DLAT (dihydrolipoamide S-acetyltransferase) - Rat Genome Database

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Gene: DLAT (dihydrolipoamide S-acetyltransferase) Canis lupus familiaris
Analyze
Symbol: DLAT
Name: dihydrolipoamide S-acetyltransferase
RGD ID: 12388517
Description: ENCODES a protein that exhibits dihydrolipoyllysine-residue acetyltransferase activity (ortholog); pyruvate dehydrogenase (NAD+) activity (ortholog); INVOLVED IN acetyl-CoA biosynthetic process from pyruvate (ortholog); pyruvate catabolic process (ortholog); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; ASSOCIATED WITH ataxia telangiectasia (ortholog); BH4-deficient hyperphenylalaninemia A (ortholog); Carney-Stratakis syndrome (ortholog); FOUND IN mitochondrial matrix (ortholog); pyruvate dehydrogenase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex); dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,062,833 - 21,094,235 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,064,026 - 21,094,153 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,985,229 - 21,016,566 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0521,086,208 - 21,117,183 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,086,325 - 21,117,555 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,147,724 - 21,178,540 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,047,717 - 21,079,036 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,096,415 - 21,127,748 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DLAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,062,833 - 21,094,235 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,064,026 - 21,094,153 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,985,229 - 21,016,566 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0521,086,208 - 21,117,183 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,086,325 - 21,117,555 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,147,724 - 21,178,540 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,047,717 - 21,079,036 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,096,415 - 21,127,748 (-)NCBIUU_Cfam_GSD_1.0
DLAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811112,025,408 - 112,064,404 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,025,033 - 112,064,404 (+)EnsemblGRCh38hg38GRCh38
GRCh3711111,896,132 - 111,935,128 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,401,381 - 111,439,799 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411111,401,387 - 111,439,798NCBI
Celera11109,048,752 - 109,088,192 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,819,561 - 107,858,905 (+)NCBIHuRef
CHM1_111111,778,793 - 111,818,192 (+)NCBICHM1_1
T2T-CHM13v2.011112,035,650 - 112,074,647 (+)NCBIT2T-CHM13v2.0
Dlat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,545,933 - 50,571,080 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,545,933 - 50,571,080 (-)EnsemblGRCm39 Ensembl
GRCm38950,634,633 - 50,659,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,634,633 - 50,659,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv37950,442,738 - 50,467,885 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,386,865 - 50,412,010 (-)NCBIMGSCv36mm8
Celera947,920,941 - 47,946,308 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Dlat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,875,537 - 59,900,947 (-)NCBIGRCr8
mRatBN7.2850,979,151 - 51,004,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,978,051 - 51,004,479 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,484,986 - 56,510,281 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,763,886 - 54,789,211 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,628,160 - 52,653,457 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,062,549 - 55,087,832 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,062,551 - 55,087,832 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,659,920 - 53,685,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,989,491 - 54,014,779 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1854,008,592 - 54,033,135 (-)NCBI
Celera850,507,581 - 50,552,393 (-)NCBICelera
Cytogenetic Map8q23NCBI
Dlat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,718,067 - 13,744,239 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,718,091 - 13,746,220 (+)NCBIChiLan1.0ChiLan1.0
DLAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,770,172 - 112,813,947 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,864,456 - 113,909,461 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011106,910,857 - 106,950,851 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,755,310 - 110,793,876 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,756,001 - 110,792,795 (+)Ensemblpanpan1.1panPan2
