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Gene: Dlat (dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)) Mus musculus
Symbol: Dlat
Name: dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Description: Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Predicted to be involved in mitochondrial acetyl-CoA biosynthetic process from pyruvate. Localizes to the mitochondrion and myelin sheath. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and respiratory system. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6332404G05Rik; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; DLTA; PDC-E2; PDCE2; pyruvate dehydrogenase complex component E2
Homo sapiens (human) : DLAT (dihydrolipoamide S-acetyltransferase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dlat (dihydrolipoamide S-acetyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlat (dihydrolipoamide S-acetyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : DLAT (dihydrolipoamide S-acetyltransferase)
Canis lupus familiaris (dog) : DLAT (dihydrolipoamide S-acetyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlat (dihydrolipoamide S-acetyltransferase)
Sus scrofa (pig) : DLAT (dihydrolipoamide S-acetyltransferase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38950,634,633 - 50,659,780 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37950,442,738 - 50,467,885 (-)NCBIGRCm37mm9NCBIm37
MGSCv36950,386,865 - 50,412,010 (-)NCBImm8
Celera947,920,941 - 47,946,308 (-)NCBICelera
Cytogenetic Map9 A5.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dlat
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735274
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.