Tmem167a (transmembrane protein 167A) - Rat Genome Database

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Gene: Tmem167a (transmembrane protein 167A) Rattus norvegicus
Analyze
Symbol: Tmem167a
Name: transmembrane protein 167A
RGD ID: 2323318
Description: Predicted to be involved in constitutive secretory pathway; intracellular transport; and protein secretion. Predicted to be located in Golgi apparatus. Orthologous to human TMEM167A (transmembrane protein 167A); INTERACTS WITH aconitine; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100359823; protein kish-A; rCG44733-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8222,933,027 - 22,951,974 (+)NCBIGRCr8
mRatBN7.2221,197,799 - 21,216,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl221,197,786 - 21,212,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx228,226,450 - 28,245,369 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0226,326,758 - 26,345,683 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0221,122,234 - 21,141,178 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0218,927,544 - 18,946,110 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl218,937,458 - 18,943,561 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0218,803,341 - 18,822,745 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4220,158,559 - 20,176,739 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera217,326,098 - 17,344,145 (+)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19942856  


Genomics

Comparative Map Data
Tmem167a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8222,933,027 - 22,951,974 (+)NCBIGRCr8
mRatBN7.2221,197,799 - 21,216,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl221,197,786 - 21,212,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx228,226,450 - 28,245,369 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0226,326,758 - 26,345,683 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0221,122,234 - 21,141,178 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0218,927,544 - 18,946,110 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl218,937,458 - 18,943,561 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0218,803,341 - 18,822,745 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4220,158,559 - 20,176,739 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera217,326,098 - 17,344,145 (+)NCBICelera
Cytogenetic Map2q12NCBI
TMEM167A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38583,052,846 - 83,077,394 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl583,052,846 - 83,077,863 (-)EnsemblGRCh38hg38GRCh38
GRCh37582,348,665 - 82,373,213 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36582,387,742 - 82,408,935 (-)NCBINCBI36Build 36hg18NCBI36
Celera578,253,269 - 78,277,876 (-)NCBICelera
Cytogenetic Map5q14.2NCBI
HuRef577,557,054 - 77,581,656 (-)NCBIHuRef
CHM1_1581,781,597 - 81,806,180 (-)NCBICHM1_1
T2T-CHM13v2.0583,538,672 - 83,566,523 (-)NCBIT2T-CHM13v2.0
Tmem167
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391390,237,843 - 90,263,047 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1390,237,242 - 90,292,026 (+)EnsemblGRCm39 Ensembl
GRCm381390,089,667 - 90,114,921 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1390,089,123 - 90,143,907 (+)EnsemblGRCm38mm10GRCm38
MGSCv371390,229,272 - 90,254,526 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361390,563,973 - 90,581,561 (+)NCBIMGSCv36mm8
Celera1393,691,682 - 93,716,939 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1345.5NCBI
Tmem167a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541827,426,354 - 27,444,845 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541827,426,354 - 27,444,845 (+)NCBIChiLan1.0ChiLan1.0
TMEM167A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2432,224,717 - 32,454,748 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1530,378,342 - 30,406,286 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0532,202,349 - 32,238,835 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1532,521,647 - 32,549,605 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl532,534,024 - 32,549,605 (+)Ensemblpanpan1.1panPan2
TMEM167A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1324,547,518 - 24,569,624 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl324,547,630 - 24,566,947 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha325,784,899 - 25,807,008 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0324,459,886 - 24,482,867 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl324,459,898 - 24,481,981 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1324,415,887 - 24,437,992 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0324,382,729 - 24,405,064 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0324,663,479 - 24,685,590 (+)NCBIUU_Cfam_GSD_1.0
Tmem167a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213180,377,465 - 180,399,765 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364692,229,423 - 2,248,256 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM167A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl291,326,674 - 91,358,164 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1291,321,398 - 91,358,270 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2293,410,337 - 93,441,210 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM167A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl477,156,043 - 77,182,699 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604926,058,553 - 26,084,928 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem167a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247433,281,564 - 3,299,169 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247433,279,133 - 3,299,199 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem167a
86 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:880
Count of miRNA genes:312
Interacting mature miRNAs:406
Transcripts:ENSRNOT00000022366, ENSRNOT00000022377
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
61368Mcs1Mammary carcinoma susceptibility QTL 14.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777223319447Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat

Markers in Region
RH128864  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2221,216,528 - 21,216,719 (+)MAPPERmRatBN7.2
Rnor_6.0218,946,824 - 18,947,014NCBIRnor6.0
Rnor_5.0218,822,604 - 18,822,794UniSTSRnor5.0
RGSC_v3.4220,177,018 - 20,177,208UniSTSRGSC3.4
Celera217,344,859 - 17,345,049UniSTS
RH143818  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2221,214,197 - 21,214,328 (+)MAPPERmRatBN7.2
Rnor_6.0218,944,493 - 18,944,623NCBIRnor6.0
Rnor_5.0218,820,273 - 18,820,403UniSTSRnor5.0
RGSC_v3.4220,174,687 - 20,174,817UniSTSRGSC3.4
Celera217,342,528 - 17,342,658UniSTS
BI303647  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2221,195,901 - 21,196,021 (+)MAPPERmRatBN7.2
Rnor_6.0218,925,682 - 18,925,801NCBIRnor6.0
Rnor_5.0218,801,462 - 18,801,581UniSTSRnor5.0
RGSC_v3.4220,156,675 - 20,156,794UniSTSRGSC3.4
Celera217,324,236 - 17,324,355UniSTS
Cytogenetic Map2q12UniSTS
RH135270  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2221,215,646 - 21,215,846 (+)MAPPERmRatBN7.2
Rnor_6.0218,945,942 - 18,946,141NCBIRnor6.0
Rnor_5.0218,821,722 - 18,821,921UniSTSRnor5.0
RGSC_v3.4220,176,136 - 20,176,335UniSTSRGSC3.4
Celera217,343,977 - 17,344,176UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022377   ⟹   ENSRNOP00000022376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl221,197,786 - 21,212,099 (+)Ensembl
Rnor_6.0 Ensembl218,937,458 - 18,943,561 (+)Ensembl
RefSeq Acc Id: NM_001399682   ⟹   NP_001386611
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,933,027 - 22,951,974 (+)NCBI
mRatBN7.2221,197,799 - 21,216,746 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386611 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022376.4
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000022376   ⟸   ENSRNOT00000022377
RefSeq Acc Id: NP_001386611   ⟸   NM_001399682
- Peptide Label: precursor
- UniProtKB: A6I4N8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKR8-F1-model_v2 AlphaFold D3ZKR8 1-71 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2323318 AgrOrtholog
BioCyc Gene G2FUF-54900 BioCyc
Ensembl Genes ENSRNOG00000016686 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022377.6 UniProtKB/TrEMBL
InterPro DUF1242 UniProtKB/TrEMBL
KEGG Report rno:100359823 UniProtKB/TrEMBL
NCBI Gene 100359823 ENTREZGENE
PANTHER PROTEIN KISH UniProtKB/TrEMBL
  PROTEIN KISH-A UniProtKB/TrEMBL
  PROTEIN KISH-A UniProtKB/TrEMBL
Pfam DUF1242 UniProtKB/TrEMBL
PhenoGen Tmem167a PhenoGen
RatGTEx ENSRNOG00000016686 RatGTEx
  ENSRNOG00000062169 RatGTEx
UniProt A6I4N8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKR8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-26 Tmem167a  transmembrane protein 167A  LOC100359823  rCG44733-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100359823  rCG44733-like      Symbol and Name status set to provisional 70820 PROVISIONAL