Ing1 (inhibitor of growth family, member 1) - Rat Genome Database

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Gene: Ing1 (inhibitor of growth family, member 1) Rattus norvegicus
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Symbol: Ing1
Name: inhibitor of growth family, member 1
RGD ID: 1306330
Description: Predicted to enable methylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within protein import into nucleus and regulation of programmed cell death. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and squamous cell carcinoma. Orthologous to human ING1 (inhibitor of growth family member 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inhibitor of growth protein 1; LOC306626; p33ING1b; p33ING1c
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81684,639,378 - 84,649,498 (-)NCBIGRCr8
mRatBN7.21677,937,276 - 77,945,320 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1677,937,279 - 77,946,264 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1683,218,530 - 83,224,410 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01686,671,172 - 86,677,052 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01681,912,593 - 81,918,491 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01683,277,055 - 83,278,120 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,276,273 - 83,278,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01682,745,096 - 82,746,161 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41682,789,254 - 82,790,319 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11682,740,651 - 82,779,666 (-)NCBI
Celera1675,737,282 - 75,743,082 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. Gunduz M, etal., Cancer Res. 2000 Jun 15;60(12):3143-6.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12054579   PMID:12477932   PMID:16098148   PMID:16728974   PMID:19198660  


Genomics

Comparative Map Data
Ing1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81684,639,378 - 84,649,498 (-)NCBIGRCr8
mRatBN7.21677,937,276 - 77,945,320 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1677,937,279 - 77,946,264 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1683,218,530 - 83,224,410 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01686,671,172 - 86,677,052 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01681,912,593 - 81,918,491 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01683,277,055 - 83,278,120 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,276,273 - 83,278,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01682,745,096 - 82,746,161 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41682,789,254 - 82,790,319 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11682,740,651 - 82,779,666 (-)NCBI
Celera1675,737,282 - 75,743,082 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
ING1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813110,712,623 - 110,723,339 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13110,712,736 - 110,723,339 (+)EnsemblGRCh38hg38GRCh38
GRCh3713111,364,970 - 111,375,686 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613110,163,084 - 110,171,422 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413110,163,625 - 110,171,421NCBI
Celera1392,211,252 - 92,219,600 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1391,963,392 - 91,971,853 (+)NCBIHuRef
CHM1_113111,333,082 - 111,341,534 (+)NCBICHM1_1
T2T-CHM13v2.013109,942,828 - 109,953,552 (+)NCBIT2T-CHM13v2.0
Ing1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39811,605,762 - 11,613,251 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl811,605,571 - 11,613,251 (+)EnsemblGRCm39 Ensembl
GRCm38811,555,762 - 11,563,251 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl811,555,571 - 11,563,251 (+)EnsemblGRCm38mm10GRCm38
MGSCv37811,556,066 - 11,563,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36811,556,038 - 11,563,222 (+)NCBIMGSCv36mm8
Celera811,736,119 - 11,737,953 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.73NCBI
Ing1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554041,998,912 - 1,999,613 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554041,998,665 - 1,999,615 (-)NCBIChiLan1.0ChiLan1.0
ING1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214112,208,086 - 112,216,613 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113110,890,357 - 110,898,880 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01391,849,153 - 91,856,943 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113110,966,199 - 110,971,831 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13110,963,405 - 110,970,691 (+)Ensemblpanpan1.1panPan2
ING1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12258,952,526 - 58,958,063 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2258,946,939 - 58,957,804 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2258,663,817 - 58,669,360 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02259,576,109 - 59,581,650 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2259,576,109 - 59,581,391 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12259,078,248 - 59,083,790 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02259,070,143 - 59,075,694 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02259,106,235 - 59,111,785 (+)NCBIUU_Cfam_GSD_1.0
Ing1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945193,812,246 - 193,819,522 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364722,132,991 - 2,140,343 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ING1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1177,270,320 - 77,277,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11177,270,272 - 77,278,346 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ING1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1388,935,764 - 88,943,887 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl388,937,297 - 88,943,046 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604645,700,604 - 45,708,993 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ing1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247932,121,290 - 2,125,598 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247932,121,290 - 2,126,573 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ing1
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:25
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000019454
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
AI875420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21677,937,387 - 77,937,497 (+)MAPPERmRatBN7.2
Rnor_6.01683,276,384 - 83,276,493NCBIRnor6.0
Rnor_5.01682,744,425 - 82,744,534UniSTSRnor5.0
RGSC_v3.41682,788,583 - 82,788,692UniSTSRGSC3.4
Celera1675,736,611 - 75,736,720UniSTS
Cytogenetic Map16q12.5UniSTS
UniSTS:498267  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21677,938,132 - 77,938,754 (+)MAPPERmRatBN7.2
Rnor_6.01683,277,128 - 83,277,749NCBIRnor6.0
Rnor_5.01682,745,169 - 82,745,790UniSTSRnor5.0
RGSC_v3.41682,789,327 - 82,789,948UniSTSRGSC3.4
Celera1675,737,355 - 75,737,976UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 34 25 19 25 2 66 29 41 11
Low 8 23 16 16 8 9 8 6 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000019454   ⟹   ENSRNOP00000019454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1677,938,077 - 77,942,336 (-)Ensembl
Rnor_6.0 Ensembl1683,276,273 - 83,278,119 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108207   ⟹   ENSRNOP00000079020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1677,937,617 - 77,946,264 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120249   ⟹   ENSRNOP00000079627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1677,937,279 - 77,943,934 (-)Ensembl
RefSeq Acc Id: NM_001038591   ⟹   NP_001033680
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,640,161 - 84,646,041 (-)NCBI
mRatBN7.21677,938,060 - 77,943,941 (-)NCBI
Rnor_6.01683,277,055 - 83,278,120 (-)NCBI
Rnor_5.01682,745,096 - 82,746,161 (-)NCBI
RGSC_v3.41682,789,254 - 82,790,319 (-)RGD
Celera1675,737,282 - 75,743,082 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094601   ⟹   XP_038950529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,639,378 - 84,649,498 (-)NCBI
mRatBN7.21677,937,276 - 77,945,320 (-)NCBI
RefSeq Acc Id: XM_039094602   ⟹   XP_038950530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,639,378 - 84,646,004 (-)NCBI
mRatBN7.21677,937,276 - 77,943,904 (-)NCBI
RefSeq Acc Id: NP_001033680   ⟸   NM_001038591
- UniProtKB: Q2TSE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019454   ⟸   ENSRNOT00000019454
RefSeq Acc Id: XP_038950529   ⟸   XM_039094601
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZM05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950530   ⟸   XM_039094602
- Peptide Label: isoform X2
- UniProtKB: G3V7V1 (UniProtKB/TrEMBL),   A6IWP1 (UniProtKB/TrEMBL),   Q2TSE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079020   ⟸   ENSRNOT00000108207
RefSeq Acc Id: ENSRNOP00000079627   ⟸   ENSRNOT00000120249
Protein Domains
PHD-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7V1-F1-model_v2 AlphaFold G3V7V1 1-234 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306330 AgrOrtholog
BioCyc Gene G2FUF-10658 BioCyc
Ensembl Genes ENSRNOG00000014520 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019454.8 UniProtKB/TrEMBL
  ENSRNOT00000108207.1 UniProtKB/TrEMBL
  ENSRNOT00000120249 ENTREZGENE
  ENSRNOT00000120249.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  6.10.140.1740 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7301709 IMAGE-MGC_LOAD
  IMAGE:7937717 IMAGE-MGC_LOAD
InterPro ING1 UniProtKB/TrEMBL
  ING_fam UniProtKB/TrEMBL
  ING_N UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:306626 UniProtKB/TrEMBL
MGC_CLONE MGC:105941 IMAGE-MGC_LOAD
  MGC:188361 IMAGE-MGC_LOAD
NCBI Gene 306626 ENTREZGENE
PANTHER PTHR10333 UniProtKB/TrEMBL
  PTHR10333:SF85 UniProtKB/TrEMBL
Pfam ING UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
PhenoGen Ing1 PhenoGen
PROSITE ZF_PHD_1 UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014520 RatGTEx
SMART ING UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
UniProt A0A8I5ZM05 ENTREZGENE, UniProtKB/TrEMBL
  A6IWP1 ENTREZGENE, UniProtKB/TrEMBL
  B2GVA7_RAT UniProtKB/TrEMBL
  G3V7V1 ENTREZGENE, UniProtKB/TrEMBL
  Q2TSE1 ENTREZGENE, UniProtKB/TrEMBL
  Q2TSE3 ENTREZGENE, UniProtKB/TrEMBL
  Q5RK29_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Ing1  inhibitor of growth family, member 1  Ing1_predicted  inhibitor of growth family, member 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ing1_predicted  inhibitor of growth family, member 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED