Ptger3 (prostaglandin E receptor 3) - Rat Genome Database

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Gene: Ptger3 (prostaglandin E receptor 3) Rattus norvegicus
Symbol: Ptger3
Name: prostaglandin E receptor 3
RGD ID: 3435
Description: Enables prostaglandin E receptor activity. Involved in several processes, including negative regulation of transport; positive regulation of smooth muscle contraction; and regulation of circadian sleep/wake cycle. Located in several cellular components, including brush border membrane; nuclear membrane; and proximal neuron projection. Used to study asthma and withdrawal disorder. Biomarker of colon cancer; membranous glomerulonephritis; and renovascular hypertension. Orthologous to human PTGER3 (prostaglandin E receptor 3); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
Previously known as: EP3; EP3R; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; prostaglandin E receptor 3 ( subtype EP3); prostaglandin E receptor 3 (subtype EP3); prostaglandin E2 receptor EP3 subtype; prostanoid EP3 receptor; rat kidney prostaglandin Ep3 receptor; Rat kidney prostaglandin EP3 receptor (alternative splicing results in two different receptors EP3a and EP3b); Rep3; rEP3a; rEP3b
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22246,606,131 - 246,750,970 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2246,606,183 - 246,684,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2254,318,634 - 254,403,084 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02252,212,449 - 252,296,915 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02247,184,945 - 247,269,307 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02263,895,093 - 263,979,682 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2263,895,241 - 263,979,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02282,614,936 - 282,760,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42255,680,691 - 255,759,202 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12255,695,297 - 255,773,809 (+)NCBI
Celera2238,415,230 - 238,493,209 (+)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
celecoxib  (EXP)
chlordecone  (ISO)
choline  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
eugenol  (ISO)
excitatory amino acid agonist  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
glafenine  (EXP)
GW 4064  (ISO)
heptachlor  (EXP)
ibuprofen  (ISO)
ketoconazole  (EXP,ISO)
L-methionine  (ISO)
methapyrilene  (ISO)
mifepristone  (EXP)
misoprostol  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
PCB138  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
pristane  (ISO)
progesterone  (EXP)
prostaglandin E2  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rofecoxib  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
Soman  (EXP)
staurosporine  (EXP)
sulforaphane  (ISO)
sulprostone  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbinafine  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vinyl carbamate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IEA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
bicarbonate transport  (ISO)
cellular response to forskolin  (IMP)
cellular response to interleukin-1  (IEP)
cellular response to lipopolysaccharide  (IEP)
desensitization of G protein-coupled receptor signaling pathway  (IMP)
female pregnancy  (IEP)
fever generation  (ISO)
inflammatory response  (IBA,IEA)
intestine smooth muscle contraction  (IBA,IEA,IMP)
maternal process involved in parturition  (IEP)
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IMP)
negative regulation of calcium ion transmembrane transport  (IMP)
negative regulation of circadian sleep/wake cycle, wakefulness  (IMP)
negative regulation of forebrain neuron differentiation  (IMP)
negative regulation of gastric acid secretion  (IBA,IEA)
negative regulation of gastrin-induced gastric acid secretion  (IMP)
negative regulation of insulin secretion  (IDA)
negative regulation of norepinephrine secretion  (IMP)
negative regulation of potassium ion transmembrane transport  (IMP)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA,IEA,ISO)
positive regulation of cAMP-mediated signaling  (IMP)
positive regulation of circadian sleep/wake cycle, non-REM sleep  (IMP)
positive regulation of colon smooth muscle contraction  (IMP)
positive regulation of cytosolic calcium ion concentration  (IBA,IEA,IMP,ISO)
positive regulation of fever generation  (ISO)
positive regulation of gastric mucosal blood circulation  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of inhibitory G protein-coupled receptor phosphorylation  (IMP)
positive regulation of miRNA transcription  (ISO)
positive regulation of myofibroblast contraction  (IMP)
positive regulation of neutrophil extravasation  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of smooth muscle contraction involved in micturition  (IMP)
positive regulation of urine volume  (ISO)
positive regulation of vasoconstriction  (IMP)
prostaglandin receptor internalization  (IMP)
receptor internalization  (IMP)
regulation of circadian sleep/wake cycle, wakefulness  (IMP)
regulation of norepinephrine secretion  (IMP)
response to estradiol  (IEP)
response to lipopolysaccharide  (ISO)
response to progesterone  (IEP)
response to salt  (IEP)
response to xenobiotic stimulus  (IEP)
urinary bladder smooth muscle contraction  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Anti-inflammatory effect of prostanoids in mouse and rat skin: evidence for a role of EP3-receptors. Ahluwalia A and Perretti M, J Pharmacol Exp Ther. 1994 Mar;268(3):1526-31.
