Akap12 (A-kinase anchoring protein 12) - Rat Genome Database

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Gene: Akap12 (A-kinase anchoring protein 12) Rattus norvegicus
Analyze
Symbol: Akap12
Name: A-kinase anchoring protein 12
RGD ID: 70988
Description: Predicted to have adenylate cyclase binding activity. Involved in several processes, including cellular response to cytokine stimulus; hepatic stellate cell activation; and positive regulation of macromolecule metabolic process. Localizes to cytoplasm and neuronal cell body. Biomarker of brain ischemia; liver cirrhosis; osteosarcoma; and sciatic neuropathy. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A kinase (PRKA) anchor protein (gravin) 12; A kinase (PRKA) anchor protein 12; A kinase anchoring protein 12 alpha; A kinase anchoring protein 12 beta; A kinase anchoring protein 12 gamma; A-kinase anchor protein 12; AKAP-12; AKAP12A; AKAP12B; AKAP12G; SSeCKS, Gravin, AKAP250
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2140,730,123 - 40,819,863 (+)NCBI
Rnor_6.0 Ensembl140,816,107 - 40,906,581 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0140,816,130 - 40,906,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0142,162,163 - 42,252,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4134,979,039 - 35,068,763 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1134,982,110 - 35,070,840 (+)NCBI
Celera136,421,269 - 36,510,639 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
cumene  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
etoposide  (ISO)
folic acid  (ISO)
genistein  (EXP,ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
mercaptopurine  (EXP)
