00000019079 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025787 ENTREZGENE
  ENSRNOP00000025787.3 UniProtKB/TrEMBL
  ENSRNOP00000073552.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025787 ENTREZGENE
  ENSRNOT00000025787.5 UniProtKB/TrEMBL
  ENSRNOT00000077749.2 UniProtKB/TrEMBL
Gene3D-CATH 2.170.120.12 UniProtKB/TrEMBL
  3.30.1360.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312277 IMAGE-MGC_LOAD
InterPro DNA-dir_RNA_pol_30-40kDasu_CS UniProtKB/TrEMBL
  DNA-dir_RNA_pol_insert UniProtKB/TrEMBL
  DNA-dir_RNA_pol_RpoA/D/Rpb3 UniProtKB/TrEMBL
  RBP11-like UniProtKB/TrEMBL
  RNAP_Rpo3/Rpb3/RPAC1 UniProtKB/TrEMBL
  RNAPI/II_AC40 UniProtKB/TrEMBL
  RNApol_insert_sf UniProtKB/TrEMBL
KEGG Report rno:301246 UniProtKB/TrEMBL
MGC_CLONE MGC:105583 IMAGE-MGC_LOAD
NCBI Gene 301246 ENTREZGENE
PANTHER PTHR11800:SF13 UniProtKB/TrEMBL
Pfam RNA_pol_A_bac UniProtKB/TrEMBL
  RNA_pol_L UniProtKB/TrEMBL
PhenoGen Polr1c PhenoGen
PROSITE RNA_POL_D_30KD UniProtKB/TrEMBL
SMART RPOLD UniProtKB/TrEMBL
Superfamily-SCOP RNAP_insert UniProtKB/TrEMBL
  RNAP_RBP11-like UniProtKB/TrEMBL
UniProt A0A0G2K5T6_RAT UniProtKB/TrEMBL
  Q5RJK9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-16 Polr1c  RNA polymerase I and III subunit C  Polr1c  RNA polymerase I subunit C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-21 Polr1c  RNA polymerase I subunit C  Polr1c  polymerase (RNA) I subunit C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-09 Polr1c  polymerase (RNA) I subunit C  Polr1c  polymerase (RNA) I polypeptide C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Polr1c  polymerase (RNA) I polypeptide C  Rpo1-1  RNA polymerase 1-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Rpo1-1  RNA polymerase 1-1  Rpo1-1_predicted  RNA polymerase 1-1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Rpo1-1_predicted  RNA polymerase 1-1 (predicted)      Symbol and Name status set to approved 70820 APPROVED