2. The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach. Araki H, etal., Aliment Pharmacol Ther. 2000 Apr;14 Suppl 1:116-24.
3. Prostaglandin E2 induces contraction of liver myofibroblasts by activating EP3 and FP prostanoid receptors. Ayabe S, etal., Br J Pharmacol. 2009 Mar;156(5):835-45. doi: 10.1111/j.1476-5381.2008.00051.x. Epub 2009 Feb 23.
4. Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope. Bhattacharya M, etal., J Biol Chem. 1999 May 28;274(22):15719-24.
5. Exploration of prostanoid receptor subtype regulating estradiol and prostaglandin E2 induction of spinophilin in developing preoptic area neurons. Burks SR, etal., Neuroscience. 2007 May 25;146(3):1117-27. Epub 2007 Apr 6.
6. Role of prostaglandin E2 receptor subtypes in ovarian follicle growth in the rat in vivo. Correlation with interleukin-8 and neutrophils. El-Nefiawy N, etal., Histol Histopathol. 2005 Jul;20(3):825-31.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. PGE2 inhibits basolateral 50 pS potassium channels in the thick ascending limb of the rat kidney. Gu R, etal., Kidney Int. 2008 Aug;74(4):478-85. doi: 10.1038/ki.2008.198. Epub 2008 May 21.
9. Hormonal regulation of prostaglandin E2 receptors: localization and expression in rat cervical tissue. Hinton AC, etal., Reprod Sci. 2010 Feb;17(2):136-46. doi: 10.1177/1933719109348068. Epub 2009 Oct 2.
10. Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon. Iizuka Y, etal., J Physiol Sci. 2014 Mar;64(2):85-96. doi: 10.1007/s12576-013-0295-2. Epub 2013 Oct 30.
11. The prostaglandin E series modulates high-voltage-activated calcium channels probably through the EP3 receptor in rat paratracheal ganglia. Ito Y, etal., Neuropharmacology. 2000 Jan 4;39(2):181-90.
12. Differential regulation of renal prostaglandin receptor mRNAs by dietary salt intake in the rat. Jensen BL, etal., Kidney Int. 1999 Aug;56(2):528-37.
13. Prostaglandins compromise basal forebrain cholinergic neuron differentiation and survival: action at EP1/3 receptors results in AIF-induced death. Jonakait GM and Ni L, Brain Res. 2009 Aug 18;1285:30-41. doi: 10.1016/j.brainres.2009.06.037. Epub 2009 Jun 22.
14. Dual action of prostaglandin E2 on gastric acid secretion through different EP-receptor subtypes in the rat. Kato S, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G64-9.
15. Expression pattern of messenger RNAs for prostanoid receptors in glial cell cultures. Kitanaka J, etal., Brain Res 1996 Jan 29;707(2):282-7.
16. Activation of EP4 receptors contributes to prostaglandin E2-mediated stimulation of renal sensory nerves. Kopp UC, etal., Am J Physiol Renal Physiol. 2004 Dec;287(6):F1269-82. Epub 2004 Aug 3.
17. 16,16-Dimethyl prostaglandin E2 inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors. Kunikata T, etal., Dig Dis Sci. 2002 Apr;47(4):894-904.
18. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Immunohistochemical characteristics of submucosal Dogiel type II neurons in rat colon. Mitsui R Cell Tissue Res. 2010 May;340(2):257-65. doi: 10.1007/s00441-010-0954-z. Epub 2010 Mar 26.
21. Immunohistochemical analysis of substance P-containing neurons in rat small intestine. Mitsui R Cell Tissue Res. 2011 Feb;343(2):331-41. doi: 10.1007/s00441-010-1080-7. Epub 2010 Nov 23.
22. Possible involvement of the locus coeruleus in inhibition by prostanoid EP(3) receptor-selective agonists of morphine withdrawal syndrome in rats. Nakagawa T, etal., Eur J Pharmacol. 2000 Mar 3;390(3):257-66.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization. Neuschafer-Rube F, etal., Br J Pharmacol. 2005 Aug;145(8):1132-42.
25. Molecular cloning and expression of a prostaglandin E2 receptor of the EP3 beta subtype from rat hepatocytes. Neuschafer-Rube F, etal., FEBS Lett 1994 Aug 29;351(1):119-22.
26. The C-terminal domain of the Gs-coupled EP4 receptor confers agonist-dependent coupling control to Gi but no coupling to Gs in a receptor hybrid with the Gi-coupled EP3 receptor. Neuschafer-Rube F, etal., FEBS Lett. 1997 Jan 20;401(2-3):185-90.
27. The C-terminal domain of the human EP4 receptor confers agonist-induced receptor desensitization in a receptor hybrid with the rat EP3beta receptor. Neuschafer-Rube F, etal., FEBS Lett. 1997 Sep 29;415(2):119-24.
28. Spinal prostaglandins facilitate exaggerated A- and C-fiber-mediated reflex responses and are critical to the development of allodynia early after L5-L6 spinal nerve ligation. O'Rielly DD and Loomis CW, Anesthesiology. 2007 Apr;106(4):795-805.
29. Identification of a prostaglandin E2 receptor splice variant and its expression in rat tissues. Oldfield S, etal., Prostaglandins Other Lipid Mediat 2001 Mar;63(4):165-73.
30. Characterization of temporal and cell-specific changes in transcripts for prostaglandin E(2) receptors in pseudopregnant rat endometrium. Papay KD and Kennedy TG, Biol Reprod. 2000 Jun;62(6):1515-25.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy. Sennlaub F, etal., Circulation. 2003 Jul 15;108(2):198-204. Epub 2003 Jun 23.
36. Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development. Shoji Y, etal., Gut. 2004 Aug;53(8):1151-8.
37. Microglial expression of prostaglandin EP3 receptor in excitotoxic lesions in the rat striatum. Slawik H, etal., Neurochem Int. 2004 Oct;45(5):653-60.
38. Prostaglandin receptor subtypes, EP3C and EP4, mediate the prostaglandin E2-induced cAMP production and sensitization of sensory neurons. Southall MD and Vasko MR, J Biol Chem. 2001 May 11;276(19):16083-91. Epub 2001 Feb 14.
39. An excitatory role for peripheral EP3 receptors in bladder afferent function. Su X, etal., Am J Physiol Renal Physiol. 2008 Aug;295(2):F585-94. doi: 10.1152/ajprenal.90273.2008. Epub 2008 Jun 18.
40. Molecular cloning and intrarenal localization of rat prostaglandin E2 receptor EP3 subtype. Takeuchi K, etal., Biochem Biophys Res Commun 1993 Jul 30;194(2):885-91.
41. Two isoforms of the rat kidney EP3 receptor derived by alternative RNA splicing: intrarenal expression co-localization. Takeuchi K, etal., Biochem Biophys Res Commun 1994 Mar 15;199(2):834-40.
42. Functional analysis and chromosomal gene assignment of rat kidney prostaglandin EP3 receptor. Takeuchi K, etal., Kidney Int Suppl. 1996 Jun;55:S183-6.
43. Biphasic actions of prostaglandin E(2) on the renal afferent arteriole : role of EP(3) and EP(4) receptors. Tang L, etal., Circ Res. 2000 Mar 31;86(6):663-70.
44. Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat). Theilig F, etal., Am J Physiol Renal Physiol. 2006 Nov;291(5):F987-94. Epub 2006 Jun 20.
45. Prostaglandin E(2) mediates inhibition of insulin secretion by interleukin-1beta. Tran PO, etal., J Biol Chem. 1999 Oct 29;274(44):31245-8.
46. Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Ushikubi F, etal., Nature 1998 Sep 17;395(6699):281-4.
47. COX-2 inhibition and prostaglandin receptors in experimental nephritis. Waldner C, etal., Eur J Clin Invest. 2003 Nov;33(11):969-75.
48. Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB. Waschbisch A, etal., J Neurochem. 2006 Feb;96(3):680-93. Epub 2006 Jan 9.
49. DNA microarray data integration by ortholog gene analysis reveals potential molecular mechanisms of estrogen-dependent growth of human uterine fibroids. Wei T, etal., BMC Womens Health. 2007 Apr 2;7:5.
50. Elevation of both cyclooxygenase-2 and prostaglandin E2 receptor EP3 expressions in rat placenta after uterine artery ischemia-reperfusion. Yamazaki K, etal., Placenta. 2006 Apr-May;27(4-5):395-401. Epub 2005 Jun 28.
51. Prostanoid EP3 and TP receptors-mediated inhibition of noradrenaline release from the isolated rat stomach. Yokotani K, etal., Eur J Pharmacol. 2003 Jan 17;459(2-3):187-93.
52. Prostaglandin E (EP) receptor subtypes and sleep: promotion by EP4 and inhibition by EP1/EP2. Yoshida Y, etal., Neuroreport. 2000 Jul 14;11(10):2127-31.
53. Effects of the prostanoid EP3-receptor agonists M&B 28767 and GR 63799X on infarct size caused by regional myocardial ischaemia in the anaesthetized rat. Zacharowski K, etal., Br J Pharmacol. 1999 Feb;126(4):849-58.
54. Adenosine A(1) and prostaglandin E receptor 3 receptors mediate global airway contraction after local epithelial injury. Zhou J, etal., Am J Respir Cell Mol Biol. 2013 Mar;48(3):299-305. doi: 10.1165/rcmb.2012-0174OC. Epub 2012 Dec 6.
55. 1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists. Zhou N, etal., Bioorg Med Chem Lett. 2010 Apr 15;20(8):2658-64. doi: 10.1016/j.bmcl.2010.02.028. Epub 2010 Feb 25.
Additional References at PubMed
PMID:7733888   PMID:7945376   PMID:8076637   PMID:8223569   PMID:8381413   PMID:9843913   PMID:10535876   PMID:14552899   PMID:14675158   PMID:14736850   PMID:15834430   PMID:17512019  
PMID:17567965   PMID:18292084   PMID:18632791   PMID:18843255   PMID:19486006   PMID:19940926   PMID:21463619   PMID:21939736   PMID:22061836   PMID:22371141   PMID:23406763   PMID:26718710  
PMID:30084511   PMID:32165825   PMID:33694300   PMID:36531208  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22246,606,131 - 246,750,970 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2246,606,183 - 246,684,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2254,318,634 - 254,403,084 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02252,212,449 - 252,296,915 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02247,184,945 - 247,269,307 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02263,895,093 - 263,979,682 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2263,895,241 - 263,979,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02282,614,936 - 282,760,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42255,680,691 - 255,759,202 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12255,695,297 - 255,773,809 (+)NCBI
Celera2238,415,230 - 238,493,209 (+)NCBICelera
Cytogenetic Map2q45NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38170,852,358 - 71,047,816 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl170,852,353 - 71,047,816 (-)EnsemblGRCh38hg38GRCh38
GRCh37171,318,041 - 71,513,499 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,090,624 - 71,286,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 34171,188,848 - 71,225,512NCBI
Celera169,607,257 - 69,802,711 (-)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef169,428,653 - 69,623,748 (-)NCBIHuRef
CHM1_1171,432,956 - 71,628,842 (-)NCBICHM1_1
T2T-CHM13v2.0170,730,386 - 70,925,810 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm393157,272,459 - 157,350,392 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3157,272,529 - 157,351,525 (+)EnsemblGRCm39 Ensembl
GRCm383157,566,821 - 157,644,758 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3157,566,892 - 157,645,888 (+)EnsemblGRCm38mm10GRCm38
MGSCv373157,229,856 - 157,307,722 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363157,502,185 - 157,580,051 (+)NCBIMGSCv36mm8
Celera3164,034,893 - 164,113,113 (+)NCBICelera
Cytogenetic Map3H4NCBI
cM Map381.32NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_00495542321,096,926 - 21,164,435 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11154,996,361 - 155,091,432 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0170,076,610 - 70,271,475 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1172,058,998 - 72,254,063 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl172,059,441 - 72,254,063 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1674,932,789 - 74,986,573 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha677,575,622 - 77,753,496 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0675,490,852 - 75,668,770 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl675,490,852 - 75,714,812 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1675,042,922 - 75,220,964 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0674,940,272 - 75,118,118 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0675,437,418 - 75,616,001 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505883,239,312 - 83,315,450 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365911,174,069 - 1,249,410 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365911,174,364 - 1,250,233 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl6141,958,955 - 142,161,286 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16141,958,955 - 142,160,437 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26131,574,664 - 131,776,520 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12062,093,830 - 62,293,360 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2062,095,458 - 62,174,959 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603355,495,971 - 55,576,801 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462474225,177,340 - 25,356,911 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ptger3
903 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:48
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000014034, ENSRNOT00000014126
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.42255,720,919 - 255,721,025UniSTSRGSC3.4
Celera2238,455,183 - 238,455,290UniSTS
Cytogenetic Map2q44-q45UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22246,649,232 - 246,649,414 (+)MAPPERmRatBN7.2
Rnor_6.02263,944,907 - 263,945,088NCBIRnor6.0
Rnor_5.02282,714,724 - 282,714,905UniSTSRnor5.0
RGSC_v3.42255,724,496 - 255,724,677UniSTSRGSC3.4
Celera2238,458,747 - 238,458,928UniSTS
RH 3.4 Map21644.8UniSTS
Cytogenetic Map2q44-q45UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22246,655,483 - 246,655,640 (+)MAPPERmRatBN7.2
Rnor_6.02263,951,158 - 263,951,314NCBIRnor6.0
Rnor_5.02282,708,498 - 282,708,654UniSTSRnor5.0
RGSC_v3.42255,730,746 - 255,730,902UniSTSRGSC3.4
Celera2238,464,998 - 238,465,154UniSTS
Cytogenetic Map2q44-q45UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 9 9 9 23 11
Low 3 22 48 32 19 32 4 4 50 12 30 11 4
Below cutoff 21 4 6 22 4


RefSeq Acc Id: ENSRNOT00000014034   ⟹   ENSRNOP00000014034
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2246,606,242 - 246,683,711 (+)Ensembl
Rnor_6.0 Ensembl2263,895,290 - 263,975,834 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000014126   ⟹   ENSRNOP00000014126
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2246,606,183 - 246,684,434 (+)Ensembl
Rnor_6.0 Ensembl2263,895,241 - 263,979,698 (+)Ensembl
RefSeq Acc Id: NM_012704   ⟹   NP_036836
Rat AssemblyChrPosition (strand)Source
mRatBN7.22246,606,242 - 246,683,711 (+)NCBI
Rnor_6.02263,895,205 - 263,978,968 (+)NCBI
Rnor_5.02282,614,936 - 282,760,641 (-)NCBI
RGSC_v3.42255,680,691 - 255,759,202 (+)RGD
Celera2238,415,230 - 238,493,209 (+)RGD
