Ptger3 (prostaglandin E receptor 3) - Rat Genome Database

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Gene: Ptger3 (prostaglandin E receptor 3) Rattus norvegicus
Analyze
Symbol: Ptger3
Name: prostaglandin E receptor 3
RGD ID: 3435
Description: Exhibits prostaglandin E receptor activity. Involved in several processes, including negative regulation of G protein-coupled receptor signaling pathway; negative regulation of transport; and positive regulation of smooth muscle contraction. Localizes to several cellular components, including brush border membrane; nuclear membrane; and proximal neuron projection. Used to study asthma and withdrawal disorder. Biomarker of colon cancer; membranous glomerulonephritis; and renovascular hypertension. Orthologous to human PTGER3 (prostaglandin E receptor 3); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: EP3; EP3R; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; prostaglandin E receptor 3 ( subtype EP3); prostaglandin E receptor 3 (subtype EP3); prostaglandin E2 receptor EP3 subtype; prostanoid EP3 receptor; rat kidney prostaglandin Ep3 receptor; Rat kidney prostaglandin EP3 receptor (alternative splicing results in two different receptors EP3a and EP3b); Rep3; rEP3a; rEP3b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22246,606,131 - 246,750,970 (+)NCBI
Rnor_6.0 Ensembl2263,895,241 - 263,979,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02263,895,093 - 263,979,682 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02282,614,936 - 282,760,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42255,680,691 - 255,759,202 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12255,695,297 - 255,773,809 (+)NCBI
Celera2238,415,230 - 238,493,209 (+)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
celecoxib  (EXP)
choline  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
eugenol  (ISO)
excitatory amino acid agonist  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
glafenine  (EXP)
GW 4064  (ISO)
heptachlor  (EXP)
ibuprofen  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
methapyrilene  (ISO)
mifepristone  (EXP)
misoprostol  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
paraquat  (EXP)
PCB138  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
pristane  (ISO)
progesterone  (EXP)
prostaglandin E2  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rofecoxib  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
Soman  (EXP)
staurosporine  (EXP)
sulforaphane  (ISO)
sulprostone  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbinafine  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vinyl carbamate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
bicarbonate transport  (ISO)
cellular response to forskolin  (IMP)
cellular response to interleukin-1  (IEP)
cellular response to lipopolysaccharide  (IEP)
desensitization of G protein-coupled receptor signaling pathway  (IMP)
female pregnancy  (IEP)
fever generation  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
inflammatory response  (IBA)
intestine smooth muscle contraction  (IBA,IMP)
maternal process involved in parturition  (IEP)
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IMP)
negative regulation of calcium ion transmembrane transport  (IMP)
negative regulation of circadian sleep/wake cycle, wakefulness  (IMP)
negative regulation of forebrain neuron differentiation  (IMP)
negative regulation of gastric acid secretion  (IBA,IMP)
negative regulation of gastrin-induced gastric acid secretion  (IMP)
negative regulation of insulin secretion  (IDA)
negative regulation of norepinephrine secretion  (IMP)
negative regulation of platelet aggregation  (IMP)
negative regulation of potassium ion transmembrane transport  (IMP)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA,ISO)
positive regulation of cAMP-mediated signaling  (IMP)
positive regulation of circadian sleep/wake cycle, non-REM sleep  (IMP)
positive regulation of colon smooth muscle contraction  (IMP)
positive regulation of cytosolic calcium ion concentration  (IBA,IMP,ISO)
positive regulation of fever generation  (ISO)
positive regulation of gastric mucosal blood circulation  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of inhibitory G protein-coupled receptor phosphorylation  (IMP)
positive regulation of myofibroblast contraction  (IMP)
positive regulation of neutrophil extravasation  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of smooth muscle contraction involved in micturition  (IMP)
positive regulation of urine volume  (ISO)
positive regulation of vasoconstriction  (IMP)
prostaglandin receptor internalization  (IMP)
receptor internalization  (IMP)
regulation of circadian sleep/wake cycle, wakefulness  (IMP)
regulation of norepinephrine secretion  (IMP)
response to drug  (IEP)
response to estradiol  (IEP)
response to lipopolysaccharide  (ISO)
response to progesterone  (IEP)
response to salt  (IEP)
urinary bladder smooth muscle contraction  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Ahluwalia A and Perretti M, J Pharmacol Exp Ther. 1994 Mar;268(3):1526-31.
2. Araki H, etal., Aliment Pharmacol Ther. 2000 Apr;14 Suppl 1:116-24.
3. Ayabe S, etal., Br J Pharmacol. 2009 Mar;156(5):835-45. doi: 10.1111/j.1476-5381.2008.00051.x. Epub 2009 Feb 23.
4. Bhattacharya M, etal., J Biol Chem. 1999 May 28;274(22):15719-24.
5. Burks SR, etal., Neuroscience. 2007 May 25;146(3):1117-27. Epub 2007 Apr 6.
6. El-Nefiawy N, etal., Histol Histopathol. 2005 Jul;20(3):825-31.
7. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Gu R, etal., Kidney Int. 2008 Aug;74(4):478-85. doi: 10.1038/ki.2008.198. Epub 2008 May 21.
