Gene: Cop1 (COP1, E3 ubiquitin ligase) Rattus norvegicus
Symbol: Cop1
Name: COP1, E3 ubiquitin ligase
Description: ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); response to ionizing radiation (ortholog); PARTICIPATES IN p53 signaling pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH abnormal circadian regulation of systemic arterial blood pressure; salt-sensitive hypertension; ASSOCIATED WITH Autistic Disorder (ortholog); FOUND IN Golgi membrane; Cul4A-RING E3 ubiquitin ligase complex (ortholog); INTERACTS WITH bisphenol A; (-)-epigallocatechin 3-gallate (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog)
Type: protein-coding
Also known as: E3 ubiquitin-protein ligase RFWD2; LOC100360800; LOC360860; MGC109175; Rfwd2; RGD1304773; ring finger and WD repeat domain 2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; similar to constitutive photomorphogenic protein 1
Homo sapiens (human) : COP1 (COP1, E3 ubiquitin ligase)  HGNC  Alliance
Mus musculus (house mouse) : Cop1 (COP1, E3 ubiquitin ligase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cop1 (COP1, E3 ubiquitin ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : COP1 (COP1, E3 ubiquitin ligase)
Canis lupus familiaris (dog) : COP1 (COP1, E3 ubiquitin ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cop1 (COP1, E3 ubiquitin ligase)
more info ...
Allele / Splice: Rfwd2em1Mcwi  
Genetic Models: SS-Rfwd2em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01376,942,883 - 77,076,015 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01381,853,391 - 81,986,197 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41374,552,876 - 74,590,608 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11374,979,314 - 74,981,857 (-)NCBI
Celera1371,277,941 - 71,371,841 (+)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
More on Cop1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1304773
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2018-02-06
Status: ACTIVE