metacetamol  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
progesterone  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
resorcinol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
2. Chapline C, etal., J Biol Chem 1996 Mar 15;271(11):6417-22.
3. Chen C, etal., Inflammation. 2013 Dec;36(6):1567-75. doi: 10.1007/s10753-013-9701-4.
4. Coats SR, etal., Biochem Biophys Res Commun 2002 Oct 11;297(5):1112-20.
5. Daino K, etal., Biochem Biophys Res Commun. 2009 Dec 18;390(3):654-8. Epub 2009 Oct 13.
6. GOA data from the GO Consortium
7. Kritzer MD, etal., Circ Heart Fail. 2014 Jul;7(4):663-72. doi: 10.1161/CIRCHEARTFAILURE.114.001266. Epub 2014 May 8.
8. Li X, etal., J Neurosci Res. 2010 Jul;88(9):1858-71. doi: 10.1002/jnr.22355.
9. Lin X, etal., Mol Cell Biol 1995 May;15(5):2754-62.
10. Liu W, etal., PLoS One. 2011;6(8):e24015. doi: 10.1371/journal.pone.0024015. Epub 2011 Aug 30.
11. MGD Curation, June 12, 2002
12. MGD data from the GO Consortium
13. NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. RGD automated data pipeline
15. RGD automated import pipeline for gene-chemical interactions
16. Siegel SM, etal., Brain Res. 2002 Feb 1;926(1-2):126-36.
17. Streb JW, etal., J Biol Chem 2004 Dec 31;279(53):56014-23. Epub 2004 Oct 20.
18. Sun LL, etal., J Mol Neurosci. 2007;32(1):16-24.
19. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
20. Wilhelm T, etal., Epigenetics. 2016;11(2):110-9. doi: 10.1080/15592294.2016.1145327. Epub 2016 Feb 18.
21. Xia W and Gelman IH, Exp Cell Res 2002 Jul 15;277(2):139-51.
22. Xia Y, etal., Neuromolecular Med. 2010 Sep;12(3):205-16. doi: 10.1007/s12017-009-8093-y. Epub 2009 Nov 25.
23. Yoshida T, etal., Int J Mol Med. 2009 Oct;24(4):539-47.
24. You QH, etal., Inflamm Res. 2010 Nov;59(11):949-58. doi: 10.1007/s00011-010-0207-3. Epub 2010 May 8.
25. You T, etal., Inflammation. 2013 Dec;36(6):1415-23. doi: 10.1007/s10753-013-9681-4.
26. Zan L, etal., Neurochem Int. 2011 Jul;58(8):872-9. doi: 10.1016/j.neuint.2011.02.014. Epub 2011 Feb 18.
Additional References at PubMed
PMID:12060780   PMID:15923193   PMID:16638134   PMID:17081159   PMID:17482576   PMID:17551670   PMID:17592532   PMID:17873283   PMID:18279585   PMID:18384053   PMID:18979197   PMID:19577259  
PMID:19757038   PMID:20111901   PMID:20204485   PMID:20232114   PMID:20367900   PMID:21423176   PMID:21573722   PMID:23238728   PMID:24623461   PMID:28281242   PMID:30053369  


Genomics

Comparative Map Data
Akap12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2140,730,123 - 40,819,863 (+)NCBI
Rnor_6.0 Ensembl140,816,107 - 40,906,581 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0140,816,130 - 40,906,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0142,162,163 - 42,252,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4134,979,039 - 35,068,763 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1134,982,110 - 35,070,840 (+)NCBI
Celera136,421,269 - 36,510,639 (+)NCBICelera
Cytogenetic Map1q11NCBI
AKAP12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6151,239,967 - 151,358,559 (+)EnsemblGRCh38hg38GRCh38
GRCh386151,239,815 - 151,358,559 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376151,561,102 - 151,679,694 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366151,603,202 - 151,719,602 (+)NCBINCBI36hg18NCBI36
Build 346151,738,936 - 151,770,022NCBI
Celera6152,295,018 - 152,413,580 (+)NCBI
Cytogenetic Map6q25.1NCBI
HuRef6149,123,664 - 149,241,939 (+)NCBIHuRef
CHM1_16151,825,190 - 151,943,865 (+)NCBICHM1_1
Akap12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39104,216,329 - 4,309,471 (+)NCBIGRCm39mm39
GRCm39 Ensembl104,216,380 - 4,309,470 (+)Ensembl
GRCm38104,266,329 - 4,359,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl104,266,380 - 4,359,470 (+)EnsemblGRCm38mm10GRCm38
MGSCv37105,987,070 - 6,080,212 (-)NCBIGRCm37mm9NCBIm37
MGSCv36105,987,070 - 6,080,163 (-)NCBImm8
Celera104,190,840 - 4,288,877 (+)NCBICelera
Cytogenetic Map10A1NCBI
Akap12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543910,238,664 - 10,263,081 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543910,241,298 - 10,262,416 (-)NCBIChiLan1.0ChiLan1.0
AKAP12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16153,839,496 - 153,873,925 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6153,757,081 - 153,873,925 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06149,058,350 - 149,176,710 (+)NCBIMhudiblu_PPA_v0panPan3
AKAP12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1141,614,893 - 41,712,350 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl141,614,714 - 41,709,798 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,456,089 - 42,553,626 (+)NCBI
ROS_Cfam_1.0141,799,868 - 41,897,347 (+)NCBI
UMICH_Zoey_3.1141,673,111 - 41,770,835 (+)NCBI
UNSW_CanFamBas_1.0141,517,208 - 41,614,636 (+)NCBI
UU_Cfam_GSD_1.0142,023,588 - 42,121,300 (+)NCBI
Akap12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946136,985,500 - 137,006,417 (+)NCBI
SpeTri2.0NW_0049364894,237,466 - 4,258,408 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKAP12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl114,908,115 - 15,017,001 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1114,904,109 - 15,017,016 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,314,971 - 17,428,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKAP12
