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Gene: DOCK6 (dedicator of cytokinesis 6) Homo sapiens
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Symbol: DOCK6
Name: dedicator of cytokinesis 6
Description: This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AOS2; dedicator of cytokinesis protein 6; ZIR1
Orthologs:
Mus musculus (house mouse) : Dock6 (dedicator of cytokinesis 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dock6 (dedicator of cytokinesis 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dock6 (dedicator of cytokinesis 6)
Pan paniscus (bonobo/pygmy chimpanzee) : DOCK6 (dedicator of cytokinesis 6)
Canis lupus familiaris (dog) : DOCK6 (dedicator of cytokinesis 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dock6 (dedicator of cytokinesis 6)
Sus scrofa (pig) : DOCK6 (dedicator of cytokinesis 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,199,295 - 11,262,524 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371911,309,969 - 11,373,168 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,170,971 - 11,234,157 (-)NCBINCBI36hg18NCBI36
Build 341911,170,972 - 11,234,128NCBI
Celera1911,204,784 - 11,268,011 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,886,047 - 10,940,482 (-)NCBIHuRef
CHM1_11911,311,180 - 11,374,238 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on DOCK6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315180
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.