Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: DOCK6 (dedicator of cytokinesis 6) Homo sapiens
Symbol: DOCK6
Name: dedicator of cytokinesis 6
Description: This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AOS2; dedicator of cytokinesis protein 6; ZIR1
Mus musculus (house mouse) : Dock6 (dedicator of cytokinesis 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dock6 (dedicator of cytokinesis 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dock6 (dedicator of cytokinesis 6)
Pan paniscus (bonobo/pygmy chimpanzee) : DOCK6 (dedicator of cytokinesis 6)
Canis lupus familiaris (dog) : DOCK6 (dedicator of cytokinesis 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dock6 (dedicator of cytokinesis 6)
Sus scrofa (pig) : DOCK6 (dedicator of cytokinesis 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381911,199,295 - 11,262,524 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371911,309,969 - 11,373,168 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,170,971 - 11,234,157 (-)NCBINCBI36hg18NCBI36
Build 341911,170,972 - 11,234,128NCBI
Celera1911,204,784 - 11,268,011 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,886,047 - 10,940,482 (-)NCBIHuRef
CHM1_11911,311,180 - 11,374,238 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DOCK6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315180
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.