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Gene: Cop1 (COP1, E3 ubiquitin ligase) Rattus norvegicus
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Symbol: Cop1
Name: COP1, E3 ubiquitin ligase
Description: Predicted to have ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Localizes to the Golgi membrane. Orthologous to human COP1 (COP1 E3 ubiquitin ligase); PARTICIPATES IN p53 signaling pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH amphetamine; bisphenol A; (-)-epigallocatechin 3-gallate (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E3 ubiquitin-protein ligase RFWD2; LOC100360800; LOC360860; MGC109175; Rfwd2; RGD1304773; ring finger and WD repeat domain 2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; similar to constitutive photomorphogenic protein 1
Orthologs:
Homo sapiens (human) : COP1 (COP1 E3 ubiquitin ligase)  HGNC  Alliance
Mus musculus (house mouse) : Cop1 (COP1, E3 ubiquitin ligase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cop1 (COP1 E3 ubiquitin ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : COP1 (COP1 E3 ubiquitin ligase)
Canis lupus familiaris (dog) : COP1 (COP1 E3 ubiquitin ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cop1 (COP1 E3 ubiquitin ligase)
Sus scrofa (pig) : COP1 (COP1 E3 ubiquitin ligase)
more info ...
Allele / Splice: Rfwd2em1Mcwi  
Genetic Models: SS-Rfwd2em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01376,942,883 - 77,076,015 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1376,942,928 - 77,075,723 (+)Ensembl
Rnor_5.01381,853,391 - 81,986,197 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41374,552,876 - 74,590,608 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11374,979,314 - 74,981,857 (-)NCBI
Celera1371,277,941 - 71,371,841 (+)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Cop1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1304773
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.