Fads2 (fatty acid desaturase 2) - Rat Genome Database

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Gene: Fads2 (fatty acid desaturase 2) Rattus norvegicus
Analyze
Symbol: Fads2
Name: fatty acid desaturase 2
RGD ID: 68339
Description: Predicted to enable stearoyl-CoA 9-desaturase activity. Involved in arachidonate metabolite production involved in inflammatory response and positive regulation of cellular response to oxidative stress. Predicted to be located in endoplasmic reticulum membrane. Used to study congestive heart failure and discrete subaortic stenosis. Biomarker of congestive heart failure and type 1 diabetes mellitus. Orthologous to human FADS2 (fatty acid desaturase 2); PARTICIPATES IN alpha-linolenic acid metabolic pathway; linoleic acid metabolic pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acyl-CoA 6-desaturase; D6D; delta(6) desaturase; delta(6) fatty acid desaturase; delta-6 desaturase; delta-6 fatty acid desaturase; Fadsd6; fatty acid desaturase 6; MGC93365
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,132,277 - 216,172,190 (-)NCBIGRCr8
mRatBN7.21206,707,384 - 206,747,333 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1206,708,783 - 206,748,789 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,087,206 - 215,125,554 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,142,298 - 222,180,658 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,837,305 - 214,875,662 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,906,582 - 226,152,568 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,114,413 - 226,152,524 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,060,345 - 233,097,316 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01232,857,004 - 232,857,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41212,512,691 - 212,542,622 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11212,671,121 - 212,701,051 (-)NCBI
Celera1204,204,027 - 204,242,387 (-)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
buspirone  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroquine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
crizotinib  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diisononyl phthalate  (ISO)
dipentyl phthalate  (EXP)
diuron  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
Ganoderic acid A  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
indinavir  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
linoleic acid  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paliperidone palmitate  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phytosterols  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
risperidone  (EXP)
rotenone  (EXP)
saquinavir  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
Yessotoxin  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and functional characterization of rat delta-6 fatty acid desaturase. Aki T, etal., Biochem Biophys Res Commun 1999 Feb 24;255(3):575-9.
2. Effects of streptozotocin and dietary fructose on delta-6 desaturation in spontaneously hypertensive rat liver. Comte C, etal., Biochimie. 2004 Nov;86(11):799-806. doi: 10.1016/j.biochi.2004.10.002.
3. The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis. D'andrea S, etal., Biochem J 2002 May 15;364(Pt 1):49-55.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Conversion of hexadecanoic acid to hexadecenoic acid by rat Delta 6-desaturase. Guillou H, etal., J Lipid Res 2003 Mar;44(3):450-4. Epub 2003 Jan 16.
7. Delta-6-desaturase links polyunsaturated fatty acid metabolism with phospholipid remodeling and disease progression in heart failure. Le CH, etal., Circ Heart Fail. 2014 Jan;7(1):172-83. doi: 10.1161/CIRCHEARTFAILURE.113.000744. Epub 2013 Nov 27.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. L-Carnitine prevents the development of ventricular fibrosis and heart failure with preserved ejection fraction in hypertensive heart disease. Omori Y, etal., J Hypertens. 2012 Sep;30(9):1834-44. doi: 10.1097/HJH.0b013e3283569c5a.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis. Saether T, etal., Biol Reprod 2003 Jul;69(1):117-24. Epub 2003 Feb 19.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9867867   PMID:12562861   PMID:14563830   PMID:14577661   PMID:19157821   PMID:19946888   PMID:21172452   PMID:22133376   PMID:22216341   PMID:22495065   PMID:23107313   PMID:25046614  
PMID:25701799   PMID:29735017  


Genomics

Comparative Map Data
Fads2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,132,277 - 216,172,190 (-)NCBIGRCr8
