Akap12 (A-kinase anchoring protein 12) - Rat Genome Database

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Gene: Akap12 (A-kinase anchoring protein 12) Rattus norvegicus
Analyze
Symbol: Akap12
Name: A-kinase anchoring protein 12
RGD ID: 70988
Description: Predicted to enable adenylate cyclase binding activity. Involved in several processes, including cellular response to cytokine stimulus; hepatic stellate cell activation; and positive regulation of ERK1 and ERK2 cascade. Located in neuronal cell body. Biomarker of brain ischemia; liver cirrhosis; osteosarcoma; and sciatic neuropathy. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A kinase (PRKA) anchor protein (gravin) 12; A kinase (PRKA) anchor protein 12; A kinase anchoring protein 12 alpha; A kinase anchoring protein 12 beta; A kinase anchoring protein 12 gamma; A-kinase anchor protein 12; AKAP-12; AKAP12A; AKAP12B; AKAP12G; SSeCKS, Gravin, AKAP250
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8143,135,515 - 43,225,245 (+)NCBIGRCr8
mRatBN7.2140,730,123 - 40,819,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl140,730,123 - 40,819,886 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx141,257,330 - 41,347,044 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,244,521 - 47,334,234 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,332,883 - 41,422,632 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0140,816,130 - 40,906,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl140,816,107 - 40,906,581 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,162,163 - 42,252,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4134,979,039 - 35,068,763 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1134,982,110 - 35,070,840 (+)NCBI
Celera136,421,269 - 36,510,639 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acids  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cumene  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (EXP,ISO)
glycidyl methacrylate  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
mercaptopurine  (EXP)
metacetamol  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
resorcinol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (EXP,ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A-kinase anchoring proteins: from protein complexes to physiology and disease. Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
2. Identification of a major protein kinase C-binding protein and substrate in rat embryo fibroblasts. Decreased expression in transformed cells. Chapline C, etal., J Biol Chem 1996 Mar 15;271(11):6417-22.
3. Vagal efferent fiber stimulation ameliorates pulmonary microvascular endothelial cell injury by downregulating inflammatory responses. Chen C, etal., Inflammation. 2013 Dec;36(6):1567-75. doi: 10.1007/s10753-013-9701-4.
4. Ligand-specific control of src-suppressed C kinase substrate gene expression. Coats SR, etal., Biochem Biophys Res Commun 2002 Oct 11;297(5):1112-20.
5. Silencing of Cited2 and Akap12 genes in radiation-induced rat osteosarcomas. Daino K, etal., Biochem Biophys Res Commun. 2009 Dec 18;390(3):654-8. Epub 2009 Oct 13.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. The scaffold protein muscle A-kinase anchoring protein beta orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Kritzer MD, etal., Circ Heart Fail. 2014 Jul;7(4):663-72. doi: 10.1161/CIRCHEARTFAILURE.114.001266. Epub 2014 May 8.
9. Involvement of Src-suppressed C kinase substrate in experimental autoimmune encephalomyelitis: a link between release of astrocyte proinflammatory factor and oligodendrocyte apoptosis. Li X, etal., J Neurosci Res. 2010 Jul;88(9):1858-71. doi: 10.1002/jnr.22355.
10. Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras. Lin X, etal., Mol Cell Biol 1995 May;15(5):2754-62.
11. Re-expression of AKAP12 inhibits progression and metastasis potential of colorectal carcinoma in vivo and in vitro. Liu W, etal., PLoS One. 2011;6(8):e24015. doi: 10.1371/journal.pone.0024015. Epub 2011 Aug 30.
12. Gene Data Set MGD Curation, June 12, 2002
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. SSeCKS immunolabeling in rat primary sensory neurons. Siegel SM, etal., Brain Res. 2002 Feb 1;926(1-2):126-36.
18. Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles. Streb JW, etal., J Biol Chem 2004 Dec 31;279(53):56014-23. Epub 2004 Oct 20.
19. Src suppressed C kinase substrate regulates the lipopolysaccharide-induced TNF-alpha biosynthesis in rat astrocytes. Sun LL, etal., J Mol Neurosci. 2007;32(1):16-24.
20. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
21. Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia. Wilhelm T, etal., Epigenetics. 2016;11(2):110-9. doi: 10.1080/15592294.2016.1145327. Epub 2016 Feb 18.
22. Mitogen-induced, FAK-dependent tyrosine phosphorylation of the SSeCKS scaffolding protein. Xia W and Gelman IH, Exp Cell Res 2002 Jul 15;277(2):139-51.
23. A critical role of SRC-suppressed C kinase substrate in rat astrocytes after chronic constriction injury. Xia Y, etal., Neuromolecular Med. 2010 Sep;12(3):205-16. doi: 10.1007/s12017-009-8093-y. Epub 2009 Nov 25.
24. Expression of SRC suppressed C kinase substrate in rat neural tissues during inflammation. Yan M, etal., Neurochem Res. 2014 Apr;39(4):748-57. doi: 10.1007/s11064-014-1265-7. Epub 2014 Mar 13.
25. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. Yoshida T, etal., Int J Mol Med. 2009 Oct;24(4):539-47.
26. Role of src-suppressed C kinase substrate in rat pulmonary microvascular endothelial hyperpermeability stimulated by inflammatory cytokines. You QH, etal., Inflamm Res. 2010 Nov;59(11):949-58. doi: 10.1007/s00011-010-0207-3. Epub 2010 May 8.
27. Increased SSeCKS expression in rat hepatic stellate cells upon activation in vitro and in vivo. You T, etal., Inflammation. 2013 Dec;36(6):1415-23. doi: 10.1007/s10753-013-9681-4.
28. Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema. Zan L, etal., Neurochem Int. 2011 Jul;58(8):872-9. doi: 10.1016/j.neuint.2011.02.014. Epub 2011 Feb 18.
Additional References at PubMed
PMID:12060780   PMID:15923193   PMID:16638134   PMID:17081159   PMID:17482576   PMID:17551670   PMID:17592532   PMID:17873283   PMID:18279585   PMID:18384053   PMID:18979197   PMID:19577259  
PMID:19757038   PMID:20111901   PMID:20204485   PMID:20232114   PMID:20367900   PMID:21423176   PMID:21573722   PMID:23238728   PMID:28281242   PMID:30053369   PMID:32357304  


Genomics

Comparative Map Data
Akap12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8143,135,515 - 43,225,245 (+)NCBIGRCr8
mRatBN7.2140,730,123 - 40,819,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl140,730,123 - 40,819,886 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx141,257,330 - 41,347,044 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,244,521 - 47,334,234 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,332,883 - 41,422,632 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0140,816,130 - 40,906,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl140,816,107 - 40,906,581 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,162,163 - 42,252,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4134,979,039 - 35,068,763 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1134,982,110 - 35,070,840 (+)NCBI
Celera136,421,269 - 36,510,639 (+)NCBICelera
Cytogenetic Map1q11NCBI
AKAP12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386151,239,967 - 151,358,559 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6151,239,967 - 151,358,559 (+)EnsemblGRCh38hg38GRCh38
GRCh376151,561,102 - 151,679,694 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366151,603,202 - 151,719,602 (+)NCBINCBI36Build 36hg18NCBI36
Build 346151,738,936 - 151,770,022NCBI
Celera6152,295,018 - 152,413,580 (+)NCBICelera
Cytogenetic Map6q25.1NCBI
HuRef6149,123,664 - 149,241,939 (+)NCBIHuRef
CHM1_16151,825,190 - 151,943,865 (+)NCBICHM1_1
T2T-CHM13v2.06152,440,587 - 152,559,135 (+)NCBIT2T-CHM13v2.0
Akap12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39104,216,329 - 4,309,471 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl104,216,380 - 4,309,470 (+)EnsemblGRCm39 Ensembl
GRCm38104,266,329 - 4,359,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl104,266,380 - 4,359,470 (+)EnsemblGRCm38mm10GRCm38
MGSCv37105,987,070 - 6,080,212 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36105,987,070 - 6,080,163 (-)NCBIMGSCv36mm8
Celera104,190,840 - 4,288,877 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.06NCBI
Akap12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543910,238,664 - 10,263,081 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543910,241,298 - 10,262,416 (-)NCBIChiLan1.0ChiLan1.0
AKAP12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25171,264,561 - 171,383,191 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16169,155,859 - 169,273,390 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06149,058,350 - 149,176,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16153,839,496 - 153,873,925 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6153,757,081 - 153,873,925 (+)Ensemblpanpan1.1panPan2
AKAP12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1141,614,893 - 41,712,350 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl141,614,714 - 41,709,798 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,456,089 - 42,553,626 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0141,799,868 - 41,897,347 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl141,799,970 - 41,895,674 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1141,673,111 - 41,770,835 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0141,517,208 - 41,614,636 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0142,023,588 - 42,121,300 (+)NCBIUU_Cfam_GSD_1.0
Akap12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946136,985,500 - 137,006,417 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364894,237,439 - 4,261,141 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364894,237,466 - 4,258,408 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKAP12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl114,904,116 - 15,016,997 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1114,904,109 - 15,017,016 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,314,971 - 17,428,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKAP12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11378,691,588 - 78,812,333 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1378,691,816 - 78,812,834 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604051,020,791 - 51,143,055 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akap12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247856,897,561 - 6,988,287 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247856,900,252 - 6,987,712 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Akap12
315 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:159
Interacting mature miRNAs:201
Transcripts:ENSRNOT00000026482, ENSRNOT00000060767
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat

Markers in Region
D1Rat13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2140,795,189 - 40,795,347 (+)MAPPERmRatBN7.2
Rnor_6.0140,881,280 - 40,881,437NCBIRnor6.0
Rnor_5.0142,227,313 - 42,227,470UniSTSRnor5.0
RGSC_v3.4135,044,092 - 35,044,250RGDRGSC3.4
RGSC_v3.4135,044,093 - 35,044,250UniSTSRGSC3.4
RGSC_v3.1135,047,037 - 35,047,195RGD
Celera136,485,613 - 36,485,766UniSTS
SHRSP x BN Map118.27UniSTS
SHRSP x BN Map118.27RGD
Cytogenetic Map1p11UniSTS
D1Rat401  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0142,227,253 - 42,227,471UniSTSRnor5.0
RGSC_v3.4135,044,032 - 35,044,251RGDRGSC3.4
RGSC_v3.4135,044,033 - 35,044,251UniSTSRGSC3.4
RGSC_v3.1135,046,977 - 35,047,196RGD
Celera136,485,553 - 36,485,767UniSTS
SHRSP x BN Map118.27UniSTS
SHRSP x BN Map118.27RGD
Cytogenetic Map1p11UniSTS
D1Rat397  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2140,795,163 - 40,795,374 (+)MAPPERmRatBN7.2
Rnor_6.0140,881,254 - 40,881,464NCBIRnor6.0
Rnor_5.0142,227,287 - 42,227,497UniSTSRnor5.0
RGSC_v3.4135,044,067 - 35,044,277UniSTSRGSC3.4
RGSC_v3.1135,047,011 - 35,047,222RGD
Celera136,485,587 - 36,485,793UniSTS
