Tmem18 (transmembrane protein 18)

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Gene: Tmem18 (transmembrane protein 18) Rattus norvegicus

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Symbol:

Tmem18

Name:

transmembrane protein 18

RGD ID:

1359389

Description:

Predicted to enable DNA binding activity. Involved in cell migration. Predicted to be located in cytoplasm. Predicted to be active in nuclear membrane. Orthologous to human TMEM18 (transmembrane protein 18); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; methamphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC93786; similar to cDNA sequence BC024093

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMEM18 (transmembrane protein 18)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Tmem18 (transmembrane protein 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmem18 (transmembrane protein 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMEM18 (transmembrane protein 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMEM18 (transmembrane protein 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmem18 (transmembrane protein 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMEM18 (transmembrane protein 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMEM18 (transmembrane protein 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmem18 (transmembrane protein 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TMEM18 (transmembrane protein 18)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tmem18 (transmembrane protein 18)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem18 (transmembrane protein 18)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Tmem18	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tmem18	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	52,934,419 - 52,941,868 (+)	NCBI		GRCr8
mRatBN7.2	6	47,206,845 - 47,214,294 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	47,206,845 - 47,214,294 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	47,512,558 - 47,518,287 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	47,827,441 - 47,833,170 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	47,262,688 - 47,268,419 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	49,529,228 - 49,534,960 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	49,529,228 - 49,536,648 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	58,209,471 - 58,215,203 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	48,467,314 - 48,473,046 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	48,470,439 - 48,476,170 (+)	NCBI
Celera	6	46,411,671 - 46,417,403 (+)	NCBI		Celera
Cytogenetic Map	6	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

obesity (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-pantothenic acid (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

butanal (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

ketoconazole (ISO)

menadione (ISO)

methamphetamine (EXP)

methylmercury chloride (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP)

phenylmercury acetate (ISO)

SB 431542 (ISO)

SCH 23390 (EXP)

tetrachloromethane (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell migration (IDA,IEA,ISO,ISS)

eating behavior (ISO)

energy homeostasis (ISO)

Cellular Component

cytoplasm (IEA)

nuclear membrane (IBA,IEA,ISO,ISS)

Molecular Function

DNA binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells.	Jurvansuu J, etal., Cancer Res. 2008 Jun 15;68(12):4614-22. doi: 10.1158/0008-5472.CAN-07-5291.
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:21779089	PMID:21952719

Genomics

Comparative Map Data

Tmem18
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	52,934,419 - 52,941,868 (+)	NCBI		GRCr8
mRatBN7.2	6	47,206,845 - 47,214,294 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	47,206,845 - 47,214,294 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	47,512,558 - 47,518,287 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	47,827,441 - 47,833,170 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	47,262,688 - 47,268,419 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	49,529,228 - 49,534,960 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	49,529,228 - 49,536,648 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	58,209,471 - 58,215,203 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	48,467,314 - 48,473,046 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	48,470,439 - 48,476,170 (+)	NCBI
Celera	6	46,411,671 - 46,417,403 (+)	NCBI		Celera
Cytogenetic Map	6	q16	NCBI

TMEM18
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	663,877 - 677,406 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	663,877 - 677,406 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	663,877 - 677,406 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	657,973 - 667,439 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	657,974 - 667,439	NCBI
Celera	2	731,656 - 741,361 (-)	NCBI		Celera
Cytogenetic Map	2	p25.3	NCBI
HuRef	2	663,304 - 672,893 (-)	NCBI		HuRef
CHM1_1	2	666,714 - 675,813 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	663,182 - 676,877 (-)	NCBI		T2T-CHM13v2.0

Tmem18
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	30,634,442 - 30,641,218 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	30,634,425 - 30,641,214 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	30,584,443 - 30,591,219 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	30,584,426 - 30,591,215 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	31,269,308 - 31,276,084 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	31,170,523 - 31,177,271 (+)	NCBI		MGSCv36	mm8
Celera	12	32,049,959 - 32,056,696 (+)	NCBI		Celera
Cytogenetic Map	12	A2	NCBI
cM Map	12	13.0	NCBI

Tmem18
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955487	473,911 - 480,142 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955487	474,478 - 480,102 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMEM18
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	125,878,780 - 125,887,853 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	125,882,753 - 125,891,759 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	648,934 - 661,967 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	642,196 - 651,344 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	642,196 - 651,344 (-)	Ensembl	panpan1.1		panPan2

TMEM18
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	474,512 - 480,849 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	476,308 - 480,435 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	463,850 - 471,072 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	533,783 - 541,006 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	535,579 - 540,964 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	458,362 - 465,584 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	478,314 - 485,824 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	483,593 - 490,815 (-)	NCBI		UU_Cfam_GSD_1.0

Tmem18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	45,614,738 - 45,619,927 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936532	370,262 - 374,931 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936532	369,794 - 374,936 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM18
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	132,426,431 - 132,431,678 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	132,424,108 - 132,431,682 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	142,024,396 - 142,029,977 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM18
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	107,078,816 - 107,087,064 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	107,079,209 - 107,089,308 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	4,921,380 - 4,930,990 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem18
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624846	1,924,230 - 1,929,601 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624846	1,924,335 - 1,929,744 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tmem18
27 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	300
Count of miRNA genes:	187
Interacting mature miRNAs:	221
Transcripts:	ENSRNOT00000006836
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	38783989	83783989	Rat
634318	Bw118	Body weight QTL 118	3.55		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	6	33309549	57730294	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	35230417	80230417	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	16536140	61536140	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	20338777	62613667	Rat
634330	Pia16	Pristane induced arthritis QTL 16	3.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	6	45790088	104200226	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	33309549	81132889	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	35691618	57730540	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	32074428	72227641	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	16536140	71636405	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	34434137	77102317	Rat
1354632	Scl29	Serum cholesterol level QTL 29	3.74		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	6	35098709	71636405	Rat

Markers in Region

BE099609

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	47,207,924 - 47,208,095 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	49,530,308 - 49,530,478	NCBI	Rnor6.0
Rnor_5.0	6	58,210,551 - 58,210,721	UniSTS	Rnor5.0
RGSC_v3.4	6	48,468,394 - 48,468,564	UniSTS	RGSC3.4
Celera	6	46,412,751 - 46,412,921	UniSTS
RH 3.4 Map	6	291.3	UniSTS
Cytogenetic Map	6	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112493	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC076388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006836 ⟹ ENSRNOP00000006836

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	47,206,845 - 47,212,575 (+)	Ensembl
Rnor_6.0 Ensembl	6	49,529,228 - 49,534,958 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000079520 ⟹ ENSRNOP00000073671

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	47,207,113 - 47,214,294 (+)	Ensembl
Rnor_6.0 Ensembl	6	49,529,669 - 49,536,648 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095621 ⟹ ENSRNOP00000082738

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	47,207,503 - 47,214,294 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108602 ⟹ ENSRNOP00000094677

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	47,207,343 - 47,214,294 (+)	Ensembl

RefSeq Acc Id:

NM_001007748 ⟹ NP_001007749

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	52,934,419 - 52,940,151 (+)	NCBI
mRatBN7.2	6	47,206,845 - 47,212,577 (+)	NCBI
Rnor_6.0	6	49,529,228 - 49,534,960 (+)	NCBI
Rnor_5.0	6	58,209,471 - 58,215,203 (+)	NCBI
RGSC_v3.4	6	48,467,314 - 48,473,046 (+)	RGD
Celera	6	46,411,671 - 46,417,403 (+)	RGD

Sequence:

show sequence

GATGCCAGTCTGTACGGAGGACGTGGATGCTGAGCTCACCCCGATTCTGTGGGGCTGACGGCAG
GCAGATCCACCCCAGGTCTATGAGGAGCACGCTGTCTGTAAAGAGCTGACCAAGATGCCCCGGG
CTGTGGGGGAAAGGTGCCGTACGGCTGCATCTGTGGAACCTACGAACCCTCCGCTTTCCGGGGA
GTTTGGGAGAAACTAGATCTCGCGAGAAGACTAGGCGACTTTCGTGGCTGTCGGAAGCGGCGGA
CTTGTCCTGGCTGTTGGGATCCCCGGCGCGATGGCGTCTCCGTATTCAGTCAGAGTCTTCCCAG
TCAGCATCCCTGCAGTGATCATGGAGACGGACTGGACAGAGCCCTGGCTCCTAGGGCTCCTTGC
CTTCCACCTGCTGTGCCTACTTCTCACATGCTTCTCCGCACAGAGGTATAAACTACAGATTGGC
CATTTCCTTTGTCTGGTAGTGTTAGTCTATTGTGCCGAGTACATCAACGAAGTGGCTGCAATGA
ACTGGAGATTGTTCGCAAAGTATCAGTACTTTGACTCCCGGGGAATGTTTATTTCTCTTGTGTT
CTCAGCACCGCTGCTCTTCAACGCCATGGTCATTGTGATTATGTGGGTACGGAAGACTTTGACT
GTGATGAGTGACCTGAAGAACTTACAGGAGAGGAGAAAGGAGAGGAAGAGGCGAAGAAAAGAAG
AATAGCACTGAGCTGGCCACACCGTGTTTGTCCTCTGACTTGGTTGTTTCCATCTGGGAGCTGC
ATATGGCCCAGATGTCTTCTGTCAGCTGACTCATGGTTGGAAAAACACACCACAAATGGTTCTT
ATATTTTACTCTGTTTGGAGCCCTCGTAAAGCTGTTCTTAAAAAACTAATGACATGACCTGGAA
GCATGGTGAATGGGGACCCATCCTTTACATGGGGAGCTTTCTGGCTCAGCCACATCATATACAG
CTTCTCACAAGTTGCTGGTAGATCTCACGATGTGACTAGAGGTCACGCAGGTTTGAGTGTGGAA
ACTGGGAAATAAACAGCCCCATCCTTCTGTGAGCACTACCTGCTCCCTCTTCTGTCTCTAGCCT
GCAGTGGTGGCTATCAGCTAAAGGTGGGTGTGTTCCCCAGAAATTTGCTGATGGTTGTCACCTC
AGGTGGACGTGGCACTTGTGTCCATAGGATAGAGCCTAGGTTGCTGAAATCCTACAGGGTACAA
GACAGCCCCACCATGGAGTATTGCTGTGTATATAATGTCAGCAGTACCCAGGCTGAGGGAGCAG
TGGGCAGGTCTGGAAAAGAATGCAGTGTGTTTCAGTTCCCATGAAGCTAGGCCTCTAAATAATT
TAGTTGGGGCTATGCCACTGGAAATGTTTTGTTTAAAAATATTAAGCTAGAATGAAAGCTGTAA
AATCAAGACTCCGTGGAAAATAGTATGTCAAATGAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039112493 ⟹ XP_038968421