Dlat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,268,188 - 94,312,532 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,393,071 - 2,437,522 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,395,452 - 2,437,592 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,738,564 - 39,796,806 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,738,639 - 39,763,813 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,595,812 - 44,605,405 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2944,530,186 - 44,541,155 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,379,165 - 103,419,585 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,380,426 - 103,420,386 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604322,562,984 - 22,603,121 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dlat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,181,671 - 7,214,751 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247847,181,550 - 7,216,779 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DLAT
348 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000022258   ⟹   ENSCAFP00000020671
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl521,064,026 - 21,094,153 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000069257   ⟹   ENSCAFP00000055186
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl521,064,026 - 21,094,153 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845003019   ⟹   ENSCAFP00845002410
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl521,086,325 - 21,117,555 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845003043   ⟹   ENSCAFP00845002429
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl521,086,325 - 21,117,555 (-)Ensembl
RefSeq Acc Id: XM_038475024   ⟹   XP_038330952
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1521,147,724 - 21,178,540 (-)NCBI
RefSeq Acc Id: XM_038536151   ⟹   XP_038392079
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0521,096,415 - 21,127,748 (-)NCBI
RefSeq Acc Id: XM_038600345   ⟹   XP_038456273
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0521,047,717 - 21,079,036 (-)NCBI
RefSeq Acc Id: XM_038664888   ⟹   XP_038520816
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0521,086,208 - 21,117,183 (-)NCBI
RefSeq Acc Id: XM_546524   ⟹   XP_546524
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1521,062,833 - 21,094,235 (-)NCBI
Dog10K_Boxer_Tasha520,985,229 - 21,016,566 (-)NCBI
Sequence:
RefSeq Acc Id: XP_546524   ⟸   XM_546524
- UniProtKB: A0A8C0NAN7 (UniProtKB/TrEMBL),   A0A8C0JYN1 (UniProtKB/TrEMBL),   A0A8I3MZS6 (UniProtKB/TrEMBL),   A0A8C0JZH9 (UniProtKB/TrEMBL),   A0A8C0N8M9 (UniProtKB/TrEMBL),   A0A8I3MGU8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000055186   ⟸   ENSCAFT00000069257
Ensembl Acc Id: ENSCAFP00000020671   ⟸   ENSCAFT00000022258
RefSeq Acc Id: XP_038330952   ⟸   XM_038475024
RefSeq Acc Id: XP_038456273   ⟸   XM_038600345
RefSeq Acc Id: XP_038520816   ⟸   XM_038664888
- UniProtKB: A0A8C0NAN7 (UniProtKB/TrEMBL),   A0A8C0JYN1 (UniProtKB/TrEMBL),   A0A8I3MZS6 (UniProtKB/TrEMBL),   A0A8C0JZH9 (UniProtKB/TrEMBL),   A0A8C0N8M9 (UniProtKB/TrEMBL),   A0A8I3MGU8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038392079   ⟸   XM_038536151
- UniProtKB: A0A8C0JYN1 (UniProtKB/TrEMBL),   A0A8C0JZH9 (UniProtKB/TrEMBL),   A0A8C0N8M9 (UniProtKB/TrEMBL),   A0A8C0NAN7 (UniProtKB/TrEMBL),   A0A8I3MGU8 (UniProtKB/TrEMBL),   A0A8I3MZS6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845002410   ⟸   ENSCAFT00845003019
Ensembl Acc Id: ENSCAFP00845002429   ⟸   ENSCAFT00845003043
Protein Domains
Lipoyl-binding   Peripheral subunit-binding (PSBD)

Promoters
RGD ID:13683161
Promoter ID:EPDNEW_C1227
Type:initiation region
Name:DLAT_1
Description:dihydrolipoamide S-acetyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1521,094,199 - 21,094,259EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014016 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012864 UniProtKB/TrEMBL
  ENSCAFG00040006073 UniProtKB/TrEMBL
  ENSCAFG00845001723 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000022258.5 UniProtKB/TrEMBL
  ENSCAFT00000069257.2 UniProtKB/TrEMBL
  ENSCAFT00030023926.1 UniProtKB/TrEMBL
  ENSCAFT00030024013.1 UniProtKB/TrEMBL
  ENSCAFT00040011407.1 UniProtKB/TrEMBL
  ENSCAFT00040011470.1 UniProtKB/TrEMBL
  ENSCAFT00845003019 ENTREZGENE
  ENSCAFT00845003019.1 UniProtKB/TrEMBL
  ENSCAFT00845003043.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.100 UniProtKB/TrEMBL
  3.30.559.10 UniProtKB/TrEMBL
  4.10.320.10 UniProtKB/TrEMBL
InterPro 2-oxoA_DH_lipoyl-BS UniProtKB/TrEMBL
  2-oxoacid_DH_actylTfrase UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/TrEMBL
  CAT-like_dom_sf UniProtKB/TrEMBL
  E2/Pdx1 UniProtKB/TrEMBL
  E3-bd_dom_sf UniProtKB/TrEMBL
  LAT1 UniProtKB/TrEMBL
  PSBD UniProtKB/TrEMBL
  Single_hybrid_motif UniProtKB/TrEMBL
KEGG Report cfa:489406 UniProtKB/TrEMBL
NCBI Gene DLAT ENTREZGENE
PANTHER DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR23151 UniProtKB/TrEMBL
Pfam 2-oxoacid_dh UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/TrEMBL
  E3_binding UniProtKB/TrEMBL
PROSITE BIOTINYL_LIPOYL UniProtKB/TrEMBL
  LIPOYL UniProtKB/TrEMBL
  PSBD UniProtKB/TrEMBL
Superfamily-SCOP CoA-dependent acyltransferases UniProtKB/TrEMBL
  SSF47005 UniProtKB/TrEMBL
  SSF51230 UniProtKB/TrEMBL
UniProt A0A8C0JYN1 ENTREZGENE
  A0A8C0JZH9 ENTREZGENE
  A0A8C0N8M9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NAN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MGU8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MZS6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39974 ENTREZGENE