SHRSP x BN Map118.19UniSTS
SHRSP x BN Map118.19RGD
SHRSP x BN Map118.27UniSTS
Cytogenetic Map1p11UniSTS
D1Rat400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2140,795,129 - 40,795,348 (+)MAPPERmRatBN7.2
Rnor_6.0140,881,220 - 40,881,438NCBIRnor6.0
Rnor_5.0142,227,252 - 42,227,471NCBIRnor5.0
Rnor_5.0142,227,253 - 42,227,471UniSTSRnor5.0
RGSC_v3.4135,044,033 - 35,044,251UniSTSRGSC3.4
RGSC_v3.1135,046,977 - 35,047,196RGD
Celera136,485,553 - 36,485,767UniSTS
SHRSP x BN Map118.27UniSTS
SHRSP x BN Map118.27RGD
Cytogenetic Map1p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026482   ⟹   ENSRNOP00000026483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl140,804,110 - 40,819,486 (+)Ensembl
Rnor_6.0 Ensembl140,891,597 - 40,906,573 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000060767   ⟹   ENSRNOP00000057494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl140,730,123 - 40,819,862 (+)Ensembl
Rnor_6.0 Ensembl140,816,107 - 40,906,581 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083702   ⟹   ENSRNOP00000070062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl140,793,657 - 40,819,862 (+)Ensembl
Rnor_6.0 Ensembl140,879,747 - 40,906,581 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099245   ⟹   ENSRNOP00000087138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl140,804,279 - 40,819,886 (+)Ensembl
RefSeq Acc Id: NM_001033653   ⟹   NP_001028825
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,199,042 - 43,225,245 (+)NCBI
mRatBN7.2140,793,657 - 40,819,863 (+)NCBI
Rnor_6.0140,879,747 - 40,906,582 (+)NCBI
Rnor_5.0142,162,163 - 42,252,615 (+)NCBI
RGSC_v3.4134,979,039 - 35,068,763 (+)RGD
Celera136,484,080 - 36,510,639 (+)NCBI
Sequence:
RefSeq Acc Id: NM_057103   ⟹   NP_476444
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,135,515 - 43,225,245 (+)NCBI
mRatBN7.2140,730,123 - 40,819,863 (+)NCBI
Rnor_6.0140,816,130 - 40,906,582 (+)NCBI
Rnor_5.0142,162,163 - 42,252,615 (+)NCBI
RGSC_v3.4134,979,039 - 35,068,763 (+)RGD
Celera136,421,269 - 36,510,639 (+)RGD
Sequence:
RefSeq Acc Id: XM_006227847   ⟹   XP_006227909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,204,701 - 43,225,245 (+)NCBI
mRatBN7.2140,804,074 - 40,819,863 (+)NCBI
Rnor_6.0140,890,061 - 40,906,582 (+)NCBI
Rnor_5.0142,162,163 - 42,252,615 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006227848   ⟹   XP_006227910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,210,509 - 43,225,245 (+)NCBI
mRatBN7.2140,805,102 - 40,819,863 (+)NCBI
Rnor_6.0140,891,139 - 40,906,582 (+)NCBI
Rnor_5.0142,162,163 - 42,252,615 (+)NCBI
Sequence:
RefSeq Acc Id: NP_476444   ⟸   NM_057103
- Peptide Label: isoform alpha
- UniProtKB: Q5QD50 (UniProtKB/Swiss-Prot),   Q5QD49 (UniProtKB/Swiss-Prot),   Q9Z1F7 (UniProtKB/Swiss-Prot),   Q5QD51 (UniProtKB/Swiss-Prot),   A6KIK8 (UniProtKB/TrEMBL),   Q62766 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001028825   ⟸   NM_001033653
- Peptide Label: isoform beta
- UniProtKB: Q62766 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227909   ⟸   XM_006227847
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QEC9 (UniProtKB/TrEMBL),   A6KIK9 (UniProtKB/TrEMBL),   Q62766 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227910   ⟸   XM_006227848
- Peptide Label: isoform X2
- UniProtKB: A6KIL0 (UniProtKB/TrEMBL),   Q62766 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057494   ⟸   ENSRNOT00000060767
Ensembl Acc Id: ENSRNOP00000026483   ⟸   ENSRNOT00000026482
Ensembl Acc Id: ENSRNOP00000070062   ⟸   ENSRNOT00000083702
Ensembl Acc Id: ENSRNOP00000087138   ⟸   ENSRNOT00000099245
Protein Domains
A kinase-anchoring proteins AKAP-5 and AKAP-12

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5QD51-F1-model_v2 AlphaFold Q5QD51 1-1687 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689584
Promoter ID:EPDNEW_R109
Type:multiple initiation site
Name:Akap12_2
Description:A-kinase anchoring protein 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R110  EPDNEW_R111  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0140,816,133 - 40,816,193EPDNEW
RGD ID:13689585
Promoter ID:EPDNEW_R110
Type:single initiation site
Name:Akap12_1
Description:A-kinase anchoring protein 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R109  EPDNEW_R111  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0140,879,753 - 40,879,813EPDNEW
RGD ID:13689592
Promoter ID:EPDNEW_R111
Type:initiation region
Name:Akap12_3
Description:A-kinase anchoring protein 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R109  EPDNEW_R110  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0140,891,626 - 40,891,686EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70988 AgrOrtholog
BioCyc Gene G2FUF-61720 BioCyc
Ensembl Genes ENSRNOG00000019549 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026482 ENTREZGENE
  ENSRNOT00000060767.5 UniProtKB/Swiss-Prot
  ENSRNOT00000083702 ENTREZGENE
  ENSRNOT00000083702.2 UniProtKB/Swiss-Prot
  ENSRNOT00000099245.1 UniProtKB/Swiss-Prot
InterPro AKAP12 UniProtKB/Swiss-Prot
  Pkinase-A_anch_WSK-motif UniProtKB/Swiss-Prot
KEGG Report rno:83425 UniProtKB/Swiss-Prot
NCBI Gene 83425 ENTREZGENE
PANTHER A-KINASE ANCHOR PROTEIN 12 UniProtKB/Swiss-Prot
  PTHR23209 UniProtKB/Swiss-Prot
Pfam WSK UniProtKB/Swiss-Prot
PhenoGen Akap12 PhenoGen
PROSITE AKAP_CAM_BD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019549 RatGTEx
UniProt A0A8L2QEC9 ENTREZGENE, UniProtKB/TrEMBL
  A6KIK8 ENTREZGENE, UniProtKB/TrEMBL
  A6KIK9 ENTREZGENE, UniProtKB/TrEMBL
  A6KIL0 ENTREZGENE, UniProtKB/TrEMBL
  AKA12_RAT UniProtKB/Swiss-Prot
  Q5QD49 ENTREZGENE
  Q5QD50 ENTREZGENE
  Q5QD51 ENTREZGENE
  Q62766 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z1F7 ENTREZGENE
UniProt Secondary Q5QD49 UniProtKB/Swiss-Prot
  Q5QD50 UniProtKB/Swiss-Prot
  Q9Z1F7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Akap12  A-kinase anchoring protein 12  Akap12  A kinase (PRKA) anchor protein 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Akap12  A kinase (PRKA) anchor protein 12  Akap12  A kinase (PRKA) anchor protein (gravin) 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Akap12  A kinase (PRKA) anchor protein (gravin) 12      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization after 24 hours of sodium butyrate treatment of transformed rat kidney fibroblasts, as cells spread and attach, Akap12 staining is strongest in the lamellipodia and at the edges of spreading cells; by 48 hours the Akap12 protein staining is highest in the perinuclear region 631986
gene_expression highest mRNA expression in testes, heart, skin and brain; highest protein levels in testes and brain 70657
gene_expression progressive transformation of REF52 cells is accompanied by progressive loss of Akap12 expression 70657
gene_pathway involved in PDGF-BB-, LPA-, EPA-, and NaB-mediated cell signaling 631986
gene_physical_interaction interacts with protein kinase C 70657
gene_process may play a role in mitogen-induced cytoskeletal reorganization 631987
gene_protein approximately 200 kDa 70657
gene_regulation transcription suppressed by transformation of Rat-6 fibroblasts by src, ras, fos and myc, but not by raf, mos or neu 70666
gene_regulation platelet-derived growth factor-BB (PDGF-BB) and lysophosphatidic acid (LPA) upregulate Akap12 in rat smooth muscle cells; eicosapentaenoic acid (EPA) induces Akap12 at lower concentrations, but at higher doses it is antagonistic to Angiotensin II induced upregulation 631986
gene_transcript three isoforms sharing >95% amino acid identity except at their N-termini are the result of tissue specific transcription from three separate but overlapping transcription units with non-redundant promoters 1358132