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11378,691,588 - 78,812,333 (+)NCBI
ChlSab1.1 Ensembl1378,691,816 - 78,812,834 (+)Ensembl
Akap12
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247856,900,252 - 6,987,712 (-)NCBI

Position Markers
D1Rat13  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0140,881,280 - 40,881,437NCBIRnor6.0
Rnor_5.0142,227,313 - 42,227,470UniSTSRnor5.0
RGSC_v3.4135,044,092 - 35,044,250RGDRGSC3.4
RGSC_v3.4135,044,093 - 35,044,250UniSTSRGSC3.4
RGSC_v3.1135,047,037 - 35,047,195RGD
Celera136,485,613 - 36,485,766UniSTS
SHRSP x BN Map118.27UniSTS
SHRSP x BN Map118.27RGD
Cytogenetic Map1p11UniSTS
D1Rat401  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0142,227,253 - 42,227,471UniSTSRnor5.0
RGSC_v3.4135,044,032 - 35,044,251RGDRGSC3.4
RGSC_v3.4135,044,033 - 35,044,251UniSTSRGSC3.4
RGSC_v3.1135,046,977 - 35,047,196RGD
Celera136,485,553 - 36,485,767UniSTS
SHRSP x BN Map118.27UniSTS
SHRSP x BN Map118.27RGD
Cytogenetic Map1p11UniSTS
D1Rat397  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0140,881,254 - 40,881,464NCBIRnor6.0
Rnor_5.0142,227,287 - 42,227,497UniSTSRnor5.0
RGSC_v3.4135,044,067 - 35,044,277UniSTSRGSC3.4
RGSC_v3.1135,047,011 - 35,047,222RGD
Celera136,485,587 - 36,485,793UniSTS
SHRSP x BN Map118.19UniSTS
SHRSP x BN Map118.19RGD
SHRSP x BN Map118.27UniSTS
Cytogenetic Map1p11UniSTS
D1Rat400  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0140,881,220 - 40,881,438NCBIRnor6.0
Rnor_5.0142,227,252 - 42,227,471NCBIRnor5.0
Rnor_5.0142,227,253 - 42,227,471UniSTSRnor5.0
RGSC_v3.4135,044,033 - 35,044,251UniSTSRGSC3.4
RGSC_v3.1135,046,977 - 35,047,196RGD
Celera136,485,553 - 36,485,767UniSTS
SHRSP x BN Map118.27UniSTS
SHRSP x BN Map118.27RGD
Cytogenetic Map1p11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1164407321Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)125439343579402Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)125439343579402Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)125439343579402Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)125439386904217Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1186804543724576Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1457869349578693Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1565577285706974Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11131448975844121Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11131448983657083Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11131448983657083Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11131448983657083Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11131448983657083Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11249343957493439Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11362925158629251Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11614314349547474Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11614314349547474Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12034156058000154Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12107930566079305Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12130082249454378Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12181262344409802Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12340642849547474Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12340642849547474Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12340642868406428Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123406428108057505Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)12429779978748000Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)125951907130917265Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13148945479689689Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13444911279449112Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13444911279449112Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13537750894364229Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13585416780854167Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13585416780854167Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13585416780854167Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13603316579689689Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13603316579689689Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:159
Interacting mature miRNAs:201
Transcripts:ENSRNOT00000026482, ENSRNOT00000060767
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 17 6 14 6 5 6 74 31 41 11 5
Low 7 40 35 5 35 3 5 4 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026482   ⟹   ENSRNOP00000026483
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl140,891,597 - 40,906,573 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000060767   ⟹   ENSRNOP00000057494
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl140,816,107 - 40,906,581 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083702   ⟹   ENSRNOP00000070062
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl140,879,747 - 40,906,581 (+)Ensembl
RefSeq Acc Id: NM_001033653   ⟹   NP_001028825
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2140,793,657 - 40,819,863 (+)NCBI
Rnor_6.0140,879,747 - 40,906,582 (+)NCBI
Rnor_5.0142,162,163 - 42,252,615 (+)NCBI
RGSC_v3.4134,979,039 - 35,068,763 (+)RGD
