Uck2 (uridine-cytidine kinase 2) - Rat Genome Database

Name: Uck2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Uck2 (uridine-cytidine kinase 2) Rattus norvegicus

Analyze

Symbol:

Uck2

Name:

uridine-cytidine kinase 2

RGD ID:

620742

Description:

Predicted to enable cytidine kinase activity; identical protein binding activity; and uridine kinase activity. Involved in cellular response to oxygen levels; feeding behavior; and response to axon injury. Orthologous to human UCK2 (uridine-cytidine kinase 2); PARTICIPATES IN pyrimidine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

cytidine monophosphokinase 2; LOC304944; UCK 2; Umpk; uridine monophosphate kinase; uridine monophosphokinase 2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UCK2 (uridine-cytidine kinase 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Uck2 (uridine-cytidine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Uck2 (uridine-cytidine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	UCK2 (uridine-cytidine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	UCK2 (uridine-cytidine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Uck2 (uridine-cytidine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	UCK2 (uridine-cytidine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	UCK2 (uridine-cytidine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Uck2 (uridine-cytidine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	UCK1 (uridine-cytidine kinase 1)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Uck2 (uridine-cytidine kinase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	UCK2 (uridine-cytidine kinase 2)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	uck2a (uridine-cytidine kinase 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	uck2b (uridine-cytidine kinase 2b)	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	DAS2	Alliance	DIOPT (Hieranoid\|InParanoid\|PANTHER)
Caenorhabditis elegans (roundworm):	B0001.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Uck	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	uck2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	79,380,807 - 79,438,121 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	79,383,846 - 79,438,352 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	82,013,671 - 82,068,184 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	83,321,316 - 83,375,604 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	80,558,961 - 80,613,449 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	85,376,716 - 85,443,976 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	85,376,716 - 85,443,976 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	101,428,775 - 101,429,259 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	13	90,035,485 - 90,087,109 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	82,892,893 - 82,949,575 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	82,907,443 - 82,914,725 (-)	NCBI
Celera	13	79,089,479 - 79,143,648 (-)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

Experimental Diabetes Mellitus (IEP)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

lung adenocarcinoma (ISO)

pancreatic cancer (ISO)

parathyroid carcinoma (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

5-fluorouracil (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

benzoates (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbamazepine (ISO)

carbofuran (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

dibutyl phthalate (ISO)

diclofenac (ISO)

dioxygen (EXP,ISO)

diquat (ISO)

doxorubicin (EXP)

endosulfan (EXP)

Enterolactone (ISO)

folic acid (ISO)

indometacin (ISO)

isoprenaline (EXP)

ivermectin (ISO)

methamphetamine (ISO)

methapyrilene (ISO)

methotrexate (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

methylphenidate (ISO)

methylseleninic acid (ISO)

miconazole (ISO)

monosodium L-glutamate (ISO)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

ozone (ISO)

paracetamol (ISO)

paraquat (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

resveratrol (ISO)

rotenone (EXP)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

toluene 2,4-diisocyanate (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to oxygen levels (IEP)

CMP biosynthetic process (IEA)

CTP salvage (IEA,ISO,ISS)

feeding behavior (IEP)

phosphorylation (IEA)

protein deubiquitination (TAS)

response to axon injury (IEP)

UMP salvage (IEA,ISO,ISS)

Cellular Component

cytoplasm (IBA)

Molecular Function

ATP binding (IEA)

cytidine kinase activity (IEA,ISO,ISS)

identical protein binding (IEA,ISO)

kinase activity (IEA)

protein binding (ISO)

uridine kinase activity (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

pyrimidine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Adverse effects of hyperbaric oxygen on uridine incorporation and uridine kinase activity in B104 rat neuroblastoma cells.	Gendimenico GJ and Haugaard N, Mol Cell Biochem. 1990 Jun 1;95(1):71-6.
3.	Effect of diabetes and fasting on the uridine triphosphate content and uridine kinase activity of rat cardiac and skeletal muscle.	Gertz BJ and Haugaard ES, Metabolism. 1979 Apr;28(4):358-62.
4.	Postnatal ontogeny of uridine kinase in the cerebellum, hypothalamus, and cerebral cortex of the rat.	Litteria M and Popoff CG, Neurochem Res. 1985 Jan;10(1):63-75.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Sensitivity of human cancer cells to the new anticancer ribo-nucleoside TAS-106 is correlated with expression of uridine-cytidine kinase 2.	Shimamoto Y, etal., Jpn J Cancer Res. 2002 Jul;93(7):825-33.
10.	Up-regulated uridine kinase gene identified by RLCS in the ventral horn after crush injury to rat sciatic nerves.	Yuh I, etal., Biochem Biophys Res Commun 1999 Dec 9;266(1):104-9.

