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Gene: Dlat (dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)) Mus musculus
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Symbol: Dlat
Name: dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Description: Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Predicted to be involved in mitochondrial acetyl-CoA biosynthetic process from pyruvate. Localizes to the mitochondrion and myelin sheath. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and respiratory system. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6332404G05Rik; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; DLTA; PDC-E2; PDCE2; pyruvate dehydrogenase complex component E2
Orthologs:
Homo sapiens (human) : DLAT (dihydrolipoamide S-acetyltransferase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dlat (dihydrolipoamide S-acetyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlat (dihydrolipoamide S-acetyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : DLAT (dihydrolipoamide S-acetyltransferase)
Canis lupus familiaris (dog) : DLAT (dihydrolipoamide S-acetyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlat (dihydrolipoamide S-acetyltransferase)
Sus scrofa (pig) : DLAT (dihydrolipoamide S-acetyltransferase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38950,634,633 - 50,659,780 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37950,442,738 - 50,467,885 (-)NCBIGRCm37mm9NCBIm37
MGSCv36950,386,865 - 50,412,010 (-)NCBImm8
Celera947,920,941 - 47,946,308 (-)NCBICelera
Cytogenetic Map9 A5.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dlat
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735274
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.