RefSeq Acc Id: XM_006233535   ⟹   XP_006233597
Rat AssemblyChrPosition (strand)Source
mRatBN7.22246,606,153 - 246,684,425 (+)NCBI
Rnor_6.02263,895,093 - 263,979,682 (+)NCBI
Rnor_5.02282,614,936 - 282,760,641 (-)NCBI
RefSeq Acc Id: XM_039101754   ⟹   XP_038957682
Rat AssemblyChrPosition (strand)Source
mRatBN7.22246,606,151 - 246,750,970 (+)NCBI
RefSeq Acc Id: XM_039101755   ⟹   XP_038957683
Rat AssemblyChrPosition (strand)Source
mRatBN7.22246,606,153 - 246,680,577 (+)NCBI
RefSeq Acc Id: XM_039101757   ⟹   XP_038957685
Rat AssemblyChrPosition (strand)Source
mRatBN7.22246,606,152 - 246,649,612 (+)NCBI
RefSeq Acc Id: XM_039101758   ⟹   XP_038957686
Rat AssemblyChrPosition (strand)Source
mRatBN7.22246,606,131 - 246,684,425 (+)NCBI
RefSeq Acc Id: NP_036836   ⟸   NM_012704
- UniProtKB: G3V7D9 (UniProtKB/TrEMBL),   A6HWS8 (UniProtKB/TrEMBL),   A6HWT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233597   ⟸   XM_006233535
- Peptide Label: isoform X2
- UniProtKB: Q64376 (UniProtKB/Swiss-Prot),   Q63194 (UniProtKB/Swiss-Prot),   P34980 (UniProtKB/Swiss-Prot),   A0A0G2JSK4 (UniProtKB/TrEMBL),   A6HWS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014034   ⟸   ENSRNOT00000014034
RefSeq Acc Id: ENSRNOP00000014126   ⟸   ENSRNOT00000014126
RefSeq Acc Id: XP_038957686   ⟸   XM_039101758
- Peptide Label: isoform X5
- UniProtKB: Q64376 (UniProtKB/Swiss-Prot),   Q63194 (UniProtKB/Swiss-Prot),   P34980 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957682   ⟸   XM_039101754
- Peptide Label: isoform X1
- UniProtKB: A6HWT0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957685   ⟸   XM_039101757
- Peptide Label: isoform X4
- UniProtKB: A6HWT0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957683   ⟸   XM_039101755
- Peptide Label: isoform X3
- UniProtKB: Q64376 (UniProtKB/Swiss-Prot),   Q63194 (UniProtKB/Swiss-Prot),   P34980 (UniProtKB/Swiss-Prot),   A0A0G2JSK4 (UniProtKB/TrEMBL),   A6HWS9 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P34980-F1-model_v2 AlphaFold P34980 1-365 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691837
Promoter ID:EPDNEW_R2362
Type:multiple initiation site
Description:prostaglandin E receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.02263,895,148 - 263,895,208EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3435 AgrOrtholog
BioCyc Gene G2FUF-50715 BioCyc
Ensembl Genes ENSRNOG00000010325 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014034 ENTREZGENE
  ENSRNOT00000014034.8 UniProtKB/TrEMBL
  ENSRNOT00000014126.6 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EP3_rcpt_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prostanoid_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prostglndn_DP_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prostglndn_EP3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24929 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11866 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11866:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptger3 PhenoGen
  PROSTANOIDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRSTNOIDE33R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRSTNOIDEP3R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010325 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P34980 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q63194 UniProtKB/Swiss-Prot
  Q64376 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Ptger3  prostaglandin E receptor 3  Ptger3  prostaglandin E receptor 3 (subtype EP3)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Ptger3  prostaglandin E receptor 3 (subtype EP3)  Ptger3  prostaglandin E receptor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ptger3  prostaglandin E receptor 3 (subtype EP3)    prostaglandin E receptor 3  Name updated 1299863 APPROVED
2003-04-09 Ptger3  prostaglandin E receptor 3    prostaglandin E receptor 3 ( subtype EP3)  Name updated 629478 APPROVED
2001-10-24 Ptger3  prostaglandin E receptor 3 ( subtype EP3)      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED