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Gene: Prss12 (serine protease 12) Rattus norvegicus
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Symbol: Prss12
Name: serine protease 12
Description: Predicted to have serine-type endopeptidase activity. Predicted to be involved in exocytosis and zymogen activation. Predicted to localize to several cellular components, including the cytoplasmic vesicle; neuron projection; and synaptic cleft. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability. Orthologous to human PRSS12 (serine protease 12); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: neurotrypsin; Nt; peptidase, serine, 12 (neurotrypsin, motopsin); protease serine 12 neurotrypsin (motopsin); protease, serine 12; protease, serine, 12; protease, serine, 12 neurotrypsin (motopsin); protease, serine, 12 neurotrypsin, (motopsin)
Orthologs:
Homo sapiens (human) : PRSS12 (serine protease 12)  HGNC  Alliance
Mus musculus (house mouse) : Prss12 (protease, serine 12 neurotrypsin (motopsin))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prss12 (serine protease 12)
Pan paniscus (bonobo/pygmy chimpanzee) : PRSS12 (serine protease 12)
Canis lupus familiaris (dog) : PRSS12 (serine protease 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prss12 (serine protease 12)
Sus scrofa (pig) : PRSS12 (serine protease 12)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02227,657,983 - 227,717,884 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02247,015,139 - 247,074,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42220,194,590 - 220,254,502 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12220,157,651 - 220,217,564 (+)NCBI
Celera2204,036,064 - 204,095,891 (+)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Prss12
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69238
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.