Additional References at PubMed

PMID:12477932	PMID:15130468	PMID:15632090

Genomics

Comparative Map Data

Uck2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	79,380,807 - 79,438,121 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	79,383,846 - 79,438,352 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	82,013,671 - 82,068,184 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	83,321,316 - 83,375,604 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	80,558,961 - 80,613,449 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	85,376,716 - 85,443,976 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	85,376,716 - 85,443,976 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	101,428,775 - 101,429,259 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	13	90,035,485 - 90,087,109 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	82,892,893 - 82,949,575 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	82,907,443 - 82,914,725 (-)	NCBI
Celera	13	79,089,479 - 79,143,648 (-)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

UCK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	165,827,614 - 165,911,618 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	165,827,614 - 165,911,618 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	165,796,851 - 165,880,855 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	164,063,514 - 164,143,967 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	138,902,284 - 138,982,715 (+)	NCBI		Celera
Cytogenetic Map	1	q24.1	NCBI
HuRef	1	137,044,441 - 137,128,457 (+)	NCBI		HuRef
CHM1_1	1	167,219,021 - 167,303,066 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	165,173,785 - 165,257,744 (+)	NCBI		T2T-CHM13v2.0

Uck2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	167,050,464 - 167,112,657 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	167,050,452 - 167,112,889 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	167,222,895 - 167,285,933 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	167,222,883 - 167,285,320 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	169,156,214 - 169,215,258 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	169,062,758 - 169,121,802 (-)	NCBI		MGSCv36	mm8
Celera	1	169,643,034 - 169,702,477 (-)	NCBI		Celera
Cytogenetic Map	1	H2.3	NCBI
cM Map	1	74.61	NCBI

Uck2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955462	10,815,389 - 10,886,227 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955462	10,815,496 - 10,925,364 (-)	NCBI	ChiLan1.0	ChiLan1.0

UCK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	83,522,848 - 83,608,323 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	141,259,057 - 141,343,122 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	145,110,561 - 145,131,894 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	145,110,434 - 145,131,894 (+)	Ensembl	panpan1.1		panPan2

UCK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	17,475,789 - 17,555,926 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	17,479,558 - 17,579,675 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	17,535,557 - 17,602,054 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	17,534,582 - 17,601,221 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	17,531,134 - 17,634,890 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	17,532,294 - 17,598,816 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	17,883,407 - 17,949,905 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	18,177,313 - 18,243,863 (-)	NCBI		UU_Cfam_GSD_1.0

Uck2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	101,658,728 - 101,713,313 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936481	19,505,459 - 19,560,083 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936481	19,505,477 - 19,560,035 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UCK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	84,838,802 - 84,919,236 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	84,838,793 - 84,919,231 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

UCK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	62,974,515 - 63,059,436 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	62,974,257 - 63,059,414 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	64,729,768 - 64,814,746 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Uck2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624826	4,163,798 - 4,229,640 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624826	4,163,830 - 4,243,048 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Uck2
215 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	96
Count of miRNA genes:	84
Interacting mature miRNAs:	87
Transcripts:	ENSRNOT00000005213
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34535218	79535218	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	37262092	82262092	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	37415584	80753406	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	37415584	82415584	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	38433408	83433408	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
12879444	Bp397	Blood pressure QTL 397			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45049404	90049404	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45514719	90514719	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45699983	90699983	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	46088046	91088046	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	46197976	84753113	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	52362171	97362171	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	56056920	101056920	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	59874408	85581182	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	69060519	86800898	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	69060519	86800898	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	69060519	86800898	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	74023918	80753406	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	74023918	97213863	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	74862117	85581182	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	74862117	101339893	Rat

Markers in Region

AA859050

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	79,384,000 - 79,384,123 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	85,390,374 - 85,390,499	NCBI	Rnor6.0
Rnor_6.0	13	85,376,871 - 85,376,993	NCBI	Rnor6.0
Rnor_5.0	13	101,428,930 - 101,429,052	UniSTS	Rnor5.0
RGSC_v3.4	13	82,893,048 - 82,893,170	UniSTS	RGSC3.4
Celera	13	79,089,545 - 79,089,667	UniSTS
RH 3.4 Map	13	541.8	UniSTS
Cytogenetic Map	13	q23	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	30	23	16	18	16			74	18	36	8
Low		13	34	25	1	25	8	11		17	5	3	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001415746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB030700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC167060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000005213 ⟹ ENSRNOP00000005213

