Eppin (epididymal peptidase inhibitor) - Rat Genome Database

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Gene: Eppin (epididymal peptidase inhibitor) Rattus norvegicus
Analyze
Symbol: Eppin
Name: epididymal peptidase inhibitor
RGD ID: 1597722
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of calcium ion import; negative regulation of flagellated sperm motility; and negative regulation of peptidase activity. Predicted to be located in acrosomal vesicle and cell surface. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Orthologous to human EPPIN-WFDC6 (EPPIN-WFDC6 readthrough) and EPPIN (epididymal peptidase inhibitor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: epididymal protease inhibitor; LOC685161; serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin); serine protease inhibitor-like with Kunitz and WAP domains 1; serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin); similar to Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1); Spinlw1; WAP four-disulfide core domain protein 8; Wfdc8
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,731,739 - 173,738,651 (-)NCBIGRCr8
GRCr8 Ensembl3173,731,739 - 173,738,651 (-)EnsemblGRCr8 Ensembl
mRatBN7.23153,312,396 - 153,319,310 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,312,396 - 153,319,310 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,122,394 - 157,129,304 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,621,354 - 165,628,265 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,364,985 - 163,371,894 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,043,761 - 161,050,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,041,727 - 161,050,557 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,222,870 - 167,229,659 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,607,326 - 155,614,193 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3151,921,822 - 151,928,632 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12909348   PMID:17567961   PMID:18331357   PMID:21796715   PMID:22075473   PMID:23070980   PMID:25494938  


Genomics

Comparative Map Data
Eppin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,731,739 - 173,738,651 (-)NCBIGRCr8
GRCr8 Ensembl3173,731,739 - 173,738,651 (-)EnsemblGRCr8 Ensembl
mRatBN7.23153,312,396 - 153,319,310 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,312,396 - 153,319,310 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,122,394 - 157,129,304 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,621,354 - 165,628,265 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,364,985 - 163,371,894 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,043,761 - 161,050,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,041,727 - 161,050,557 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,222,870 - 167,229,659 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,607,326 - 155,614,193 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3151,921,822 - 151,928,632 (-)NCBICelera
Cytogenetic Map3q42NCBI
EPPIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,540,626 - 45,547,401 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,540,626 - 45,547,752 (-)EnsemblGRCh38hg38GRCh38
GRCh372044,169,265 - 44,176,040 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,602,679 - 43,609,442 (-)NCBINCBI36Build 36hg18NCBI36
Build 342043,602,680 - 43,608,430NCBI
Celera2040,877,785 - 40,884,548 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,910,738 - 40,917,538 (-)NCBIHuRef
CHM1_12044,071,829 - 44,078,629 (-)NCBICHM1_1
T2T-CHM13v2.02047,276,483 - 47,283,258 (-)NCBIT2T-CHM13v2.0
Eppin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,430,263 - 164,435,491 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,430,263 - 164,435,514 (-)EnsemblGRCm39 Ensembl
GRCm382164,588,343 - 164,593,571 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,588,343 - 164,593,594 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,413,843 - 164,419,071 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362164,279,548 - 164,284,776 (-)NCBIMGSCv36mm8
Celera2170,525,008 - 170,530,236 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.21NCBI
EPPIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22151,280,058 - 51,289,699 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12051,273,167 - 51,282,808 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,877,561 - 41,884,375 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,967,885 - 42,973,479 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,967,885 - 42,973,479 (-)Ensemblpanpan1.1panPan2
LOC119865675
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.02433,510,669 - 33,515,510 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12432,771,769 - 32,776,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,887,464 - 32,892,305 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,431,801 - 33,436,642 (-)NCBIUU_Cfam_GSD_1.0
Eppin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640191,933,312 - 191,946,245 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365147,387,348 - 7,392,788 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365147,387,348 - 7,392,274 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPPIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,289,659 - 18,295,622 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,290,916 - 18,295,317 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605066,932,070 - 66,936,813 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000019829
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
RH139903  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83173,737,959 - 173,738,578 (+)Marker Load Pipeline
mRatBN7.23153,318,618 - 153,319,237 (+)MAPPERmRatBN7.2
Rnor_6.03161,049,859 - 161,050,477NCBIRnor6.0
Rnor_5.03167,228,968 - 167,229,586UniSTSRnor5.0
RGSC_v3.43155,613,502 - 155,614,120UniSTSRGSC3.4
Celera3151,927,941 - 151,928,559UniSTS
RH 3.4 Map31420.7UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 10 16 51 55 54 23 25 23 6 126 63 31 23 53 31 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000019829   ⟹   ENSRNOP00000019829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,731,739 - 173,738,651 (-)Ensembl
mRatBN7.2 Ensembl3153,312,396 - 153,319,310 (-)Ensembl
Rnor_6.0 Ensembl3161,041,727 - 161,050,557 (-)Ensembl
RefSeq Acc Id: NM_001109457   ⟹   NP_001102927
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,731,739 - 173,738,651 (-)NCBI
mRatBN7.23153,312,396 - 153,319,310 (-)NCBI
Rnor_6.03161,043,761 - 161,050,550 (-)NCBI
Rnor_5.03167,222,870 - 167,229,659 (-)NCBI
RGSC_v3.43155,607,326 - 155,614,193 (-)RGD
Celera3151,921,822 - 151,928,632 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102927 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4A2Z2 (Get FASTA)   NCBI Sequence Viewer  
  EDL96509 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019829
  ENSRNOP00000019829.5
RefSeq Acc Id: NP_001102927   ⟸   NM_001109457
- Peptide Label: precursor
- UniProtKB: D4A2Z2 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019829   ⟸   ENSRNOT00000019829
Protein Domains
BPTI/Kunitz inhibitor   WAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2Z2-F1-model_v2 AlphaFold D4A2Z2 1-134 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692658
Promoter ID:EPDNEW_R3183
Type:single initiation site
Name:Eppin_1
Description:epididymal peptidase inhibitor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03161,050,557 - 161,050,617EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597722 AgrOrtholog
BioCyc Gene G2FUF-46846 BioCyc
Ensembl Genes ENSRNOG00000028908 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019829 ENTREZGENE
  ENSRNOT00000019829.7 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.410.10 UniProtKB/Swiss-Prot
  4.10.75.10 UniProtKB/Swiss-Prot
InterPro Elafin-like_sf UniProtKB/Swiss-Prot
  Kunitz_BPTI UniProtKB/Swiss-Prot
  Kunitz_BPTI_sf UniProtKB/Swiss-Prot
  Prtase_inh_Kunz-CS UniProtKB/Swiss-Prot
  Serpin_venom_toxin UniProtKB/Swiss-Prot
  WAP_dom UniProtKB/Swiss-Prot
KEGG Report rno:685161 UniProtKB/Swiss-Prot
NCBI Gene 685161 ENTREZGENE
PANTHER EPPIN UniProtKB/Swiss-Prot
  EPPIN UniProtKB/Swiss-Prot
Pfam Kunitz_BPTI UniProtKB/Swiss-Prot
  WAP UniProtKB/Swiss-Prot
PhenoGen Eppin PhenoGen
PRINTS BASICPTASE UniProtKB/Swiss-Prot
PROSITE BPTI_KUNITZ_1 UniProtKB/Swiss-Prot
  BPTI_KUNITZ_2 UniProtKB/Swiss-Prot
  WAP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028908 RatGTEx
SMART SM00131 UniProtKB/Swiss-Prot
  WAP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57256 UniProtKB/Swiss-Prot
  SSF57362 UniProtKB/Swiss-Prot
UniProt D4A2Z2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-16 Eppin  epididymal peptidase inhibitor  Spinlw1  serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Spinlw1  serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)  Spinlw1  serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Spinlw1  serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin)  LOC685161  similar to Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC685161  similar to Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1)  LOC684712  similar to Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1)  Data merged from RGD:1586780 1643240 APPROVED
2006-11-20 LOC685161  similar to Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684712  similar to Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1)      Symbol and Name status set to provisional 70820 PROVISIONAL