Uck2 (uridine-cytidine kinase 2) - Rat Genome Database

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Gene: Uck2 (uridine-cytidine kinase 2) Rattus norvegicus
Analyze
Symbol: Uck2
Name: uridine-cytidine kinase 2
RGD ID: 620742
Description: Predicted to enable cytidine kinase activity; identical protein binding activity; and uridine kinase activity. Involved in cellular response to oxygen levels; feeding behavior; and response to axon injury. Located in cytosol and intracellular membrane-bounded organelle. Orthologous to human UCK2 (uridine-cytidine kinase 2); PARTICIPATES IN pyrimidine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytidine monophosphokinase 2; LOC304944; UCK 2; Umpk; uridine monophosphate kinase; uridine monophosphokinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21379,380,807 - 79,438,352 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1379,383,846 - 79,438,352 (-)Ensembl
Rnor_6.01385,376,716 - 85,443,976 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1385,376,716 - 85,443,976 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013101,428,775 - 101,429,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01390,035,485 - 90,087,109 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41382,892,893 - 82,949,575 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11382,907,443 - 82,914,725 (-)NCBI
Celera1379,089,479 - 79,143,648 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-fluorouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
Enterolactone  (ISO)
folic acid  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Adverse effects of hyperbaric oxygen on uridine incorporation and uridine kinase activity in B104 rat neuroblastoma cells. Gendimenico GJ and Haugaard N, Mol Cell Biochem. 1990 Jun 1;95(1):71-6.
3. Effect of diabetes and fasting on the uridine triphosphate content and uridine kinase activity of rat cardiac and skeletal muscle. Gertz BJ and Haugaard ES, Metabolism. 1979 Apr;28(4):358-62.
4. Postnatal ontogeny of uridine kinase in the cerebellum, hypothalamus, and cerebral cortex of the rat. Litteria M and Popoff CG, Neurochem Res. 1985 Jan;10(1):63-75.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Sensitivity of human cancer cells to the new anticancer ribo-nucleoside TAS-106 is correlated with expression of uridine-cytidine kinase 2. Shimamoto Y, etal., Jpn J Cancer Res. 2002 Jul;93(7):825-33.
10. Up-regulated uridine kinase gene identified by RLCS in the ventral horn after crush injury to rat sciatic nerves. Yuh I, etal., Biochem Biophys Res Commun 1999 Dec 9;266(1):104-9.
Additional References at PubMed
PMID:12477932   PMID:15130468   PMID:15632090  