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	79,383,846 - 79,438,352 (-)	Ensembl
Rnor_6.0 Ensembl	13	85,376,716 - 85,443,976 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000076125 ⟹ ENSRNOP00000068308

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	79,384,190 - 79,438,352 (-)	Ensembl
Rnor_6.0 Ensembl	13	85,392,600 - 85,443,784 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000090668 ⟹ ENSRNOP00000070085

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	79,383,888 - 79,438,224 (-)	Ensembl
Rnor_6.0 Ensembl	13	85,376,772 - 85,443,727 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098075 ⟹ ENSRNOP00000095493

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	79,383,923 - 79,438,073 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108935 ⟹ ENSRNOP00000093147

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	79,383,888 - 79,437,660 (-)	Ensembl

RefSeq Acc Id:

NM_001415746 ⟹ NP_001402675

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	79,383,893 - 79,438,121 (-)	NCBI

RefSeq Acc Id:

XM_039090790 ⟹ XP_038946718

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	79,380,807 - 79,437,545 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001402675	(Get FASTA)	NCBI Sequence Viewer
	XP_038946718	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI67060	(Get FASTA)	NCBI Sequence Viewer
	BAA83085	(Get FASTA)	NCBI Sequence Viewer
	EDM09286	(Get FASTA)	NCBI Sequence Viewer
	EDM09287	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005213.6
	ENSRNOP00000068308.2
	ENSRNOP00000070085
	ENSRNOP00000093147.1
	ENSRNOP00000095493.1
GenBank Protein	Q9QYG8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000070085 ⟸ ENSRNOT00000090668

RefSeq Acc Id:

ENSRNOP00000005213 ⟸ ENSRNOT00000005213

RefSeq Acc Id:

ENSRNOP00000068308 ⟸ ENSRNOT00000076125

RefSeq Acc Id:	XP_038946718 ⟸ XM_039090790
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AI33 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000095493 ⟸ ENSRNOT00000098075

RefSeq Acc Id:

ENSRNOP00000093147 ⟸ ENSRNOT00000108935

RefSeq Acc Id:	NP_001402675 ⟸ NM_001415746
- UniProtKB:	Q9QYG8 (UniProtKB/Swiss-Prot), B2RZ83 (UniProtKB/Swiss-Prot), A0A0G2JX05 (UniProtKB/TrEMBL)

Protein Domains

Phosphoribulokinase/uridine kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9QYG8-F1-model_v2	AlphaFold	Q9QYG8	1-261	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698976

Promoter ID:

EPDNEW_R9496

Type:

initiation region

Name:

Uck2_1

Description:

uridine-cytidine kinase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	85,443,715 - 85,443,775	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620742	AgrOrtholog
BioCyc Gene	G2FUF-17528	BioCyc
BioCyc Pathway	PWY-7193 [pyrimidine ribonucleosides salvage I]	BioCyc
Ensembl Genes	ENSRNOG00000003917	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005213.9	UniProtKB/TrEMBL
	ENSRNOT00000076125.3	UniProtKB/TrEMBL
	ENSRNOT00000090668	ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOT00000098075.1	UniProtKB/TrEMBL
	ENSRNOT00000108935.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9031892	IMAGE-MGC_LOAD
InterPro	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PRK/URK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Uridine_kinase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:304944	UniProtKB/TrEMBL
MGC_CLONE	MGC:189371	IMAGE-MGC_LOAD
NCBI Gene	304944	ENTREZGENE
PANTHER	PTHR10285:SF131	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	URIDINE KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PRK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	UCK2	RGD
PhenoGen	Uck2	PhenoGen
PRINTS	URIDINKINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003917	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A096MJY5_RAT	UniProtKB/TrEMBL
	A0A0G2JX05	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AI33	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ANJ5_RAT	UniProtKB/TrEMBL
	B2RZ83	ENTREZGENE
	D3Z885_RAT	UniProtKB/TrEMBL
	Q9QYG8	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	B2RZ83	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2007-10-22	Uck2	uridine-cytidine kinase 2	Umpk_predicted	uridine monophosphate kinase (predicted)	Data merged from RGD:1304844	737654	APPROVED
2005-07-08	Uck2	uridine-cytidine kinase 2			Symbol and Name status set to approved	1299863	APPROVED
2005-01-12	Umpk_predicted	uridine monophosphate kinase (predicted)			Symbol and Name status set to approved	70820	APPROVED
2002-08-07	Uck2	uridine-cytidine kinase 2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA increased at 14 post-operative day (POD) of sciatic nerve crush injury	634248

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)