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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b3
Name: cytochrome P450, family 2, subfamily b, polypeptide 3
Acc ID: CHEBI:9325
Term: sulconazole
Definition: A racemate comprising equimolar amounts of (R)- and (S)-sulconazole. An antifungal agent with activity against Candida species, it is used (generally as the nitrate salt) for the topical treatment of fungal skin infections.
Chemical ID: MESH:C033308
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b3increases expressionISOCYP2B6 (Homo sapiens)6480464CTDsulconazole results in increased expression of CYP2B6 mRNAPMID:31312845
Cyp2b3multiple interactionsISOCYP2B6 (Homo sapiens)6480464CTD[sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNAPMID:31312845
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