9. Hinton AC, etal., Reprod Sci. 2010 Feb;17(2):136-46. doi: 10.1177/1933719109348068. Epub 2009 Oct 2.
10. Iizuka Y, etal., J Physiol Sci. 2014 Mar;64(2):85-96. doi: 10.1007/s12576-013-0295-2. Epub 2013 Oct 30.
11. Ito Y, etal., Neuropharmacology. 2000 Jan 4;39(2):181-90.
12. Jensen BL, etal., Kidney Int. 1999 Aug;56(2):528-37.
13. Jonakait GM and Ni L, Brain Res. 2009 Aug 18;1285:30-41. doi: 10.1016/j.brainres.2009.06.037. Epub 2009 Jun 22.
14. Kato S, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G64-9.
15. Kitanaka J, etal., Brain Res 1996 Jan 29;707(2):282-7.
16. Kopp UC, etal., Am J Physiol Renal Physiol. 2004 Dec;287(6):F1269-82. Epub 2004 Aug 3.
17. Kunikata T, etal., Dig Dis Sci. 2002 Apr;47(4):894-904.
18. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
19. MGD data from the GO Consortium
20. Mitsui R Cell Tissue Res. 2010 May;340(2):257-65. doi: 10.1007/s00441-010-0954-z. Epub 2010 Mar 26.
21. Mitsui R Cell Tissue Res. 2011 Feb;343(2):331-41. doi: 10.1007/s00441-010-1080-7. Epub 2010 Nov 23.
22. Nakagawa T, etal., Eur J Pharmacol. 2000 Mar 3;390(3):257-66.
23. NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Neuschafer-Rube F, etal., Br J Pharmacol. 2005 Aug;145(8):1132-42.
25. Neuschafer-Rube F, etal., FEBS Lett 1994 Aug 29;351(1):119-22.
26. Neuschafer-Rube F, etal., FEBS Lett. 1997 Jan 20;401(2-3):185-90.
27. Neuschafer-Rube F, etal., FEBS Lett. 1997 Sep 29;415(2):119-24.
28. O'Rielly DD and Loomis CW, Anesthesiology. 2007 Apr;106(4):795-805.
29. Oldfield S, etal., Prostaglandins Other Lipid Mediat 2001 Mar;63(4):165-73.
30. Papay KD and Kennedy TG, Biol Reprod. 2000 Jun;62(6):1515-25.
31. Pipeline to import KEGG annotations from KEGG into RGD
32. RGD automated data pipeline
33. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. RGD automated import pipeline for gene-chemical interactions
35. Sennlaub F, etal., Circulation. 2003 Jul 15;108(2):198-204. Epub 2003 Jun 23.
36. Shoji Y, etal., Gut. 2004 Aug;53(8):1151-8.
37. Slawik H, etal., Neurochem Int. 2004 Oct;45(5):653-60.
38. Southall MD and Vasko MR, J Biol Chem. 2001 May 11;276(19):16083-91. Epub 2001 Feb 14.
39. Su X, etal., Am J Physiol Renal Physiol. 2008 Aug;295(2):F585-94. doi: 10.1152/ajprenal.90273.2008. Epub 2008 Jun 18.
