Dlat (dihydrolipoamide S-acetyltransferase) - Rat Genome Database

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Gene: Dlat (dihydrolipoamide S-acetyltransferase) Rattus norvegicus
Analyze
Symbol: Dlat
Name: dihydrolipoamide S-acetyltransferase
RGD ID: 619859
Description: Enables dihydrolipoyllysine-residue acetyltransferase activity. Involved in pyruvate decarboxylation to acetyl-CoA. Located in mitochondrion. Part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; INTERACTS WITH (R)-adrenaline; 17alpha-ethynylestradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; dihydrolipoamide acetyltransferase; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex); dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; E2; PBC; PDC-E2; PDCE2; pyruvate dehydrogenase complex component E2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Dlat-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,875,537 - 59,900,947 (-)NCBIGRCr8
mRatBN7.2850,979,151 - 51,004,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,978,051 - 51,004,479 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl133,231,226 - 33,233,129 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,484,986 - 56,510,281 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,763,886 - 54,789,211 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,628,160 - 52,653,457 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,062,549 - 55,087,832 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,062,551 - 55,087,832 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,659,920 - 53,685,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,989,491 - 54,014,779 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1854,008,592 - 54,033,135 (-)NCBI
Celera850,507,581 - 50,552,393 (-)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clozapine  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diethylstilbestrol  (EXP)
dinophysistoxin 1  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elesclomol  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
haloperidol  (EXP)
hydralazine  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
metformin  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (EXP,ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrial matrix  (IEA,ISO)
mitochondrion  (IDA,IEA,ISO)
pyruvate dehydrogenase complex  (IBA,IDA,IEA,ISO,TAS)

References

References - curated
# Reference Title Reference Citation
1. Halothane metabolism: the dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex molecularly mimics trifluoroacetyl-protein adducts. Christen U, etal., Biochemistry. 1993 Feb 16;32(6):1492-9.
2. Changes in brain gene expression after long-term sleep deprivation. Cirelli C, etal., J Neurochem. 2006 Sep;98(5):1632-45.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis. Gershwin ME, etal., J Immunol. 1987 May 15;138(10):3525-31.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Molecular cloning of dihydrolipoamide acetyltransferase of the rat pyruvate dehydrogenase complex: sequence comparison and evolutionary relationship to other dihydrolipoamide acyltransferases. Matuda S, etal., Biochim Biophys Acta 1992 May 7;1131(1):114-8.
7. Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat. Maury J, etal., Biochem J. 1995 Oct 15;311 ( Pt 2):531-5.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9045657   PMID:9242632   PMID:12477932   PMID:14651853   PMID:15489334   PMID:17634366   PMID:18184587   PMID:18184588   PMID:18614015   PMID:20833797   PMID:25525879   PMID:26316108  
PMID:26945066   PMID:29476059   PMID:32357304  


Genomics

Comparative Map Data
Dlat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,875,537 - 59,900,947 (-)NCBIGRCr8
mRatBN7.2850,979,151 - 51,004,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,978,051 - 51,004,479 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl133,231,226 - 33,233,129 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,484,986 - 56,510,281 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,763,886 - 54,789,211 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,628,160 - 52,653,457 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,062,549 - 55,087,832 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,062,551 - 55,087,832 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,659,920 - 53,685,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,989,491 - 54,014,779 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1854,008,592 - 54,033,135 (-)NCBI
Celera850,507,581 - 50,552,393 (-)NCBICelera
Cytogenetic Map8q23NCBI
DLAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811112,025,408 - 112,064,404 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,025,033 - 112,064,404 (+)EnsemblGRCh38hg38GRCh38
GRCh3711111,896,132 - 111,935,128 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,401,381 - 111,439,799 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411111,401,387 - 111,439,798NCBI
Celera11109,048,752 - 109,088,192 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,819,561 - 107,858,905 (+)NCBIHuRef
CHM1_111111,778,793 - 111,818,192 (+)NCBICHM1_1
T2T-CHM13v2.011112,035,650 - 112,074,647 (+)NCBIT2T-CHM13v2.0
Dlat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,545,933 - 50,571,080 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,545,933 - 50,571,080 (-)EnsemblGRCm39 Ensembl
GRCm38950,634,633 - 50,659,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,634,633 - 50,659,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv37950,442,738 - 50,467,885 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,386,865 - 50,412,010 (-)NCBIMGSCv36mm8
Celera947,920,941 - 47,946,308 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Dlat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,718,067 - 13,744,239 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,718,091 - 13,746,220 (+)NCBIChiLan1.0ChiLan1.0
DLAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,770,172 - 112,813,947 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,864,456 - 113,909,461 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011106,910,857 - 106,950,851 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,755,310 - 110,793,876 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,756,001 - 110,792,795 (+)Ensemblpanpan1.1panPan2
DLAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,062,833 - 21,094,235 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,064,026 - 21,094,153 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,985,229 - 21,016,566 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0521,086,208 - 21,117,183 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,086,325 - 21,117,555 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,147,724 - 21,178,540 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,047,717 - 21,079,036 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,096,415 - 21,127,748 (-)NCBIUU_Cfam_GSD_1.0
Dlat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,268,188 - 94,312,532 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,393,071 - 2,437,522 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,395,452 - 2,437,592 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,738,564 - 39,796,806 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,738,639 - 39,763,813 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,595,812 - 44,605,405 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2944,530,186 - 44,541,155 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,379,165 - 103,419,585 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,380,426 - 103,420,386 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604322,562,984 - 22,603,121 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dlat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,181,671 - 7,214,751 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247847,181,550 - 7,216,779 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dlat
83 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:66
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000032152
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat

Markers in Region
DLAT  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2133,232,108 - 33,233,092 (+)MAPPERmRatBN7.2
mRatBN7.2133,232,998 - 33,233,092 (+)MAPPERmRatBN7.2
mRatBN7.2850,979,880 - 50,979,975 (-)MAPPERmRatBN7.2
mRatBN7.2133,232,108 - 33,233,702 (+)MAPPERmRatBN7.2
Rnor_6.0135,868,892 - 35,869,875NCBIRnor6.0
Rnor_6.0135,868,892 - 35,870,578NCBIRnor6.0
Rnor_5.0137,266,408 - 37,268,094UniSTSRnor5.0
Rnor_5.0137,266,408 - 37,267,391UniSTSRnor5.0
RGSC_v3.4173,379,962 - 3,380,945UniSTSRGSC3.4
Celera131,843,186 - 31,844,169UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map8q23UniSTS
RH139711  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2851,007,856 - 51,008,020 (+)MAPPERmRatBN7.2
Rnor_6.0855,091,254 - 55,091,417NCBIRnor6.0
Rnor_5.0853,688,660 - 53,688,823UniSTSRnor5.0
RGSC_v3.4854,018,201 - 54,018,364UniSTSRGSC3.4
Celera850,555,815 - 50,555,978UniSTS
RH 3.4 Map8548.2UniSTS
Cytogenetic Map8q23UniSTS
RH127531  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2850,975,229 - 50,975,431 (+)MAPPERmRatBN7.2
Rnor_6.0855,058,628 - 55,058,829NCBIRnor6.0
Rnor_5.0853,655,999 - 53,656,200UniSTSRnor5.0
RGSC_v3.4853,985,570 - 53,985,771UniSTSRGSC3.4
Celera850,523,425 - 50,523,626UniSTS
RH 3.4 Map8549.8UniSTS
Cytogenetic Map8q23UniSTS
RH128680  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2851,009,346 - 51,009,496 (+)MAPPERmRatBN7.2
Rnor_6.0855,092,743 - 55,092,892NCBIRnor6.0
Rnor_5.0853,690,149 - 53,690,298UniSTSRnor5.0
RGSC_v3.4854,019,690 - 54,019,839UniSTSRGSC3.4
Celera850,557,304 - 50,557,453UniSTS
RH 3.4 Map8545.1UniSTS
Cytogenetic Map8q23UniSTS
RH132308  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2850,977,083 - 50,977,265 (+)MAPPERmRatBN7.2
Rnor_6.0855,060,482 - 55,060,663NCBIRnor6.0
Rnor_5.0853,657,853 - 53,658,034UniSTSRnor5.0
RGSC_v3.4853,987,424 - 53,987,605UniSTSRGSC3.4
Celera850,525,279 - 50,525,460UniSTS
RH 3.4 Map8546.9UniSTS
Cytogenetic Map8q23UniSTS
RH132630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2850,963,394 - 50,963,610 (+)MAPPERmRatBN7.2
Rnor_6.0855,046,794 - 55,047,009NCBIRnor6.0
Rnor_5.0853,644,116 - 53,644,331UniSTSRnor5.0
RGSC_v3.4853,973,737 - 53,973,952UniSTSRGSC3.4
Celera850,511,814 - 50,512,029UniSTS
RH 3.4 Map8548.3UniSTS
Cytogenetic Map8q23UniSTS
RH138741  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2850,978,712 - 50,978,868 (+)MAPPERmRatBN7.2
mRatBN7.2133,234,104 - 33,234,260 (-)MAPPERmRatBN7.2
mRatBN7.2850,978,712 - 50,978,868 (-)MAPPERmRatBN7.2
mRatBN7.2133,234,104 - 33,234,260 (+)MAPPERmRatBN7.2
Rnor_6.0855,062,111 - 55,062,266NCBIRnor6.0
Rnor_6.0135,871,591 - 35,871,746NCBIRnor6.0
Rnor_5.0853,659,482 - 53,659,637UniSTSRnor5.0
Rnor_5.0137,269,107 - 37,269,262UniSTSRnor5.0
RGSC_v3.4853,989,053 - 53,989,208UniSTSRGSC3.4
RGSC_v3.4173,381,958 - 3,382,113UniSTSRGSC3.4
Celera850,526,908 - 50,527,063UniSTS
Celera131,845,182 - 31,845,337UniSTS
Cytogenetic Map8q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000032152   ⟹   ENSRNOP00000032890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl850,978,051 - 51,004,479 (-)Ensembl
Rnor_6.0 Ensembl855,062,551 - 55,087,832 (-)Ensembl
RefSeq Acc Id: NM_031025   ⟹   NP_112287
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,875,537 - 59,900,818 (-)NCBI