Celera136,484,080 - 36,510,639 (+)NCBI
Sequence:
RefSeq Acc Id: NM_057103   ⟹   NP_476444
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2140,730,123 - 40,819,863 (+)NCBI
Rnor_6.0140,816,130 - 40,906,582 (+)NCBI
Rnor_5.0142,162,163 - 42,252,615 (+)NCBI
RGSC_v3.4134,979,039 - 35,068,763 (+)RGD
Celera136,421,269 - 36,510,639 (+)RGD
Sequence:
RefSeq Acc Id: XM_006227847   ⟹   XP_006227909
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2140,804,074 - 40,819,863 (+)NCBI
Rnor_6.0140,890,061 - 40,906,582 (+)NCBI
Rnor_5.0142,162,163 - 42,252,615 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006227848   ⟹   XP_006227910
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2140,805,102 - 40,819,863 (+)NCBI
Rnor_6.0140,891,139 - 40,906,582 (+)NCBI
Rnor_5.0142,162,163 - 42,252,615 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_476444   ⟸   NM_057103
- Peptide Label: isoform alpha
- UniProtKB: Q5QD51 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001028825   ⟸   NM_001033653
- Peptide Label: isoform beta
- UniProtKB: Q5QD51 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006227909   ⟸   XM_006227847
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006227910   ⟸   XM_006227848
- Peptide Label: isoform X2
- UniProtKB: Q5QD51 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000057494   ⟸   ENSRNOT00000060767
RefSeq Acc Id: ENSRNOP00000026483   ⟸   ENSRNOT00000026482
RefSeq Acc Id: ENSRNOP00000070062   ⟸   ENSRNOT00000083702

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689584
Promoter ID:EPDNEW_R109
Type:multiple initiation site
Name:Akap12_2
Description:A-kinase anchoring protein 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R110  EPDNEW_R111  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0140,816,133 - 40,816,193EPDNEW
RGD ID:13689585
Promoter ID:EPDNEW_R110
Type:single initiation site
Name:Akap12_1
Description:A-kinase anchoring protein 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R109  EPDNEW_R111  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0140,879,753 - 40,879,813EPDNEW
RGD ID:13689592
Promoter ID:EPDNEW_R111
Type:initiation region
Name:Akap12_3
Description:A-kinase anchoring protein 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R109  EPDNEW_R110  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0140,891,626 - 40,891,686EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 42162421 42162422 G A snv DOB/Oda (KyushuU)
1 42249313 42249314 G T snv DOB/Oda (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70988 AgrOrtholog
Ensembl Genes ENSRNOG00000019549 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000026483 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000057494 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000070062 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026482 UniProtKB/Swiss-Prot
  ENSRNOT00000060767 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000083702 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro AKAP12 UniProtKB/Swiss-Prot
  Pkinase-A_anch_WSK-motif UniProtKB/Swiss-Prot
KEGG Report rno:83425 UniProtKB/Swiss-Prot
NCBI Gene 83425 ENTREZGENE
PANTHER PTHR23209 UniProtKB/Swiss-Prot
Pfam WSK UniProtKB/Swiss-Prot
PhenoGen Akap12 PhenoGen
PROSITE AKAP_CAM_BD UniProtKB/Swiss-Prot
UniProt AKA12_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q5QD49 UniProtKB/Swiss-Prot
  Q5QD50 UniProtKB/Swiss-Prot
  Q9Z1F7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Akap12  A-kinase anchoring protein 12  Akap12  A kinase (PRKA) anchor protein 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Akap12  A kinase (PRKA) anchor protein 12  Akap12  A kinase (PRKA) anchor protein (gravin) 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Akap12  A kinase (PRKA) anchor protein (gravin) 12      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization after 24 hours of sodium butyrate treatment of transformed rat kidney fibroblasts, as cells spread and attach, Akap12 staining is strongest in the lamellipodia and at the edges of spreading cells; by 48 hours the Akap12 protein staining is highest in the perinuclear region 631986
gene_expression highest mRNA expression in testes, heart, skin and brain; highest protein levels in testes and brain 70657
gene_expression progressive transformation of REF52 cells is accompanied by progressive loss of Akap12 expression 70657
gene_pathway involved in PDGF-BB-, LPA-, EPA-, and NaB-mediated cell signaling 631986
gene_physical_interaction interacts with protein kinase C 70657
gene_process may play a role in mitogen-induced cytoskeletal reorganization 631987
gene_protein approximately 200 kDa 70657
gene_regulation transcription suppressed by transformation of Rat-6 fibroblasts by src, ras, fos and myc, but not by raf, mos or neu 70666
gene_regulation platelet-derived growth factor-BB (PDGF-BB) and lysophosphatidic acid (LPA) upregulate Akap12 in rat smooth muscle cells; eicosapentaenoic acid (EPA) induces Akap12 at lower concentrations, but at higher doses it is antagonistic to Angiotensin II induced upregulation 631986
gene_transcript three isoforms sharing >95% amino acid identity except at their N-termini are the result of tissue specific transcription from three separate but overlapping transcription units with non-redundant promoters 1358132