mRatBN7.21206,707,384 - 206,747,333 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1206,708,783 - 206,748,789 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,087,206 - 215,125,554 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,142,298 - 222,180,658 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,837,305 - 214,875,662 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,906,582 - 226,152,568 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,114,413 - 226,152,524 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,060,345 - 233,097,316 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01232,857,004 - 232,857,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41212,512,691 - 212,542,622 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11212,671,121 - 212,701,051 (-)NCBI
Celera1204,204,027 - 204,242,387 (-)NCBICelera
Cytogenetic Map1q43NCBI
FADS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,816,203 - 61,867,354 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,792,980 - 61,867,354 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,583,675 - 61,634,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,352,289 - 61,391,401 (+)NCBINCBI36Build 36hg18NCBI36
Build 341161,352,288 - 61,391,401NCBI
Celera1158,931,086 - 58,970,195 (+)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1157,911,912 - 57,963,064 (+)NCBIHuRef
CHM1_11161,466,890 - 61,518,047 (+)NCBICHM1_1
T2T-CHM13v2.01161,805,120 - 61,856,305 (+)NCBIT2T-CHM13v2.0
Fads2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,040,129 - 10,078,867 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,040,129 - 10,079,110 (-)EnsemblGRCm39 Ensembl
GRCm381910,062,765 - 10,101,503 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,062,765 - 10,101,746 (-)EnsemblGRCm38mm10GRCm38
MGSCv371910,138,654 - 10,175,993 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361910,131,209 - 10,168,548 (-)NCBIMGSCv36mm8
Celera1910,758,331 - 10,797,423 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map196.36NCBI
Fads2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555115,827,797 - 5,842,760 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555115,827,797 - 5,842,745 (-)NCBIChiLan1.0ChiLan1.0
FADS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2963,061,268 - 63,101,363 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11164,105,033 - 64,145,117 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01157,192,881 - 57,232,574 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11160,552,600 - 60,591,649 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1160,476,082 - 60,591,649 (+)Ensemblpanpan1.1panPan2
FADS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,552,105 - 54,581,553 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,553,366 - 54,659,654 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1853,133,977 - 53,163,472 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01855,605,529 - 55,634,998 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1855,605,530 - 55,713,111 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11854,666,552 - 54,696,035 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01854,287,830 - 54,317,326 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01855,154,814 - 55,184,306 (-)NCBIUU_Cfam_GSD_1.0
Fads2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,089,588 - 11,119,295 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365811,203,366 - 1,233,469 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365811,203,410 - 1,233,330 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FADS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl29,629,423 - 9,735,576 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.129,633,941 - 9,666,666 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.229,119,484 - 9,152,213 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FADS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1111,934,352 - 11,978,355 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl111,934,270 - 11,974,030 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038109,308,070 - 109,412,986 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fads2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624926528,791 - 548,854 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624926529,456 - 548,800 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fads2
167 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:58
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000027756
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1206329708222745518Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000027756   ⟹   ENSRNOP00000027756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1206,708,785 - 206,747,142 (-)Ensembl
Rnor_6.0 Ensembl1226,114,413 - 226,152,524 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101295   ⟹   ENSRNOP00000083431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1206,708,785 - 206,747,142 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120292   ⟹   ENSRNOP00000088570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1206,708,783 - 206,748,789 (-)Ensembl
RefSeq Acc Id: NM_031344   ⟹   NP_112634
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,133,675 - 216,172,033 (-)NCBI
mRatBN7.21206,708,782 - 206,747,142 (-)NCBI
Rnor_6.01225,906,797 - 226,152,568 (-)NCBI
Rnor_5.01232,857,004 - 232,857,656 (-)NCBI
Rnor_5.01233,060,345 - 233,097,316 (-)NCBI
RGSC_v3.41212,512,691 - 212,542,622 (-)RGD
Celera1204,204,027 - 204,242,387 (-)RGD
Sequence:
RefSeq Acc Id: XM_008760244   ⟹   XP_008758466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,132,277 - 216,169,901 (-)NCBI
mRatBN7.21206,707,384 - 206,745,010 (-)NCBI
Rnor_6.01225,906,582 - 226,152,181 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092480   ⟹   XP_038948408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,132,277 - 216,172,190 (-)NCBI
mRatBN7.21206,707,384 - 206,747,333 (-)NCBI
RefSeq Acc Id: NP_112634   ⟸   NM_031344
- UniProtKB: Q9Z122 (UniProtKB/Swiss-Prot),   H2BF31 (UniProtKB/Swiss-Prot),   A0A8I5ZWZ8 (UniProtKB/TrEMBL),   A6I009 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758466   ⟸   XM_008760244
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWZ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027756   ⟸   ENSRNOT00000027756
RefSeq Acc Id: XP_038948408   ⟸   XM_039092480
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZWZ8 (UniProtKB/TrEMBL),   A0A8I6A6F8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083431   ⟸   ENSRNOT00000101295
Ensembl Acc Id: ENSRNOP00000088570   ⟸   ENSRNOT00000120292
Protein Domains
Cytochrome b5 heme-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z122-F1-model_v2 AlphaFold Q9Z122 1-444 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690765
Promoter ID:EPDNEW_R1290
Type:multiple initiation site
Name:Fads2_1
Description:fatty acid desaturase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01226,152,497 - 226,152,557EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68339 AgrOrtholog
BioCyc Gene G2FUF-56442 BioCyc
BioCyc Pathway PWY-6000 [gamma-linolenate biosynthesis II (animals)] BioCyc
  PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)] BioCyc
  PWY-7606 [docosahexaenoate biosynthesis III (6-desaturase, mammals)] BioCyc
  PWY-7726 [(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)] BioCyc
BioCyc Pathway Image PWY-6000 BioCyc
  PWY-7049 BioCyc
  PWY-7606 BioCyc
  PWY-7726 BioCyc
Ensembl Genes ENSRNOG00000020440 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055017917 UniProtKB/Swiss-Prot
  ENSRNOG00060030734 UniProtKB/Swiss-Prot
  ENSRNOG00065033960 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027756 UniProtKB/TrEMBL
  ENSRNOT00000027756.7 UniProtKB/Swiss-Prot
  ENSRNOT00000101295.1 UniProtKB/TrEMBL
  ENSRNOT00000120292.1 UniProtKB/TrEMBL
  ENSRNOT00055030351 UniProtKB/Swiss-Prot
  ENSRNOT00060053425 UniProtKB/Swiss-Prot
  ENSRNOT00065058334 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128630 IMAGE-MGC_LOAD
InterPro Cyt_B5-like_heme/steroid-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_B5-like_heme/steroid_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA_desaturase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fatty_acid_desaturase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83512 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93365 IMAGE-MGC_LOAD
NCBI Gene Fads2 ENTREZGENE
PANTHER ACYL-COA 6-DESATURASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cyt-b5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA_desaturase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fads2 PhenoGen
PIRSF FA_sphinglp_des UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_B5_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020440 RatGTEx
  ENSRNOG00055017917 RatGTEx
  ENSRNOG00060030734 RatGTEx
  ENSRNOG00065033960 RatGTEx
SMART Cyt-b5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55856 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208400
UniProt A0A140TAE1_RAT UniProtKB/TrEMBL
  A0A8I5ZWZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6F8 ENTREZGENE, UniProtKB/TrEMBL
  A6I009 ENTREZGENE, UniProtKB/TrEMBL
  FADS2_RAT UniProtKB/Swiss-Prot
  H2BF31 ENTREZGENE
  Q9Z122 ENTREZGENE
UniProt Secondary H2BF31 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fads2  fatty acid desaturase 2      Name updated 70584 APPROVED
2002-02-27 Fads2  fatty acid desaturase 2      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in skin fibroblasts 70542
gene_function delta-6 desaturates 18 and 24-carbon very-long-chain polyunsaturated fatty acids, converting C(18:3) n-3 to C(18:4) n-3 and C(24:5) n-3 to C(24:6) n-3 68244
gene_function delta-6 desaturates 18 and 24-carbon very-long-chain polyunsaturated fatty acids, converting C(18:3) n-3 to C(18:4) n-3 and C(24:5) n-3 to C(24:6) n-3 70542
gene_function catalyzes palmitic acid Delta 6 -desaturation 1299149
gene_process functions in very-long-chain polyunsaturated fatty acid biosynthesis 68244
gene_process functions in very-long-chain polyunsaturated fatty acid biosynthesis 70542