Genomics

Comparative Map Data
Uck2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21379,380,807 - 79,438,352 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1379,383,846 - 79,438,352 (-)Ensembl
Rnor_6.01385,376,716 - 85,443,976 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1385,376,716 - 85,443,976 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013101,428,775 - 101,429,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01390,035,485 - 90,087,109 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41382,892,893 - 82,949,575 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11382,907,443 - 82,914,725 (-)NCBI
Celera1379,089,479 - 79,143,648 (-)NCBICelera
Cytogenetic Map13q24NCBI
UCK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,827,614 - 165,911,618 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1165,827,614 - 165,911,618 (+)EnsemblGRCh38hg38GRCh38
GRCh371165,796,851 - 165,880,855 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,063,514 - 164,143,967 (+)NCBINCBI36hg18NCBI36
Celera1138,902,284 - 138,982,715 (+)NCBI
Cytogenetic Map1q24.1NCBI
HuRef1137,044,441 - 137,128,457 (+)NCBIHuRef
CHM1_11167,219,021 - 167,303,066 (+)NCBICHM1_1
T2T-CHM13v2.01165,173,785 - 165,257,744 (+)NCBI
Uck2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391167,050,464 - 167,112,926 (-)NCBIGRCm39mm39
GRCm39 Ensembl1167,050,452 - 167,112,889 (-)Ensembl
GRCm381167,222,895 - 167,285,933 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1167,222,883 - 167,285,320 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,156,214 - 169,215,258 (-)NCBIGRCm37mm9NCBIm37
MGSCv361169,062,758 - 169,121,802 (-)NCBImm8
Celera1169,643,034 - 169,702,477 (-)NCBICelera
Cytogenetic Map1H2.3NCBI
Uck2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546210,815,389 - 10,886,227 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546210,815,496 - 10,925,364 (-)NCBIChiLan1.0ChiLan1.0
UCK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11145,110,561 - 145,131,894 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1145,110,434 - 145,131,894 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01141,259,057 - 141,343,122 (+)NCBIMhudiblu_PPA_v0panPan3
UCK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13817,475,789 - 17,555,926 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3817,479,558 - 17,579,675 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3817,535,557 - 17,602,054 (-)NCBI
ROS_Cfam_1.03817,534,582 - 17,601,221 (-)NCBI
ROS_Cfam_1.0 Ensembl3817,531,134 - 17,634,890 (-)Ensembl
UMICH_Zoey_3.13817,532,294 - 17,598,816 (-)NCBI
UNSW_CanFamBas_1.03817,883,407 - 17,949,905 (-)NCBI
UU_Cfam_GSD_1.03818,177,313 - 18,243,863 (-)NCBI
Uck2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344101,658,728 - 101,713,313 (-)NCBI
SpeTri2.0NW_00493648119,505,477 - 19,560,035 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl484,838,802 - 84,919,236 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1484,838,793 - 84,919,231 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
UCK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12562,974,515 - 63,059,436 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2562,974,257 - 63,059,414 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605564,729,768 - 64,814,746 (-)NCBIVero_WHO_p1.0
Uck2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248264,163,798 - 4,229,640 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248264,163,830 - 4,243,048 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AA859050  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21379,384,000 - 79,384,123 (+)MAPPERmRatBN7.2
Rnor_6.01385,390,374 - 85,390,499NCBIRnor6.0
Rnor_6.01385,376,871 - 85,376,993NCBIRnor6.0
Rnor_5.013101,428,930 - 101,429,052UniSTSRnor5.0
RGSC_v3.41382,893,048 - 82,893,170UniSTSRGSC3.4
Celera1379,089,545 - 79,089,667UniSTS
RH 3.4 Map13541.8UniSTS
Cytogenetic Map13q23UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:84
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000005213
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 30 23 16 18 16 74 18 36 8
Low 13 34 25 1 25 8 11 17 5 3 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005213   ⟹   ENSRNOP00000005213
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1379,383,846 - 79,438,352 (-)Ensembl
Rnor_6.0 Ensembl1385,376,716 - 85,443,976 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076125   ⟹   ENSRNOP00000068308
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1379,384,190 - 79,438,352 (-)Ensembl
Rnor_6.0 Ensembl1385,392,600 - 85,443,784 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090668   ⟹   ENSRNOP00000070085
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1379,383,888 - 79,438,224 (-)Ensembl
Rnor_6.0 Ensembl1385,376,772 - 85,443,727 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098075   ⟹   ENSRNOP00000095493
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1379,383,923 - 79,438,073 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108935   ⟹   ENSRNOP00000093147
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1379,383,888 - 79,437,660 (-)Ensembl
RefSeq Acc Id: NM_001102408   ⟹   NP_001095878
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21379,383,846 - 79,438,352 (-)NCBI
Rnor_6.01385,376,716 - 85,443,976 (-)NCBI
Rnor_5.01390,035,485 - 90,087,109 (-)NCBI
Rnor_5.013101,428,775 - 101,429,259 (-)NCBI
RGSC_v3.41382,892,893 - 82,949,575 (-)RGD
Celera1379,089,479 - 79,143,648 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090790   ⟹   XP_038946718
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21379,380,807 - 79,437,545 (-)NCBI
RefSeq Acc Id: XM_039090791   ⟹   XP_038946719
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21379,380,807 - 79,438,347 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001095878   ⟸   NM_001102408
- UniProtKB: D3Z885 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070085   ⟸   ENSRNOT00000090668
RefSeq Acc Id: ENSRNOP00000005213   ⟸   ENSRNOT00000005213
RefSeq Acc Id: ENSRNOP00000068308   ⟸   ENSRNOT00000076125
RefSeq Acc Id: XP_038946719   ⟸   XM_039090791
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038946718   ⟸   XM_039090790
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000095493   ⟸   ENSRNOT00000098075
RefSeq Acc Id: ENSRNOP00000093147   ⟸   ENSRNOT00000108935
Protein Domains
PRK

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYG8-F1-model_v2 AlphaFold Q9QYG8 1-261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698976
Promoter ID:EPDNEW_R9496
Type:initiation region
Name:Uck2_1
Description:uridine-cytidine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01385,443,715 - 85,443,775EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620742 AgrOrtholog
BioCyc Gene G2FUF-17528 BioCyc
BioCyc Pathway PWY-7193 [pyrimidine ribonucleosides salvage I] BioCyc
Ensembl Genes ENSRNOG00000003917 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005213 ENTREZGENE
  ENSRNOP00000005213.6 UniProtKB/TrEMBL
  ENSRNOP00000068308.2 UniProtKB/TrEMBL
  ENSRNOP00000070085 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000093147.1 UniProtKB/TrEMBL
  ENSRNOP00000095493.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005213 ENTREZGENE
  ENSRNOT00000005213.9 UniProtKB/TrEMBL
  ENSRNOT00000076125.3 UniProtKB/TrEMBL
  ENSRNOT00000090668 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000098075.1 UniProtKB/TrEMBL
  ENSRNOT00000108935.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9031892 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRK/URK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UCK-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Uridine_kinase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:304944 UniProtKB/TrEMBL
MGC_CLONE MGC:189371 IMAGE-MGC_LOAD
NCBI Gene 304944 ENTREZGENE
PANTHER PTHR10285:SF131 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PRK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB UCK2 RGD
PhenoGen Uck2 PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs udk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MJY5_RAT UniProtKB/TrEMBL
  A0A0G2JX05_RAT UniProtKB/TrEMBL
  A0A8I6AI33_RAT UniProtKB/TrEMBL
  A0A8I6ANJ5_RAT UniProtKB/TrEMBL
  D3Z885 ENTREZGENE, UniProtKB/TrEMBL
  Q9QYG8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RZ83 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-10-22 Uck2  uridine-cytidine kinase 2  Umpk_predicted  uridine monophosphate kinase (predicted)  Data Merged 737654 APPROVED
2005-07-08 Uck2  uridine-cytidine kinase 2      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Umpk_predicted  uridine monophosphate kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Uck2  uridine-cytidine kinase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA increased at 14 post-operative day (POD) of sciatic nerve crush injury 634248