Hsbp1 (heat shock factor binding protein 1) - Rat Genome Database

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Gene: Hsbp1 (heat shock factor binding protein 1) Rattus norvegicus
Analyze
Symbol: Hsbp1
Name: heat shock factor binding protein 1
RGD ID: 628632
Description: Predicted to enable identical protein binding activity. Involved in muscle contraction. Predicted to be located in axon cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human HSBP1 (heat shock factor binding protein 1); INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: heat shock factor-binding protein 1; Hsp25
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,309,703 - 64,314,035 (+)NCBIGRCr8
mRatBN7.21947,401,039 - 47,405,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,400,966 - 47,435,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1954,195,408 - 54,199,740 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01954,875,905 - 54,880,295 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,090,522 - 57,094,858 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01951,985,196 - 51,989,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1951,985,170 - 51,989,544 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01962,733,736 - 62,738,068 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,589,574 - 49,594,599 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11949,594,451 - 49,599,480 (+)NCBI
Celera1946,660,240 - 46,664,572 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon cytoplasm  (IEA)
cytosol  (IBA)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions. Koh TJ and Escobedo J, Am J Physiol Cell Physiol 2004 Mar;286(3):C713-22. Epub 2003 Nov 19.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:18156166   PMID:18583709   PMID:24380799   PMID:25416956   PMID:36321738  


Genomics

Comparative Map Data
Hsbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,309,703 - 64,314,035 (+)NCBIGRCr8
mRatBN7.21947,401,039 - 47,405,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,400,966 - 47,435,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1954,195,408 - 54,199,740 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01954,875,905 - 54,880,295 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,090,522 - 57,094,858 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01951,985,196 - 51,989,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1951,985,170 - 51,989,544 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01962,733,736 - 62,738,068 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,589,574 - 49,594,599 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11949,594,451 - 49,599,480 (+)NCBI
Celera1946,660,240 - 46,664,572 (+)NCBICelera
Cytogenetic Map19q12NCBI
HSBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381683,807,978 - 83,819,737 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1683,719,311 - 83,819,737 (+)EnsemblGRCh38hg38GRCh38
GRCh371683,841,583 - 83,853,342 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361682,399,094 - 82,404,095 (+)NCBINCBI36Build 36hg18NCBI36
Build 341682,399,093 - 82,404,095NCBI
Celera1668,142,699 - 68,147,697 (+)NCBICelera
Cytogenetic Map16q23.3NCBI
HuRef1669,593,015 - 69,598,111 (+)NCBIHuRef
CHM1_11685,252,863 - 85,257,959 (+)NCBICHM1_1
T2T-CHM13v2.01689,873,707 - 89,885,464 (+)NCBIT2T-CHM13v2.0
Hsbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,071,277 - 120,075,668 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,071,227 - 120,075,661 (+)EnsemblGRCm39 Ensembl
GRCm388119,344,538 - 119,348,929 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,344,488 - 119,348,922 (+)EnsemblGRCm38mm10GRCm38
MGSCv378121,868,438 - 121,872,829 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368122,230,515 - 122,234,906 (+)NCBIMGSCv36mm8
Celera8123,560,285 - 123,564,676 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map867.54NCBI
Hsbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955564396,133 - 401,251 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955564396,985 - 400,975 (-)NCBIChiLan1.0ChiLan1.0
HSBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21893,552,976 - 93,558,004 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11699,471,430 - 99,476,467 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01664,429,442 - 64,434,467 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11683,821,821 - 83,830,023 (+)NCBIpanpan1.1PanPan1.1panPan2
HSBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1568,474,960 - 68,479,206 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl568,475,948 - 68,479,145 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha568,488,788 - 68,492,964 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0568,773,360 - 68,777,530 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl568,773,360 - 68,777,489 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1568,720,849 - 68,725,018 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0568,557,358 - 68,561,548 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0568,973,475 - 68,977,644 (-)NCBIUU_Cfam_GSD_1.0
Hsbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934928,158,396 - 28,162,850 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366413,911,943 - 3,916,397 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,788,313 - 4,798,191 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.164,795,203 - 4,798,158 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HSBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1569,224,715 - 69,228,607 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660476,592,908 - 6,597,926 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,685,189 - 3,690,642 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247463,686,523 - 3,690,585 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsbp1
25 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:475
Count of miRNA genes:236
Interacting mature miRNAs:280
Transcripts:ENSRNOT00000019443
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat

Markers in Region
RH127949  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,405,065 - 47,405,284 (+)MAPPERmRatBN7.2
Rnor_6.01951,989,221 - 51,989,439NCBIRnor6.0
Rnor_5.01962,737,761 - 62,737,979UniSTSRnor5.0
RGSC_v3.41949,594,295 - 49,594,513UniSTSRGSC3.4
Celera1946,664,265 - 46,664,483UniSTS
RH 3.4 Map19654.0UniSTS
Cytogenetic Map19q12UniSTS
RH124761  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,405,251 - 47,405,335 (+)MAPPERmRatBN7.2
Rnor_6.01951,989,407 - 51,989,490NCBIRnor6.0
Rnor_5.01962,737,947 - 62,738,030UniSTSRnor5.0
RGSC_v3.41949,594,481 - 49,594,564UniSTSRGSC3.4
Celera1946,664,451 - 46,664,534UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000019443   ⟹   ENSRNOP00000019443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1947,400,966 - 47,435,821 (+)Ensembl
Rnor_6.0 Ensembl1951,985,170 - 51,989,544 (+)Ensembl
RefSeq Acc Id: NM_173119   ⟹   NP_775142
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,309,703 - 64,314,035 (+)NCBI
mRatBN7.21947,401,039 - 47,405,373 (+)NCBI
Rnor_6.01951,985,196 - 51,989,528 (+)NCBI
Rnor_5.01962,733,736 - 62,738,068 (+)NCBI
RGSC_v3.41949,589,574 - 49,594,599 (+)RGD
Celera1946,660,240 - 46,664,572 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_775142 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH58131 (Get FASTA)   NCBI Sequence Viewer  
  AAM81322 (Get FASTA)   NCBI Sequence Viewer  
  EDL92660 (Get FASTA)   NCBI Sequence Viewer  
  EDL92661 (Get FASTA)   NCBI Sequence Viewer  
  EDL92662 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019443
  ENSRNOP00000019443.4
GenBank Protein Q8K3X8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_775142   ⟸   NM_173119
- UniProtKB: Q8K3X8 (UniProtKB/Swiss-Prot),   A6IZI3 (UniProtKB/TrEMBL),   A0A8L2Q9S5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019443   ⟸   ENSRNOT00000019443

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K3X8-F1-model_v2 AlphaFold Q8K3X8 1-76 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701177
Promoter ID:EPDNEW_R11699
Type:initiation region
Name:Hsbp1_1
Description:heat shock factor binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01951,985,215 - 51,985,275EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628632 AgrOrtholog
BioCyc Gene G2FUF-5522 BioCyc
Ensembl Genes ENSRNOG00000014415 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019443 ENTREZGENE
  ENSRNOT00000019443.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6919748 IMAGE-MGC_LOAD
InterPro HS1-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:286899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72658 IMAGE-MGC_LOAD
NCBI Gene 286899 ENTREZGENE
PANTHER HEAT SHOCK FACTOR-BINDING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSBP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsbp1 PhenoGen
RatGTEx ENSRNOG00000014415 RatGTEx
UniProt A0A8L2Q9S5 ENTREZGENE, UniProtKB/TrEMBL
  A6IZI2_RAT UniProtKB/TrEMBL
  A6IZI3 ENTREZGENE, UniProtKB/TrEMBL
  HSBP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Hsbp1  heat shock factor binding protein 1      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Hsbp1  heat shock factor binding protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL