Dock6 (dedicator of cytokinesis 6) - Rat Genome Database

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Gene: Dock6 (dedicator of cytokinesis 6) Rattus norvegicus
Analyze
Symbol: Dock6
Name: dedicator of cytokinesis 6
RGD ID: 1306517
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DOCK6 (dedicator of cytokinesis 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; aristolochic acid A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dedicator of cytokinesis protein 6; LOC367039
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,618,523 - 28,670,741 (-)NCBIGRCr8
mRatBN7.2820,342,430 - 20,394,660 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,342,089 - 20,394,552 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,377,909 - 24,430,028 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,673,454 - 22,725,573 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,572,031 - 20,624,157 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,822,412 - 22,874,670 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,822,412 - 22,874,645 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,876,566 - 22,928,950 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,896,180 - 20,966,159 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,894,958 - 20,962,815 (-)NCBI
Celera821,732,745 - 21,785,834 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dock6RatAdams-Oliver syndrome  ISORGD:1315180155791566DNA:mutations:cds:RGD 
Dock6RatLiver Metastasis amelioratesISORGD:1315180155791564associated with stomach cancer;RGD 
Dock6Ratoral squamous cell carcinoma disease_progressionISORGD:1315180155791563 RGD 
Dock6Ratstomach cancer severityISORGD:1315180155791564 RGD 
Dock6Ratstomach cancer disease_progressionISORGD:1315180155791565 RGD 
1 to 17 of 17 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dock6RatAdams-Oliver syndrome  ISORGD:13151808554872ClinVar Annotator: match by term: Adams-Oliver syndrome | ClinVar Annotator: match by term: Scalp defects more ...ClinVarPMID:21820096|PMID:24033266|PMID:25558065|PMID:25741868|PMID:25824905|PMID:26457590|PMID:28492532|PMID:29924900
Dock6RatAdams-Oliver Syndrome 1  ISORGD:13151808554872ClinVar Annotator: match by term: Adams-Oliver syndrome 1ClinVarPMID:21820096|PMID:25741868|PMID:25824905|PMID:26457590|PMID:28492532|PMID:29924900
Dock6RatAdams-Oliver Syndrome 2  ISORGD:13151808554872ClinVar Annotator: match by term: Adams-Oliver syndrome 2 | ClinVar Annotator: match by term: DOCK6-related more ...ClinVarPMID:16199547|PMID:17159513|PMID:17576681|PMID:21820096|PMID:23522784|PMID:25091416|PMID:25558065|PMID:25724810|PMID:25741868|PMID:25824905|PMID:26457590|PMID:28135719|PMID:28160419|PMID:28492532|PMID:28884918|PMID:29924900|PMID:29961505|PMID:30111349|PMID:30293987|PMID:31131953|PMID:8849019|PMID:9536098
Dock6Ratalpha-mannosidosis  ISORGD:13151808554872ClinVar Annotator: match by term: Deficiency of alpha-mannosidaseClinVarPMID:28492532
Dock6RatCharcot-Marie-Tooth disease dominant intermediate B  ISORGD:13151808554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate BClinVarPMID:28492532
Dock6Ratepisodic ataxia type 2  ISORGD:13151808554872ClinVar Annotator: match by term: Episodic ataxia type 2ClinVarPMID:28492532
Dock6RatFamilial Hypercholanemia 1  ISORGD:13151808554872ClinVar Annotator: match by term: Hypercholanemia, familial 1ClinVar 
Dock6Ratfamilial hypercholesterolemia  ISORGD:13151808554872ClinVar Annotator: match by term: Hypercholesterolemia, familial, 1ClinVarPMID:14756670|PMID:17094996|PMID:19538517|PMID:20045108|PMID:22698793|PMID:25741868
Dock6Ratgenetic disease  ISORGD:13151808554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:16199547|PMID:21820096|PMID:23522784|PMID:25091416|PMID:25558065|PMID:25724810|PMID:25741868|PMID:25824905|PMID:25954003|PMID:27618451|PMID:28160419|PMID:28490743|PMID:28492532|PMID:28884918|PMID:29961505|PMID:30111349|PMID:30293987|PMID:31131953
Dock6Ratglutaric acidemia I  ISORGD:13151808554872ClinVar Annotator: match by term: Glutaric aciduria, type 1ClinVarPMID:28492532
Dock6Ratglycogen storage disease III  ISORGD:13151808554872ClinVar Annotator: match by term: Cori diseaseClinVarPMID:11727201|PMID:12673792|PMID:12955720|PMID:16385454|PMID:16783378|PMID:20301500|PMID:20301601|PMID:20301718|PMID:20301788|PMID:21735565|PMID:21820096|PMID:25741868|PMID:28492532
Dock6Rathydrocephalus  ISORGD:13151808554872ClinVar Annotator: match by term: Hydrocephalus, nonsyndromic, autosomal recessive 1ClinVar 
Dock6Ratintellectual disability  ISORGD:13151808554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25741868|PMID:28492532
Dock6Ratmicrocephaly  ISORGD:13151808554872ClinVar Annotator: match by term: MicrocephalyClinVarPMID:25741868|PMID:28492532
Dock6Ratneurodegeneration with brain iron accumulation 2A  ISORGD:13151808554872ClinVar Annotator: match by term: Infantile neuroaxonal dystrophy 1ClinVarPMID:11727201|PMID:12673792|PMID:12955720|PMID:16385454|PMID:16783378|PMID:20301500|PMID:20301601|PMID:20301718|PMID:20301788|PMID:21735565|PMID:21820096|PMID:25741868|PMID:28492532
Dock6RatPaget's disease of bone  ISORGD:13151808554872ClinVar Annotator: match by term: Paget disease of boneClinVarPMID:25741868|PMID:28492532
Dock6Ratrhabdoid tumor predisposition syndrome 2  ISORGD:13151808554872ClinVar Annotator: match by term: Rhabdoid tumor predisposition syndrome 2ClinVarPMID:28492532
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Object Symbol
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Qualifier
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Reference
Notes
Source
Original Reference(s)
Dock6RatAdams-Oliver syndrome  ISORGD:131518011554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dock6RatAdams-Oliver Syndrome 2  ISORGD:13151807240710 OMIM 

1 to 20 of 80 rows

  
Object Symbol
Species
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Qualifier
Evidence
With
Reference
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Source
Original Reference(s)
Dock6Rat1,2-dimethylhydrazine affects expressionISORGD:155688964804641,2-Dimethylhydrazine affects the expression of DOCK6 mRNACTDPMID:22206623
Dock6Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of DOCK6 mRNACTDPMID:34747641
Dock6Rat2-hydroxypropanoic acid decreases expressionISORGD:13151806480464Lactic Acid results in decreased expression of DOCK6 mRNACTDPMID:30851411
Dock6Rat4,4'-sulfonyldiphenol increases methylationISORGD:15568896480464bisphenol S results in increased methylation of DOCK6 exonCTDPMID:33297965
Dock6Rat4,4'-sulfonyldiphenol multiple interactionsISORGD:13151806480464[bisphenol S co-treated with Fulvestrant] results in increased methylation of DOCK6 geneCTDPMID:31601247
Dock6Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of DOCK6 mRNACTDPMID:31881176
Dock6Ratacrylamide decreases expressionISORGD:13151806480464Acrylamide results in decreased expression of DOCK6 mRNACTDPMID:32763439
Dock6Rataflatoxin B1 decreases methylationISORGD:13151806480464Aflatoxin B1 results in decreased methylation of DOCK6 intronCTDPMID:30157460
Dock6RatAflatoxin B2 alpha increases methylationISORGD:13151806480464aflatoxin B2 results in increased methylation of DOCK6 exonCTDPMID:30157460
Dock6Ratall-trans-retinoic acid decreases expressionISORGD:13151806480464Tretinoin results in decreased expression of DOCK6 mRNACTDPMID:33167477
Dock6Ratantirheumatic drug increases expressionISORGD:13151806480464Antirheumatic Agents results in increased expression of DOCK6 mRNACTDPMID:24449571
Dock6Rataristolochic acid A increases expressionEXP 6480464aristolochic acid I results in increased expression of DOCK6 proteinCTDPMID:38428544
Dock6Rataristolochic acid A multiple interactionsEXP 6480464[aristolochic acid I co-treated with Probenecid] results in increased expression of DOCK6 proteinCTDPMID:38428544
Dock6Rataristolochic acids increases expressionEXP 6480464Aristolochic Acids results in increased expression of DOCK6 mRNACTDPMID:19717638
Dock6Ratarsenite(3-) decreases methylationISORGD:13151806480464arsenite results in decreased methylation of DOCK6 promoterCTDPMID:23974009
Dock6Ratarsenite(3-) multiple interactionsISORGD:13151806480464arsenite inhibits the reaction [G3BP1 protein binds to DOCK6 mRNA]CTDPMID:32406909
Dock6Ratatrazine increases expressionISORGD:13151806480464Atrazine results in increased expression of DOCK6 mRNACTDPMID:22378314
Dock6Ratatrazine affects methylationEXP 6480464Atrazine affects the methylation of DOCK6 geneCTDPMID:35440735
Dock6Ratbenzo[a]pyrene increases methylationISORGD:15568896480464Benzo(a)pyrene results in increased methylation of DOCK6 exon; Benzo(a)pyrene results in increased methylation of DOCK6 more ...CTDPMID:27901495
Dock6Ratbenzo[a]pyrene affects methylationISORGD:13151806480464Benzo(a)pyrene affects the methylation of DOCK6 exonCTDPMID:30157460

1 to 20 of 80 rows

Biological Process

  
Object Symbol
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Source
Original Reference(s)
Dock6Ratregulation of Rho protein signal transduction involved_inIBAFB:FBgn0031216|PANTHER:PTN0005939871600115GO_REF:0000033GO_CentralGO_REF:0000033
Dock6Ratsmall GTPase-mediated signal transduction involved_inIEAInterPro:IPR0267911600115GO_REF:0000002InterProGO_REF:0000002

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
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Source
Original Reference(s)
Dock6Ratcytosol located_inISORGD:13151801624291 RGDGO_REF:0000052
Dock6Ratcytosol located_inIEAUniProtKB:Q96HP0|ensembl:ENSP000002946181600115GO_REF:0000107EnsemblGO_REF:0000107
Dock6Ratcytosol is_active_inIBAPANTHER:PTN002762118|UniProtKB:Q96HP01600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Dock6Ratguanyl-nucleotide exchange factor activity enablesIEAInterPro:IPR0267911600115GO_REF:0000002InterProGO_REF:0000002
Dock6Ratguanyl-nucleotide exchange factor activity enablesIBAFB:FBgn0031216|MGI:106321|MGI:1921396|MGI:1923224|MGI:2146320|PANTHER:PTN000593987|TAIR:locus:2130484|UniProtKB:Q8NF501600115GO_REF:0000033GO_CentralGO_REF:0000033
Dock6Ratguanyl-nucleotide exchange factor activity enablesIEAUniProtKB-KW:KW-03441600115GO_REF:0000043UniProtGO_REF:0000043
Dock6Ratprotein binding enablesISORGD:13151801624291UniProtKB:O75427 PMID:32203420RGDPMID:32203420


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#
Reference Title
Reference Citation
1. DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits. Chi HC, etal., Oncogene. 2020 Sep;39(37):5933-5949. doi: 10.1038/s41388-020-01390-0. Epub 2020 Aug 4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis. Li X, etal., J Exp Clin Cancer Res. 2018 Mar 27;37(1):71. doi: 10.1186/s13046-018-0729-z.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. DOCK6 mutations are responsible for a distinct autosomal-recessive variant of Adams-Oliver syndrome associated with brain and eye anomalies. Sukalo M, etal., Hum Mutat. 2015 Jun;36(6):593-8. doi: 10.1002/humu.22795. Epub 2015 Apr 21.
9. Overexpression of DOCK6 in oral squamous cell cancer promotes cellular migration and invasion and is associated with poor prognosis. Zhang ZY, etal., Arch Oral Biol. 2022 Jan;133:105297. doi: 10.1016/j.archoralbio.2021.105297. Epub 2021 Oct 28.
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Dock6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,618,523 - 28,670,741 (-)NCBIGRCr8
mRatBN7.2820,342,430 - 20,394,660 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,342,089 - 20,394,552 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,377,909 - 24,430,028 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,673,454 - 22,725,573 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,572,031 - 20,624,157 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,822,412 - 22,874,670 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,822,412 - 22,874,645 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,876,566 - 22,928,950 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,896,180 - 20,966,159 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,894,958 - 20,962,815 (-)NCBI
Celera821,732,745 - 21,785,834 (-)NCBICelera
Cytogenetic Map8q13NCBI
DOCK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,199,295 - 11,262,524 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,199,295 - 11,262,524 (-)EnsemblGRCh38hg38GRCh38
GRCh371911,309,971 - 11,373,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,170,971 - 11,234,157 (-)NCBINCBI36Build 36hg18NCBI36
Build 341911,170,972 - 11,234,128NCBI
Celera1911,204,784 - 11,268,011 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,886,047 - 10,940,482 (-)NCBIHuRef
CHM1_11911,311,180 - 11,374,238 (-)NCBICHM1_1
T2T-CHM13v2.01911,326,296 - 11,389,499 (-)NCBIT2T-CHM13v2.0
Dock6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,711,476 - 21,764,006 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,711,156 - 21,763,931 (-)EnsemblGRCm39 Ensembl
GRCm38921,800,180 - 21,852,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,799,860 - 21,852,635 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,604,624 - 21,657,079 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,594,033 - 21,603,018 (-)NCBIMGSCv36mm8
Celera919,069,771 - 19,122,226 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.89NCBI
Dock6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,174,966 - 2,216,423 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,174,802 - 2,216,424 (-)NCBIChiLan1.0ChiLan1.0
DOCK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,114,565 - 16,178,192 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,113,252 - 15,176,888 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,747,850 - 10,811,483 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11911,458,860 - 11,521,029 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,459,062 - 11,513,220 (-)Ensemblpanpan1.1panPan2
DOCK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,029,354 - 50,066,829 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,029,369 - 50,066,829 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,898,472 - 49,940,350 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02050,545,683 - 50,587,769 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,545,643 - 50,587,757 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,756,044 - 49,797,955 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,182,747 - 50,224,812 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,425,668 - 50,467,527 (+)NCBIUU_Cfam_GSD_1.0
Dock6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,967,152 - 209,013,562 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,341,331 - 1,379,728 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,341,144 - 1,394,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOCK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,925,854 - 69,972,316 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,925,853 - 69,972,326 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DOCK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,133,688 - 10,191,995 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660749,693,698 - 9,753,875 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dock6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,063,281 - 3,110,541 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,063,094 - 3,110,603 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Dock6
138 total Variants

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:126
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000064551
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 23 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat

1 to 10 of 23 rows
D8Rat52  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,391,196 - 20,391,407 (+)MAPPERmRatBN7.2
Rnor_6.0822,871,284 - 22,871,494NCBIRnor6.0
Rnor_5.0822,925,583 - 22,925,793UniSTSRnor5.0
RGSC_v3.4820,962,778 - 20,963,147RGDRGSC3.4
RGSC_v3.4820,962,806 - 20,963,016UniSTSRGSC3.4
RGSC_v3.1820,962,806 - 20,963,016RGD
Celera821,782,481 - 21,782,691UniSTS
RH 3.4 Map8207.89RGD
RH 3.4 Map8207.89UniSTS
SHRSP x BN Map814.26UniSTS
SHRSP x BN Map814.26RGD
FHH x ACI Map810.7699RGD
Cytogenetic Map8q13UniSTS
BI274505  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,378,226 - 20,378,386 (+)MAPPERmRatBN7.2
Rnor_6.0822,858,304 - 22,858,463NCBIRnor6.0
Rnor_5.0822,912,744 - 22,912,903UniSTSRnor5.0
RGSC_v3.4820,949,826 - 20,949,985UniSTSRGSC3.4
Celera821,769,503 - 21,769,662UniSTS
RH 3.4 Map1962.71UniSTS
Cytogenetic Map8q13UniSTS
BI282731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,376,710 - 20,377,030 (+)MAPPERmRatBN7.2
Rnor_6.0822,856,788 - 22,857,107NCBIRnor6.0
Rnor_5.0822,911,228 - 22,911,547UniSTSRnor5.0
RGSC_v3.4820,948,310 - 20,948,629UniSTSRGSC3.4
Celera821,767,987 - 21,768,306UniSTS
Cytogenetic Map8q13UniSTS
AI009950  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,379,223 - 20,379,454 (+)MAPPERmRatBN7.2
Rnor_6.0822,859,301 - 22,859,531NCBIRnor6.0
Rnor_5.0822,913,601 - 22,913,831UniSTSRnor5.0
RGSC_v3.4820,950,823 - 20,951,053UniSTSRGSC3.4
Celera821,770,500 - 21,770,730UniSTS
Cytogenetic Map8q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000064551   ⟹   ENSRNOP00000063161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,342,089 - 20,394,552 (-)Ensembl
Rnor_6.0 Ensembl822,822,412 - 22,874,637 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090424   ⟹   ENSRNOP00000075398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,342,089 - 20,394,552 (-)Ensembl
Rnor_6.0 Ensembl822,822,729 - 22,874,645 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106365   ⟹   ENSRNOP00000079526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,342,089 - 20,389,096 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118947   ⟹   ENSRNOP00000096113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,342,089 - 20,389,096 (-)Ensembl
RefSeq Acc Id: NM_001394344   ⟹   NP_001381273
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,618,523 - 28,670,648 (-)NCBI
mRatBN7.2820,342,430 - 20,394,557 (-)NCBI
RefSeq Acc Id: NM_001413911   ⟹   NP_001400840
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,618,523 - 28,670,648 (-)NCBI
mRatBN7.2820,342,430 - 20,394,557 (-)NCBI
RefSeq Acc Id: XM_039081850   ⟹   XP_038937778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,618,523 - 28,670,726 (-)NCBI
mRatBN7.2820,342,430 - 20,394,635 (-)NCBI
RefSeq Acc Id: XM_039081851   ⟹   XP_038937779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,618,523 - 28,670,726 (-)NCBI
mRatBN7.2820,342,430 - 20,394,635 (-)NCBI
RefSeq Acc Id: XM_039081852   ⟹   XP_038937780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,618,523 - 28,670,726 (-)NCBI
mRatBN7.2820,342,430 - 20,394,635 (-)NCBI
RefSeq Acc Id: XM_039081854   ⟹   XP_038937782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,623,124 - 28,670,729 (-)NCBI
mRatBN7.2820,347,263 - 20,394,654 (-)NCBI
RefSeq Acc Id: XM_039081855   ⟹   XP_038937783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,632,872 - 28,670,741 (-)NCBI
mRatBN7.2820,356,779 - 20,394,660 (-)NCBI
RefSeq Acc Id: XM_063265869   ⟹   XP_063121939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,619,855 - 28,670,726 (-)NCBI
RefSeq Acc Id: XM_063265870   ⟹   XP_063121940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,618,523 - 28,664,514 (-)NCBI
1 to 5 of 13 rows
1 to 5 of 13 rows
Ensembl Acc Id: ENSRNOP00000075398   ⟸   ENSRNOT00000090424
Ensembl Acc Id: ENSRNOP00000063161   ⟸   ENSRNOT00000064551
RefSeq Acc Id: XP_038937780   ⟸   XM_039081852
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ANH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937779   ⟸   XM_039081851
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ANH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937778   ⟸   XM_039081850
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ANH8 (UniProtKB/TrEMBL)
C2 DOCK-type   DOCKER

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAH4-F1-model_v2 AlphaFold A0A0G2KAH4 1-2113 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695791
Promoter ID:EPDNEW_R6315
Type:multiple initiation site
Name:Dock6_1
Description:dedicator of cytokinesis 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0822,874,640 - 22,874,700EPDNEW


1 to 40 of 41 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-31408 BioCyc
Ensembl Genes ENSRNOG00000010652 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064551 ENTREZGENE
  ENSRNOT00000064551.3 UniProtKB/TrEMBL
  ENSRNOT00000090424 ENTREZGENE
  ENSRNOT00000090424.2 UniProtKB/TrEMBL
  ENSRNOT00000106365 ENTREZGENE
  ENSRNOT00000106365.1 UniProtKB/TrEMBL
  ENSRNOT00000118947.1 UniProtKB/TrEMBL
  ENSRNOT00000162151 ENTREZGENE
Gene3D-CATH 1.20.58.740 UniProtKB/TrEMBL
  1.25.40.410 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro C2_Dock-C UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DHR-2 UniProtKB/TrEMBL
  DOCK UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DOCK_C_lobe_A UniProtKB/TrEMBL
  DOCK_C_lobe_C UniProtKB/TrEMBL
  DOCKER_Lobe_A UniProtKB/TrEMBL
  DOCKER_Lobe_B UniProtKB/TrEMBL
  DOCKER_Lobe_C UniProtKB/TrEMBL
  DUF3398 UniProtKB/TrEMBL
NCBI Gene 367039 ENTREZGENE
PANTHER DEDICATOR OF CYTOKINESIS PROTEIN 6 UniProtKB/TrEMBL
  PTHR23317 UniProtKB/TrEMBL
Pfam DHR-2 UniProtKB/TrEMBL
  DHR-2_Lobe_B UniProtKB/TrEMBL
  DHR-2_Lobe_C UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DUF3398 UniProtKB/TrEMBL
PhenoGen Dock6 PhenoGen
PROSITE DHR_1 UniProtKB/TrEMBL
  DHR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010652 RatGTEx
UniProt A0A0G2KAH4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNP4_RAT UniProtKB/TrEMBL
  A0A8I6ANH8 ENTREZGENE, UniProtKB/TrEMBL
  A6JNU8 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Dock6  dedicator of cytokinesis 6   Dock6_predicted  dedicator of cytokinesis 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dock6_predicted  dedicator of cytokinesis 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED