Fads2 (fatty acid desaturase 2) - Rat Genome Database

Name: Fads2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Fads2 (fatty acid desaturase 2) Rattus norvegicus

Analyze

Symbol:

Fads2

Name:

fatty acid desaturase 2

RGD ID:

68339

Description:

Predicted to enable stearoyl-CoA 9-desaturase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human FADS2 (fatty acid desaturase 2); PARTICIPATES IN alpha-linolenic acid metabolic pathway; linoleic acid metabolic pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

acyl-CoA 6-desaturase; D6D; delta(6) desaturase; delta(6) fatty acid desaturase; delta-6 desaturase; delta-6 fatty acid desaturase; Fadsd6; fatty acid desaturase 6; MGC93365

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FADS2 (fatty acid desaturase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Fads2 (fatty acid desaturase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fads2 (fatty acid desaturase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FADS2 (fatty acid desaturase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FADS2 (fatty acid desaturase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fads2 (fatty acid desaturase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FADS2 (fatty acid desaturase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FADS2 (fatty acid desaturase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fads2 (fatty acid desaturase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FADS1 (fatty acid desaturase 1)	HGNC	OrthoDB
Homo sapiens (human):	FADS3 (fatty acid desaturase 3)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	FADS2 (fatty acid desaturase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fads2 (fatty acid desaturase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fads2 (fatty acid desaturase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	fat-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	fat-4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	206,707,384 - 206,747,333 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	206,708,783 - 206,748,789 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	215,087,206 - 215,125,554 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	222,142,298 - 222,180,658 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	214,837,305 - 214,875,662 (-)	NCBI	Rnor_WKY
Rnor_6.0	1	225,906,582 - 226,152,568 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	226,114,413 - 226,152,524 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	233,060,345 - 233,097,316 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	1	232,857,004 - 232,857,656 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	212,512,691 - 212,542,622 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	212,671,121 - 212,701,051 (-)	NCBI
Celera	1	204,204,027 - 204,242,387 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

bipolar disorder (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Colorectal Neoplasms (ISO)

familial temporal lobe epilepsy 8 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

leukocyte adhesion deficiency 3 (ISO)

lipid storage disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-butoxyethanol (ISO)

3,3',5-triiodo-L-thyronine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-azacytidine (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amiodarone (EXP,ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arachidonic acid (ISO)

arsane (EXP)

arsenic atom (EXP)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bexarotene (EXP)

bezafibrate (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bortezomib (ISO)

bromobenzene (EXP)

bucladesine (ISO)

buspirone (EXP)

butanal (ISO)

cadmium dichloride (EXP,ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chloroquine (EXP)

choline (ISO)

chrysin (ISO)

cisplatin (ISO)

clobetasol (ISO)

clofibrate (EXP)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

crizotinib (ISO)

curcumin (EXP,ISO)

cyanocob(III)alamin (EXP)

dexamethasone (ISO)

dextran sulfate (ISO)

Di-n-hexyl phthalate (ISO)

dibutyl phthalate (EXP)

dipentyl phthalate (EXP)

diuron (EXP)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (EXP,ISO)

Ganoderic acid A (ISO)

gemfibrozil (EXP)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

indinavir (ISO)

indole-3-methanol (EXP)

indometacin (ISO)

isoflavones (ISO)

isotretinoin (ISO)

ivermectin (ISO)

L-ethionine (EXP)

L-methionine (ISO)

lamivudine (ISO)

linoleic acid (ISO)

lithocholic acid (ISO)

lovastatin (ISO)

manganese(II) chloride (EXP)

medroxyprogesterone acetate (ISO)

methidathion (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

miconazole (ISO)

microcystin-LR (ISO)

monosodium L-glutamate (ISO)

N-acetyl-L-cysteine (EXP)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (EXP,ISO)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

omeprazole (EXP)

oxaliplatin (EXP)

paliperidone palmitate (EXP)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (EXP)

perfluorooctanoic acid (EXP,ISO)

phenethyl isothiocyanate (ISO)

phenobarbital (ISO)

phytosterols (ISO)

pirinixic acid (EXP,ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

risperidone (EXP)

rotenone (EXP)

saquinavir (ISO)

sevoflurane (EXP)

silicon dioxide (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

sunitinib (ISO)

tamoxifen (EXP,ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (EXP)

thimerosal (ISO)

thioacetamide (EXP)

topotecan (EXP)

trichloroethene (ISO)

trichostatin A (ISO)

Triptolide (ISO)

troglitazone (EXP,ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Yessotoxin (ISO)

zidovudine (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

lipid metabolic process (IBA)

unsaturated fatty acid biosynthetic process (IEA)

very long-chain fatty acid biosynthetic process (TAS)

Cellular Component

endoplasmic reticulum membrane (IEA,TAS)

Molecular Function

linoleoyl-CoA desaturase activity (IEA)

omega-6 fatty acid desaturase activity (TAS)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (IEA)

oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (IBA)

protein binding (ISO)

stearoyl-CoA 9-desaturase activity (IEA,ISO,TAS)

Molecular Pathway Annotations Click to see Annotation Detail View

alpha-linolenic acid metabolic pathway (IEA,ISO)

eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma (IEA)

linoleic acid metabolic pathway (ISO)

unsaturated fatty acid biosynthetic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular cloning and functional characterization of rat delta-6 fatty acid desaturase.	Aki T, etal., Biochem Biophys Res Commun 1999 Feb 24;255(3):575-9.
2.	The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis.	D'andrea S, etal., Biochem J 2002 May 15;364(Pt 1):49-55.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Conversion of hexadecanoic acid to hexadecenoic acid by rat Delta 6-desaturase.	Guillou H, etal., J Lipid Res 2003 Mar;44(3):450-4. Epub 2003 Jan 16.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis.	Saether T, etal., Biol Reprod 2003 Jul;69(1):117-24. Epub 2003 Feb 19.
14.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:9867867	PMID:12562861	PMID:14563830	PMID:14577661	PMID:15589689	PMID:19157821	PMID:19946888	PMID:21172452	PMID:22133376	PMID:22216341	PMID:22495065	PMID:23107313
PMID:24284026	PMID:25046614	PMID:25701799	PMID:29735017

Genomics

Comparative Map Data

Fads2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	206,707,384 - 206,747,333 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	206,708,783 - 206,748,789 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	215,087,206 - 215,125,554 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	222,142,298 - 222,180,658 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	214,837,305 - 214,875,662 (-)	NCBI	Rnor_WKY
Rnor_6.0	1	225,906,582 - 226,152,568 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	226,114,413 - 226,152,524 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	233,060,345 - 233,097,316 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	1	232,857,004 - 232,857,656 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	212,512,691 - 212,542,622 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	212,671,121 - 212,701,051 (-)	NCBI
Celera	1	204,204,027 - 204,242,387 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

FADS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	61,816,203 - 61,867,354 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	11	61,792,980 - 61,867,354 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	61,583,675 - 61,634,826 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	61,352,289 - 61,391,401 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	61,352,288 - 61,391,401	NCBI
Celera	11	58,931,086 - 58,970,195 (+)	NCBI		Celera
Cytogenetic Map	11	q12.2	NCBI
HuRef	11	57,911,912 - 57,963,064 (+)	NCBI		HuRef
CHM1_1	11	61,466,890 - 61,518,047 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	61,805,120 - 61,856,305 (+)	NCBI		T2T-CHM13v2.0

Fads2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	10,040,129 - 10,078,867 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	10,040,129 - 10,079,110 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	10,062,765 - 10,101,503 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	10,062,765 - 10,101,746 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	10,138,654 - 10,175,993 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	10,131,209 - 10,168,548 (-)	NCBI		MGSCv36	mm8
Celera	19	10,758,331 - 10,797,423 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI

Fads2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955511	5,827,797 - 5,842,760 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955511	5,827,797 - 5,842,745 (-)	NCBI	ChiLan1.0	ChiLan1.0

FADS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	60,552,600 - 60,591,649 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	60,476,082 - 60,591,649 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	57,192,881 - 57,232,574 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

FADS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	54,552,105 - 54,581,553 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	54,553,366 - 54,659,654 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	53,133,977 - 53,163,472 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	55,605,529 - 55,634,998 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	55,605,530 - 55,713,111 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	54,666,552 - 54,696,035 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	54,287,830 - 54,317,326 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	55,154,814 - 55,184,306 (-)	NCBI		UU_Cfam_GSD_1.0

Fads2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	11,089,588 - 11,119,295 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936581	1,203,366 - 1,233,469 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936581	1,203,410 - 1,233,330 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FADS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	9,629,423 - 9,735,576 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	9,633,941 - 9,666,666 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	9,119,484 - 9,152,213 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FADS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	11,934,352 - 11,978,355 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	11,934,270 - 11,974,030 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	109,308,070 - 109,412,986 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fads2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624926	528,791 - 548,854 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624926	529,456 - 548,800 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fads2
141 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	61
Count of miRNA genes:	58
Interacting mature miRNAs:	61
Transcripts:	ENSRNOT00000027756
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642722	214537671	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	213533942	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164747424	209747424	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	164747424	209747424	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	167909849	212909849	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169537671	214537671	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	169537671	214537671	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	171310381	216310381	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	171629477	216629477	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	171629477	216629477	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	171629477	216629477	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	171629477	216629477	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	171629477	216629477	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	171629477	216629477	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	172609619	217609619	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	173108781	218108781	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	174133260	219133260	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	176550523	221550523	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	176869060	221869060	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	178784622	223784622	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1302787	Stl25	Serum triglyceride level QTL 25	2.7	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	180359209	210702199	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	180359209	218108781	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	181133855	226133855	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	181759564	214537555	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	181829673	224569684	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	182623426	219932796	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	184550676	229550676	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	185145134	221264292	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	188377360	224054420	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	191019702	246062233	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	191033875	236033875	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	192825253	243914732	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	193113876	238113876	Rat
634338	Hcar4	Hepatocarcinoma resistance QTL 4	4.6		liver integrity trait (VT:0010547)	liver tumorous lesion number to liver area ratio (CMO:0001210)	1	193422268	214537671	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	196248093	241248093	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	0.00000081	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	196248093	241248093	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	197670404	242670404	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	197697768	238755659	Rat
2302375	Bw83	Body weight QTL 83	4.87	0.0002	body mass (VT:0001259)	body weight (CMO:0000012)	1	197697768	242697768	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	197814409	242814409	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	197814409	242814409	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	197814409	242814409	Rat
1331790	Bp201	Blood pressure QTL 201	3.127		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	198211513	225126682	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	199050459	259647894	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	199368955	224569684	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	201554356	246554356	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	201554356	246554356	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	201554356	246554356	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	201554356	246554356	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	201554356	246554356	Rat
10059587	Bw173	Body weight QTL 173	3.23	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	1	202069611	247069611	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	203995416	244113296	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	206081677	251081677	Rat
61403	Niddm4	Non-insulin dependent diabetes mellitus QTL 4			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	206329708	222745518	Rat
1357399	Bw45	Body weight QTL 45	3.05		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	1	206329708	251329708	Rat
1357404	Bw42	Body weight QTL 42	4.49	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	206329708	251329708	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High			4	1		1
Medium	3	34	55	40	18	40	1	2	74	35	41	11	1
Low		9	1		1		7	9					7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB021980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081776	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209848	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HQ909027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000027756 ⟹ ENSRNOP00000027756

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	206,708,785 - 206,747,142 (-)	Ensembl
Rnor_6.0 Ensembl	1	226,114,413 - 226,152,524 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101295 ⟹ ENSRNOP00000083431

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	206,708,785 - 206,747,142 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000120292 ⟹ ENSRNOP00000088570

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	206,708,783 - 206,748,789 (-)	Ensembl

RefSeq Acc Id:

NM_031344 ⟹ NP_112634

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	206,708,782 - 206,747,142 (-)	NCBI
Rnor_6.0	1	225,906,797 - 226,152,568 (-)	NCBI
Rnor_5.0	1	232,857,004 - 232,857,656 (-)	NCBI
Rnor_5.0	1	233,060,345 - 233,097,316 (-)	NCBI
RGSC_v3.4	1	212,512,691 - 212,542,622 (-)	RGD
Celera	1	204,204,027 - 204,242,387 (-)	RGD

Sequence:

show sequence

GCGAAGGCGAGGGGAGGAGGCGCGGTGGGAGGAGGAGTAGAAGACAAAAGCTGAAAGCGAGGAG
GGCGCCTACCGCACACTGCGGCCAGGAGAGGGACCGTCGGTGCTGCGAGCCGCGGGCGCCCGGA
GGGCCGTAGCGCACGGGTCATCCGGGTAGACAGGCAGCATGGGGAAGGGAGGTAACCAGGGAGA
GGGGAGCACCGAGCTCCAGGCTCCGATGCCCACCTTCCGCTGGGAGGAGATTCAGAAGCACAAC
CTGCGCACCGACCGGTGGCTCGTCATCGACCGCAAGGTCTACAACGTTACCAAATGGTCCCAGC
GGCACCCAGGGGGGCACCGTGTCATCGGACACTATTCGGGAGAAGATGCTACGGATGCCTTCCG
TGCCTTCCACCTGGACCTGGATTTCGTGGGCAAGTTCTTGAAGCCCCTGCTGATTGGTGAGCTG
GCCCCAGAGGAGCCCAGCCTGGACCGGGGCAAAAGCTCTCAGATCACCGAGGACTTCAGGGCCC
TGAAGAAGACTGCTGAGGACATGAACCTTTTCAAAACCAACCACCTGTTCTTCTTTCTCCTCCT
GTCCCACATCATCGTCATGGAAAGCATCGCCTGGTTCATCCTCTCGTACTTCGGCAATGGCTGG
ATTCCCACCGTCATCACGGCCTTTGTCCTTGCTACCTCCCAGGCCCAAGCTGGATGGCTACAAC
ATGATTATGGCCACCTTTCTGTCTATAAGAAATCCATATGGAACCACATTGTCCACAAGTTTGT
CATTGGCCACTTAAAGGGTGCCTCCGCCAACTGGTGGAACCATCGACATTTCCAGCACCATGCG
AAGCCCAACATCTTCCACAAGGACCCCGACATAAAGAGCCTGCACGTGTTTGTCCTTGGAGAGT
GGCAGCCCCTCGAGTATGGCAAGAAGAAGCTGAAATATCTGCCCTACAACCACCAGCATGAATA
CTTCTTCCTGATCGGACCACCGCTGCTCATCCCTATGTACTTCCAGTACCAGATCATCATGACC
ATGATCAGACGCAGAGACTGGGTGGACTTGGCCTGGGCCATCAGCTACTATGCACGTTTCTTCT
ACACCTATATCCCTTTCTATGGCATCTTGGGAGCCCTGGTTTTCCTCAACTTTATCAGGTTCCT
GGAGAGCCACTGGTTTGTGTGGGTCACACAGATGAACCACATTGTCATGGAGATTGATCTTGAT
CACTACCGGGACTGGTTCAGCAGCCAGCTGGCAGCCACCTGCAATGTGGAGCAGTCCTTCTTCA
ATGACTGGTTCAGCGGGCACCTCAATTTCCAGATTGAGCACCACCTCTTCCCCACTATGCCAAG
ACACAACTTGCACAAGATTGCCCCACTGGTGAAGTCTCTCTGCGCCAAGCATGGCATTGAATAC
CAAGAGAAGCCGCTGCTGAGGGCCCTGCTCGACATTGTGAGTTCACTGAAGAAGTCTGGGGAGC
TGTGGCTGGATGCCTACCTCCACAAATGAAGCAGCAGACCTCGTGGCACCCTTGGGAAGGGGGC
ACAGTTGGGTGACAGCCAGAGGGAGGGGAGGGCTTTTGTTCTGAAGGGTTCTCGTGAGACTGAA
GGGTCTGCTGGCTCACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008760244 ⟹ XP_008758466

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	206,707,384 - 206,745,010 (-)	NCBI
Rnor_6.0	1	225,906,582 - 226,152,181 (-)	NCBI

Sequence:

show sequence

GTGCCGGCCATTCTTGTCTGCTGCAGGCTGGTGTCAGGAGCCCGGGGTCGCTGGGCGCCAAACA
GATCTCCAGTTCTTAATGGAGCGCAGGACGTCCAACAGGGAAAGAAAGTACCTACTGCTCTCAT
CTCGCTCCCGGAATCGTCCTCCTCTGGGTCCGCTGGGCAGACTTGGGCCGAGCCTTTTGAACAC
CAGGCCTTAGCACCTCTGTGAAAGTCCCATTAGTAGCAAACTGTCTGGTGCATGTCACAGCGCA
TGCTGCGCGCTGGTCCAGTCGGAGCCAGGGACTCTCCAAAGGGGGCGCTAGGGCCTTCGTGCTT
TGGCGCTCCCCAAGTGGAAGATGGCCACCCTTGGGCGCCGCGGAGAGGAGCCTGAGAGCGGACC
ATATGTGGGACTCTCCTGCCAGACCGGGGTGGGGGGCGGAGAAGAAAAGCTGGTTCCTGGCCAG
GACTCGCTCCTGCTTGGACTCCTGTCTGAAAAGGTCCACAATGGCTGCCCGACCGAGACTGCCT
AGTAGTTCAGATTCCCACGCTCCCGCTCCCGAGGATTATCCCGACTCACTCCAAGTGCCAGCCT
TCTGGGAAATTCTGGTGGGGAGTTGGTGGAAGGCGAACGGGCTGAATTTTGCAAAATTCAGGTC
CGCAGGGGATCTAGAAGGTGAATCTAGTAGCACCAAGACTGGCTTGGCAACAGGTCCATGTGCC
TCTGGGGTTACTATCGGGCATTCAACTCAATAGCCCTCTGTTTTTAGAACCTGTCAGAATCGCC
CTTCCGCTCTTGCCCTTCTGGAGGTTGTTGAAATCTCAGGAACCTCTGTGGAACTGAGGCTACC
CTTATGTACACCAAATGTGGGTCTACCCTCTATTTGCATAGTATCCCATATCGTGCCTGGCCCC
ACCTCCACCCATAAAGGGATTGTGTAGTCAGGTGGTTAAGAAGAGAAGCAAAGTCAAGGAGGAA
AACCAGACCTTTCTTGGCACCTTTCTTGGGGAGCTGAAAGCAGAGGAAAAGATGTTTCTGGAGA
GAGCTTGGGAAAGATGAGTGGAAAGAGGCTGAGAAGAGGGGTAAACGTCTCAGAAGGCACTCCA
CATCGAAGTCCAGATGCCGACCTGTGTGTGGGCTTTTCTTTCCCAAGTTCGTTAGTTTCAATTC
TTAGCTTCCACATCTTTTCTCTTTGAGACCAGCCTAGGTGGCCAGCTTCTGATCAGTGGATTGG
GGGCTTTGATGAACAGGACCCAATCTTATGCTAGACTGAGGAGAGAGCTGACACTGCCTAAAGC
CTATTTTCCTTGCTCATGGACTCCGCTTAAGCCCGTGGGGCTGGTGATGCTAACCAGACCTGGA
GAGCGCAAGCTTTTCAAGTTCCTTGAGTGCCCTAGCTCTCTTGGACCTTTTCACAACCGGAGAA
GTCCTCAGTTTCCCAGGGAGATGACTTTCCAGCTCCTGCCTCGGGGGTCTTTCTACTTTTTTGT
CTGCTGGCGTGTGCATGACTCTGTAGGTGAGTTGCAGATGGCTCCTCCTTCTTCCAGGCTCTTA
CCAAACAGTTTCCTAAAAAGTAAAGCAAAGCTGTGATCGGTTTGAGCCAAATGTTCCATGTTGT
GCGATAAGTAGGTTTTCCTGTGAGGAGGTTCAGCCCACAACAGCCTTGAACTTTATAGTTTATT
GAAGAAGCCAGACGTATTTCATCCTTGTTTTGGAAGTTCTTAGGGCTTTCCTGACCCAGTTTTC
TCCAATGTCTGTGTTCAGATCTAACCCAGCAGACACCTGGACAGCTTGCTCTTAAGTTCTGAAA
ACCTGACGACCTCTCTGCCTGTTTCCTGTGTCATTTTCATTGGTTCTGAGTCTGGGGTCTGTGA
TGTTAATGCCCCATGACAGGAGAGGATGCCTTCCGTGCCTTCCACCTGGACCTGGATTTCGTGG
GCAAGTTCTTGAAGCCCCTGCTGATTGGTGAGCTGGCCCCAGAGGAGCCCAGCCTGGACCGGGG
CAAAAGCTCTCAGATCACCGAGGACTTCAGGGCCCTGAAGAAGACTGCTGAGGACATGAACCTT
TTCAAAACCAACCACCTGTTCTTCTTTCTCCTCCTGTCCCACATCATCGTCATGGAAAGCATCG
CCTGGTTCATCCTCTCGTACTTCGGCAATGGCTGGATTCCCACCGTCATCACGGCCTTTGTCCT
TGCTACCTCCCAGGCCCAAGCTGGATGGCTACAACATGATTATGGCCACCTTTCTGTCTATAAG
AAATCCATATGGAACCACATTGTCCACAAGTTTGTCATTGGCCACTTAAAGGGTGCCTCCGCCA
ACTGGTGGAACCATCGACATTTCCAGCACCATGCGAAGCCCAACATCTTCCACAAGGACCCCGA
CATAAAGAGCCTGCACGTGTTTGTCCTTGGAGAGTGGCAGCCCCTCGAGTATGGCAAGAAGAAG
CTGAAATATCTGCCCTACAACCACCAGCATGAATACTTCTTCCTGATCGGACCACCGCTGCTCA
TCCCTATGTACTTCCAGTACCAGATCATCATGACCATGATCAGACGCAGAGACTGGGTGGACTT
GGCCTGGGCCATCAGCTACTATGCACGTTTCTTCTACACCTATATCCCTTTCTATGGCATCTTG
GGAGCCCTGGTTTTCCTCAACTTTATCAGGTTCCTGGAGAGCCACTGGTTTGTGTGGGTCACAC
AGATGAACCACATTGTCATGGAGATTGATCTTGATCACTACCGGGACTGGTTCAGCAGCCAGCT
GGCAGCCACCTGCAATGTGGAGCAGTCCTTCTTCAATGACTGGTTCAGCGGGCACCTCAATTTC
CAGATTGAGCACCACCTCTTCCCCACTATGCCAAGACACAACTTGCACAAGATTGCCCCACTGG
TGAAGTCTCTCTGCGCCAAGCATGGCATTGAATACCAAGAGAAGCCGCTGCTGAGGGCCCTGCT
CGACATTGTGAGTTCACTGAAGAAGTCTGGGGAGCTGTGGCTGGATGCCTACCTCCACAAATGA
AGCAGCAGACCTCGTGGCACCCTTGGGAAGGGGGCACAGTTGGGTGACAGCCAGAGGGAGGGGA
GGGCTTTTGTTCTGAAGGGTTCTCGTGAGACTGAAGGGTCTGCTGGCTCACATTCCCCGTGCTT
GGTTTTTCATCCTTTCTTGTTCTTCTCTTCCCTCACCCCGACCTACCCTATCCTCATGGAGTTC
CCCTTTGTCAGTTCTCAGCCCTAGTTCCCCTCTGCCTCCCAGCCCCTTCTCCCAAAGAGCTGGA
GAGGTGGCTGTACCAGGTGTCCAGCTCTAAGCTTCTGCACCTAAAGATCCTGGTAAAAAATTCT
GCTTCCTTGCA

hide sequence

RefSeq Acc Id:

XM_039092480 ⟹ XP_038948408

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	206,707,384 - 206,747,333 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_112634	(Get FASTA)	NCBI Sequence Viewer
	XP_008758466	(Get FASTA)	NCBI Sequence Viewer
	XP_038948408	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81776	(Get FASTA)	NCBI Sequence Viewer
	AEX15918	(Get FASTA)	NCBI Sequence Viewer
	BAA75496	(Get FASTA)	NCBI Sequence Viewer
	EDM12790	(Get FASTA)	NCBI Sequence Viewer
	Q9Z122	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_112634 ⟸ NM_031344

- UniProtKB:

H2BF31 (UniProtKB/Swiss-Prot), Q9Z122 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MGKGGNQGEGSTELQAPMPTFRWEEIQKHNLRTDRWLVIDRKVYNVTKWSQRHPGGHRVIGHYS
GEDATDAFRAFHLDLDFVGKFLKPLLIGELAPEEPSLDRGKSSQITEDFRALKKTAEDMNLFKT
NHLFFFLLLSHIIVMESIAWFILSYFGNGWIPTVITAFVLATSQAQAGWLQHDYGHLSVYKKSI
WNHIVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDIKSLHVFVLGEWQPLEYGKKKLKY
LPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIRRRDWVDLAWAISYYARFFYTYIPFYGILGAL
VFLNFIRFLESHWFVWVTQMNHIVMEIDLDHYRDWFSSQLAATCNVEQSFFNDWFSGHLNFQIE
HHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIVSSLKKSGELWLDAYLHK

hide sequence

RefSeq Acc Id:

XP_008758466 ⟸ XM_008760244

- Peptide Label:

isoform X2

- Sequence:

show sequence

MTGEDAFRAFHLDLDFVGKFLKPLLIGELAPEEPSLDRGKSSQITEDFRALKKTAEDMNLFKTN
HLFFFLLLSHIIVMESIAWFILSYFGNGWIPTVITAFVLATSQAQAGWLQHDYGHLSVYKKSIW
NHIVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDIKSLHVFVLGEWQPLEYGKKKLKYL
PYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIRRRDWVDLAWAISYYARFFYTYIPFYGILGALV
FLNFIRFLESHWFVWVTQMNHIVMEIDLDHYRDWFSSQLAATCNVEQSFFNDWFSGHLNFQIEH
HLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIVSSLKKSGELWLDAYLHK

hide sequence

RefSeq Acc Id:

ENSRNOP00000027756 ⟸ ENSRNOT00000027756

RefSeq Acc Id:	XP_038948408 ⟸ XM_039092480
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A6F8 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000083431 ⟸ ENSRNOT00000101295

RefSeq Acc Id:

ENSRNOP00000088570 ⟸ ENSRNOT00000120292

Protein Domains

Cytochrome b5 heme-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9Z122-F1-model_v2	AlphaFold	Q9Z122	1-444	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690765

Promoter ID:

EPDNEW_R1290

Type:

multiple initiation site

Name:

Fads2_1

Description:

fatty acid desaturase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	226,152,497 - 226,152,557	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:68339	AgrOrtholog
BioCyc Gene	G2FUF-56442	BioCyc
BioCyc Pathway	PWY-6000 [gamma-linolenate biosynthesis II (animals)]	BioCyc
	PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)]	BioCyc
	PWY-7606 [docosahexaenoate biosynthesis III (6-desaturase, mammals)]	BioCyc
	PWY-7726 [(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)]	BioCyc
Ensembl Genes	ENSRNOG00000020440	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000027756	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000027756.6	UniProtKB/Swiss-Prot
	ENSRNOP00000083431.1	UniProtKB/TrEMBL
	ENSRNOP00000088570	ENTREZGENE
	ENSRNOP00000088570.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027756	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000027756.7	UniProtKB/Swiss-Prot
	ENSRNOT00000101295.1	UniProtKB/TrEMBL
	ENSRNOT00000120292	ENTREZGENE
	ENSRNOT00000120292.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.120.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7128630	IMAGE-MGC_LOAD
InterPro	Cyt_B5-like_heme/steroid-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cyt_B5-like_heme/steroid_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FA_desaturase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Fatty_acid_desaturase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:83512	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93365	IMAGE-MGC_LOAD
NCBI Gene	83512	ENTREZGENE
PANTHER	ACYL-COA 6-DESATURASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR19353	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Cyt-b5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FA_desaturase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Fads2	PhenoGen
PIRSF	FA_sphinglp_des	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	CYTOCHROME_B5_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	Cyt-b5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF55856	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC208400
UniProt	A0A140TAE1_RAT	UniProtKB/TrEMBL
	A0A8I5ZWZ8_RAT	UniProtKB/TrEMBL
	A0A8I6A6F8	ENTREZGENE, UniProtKB/TrEMBL
	FADS2_RAT	UniProtKB/Swiss-Prot
	H2BF31	ENTREZGENE
	Q9Z122	ENTREZGENE
UniProt Secondary	H2BF31	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Fads2	fatty acid desaturase 2			Name updated	70584	APPROVED
2002-02-27	Fads2	fatty acid desaturase 2			Symbol and Name updated to reflect Human and Mouse nomenclature	70292	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in skin fibroblasts	70542
gene_function	delta-6 desaturates 18 and 24-carbon very-long-chain polyunsaturated fatty acids, converting C(18:3) n-3 to C(18:4) n-3 and C(24:5) n-3 to C(24:6) n-3	68244
gene_function	delta-6 desaturates 18 and 24-carbon very-long-chain polyunsaturated fatty acids, converting C(18:3) n-3 to C(18:4) n-3 and C(24:5) n-3 to C(24:6) n-3	70542
gene_function	catalyzes palmitic acid Delta 6 -desaturation	1299149
gene_process	functions in very-long-chain polyunsaturated fatty acid biosynthesis	68244
gene_process	functions in very-long-chain polyunsaturated fatty acid biosynthesis	70542

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
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InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)