Gene: Eppin (epididymal peptidase inhibitor) Rattus norvegicus
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Symbol:
Eppin
Name:
epididymal peptidase inhibitor
RGD ID:
1597722
Description:
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of calcium ion import; negative regulation of flagellated sperm motility; and negative regulation of peptidase activity. Predicted to be located in acrosomal vesicle and cell surface. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Orthologous to human EPPIN-WFDC6 (EPPIN-WFDC6 readthrough) and EPPIN (epididymal peptidase inhibitor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
epididymal protease inhibitor; LOC685161; serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin); serine protease inhibitor-like with Kunitz and WAP domains 1; serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin); similar to Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1); Spinlw1; WAP four-disulfide core domain protein 8; Wfdc8
RGD Orthologs
Alliance Orthologs
More Info
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More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 3 173,731,739 - 173,738,651 (-) NCBI GRCr8 GRCr8 Ensembl 3 173,731,739 - 173,738,651 (-) Ensembl GRCr8 Ensembl mRatBN7.2 3 153,312,396 - 153,319,310 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 3 153,312,396 - 153,319,310 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 3 157,122,394 - 157,129,304 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 3 165,621,354 - 165,628,265 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 3 163,364,985 - 163,371,894 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 3 161,043,761 - 161,050,550 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 3 161,041,727 - 161,050,557 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 3 167,222,870 - 167,229,659 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 3 155,607,326 - 155,614,193 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 Celera 3 151,921,822 - 151,928,632 (-) NCBI Celera Cytogenetic Map 3 q42 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - ClinVar
Only show annotations with direct experimental evidence (0 objects hidden)
Eppin Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Eppin (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Eppin Rat 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactions ISO Eppin (Mus musculus) 6480464 Metribolone inhibits the reaction [Ketoconazole results in decreased expression of EPPIN mRNA] CTD PMID:19587329 Eppin Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Eppin (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Eppin Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Eppin (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Eppin Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of EPPIN mRNA CTD PMID:33387578 Eppin Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Eppin (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Eppin Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of EPPIN mRNA CTD PMID:30047161 Eppin Rat aflatoxin B1 increases methylation ISO EPPIN (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of EPPIN gene CTD PMID:27153756 Eppin Rat all-trans-retinoic acid multiple interactions ISO Eppin (Mus musculus) 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of EPPIN mRNA CTD PMID:36189433 Eppin Rat all-trans-retinoic acid decreases expression ISO Eppin (Mus musculus) 6480464 Tretinoin results in decreased expression of EPPIN mRNA CTD PMID:36189433 Eppin Rat amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of EPPIN mRNA CTD PMID:30047161 Eppin Rat benzo[a]pyrene affects methylation ISO EPPIN (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of EPPIN exon CTD PMID:27901495 Eppin Rat benzo[a]pyrene increases methylation ISO EPPIN (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of EPPIN 3' UTR CTD PMID:27901495 Eppin Rat benzo[a]pyrene decreases methylation ISO EPPIN (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of EPPIN promoter CTD PMID:27901495 Eppin Rat bicalutamide multiple interactions ISO Eppin (Mus musculus) 6480464 FSHB protein inhibits the reaction [bicalutamide results in decreased expression of EPPIN protein] CTD PMID:19587329 Eppin Rat bicalutamide decreases expression ISO Eppin (Mus musculus) 6480464 bicalutamide results in decreased expression of EPPIN mRNA CTD PMID:19587329 Eppin Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of EPPIN mRNA CTD PMID:30816183|PMID:32528016 Eppin Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of EPPIN mRNA CTD PMID:25181051 Eppin Rat cadmium dichloride decreases expression ISO EPPIN (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of EPPIN mRNA CTD PMID:26472689 Eppin Rat cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of EPPIN mRNA CTD PMID:33453195 Eppin Rat CGP 52608 multiple interactions ISO EPPIN (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to EPPIN gene] CTD PMID:28238834 Eppin Rat Cuprizon decreases expression EXP 6480464 Cuprizone results in decreased expression of EPPIN mRNA CTD PMID:26577399 Eppin Rat dimethyl sulfoxide affects expression ISO EPPIN (Homo sapiens) 6480464 Dimethyl Sulfoxide affects the expression of EPPIN mRNA CTD PMID:24834073 Eppin Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of EPPIN mRNA CTD PMID:33387578 Eppin Rat ketoconazole multiple interactions ISO Eppin (Mus musculus) 6480464 Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Metribolone inhibits more ... CTD PMID:19587329 Eppin Rat ketoconazole decreases expression ISO Eppin (Mus musculus) 6480464 Ketoconazole results in decreased expression of EPPIN mRNA CTD PMID:19587329 Eppin Rat methimazole decreases expression EXP 6480464 Methimazole results in decreased expression of EPPIN mRNA CTD PMID:30047161 Eppin Rat mono(2-ethylhexyl) phthalate multiple interactions ISO Eppin (Mus musculus) 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of EPPIN mRNA CTD PMID:36189433 Eppin Rat PCB138 multiple interactions ISO Eppin (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Eppin Rat resveratrol multiple interactions ISO EPPIN (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in decreased expression of EPPIN mRNA CTD PMID:23557933 Eppin Rat sulfadimethoxine decreases expression EXP 6480464 Sulfadimethoxine results in decreased expression of EPPIN mRNA CTD PMID:30047161 Eppin Rat triadimefon decreases expression EXP 6480464 triadimefon results in decreased expression of EPPIN mRNA CTD PMID:30047161 Eppin Rat valproic acid decreases methylation ISO EPPIN (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of EPPIN gene CTD PMID:29154799 Eppin Rat vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of EPPIN mRNA CTD PMID:22570695 Eppin Rat vinclozolin decreases methylation EXP 6480464 vinclozolin results in decreased methylation of EPPIN gene CTD PMID:31682807