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Gene: Dlat (dihydrolipoamide S-acetyltransferase) Rattus norvegicus
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Symbol: Dlat
Name: dihydrolipoamide S-acetyltransferase
Description: Exhibits dihydrolipoyllysine-residue acetyltransferase activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Involved in acetyl-CoA biosynthetic process from pyruvate and sleep. Localizes to the mitochondrion and pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; INTERACTS WITH (R)-adrenaline; 17alpha-ethynylestradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; dihydrolipoamide acetyltransferase; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex); dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; E2; PBC; PDC-E2; PDCE2; pyruvate dehydrogenase complex component E2
Orthologs:
Homo sapiens (human) : DLAT (dihydrolipoamide S-acetyltransferase)  HGNC  Alliance
Mus musculus (house mouse) : Dlat (dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlat (dihydrolipoamide S-acetyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : DLAT (dihydrolipoamide S-acetyltransferase)
Canis lupus familiaris (dog) : DLAT (dihydrolipoamide S-acetyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlat (dihydrolipoamide S-acetyltransferase)
Sus scrofa (pig) : DLAT (dihydrolipoamide S-acetyltransferase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0855,062,549 - 55,087,832 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0853,659,920 - 53,685,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,989,491 - 54,014,779 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1854,008,592 - 54,033,135 (-)NCBI
Celera850,507,581 - 50,552,393 (-)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Dlat
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619859
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.