mRatBN7.2850,979,151 - 51,004,435 (-)NCBI
Rnor_6.0855,062,549 - 55,087,832 (-)NCBI
Rnor_5.0853,659,920 - 53,685,238 (-)NCBI
RGSC_v3.4853,989,491 - 54,014,779 (-)RGD
Celera850,507,581 - 50,552,393 (-)RGD
Sequence:
RefSeq Acc Id: XM_063266204   ⟹   XP_063122274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,885,292 - 59,900,947 (-)NCBI
RefSeq Acc Id: NP_112287   ⟸   NM_031025
- UniProtKB: Q3B7V7 (UniProtKB/Swiss-Prot),   P08461 (UniProtKB/Swiss-Prot),   A6J4E7 (UniProtKB/TrEMBL),   A0A8I6B5J2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032890   ⟸   ENSRNOT00000032152
RefSeq Acc Id: XP_063122274   ⟸   XM_063266204
- Peptide Label: isoform X1
Protein Domains
Lipoyl-binding   Peripheral subunit-binding (PSBD)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08461-F1-model_v2 AlphaFold P08461 1-632 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695950
Promoter ID:EPDNEW_R6474
Type:initiation region
Name:Dlat_1
Description:dihydrolipoamide S-acetyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0855,087,882 - 55,087,942EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619859 AgrOrtholog
BioCyc Gene G2FUF-30556 BioCyc
BioCyc Pathway PYRUVDEHYD-PWY [pyruvate decarboxylation to acetyl CoA I] BioCyc
BioCyc Pathway Image PYRUVDEHYD-PWY BioCyc
Ensembl Genes ENSRNOG00000009994 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000017095 Ensembl
Ensembl Transcript ENSRNOT00000032152.5 UniProtKB/Swiss-Prot
  ENSRNOT00000148798 ENTREZGENE
Gene3D-CATH 2.40.50.100 UniProtKB/Swiss-Prot
  3.30.559.10 UniProtKB/Swiss-Prot
  4.10.320.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7115402 IMAGE-MGC_LOAD
InterPro 2-oxoA_DH_lipoyl-BS UniProtKB/Swiss-Prot
  2-oxoacid_DH_actylTfrase UniProtKB/Swiss-Prot
  Biotin_lipoyl UniProtKB/Swiss-Prot
  CAT-like_dom_sf UniProtKB/Swiss-Prot
  E2/Pdx1 UniProtKB/Swiss-Prot
  E3-bd_dom_sf UniProtKB/Swiss-Prot
  LAT1 UniProtKB/Swiss-Prot
  PSBD UniProtKB/Swiss-Prot
  Single_hybrid_motif UniProtKB/Swiss-Prot
KEGG Report rno:81654 UniProtKB/Swiss-Prot
MGC_CLONE MGC:125038 IMAGE-MGC_LOAD
NCBI Gene 81654 ENTREZGENE
PANTHER DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR23151 UniProtKB/Swiss-Prot
Pfam 2-oxoacid_dh UniProtKB/Swiss-Prot
  Biotin_lipoyl UniProtKB/Swiss-Prot
  E3_binding UniProtKB/Swiss-Prot
PhenoGen Dlat PhenoGen
PROSITE BIOTINYL_LIPOYL UniProtKB/Swiss-Prot
  LIPOYL UniProtKB/Swiss-Prot
  PSBD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009994 RatGTEx
  ENSRNOG00000017095 RatGTEx
Superfamily-SCOP CoA-dependent acyltransferases UniProtKB/Swiss-Prot
  SSF47005 UniProtKB/Swiss-Prot
  SSF51230 UniProtKB/Swiss-Prot
UniProt A0A8I6B5J2 ENTREZGENE, UniProtKB/TrEMBL
  A6J4E7 ENTREZGENE, UniProtKB/TrEMBL
  ODP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q3B7V7 ENTREZGENE
UniProt Secondary Q3B7V7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-15 Dlat  dihydrolipoamide S-acetyltransferase  Dlat  dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Dlat  dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)    dihydrolipoamide acetyltransferase  Name updated 1299863 APPROVED
2002-08-07 Dlat  dihydrolipoamide acetyltransferase      Symbol and Name status set to provisional 70820 PROVISIONAL