40. Takeuchi K, etal., Biochem Biophys Res Commun 1993 Jul 30;194(2):885-91.
41. Takeuchi K, etal., Biochem Biophys Res Commun 1994 Mar 15;199(2):834-40.
42. Takeuchi K, etal., Kidney Int Suppl. 1996 Jun;55:S183-6.
43. Tang L, etal., Circ Res. 2000 Mar 31;86(6):663-70.
44. Theilig F, etal., Am J Physiol Renal Physiol. 2006 Nov;291(5):F987-94. Epub 2006 Jun 20.
45. Tran PO, etal., J Biol Chem. 1999 Oct 29;274(44):31245-8.
46. Ushikubi F, etal., Nature 1998 Sep 17;395(6699):281-4.
47. Waldner C, etal., Eur J Clin Invest. 2003 Nov;33(11):969-75.
48. Waschbisch A, etal., J Neurochem. 2006 Feb;96(3):680-93. Epub 2006 Jan 9.
49. Wei T, etal., BMC Womens Health. 2007 Apr 2;7:5.
50. Yamazaki K, etal., Placenta. 2006 Apr-May;27(4-5):395-401. Epub 2005 Jun 28.
51. Yokotani K, etal., Eur J Pharmacol. 2003 Jan 17;459(2-3):187-93.
52. Yoshida Y, etal., Neuroreport. 2000 Jul 14;11(10):2127-31.
53. Zacharowski K, etal., Br J Pharmacol. 1999 Feb;126(4):849-58.
54. Zhou J, etal., Am J Respir Cell Mol Biol. 2013 Mar;48(3):299-305. doi: 10.1165/rcmb.2012-0174OC. Epub 2012 Dec 6.
55. Zhou N, etal., Bioorg Med Chem Lett. 2010 Apr 15;20(8):2658-64. doi: 10.1016/j.bmcl.2010.02.028. Epub 2010 Feb 25.
Additional References at PubMed
PMID:7733888   PMID:7945376   PMID:8076637   PMID:8223569   PMID:8381413   PMID:9843913   PMID:10535876   PMID:14552899   PMID:14675158   PMID:14736850   PMID:15834430   PMID:17512019  
PMID:17567965   PMID:18292084   PMID:18632791   PMID:18843255   PMID:19486006   PMID:19940926   PMID:21463619   PMID:21939736   PMID:22061836   PMID:22371141   PMID:23406763   PMID:26718710  
PMID:30084511   PMID:32165825  


Genomics

Comparative Map Data
Ptger3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22246,606,131 - 246,750,970 (+)NCBI
Rnor_6.0 Ensembl2263,895,241 - 263,979,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02263,895,093 - 263,979,682 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02282,614,936 - 282,760,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42255,680,691 - 255,759,202 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12255,695,297 - 255,773,809 (+)NCBI
Celera2238,415,230 - 238,493,209 (+)NCBICelera
Cytogenetic Map2q45NCBI
PTGER3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl170,852,353 - 71,047,808 (-)EnsemblGRCh38hg38GRCh38
GRCh38170,852,358 - 71,047,816 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37171,318,041 - 71,513,499 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,090,624 - 71,286,079 (-)NCBINCBI36hg18NCBI36
Build 34171,188,848 - 71,225,512NCBI
Celera169,607,257 - 69,802,711 (-)NCBI
Cytogenetic Map1p31.1NCBI
HuRef169,428,653 - 69,623,748 (-)NCBIHuRef
CHM1_1171,432,956 - 71,628,842 (-)NCBICHM1_1
Ptger3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393157,272,459 - 157,350,392 (+)NCBIGRCm39mm39
GRCm39 Ensembl3157,272,529 - 157,351,525 (+)Ensembl
GRCm383157,566,821 - 157,644,758 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3157,566,892 - 157,645,888 (+)EnsemblGRCm38mm10GRCm38
MGSCv373157,229,856 - 157,307,722 (+)NCBIGRCm37mm9NCBIm37
MGSCv363157,502,185 - 157,580,051 (+)NCBImm8
Celera3164,034,893 - 164,113,113 (+)NCBICelera
Cytogenetic Map3H4NCBI
cM Map381.32NCBI
Ptger3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542321,096,926 - 21,164,435 (+)NCBIChiLan1.0ChiLan1.0
PTGER3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1172,058,998 - 72,254,063 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl172,059,441 - 72,254,063 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0170,076,610 - 70,271,475 (-)NCBIMhudiblu_PPA_v0panPan3
PTGER3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1674,932,789 - 74,986,573 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha677,575,622 - 77,753,496 (+)NCBI
ROS_Cfam_1.0675,490,852 - 75,668,770 (+)NCBI
UMICH_Zoey_3.1675,042,922 - 75,220,964 (+)NCBI
UNSW_CanFamBas_1.0674,940,272 - 75,118,118 (+)NCBI
UU_Cfam_GSD_1.0675,437,418 - 75,616,001 (+)NCBI
Ptger3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505883,239,312 - 83,315,450 (-)NCBI
SpeTri2.0NW_0049365911,174,364 - 1,250,233 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGER3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6141,958,954 - 142,161,292 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16141,958,955 - 142,160,437 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26131,574,664 - 131,776,520 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTGER3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12062,093,830 - 62,293,360 (+)NCBI
ChlSab1.1 Ensembl2062,095,458 - 62,174,959 (+)Ensembl
Vero_WHO_p1.0NW_02366603355,495,971 - 55,576,801 (-)NCBI
Ptger3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474225,177,340 - 25,356,911 (+)NCBI

Position Markers
D17406  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.42255,720,919 - 255,721,025UniSTSRGSC3.4
Celera2238,455,183 - 238,455,290UniSTS
Cytogenetic Map2q44-q45UniSTS
RH131341  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22246,649,232 - 246,649,414 (+)MAPPER
Rnor_6.02263,944,907 - 263,945,088NCBIRnor6.0
Rnor_5.02282,714,724 - 282,714,905UniSTSRnor5.0
RGSC_v3.42255,724,496 - 255,724,677UniSTSRGSC3.4
Celera2238,458,747 - 238,458,928UniSTS
RH 3.4 Map21644.8UniSTS
Cytogenetic Map2q44-q45UniSTS
09.mHAa3d9.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22246,655,483 - 246,655,640 (+)MAPPER
Rnor_6.02263,951,158 - 263,951,314NCBIRnor6.0
Rnor_5.02282,708,498 - 282,708,654UniSTSRnor5.0
RGSC_v3.42255,730,746 - 255,730,902UniSTSRGSC3.4
Celera2238,464,998 - 238,465,154UniSTS
Cytogenetic Map2q44-q45UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2228712271266435125Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2228712271266435125Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2228712271266435125Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2228712271266435125Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2228712271266435125Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2229606682264899009Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2229793522266435125Rat
631514Scl8Serum cholesterol level QTL84.4blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)2231621666266435125Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2236318496264899009Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2236318496264899009Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2240679103266435125Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2240679103266435125Rat
631563Hcuc3Hepatic copper content QTL 33.87hepatic copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2245893572266435125Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:48
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000014034, ENSRNOT00000014126
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 9 9 9 23 11
Low 3 22 48 32 19 32 4 4 50 12 30 11 4
Below cutoff 21 4 6 22 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014034   ⟹   ENSRNOP00000014034
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2263,895,290 - 263,975,834 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000014126   ⟹   ENSRNOP00000014126
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2263,895,241 - 263,979,698 (+)Ensembl
RefSeq Acc Id: NM_012704   ⟹   NP_036836
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22246,606,242 - 246,683,711 (+)NCBI
Rnor_6.02263,895,205 - 263,978,968 (+)NCBI
Rnor_5.02282,614,936 - 282,760,641 (-)NCBI
RGSC_v3.42255,680,691 - 255,759,202 (+)RGD
Celera2238,415,230 - 238,493,209 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233535   ⟹   XP_006233597
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22246,606,153 - 246,684,425 (+)NCBI
Rnor_6.02263,895,093 - 263,979,682 (+)NCBI
Rnor_5.02282,614,936 - 282,760,641 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101754   ⟹   XP_038957682
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22246,606,151 - 246,750,970 (+)NCBI
RefSeq Acc Id: XM_039101755   ⟹   XP_038957683
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22246,606,153 - 246,680,577 (+)NCBI
RefSeq Acc Id: XM_039101757   ⟹   XP_038957685
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22246,606,152 - 246,649,612 (+)NCBI
RefSeq Acc Id: XM_039101758   ⟹   XP_038957686
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22246,606,131 - 246,684,425 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036836   ⟸   NM_012704
- UniProtKB: P34980 (UniProtKB/Swiss-Prot),   A0A0G2JSK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233597   ⟸   XM_006233535
- Peptide Label: isoform X2
- UniProtKB: G3V7D9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014034   ⟸   ENSRNOT00000014034
RefSeq Acc Id: ENSRNOP00000014126   ⟸   ENSRNOT00000014126
RefSeq Acc Id: XP_038957686   ⟸   XM_039101758
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038957682   ⟸   XM_039101754
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957685   ⟸   XM_039101757
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038957683   ⟸   XM_039101755
- Peptide Label: isoform X3
Protein Domains
G_PROTEIN_RECEP_F1_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691837
Promoter ID:EPDNEW_R2362
Type:multiple initiation site
Name:Ptger3_1
Description:prostaglandin E receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02263,895,148 - 263,895,208EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3435 AgrOrtholog
Ensembl Genes ENSRNOG00000010325 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014034 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000014126 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014034 UniProtKB/TrEMBL
  ENSRNOT00000014126 ENTREZGENE, UniProtKB/TrEMBL
InterPro EP3_rcpt_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prostanoid_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prostglndn_DP_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prostglndn_EP3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24929 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24929 ENTREZGENE
PANTHER PTHR11866 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11866:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptger3 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROSTAGLNDNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROSTANOIDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRSTNOIDE33R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRSTNOIDEP3R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSK4 ENTREZGENE, UniProtKB/TrEMBL
  G3V7D9 ENTREZGENE, UniProtKB/TrEMBL
  P34980 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q63194 UniProtKB/Swiss-Prot
  Q64376 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Ptger3  prostaglandin E receptor 3  Ptger3  prostaglandin E receptor 3 (subtype EP3)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Ptger3  prostaglandin E receptor 3 (subtype EP3)  Ptger3  prostaglandin E receptor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ptger3  prostaglandin E receptor 3 (subtype EP3)    prostaglandin E receptor 3  Name updated 1299863 APPROVED
2003-04-09 Ptger3  prostaglandin E receptor 3    prostaglandin E receptor 3 ( subtype EP3)  Name updated 629478 APPROVED
2001-10-24 Ptger3  prostaglandin E receptor 3 ( subtype EP3)      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED