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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68339
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fads2
Name: fatty acid desaturase 2
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fads2decreases activityEXP 6480464CTDFolic Acid results in decreased activity of FADS2 proteinPMID:22133376
Fads2multiple interactionsEXP 6480464CTD[Vitamin B 12 deficiency co-treated with Folic Acid] results in decreased activity of FADS2 protein; Folic Acid inhibits the reaction [[Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS2 protein]PMID:22133376
Fads2increases expressionISOFads2 (Mus musculus)6480464CTDFolic Acid results in increased expression of FADS2 mRNAPMID:25629700
Fads2multiple interactionsISOFads2 (Mus musculus)6480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FADS2 genePMID:20938992
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