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	52,934,870 - 52,941,868 (+)	NCBI
mRatBN7.2	6	47,207,294 - 47,214,294 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001007749	(Get FASTA)	NCBI Sequence Viewer
	XP_038968421	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH76388	(Get FASTA)	NCBI Sequence Viewer
	EDM03237	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006836.3
	ENSRNOP00000073671.2
	ENSRNOP00000082738.1
	ENSRNOP00000094677.1
	ENSRNOP00055007466
	ENSRNOP00060010023
	ENSRNOP00065013370
GenBank Protein	Q6DGF8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001007749 ⟸ NM_001007748
- UniProtKB:	Q6DGF8 (UniProtKB/Swiss-Prot), A6HB32 (UniProtKB/TrEMBL), A0A8L2R7M5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASPYSVRVFPVSIPAVIMETDWTEPWLLGLLAFHLLCLLLTCFSAQRYKLQIGHFLCLVVLVY CAEYINEVAAMNWRLFAKYQYFDSRGMFISLVFSAPLLFNAMVIVIMWVRKTLTVMSDLKNLQE RRKERKRRRKEE hide sequence

Ensembl Acc Id:

ENSRNOP00000006836 ⟸ ENSRNOT00000006836

Ensembl Acc Id:

ENSRNOP00000073671 ⟸ ENSRNOT00000079520

RefSeq Acc Id:	XP_038968421 ⟸ XM_039112493
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2R7M5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000082738 ⟸ ENSRNOT00000095621

Ensembl Acc Id:

ENSRNOP00000094677 ⟸ ENSRNOT00000108602

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6DGF8-F1-model_v2	AlphaFold	Q6DGF8	1-140	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694541

Promoter ID:

EPDNEW_R5062

Type:

initiation region

Name:

Tmem18_1

Description:

transmembrane protein 18

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	49,529,693 - 49,529,753	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359389	AgrOrtholog
BioCyc Gene	G2FUF-37932	BioCyc
Ensembl Genes	ENSRNOG00000005144	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055005957	UniProtKB/Swiss-Prot
	ENSRNOG00060008016	UniProtKB/Swiss-Prot
	ENSRNOG00065010771	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000006836.6	UniProtKB/Swiss-Prot
	ENSRNOT00000079520.2	UniProtKB/TrEMBL
	ENSRNOT00000095621.1	UniProtKB/TrEMBL
	ENSRNOT00000108602.1	UniProtKB/TrEMBL
	ENSRNOT00055009662	UniProtKB/Swiss-Prot
	ENSRNOT00060013212	UniProtKB/Swiss-Prot
	ENSRNOT00065017437	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7109513	IMAGE-MGC_LOAD
InterPro	TMEM18	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:362722	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93786	IMAGE-MGC_LOAD
NCBI Gene	362722	ENTREZGENE
PANTHER	TRANSMEMBRANE PROTEIN 18	UniProtKB/Swiss-Prot
	TRANSMEMBRANE PROTEIN 18	UniProtKB/Swiss-Prot
	TRANSMEMBRANE PROTEIN 18	UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEIN 18	UniProtKB/TrEMBL
Pfam	TMEM18	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tmem18	PhenoGen
RatGTEx	ENSRNOG00000005144	RatGTEx
	ENSRNOG00055005957	RatGTEx
	ENSRNOG00060008016	RatGTEx
	ENSRNOG00065010771	RatGTEx
UniProt	A0A8I5ZXN9_RAT	UniProtKB/TrEMBL
	A0A8I6ALA0_RAT	UniProtKB/TrEMBL
	A0A8L2R7M5	ENTREZGENE, UniProtKB/TrEMBL
	A6HB32	ENTREZGENE, UniProtKB/TrEMBL
	Q6DGF8	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Tmem18	transmembrane protein 18	MGC93786	similar to cDNA sequence BC024093	Symbol and Name updated	1299863	APPROVED
2005-07-29	MGC93786	similar to cDNA sequence BC024093			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD