Gene: Nr2f1 (nuclear receptor subfamily 2, group F, member 1) Rattus norvegicus
Analyze
Symbol:
Nr2f1
Name:
nuclear receptor subfamily 2, group F, member 1
RGD ID:
621682
Description:
Exhibits retinoic acid-responsive element binding activity. Involved in negative regulation of neuron projection development and positive regulation of transcription by RNA polymerase II. Predicted to localize to cytosol and nucleoplasm. Orthologous to human NR2F1 (nuclear receptor subfamily 2 group F member 1); INTERACTS WITH 1,2-dimethylhydrazine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
COUP transcription factor 1; COUP-TFI; LOC360330
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
NR2F1 (nuclear receptor subfamily 2 group F member 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Nr2f1 (nuclear receptor subfamily 2, group F, member 1) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Nr2f1 (nuclear receptor subfamily 2 group F member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
NR2F1 (nuclear receptor subfamily 2 group F member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
NR2F1 (nuclear receptor subfamily 2 group F member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Nr2f1 (nuclear receptor subfamily 2 group F member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
NR2F1 (nuclear receptor subfamily 2 group F member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
NR2F1 (nuclear receptor subfamily 2 group F member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Nr2f1 (nuclear receptor subfamily 2 group F member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
NR2F2 (nuclear receptor subfamily 2 group F member 2) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
NR2F1 (nuclear receptor subfamily 2 group F member 1)
Alliance
DIOPT (HGNC|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 2 5,569,954 - 5,579,894 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 2 5,569,935 - 5,579,894 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 2 5,553,211 - 5,563,152 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 2 5,765,399 - 5,794,104 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 2 5,791,963 - 5,820,665 (-) NCBI Celera 2 4,489,100 - 4,498,590 (-) NCBI Celera Cytogenetic Map 2 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
Breast Neoplasms ISO RGD:732429 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11850205 ovarian cyst ISO RGD:732429 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21239663
Imported Annotations - OMIM
Bosch-Boonstra-Schaaf Optic Atrophy Syndrome ISO RGD:732429 7240710 OMIM
1,2-dimethylhydrazine multiple interactions EXP 6480464 [APC protein affects the susceptibility to 1, 2-Dimethylhydrazine] which results in decreased expression of NR2F1 mRNA CTD PMID:27840820 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine increases expression EXP 6480464 chlorcyclizine results in increased expression of NR2F1 mRNA CTD PMID:21058326 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of NR2F1 mRNA CTD PMID:15576828 , PMID:17557909 17alpha-ethynylestradiol affects expression ISO RGD:1317579 6480464 Ethinyl Estradiol affects the expression of NR2F1 mRNA CTD PMID:17555576 17beta-estradiol increases expression ISO RGD:1317579 6480464 Estradiol results in increased expression of NR2F1 mRNA CTD PMID:19484750 17beta-estradiol multiple interactions ISO RGD:732429 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NR2F1 mRNA CTD PMID:20823114 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1317579 6480464 Tetrachlorodibenzodioxin affects the expression of NR2F1 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732429 6480464 NR2F1 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:10620335 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1317579 6480464 Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to NR2F1 promoter] CTD PMID:19654925 2,4,6-trinitrobenzenesulfonic acid increases expression EXP 6480464 Trinitrobenzenesulfonic Acid results in increased expression of NR2F1 mRNA CTD PMID:23537331 2-methylcholine affects expression ISO RGD:732429 6480464 beta-methylcholine affects the expression of NR2F1 mRNA CTD PMID:21179406 3,3',5,5'-tetrabromobisphenol A decreases expression ISO RGD:1317579 6480464 tetrabromobisphenol A results in decreased expression of NR2F1 mRNA CTD PMID:25172293 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of NR2F1 mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of NR2F1 mRNA CTD PMID:30723492 5-aza-2'-deoxycytidine multiple interactions ISO RGD:732429 6480464 TP53 protein affects the reaction [Decitabine results in decreased expression of NR2F1 mRNA] CTD PMID:19363521 5-aza-2'-deoxycytidine decreases expression ISO RGD:732429 6480464 Decitabine results in decreased expression of NR2F1 mRNA CTD PMID:19363521 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of NR2F1 mRNA CTD PMID:24780913 7,12-dimethyltetraphene decreases expression EXP 6480464 9 more ... CTD PMID:19480007 acetamide increases expression EXP 6480464 acetamide results in increased expression of NR2F1 mRNA CTD PMID:31881176 aldehydo-D-glucose multiple interactions ISO RGD:732429 6480464 Glucose affects the reaction [NR2F1 protein binds to SHBG promoter] CTD PMID:17992261 all-trans-retinoic acid increases expression ISO RGD:732429 6480464 Tretinoin results in increased expression of NR2F1 mRNA CTD PMID:22906706 , PMID:30416051 alpha-naphthoflavone affects binding ISO RGD:732429 6480464 [alpha-naphthoflavone binds to AHR protein] which binds to NR2F1 protein CTD PMID:10620335 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of NR2F1 mRNA CTD PMID:16483693 arachidonic acid decreases expression ISO RGD:732429 6480464 Arachidonic Acid results in decreased expression of NR2F1 mRNA CTD PMID:16704987 atrazine decreases expression ISO RGD:732429 6480464 Atrazine results in decreased expression of NR2F1 mRNA CTD PMID:22378314 benzo[a]pyrene multiple interactions ISO RGD:1317579 6480464 Benzo(a)pyrene affects the reaction [AHR protein binds to NR2F1 promoter] CTD PMID:19654925 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:732429 6480464 7 more ... CTD PMID:19150397 beta-naphthoflavone affects binding ISO RGD:732429 6480464 [beta-Naphthoflavone binds to AHR protein] which binds to NR2F1 protein CTD PMID:10620335 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of NR2F1 mRNA CTD PMID:25181051 bisphenol A affects methylation ISO RGD:1317579 6480464 bisphenol A affects the methylation of NR2F1 promoter CTD PMID:27334623 bucladesine multiple interactions ISO RGD:732429 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NR2F1 mRNA CTD PMID:20823114 butanal decreases expression ISO RGD:732429 6480464 butyraldehyde results in decreased expression of NR2F1 mRNA CTD PMID:26079696 cadmium dichloride decreases expression ISO RGD:1317579 6480464 Cadmium Chloride results in decreased expression of NR2F1 mRNA CTD PMID:18974090 calcitriol increases expression ISO RGD:732429 6480464 Calcitriol results in increased expression of NR2F1 mRNA CTD PMID:16002434 carbamazepine affects expression ISO RGD:732429 6480464 Carbamazepine affects the expression of NR2F1 mRNA CTD PMID:24752500 carbon nanotube decreases expression ISO RGD:1317579 6480464 Nanotubes, Carbon analog results in decreased expression of NR2F1 mRNA CTD PMID:25554681 carmustine affects response to substance ISO RGD:732429 6480464 NR2F1 mRNA affects the susceptibility to Carmustine CTD PMID:16365179 ciglitazone multiple interactions ISO RGD:732429 6480464 NR2F1 protein promotes the reaction [[SR 11237 co-treated with ciglitazone] results in increased expression of RARB protein] CTD PMID:12839938 cisplatin multiple interactions ISO RGD:732429 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of NR2F1 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:732429 6480464 Cisplatin results in decreased expression of NR2F1 mRNA CTD PMID:27392435 clobetasol decreases expression ISO RGD:1317579 6480464 Clobetasol results in decreased expression of NR2F1 mRNA CTD PMID:27462272 cobalt dichloride decreases expression ISO RGD:732429 6480464 cobaltous chloride results in decreased expression of NR2F1 mRNA CTD PMID:19376846 copper atom multiple interactions ISO RGD:732429 6480464 [NSC 689534 binds to Copper] which results in decreased expression of NR2F1 mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:732429 6480464 [NSC 689534 binds to Copper] which results in decreased expression of NR2F1 mRNA CTD PMID:20971185 copper(II) sulfate decreases expression ISO RGD:732429 6480464 Copper Sulfate results in decreased expression of NR2F1 mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:732429 6480464 Cyclosporine results in decreased expression of NR2F1 mRNA CTD PMID:20106945 more ... D-glucose multiple interactions ISO RGD:732429 6480464 Glucose affects the reaction [NR2F1 protein binds to SHBG promoter] CTD PMID:17992261 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of NR2F1 mRNA CTD PMID:20032058 dexamethasone decreases expression ISO RGD:1317579 6480464 Dexamethasone results in decreased expression of NR2F1 mRNA CTD PMID:22733784 dexamethasone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of NR2F1 mRNA] CTD PMID:20032058 dexamethasone increases expression ISO RGD:732429 6480464 Dexamethasone results in increased expression of NR2F1 mRNA CTD PMID:19022236 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of NR2F1 mRNA CTD PMID:18636392 diclofenac affects expression ISO RGD:732429 6480464 Diclofenac affects the expression of NR2F1 mRNA CTD PMID:24752500 dicrotophos increases expression ISO RGD:732429 6480464 dicrotophos results in increased expression of NR2F1 mRNA CTD PMID:28302478 dioxygen multiple interactions ISO RGD:1317579 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of NR2F1 mRNA CTD PMID:30529165 dorsomorphin multiple interactions ISO RGD:732429 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of NR2F1 mRNA CTD PMID:29391264 entinostat decreases expression ISO RGD:732429 6480464 entinostat results in decreased expression of NR2F1 mRNA CTD PMID:26272509 entinostat multiple interactions ISO RGD:732429 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2F1 mRNA CTD PMID:27188386 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of NR2F1 mRNA CTD PMID:15353170 ethanol affects expression ISO RGD:1317579 6480464 Ethanol affects the expression of NR2F1 mRNA CTD PMID:30319688 ethyl methanesulfonate decreases expression ISO RGD:732429 6480464 Ethyl Methanesulfonate results in decreased expression of NR2F1 mRNA CTD PMID:23649840 fructose multiple interactions ISO RGD:732429 6480464 Fructose affects the reaction [NR2F1 protein binds to SHBG promoter] CTD PMID:17992261 geraniol decreases expression ISO RGD:732429 6480464 geraniol results in decreased expression of NR2F1 mRNA CTD PMID:27683099 glucose multiple interactions ISO RGD:732429 6480464 Glucose affects the reaction [NR2F1 protein binds to SHBG promoter] CTD PMID:17992261 hydroquinone O-beta-D-glucopyranoside increases expression ISO RGD:732429 6480464 Arbutin results in increased expression of NR2F1 mRNA CTD PMID:17103032 isotretinoin increases expression ISO RGD:732429 6480464 Isotretinoin results in increased expression of NR2F1 mRNA CTD PMID:20436886 manganese atom decreases expression ISO RGD:1317579 6480464 Manganese results in decreased expression of NR2F1 mRNA CTD PMID:23976782 manganese atom increases methylation ISO RGD:1317579 6480464 Manganese results in increased methylation of NR2F1 promoter CTD PMID:23976782 manganese(0) decreases expression ISO RGD:1317579 6480464 Manganese results in decreased expression of NR2F1 mRNA CTD PMID:23976782 manganese(0) increases methylation ISO RGD:1317579 6480464 Manganese results in increased methylation of NR2F1 promoter CTD PMID:23976782 medroxyprogesterone acetate multiple interactions ISO RGD:732429 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NR2F1 mRNA CTD PMID:20823114 mercury dibromide decreases expression ISO RGD:732429 6480464 mercuric bromide results in decreased expression of NR2F1 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:732429 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2F1 mRNA CTD PMID:27188386 methyl methanesulfonate decreases expression ISO RGD:732429 6480464 Methyl Methanesulfonate results in decreased expression of NR2F1 mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:732429 6480464 methylmercuric chloride results in decreased expression of NR2F1 mRNA CTD PMID:28001369 N-methyl-4-phenylpyridinium decreases expression ISO RGD:732429 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of NR2F1 mRNA CTD PMID:24810058 oxaliplatin increases expression ISO RGD:732429 6480464 oxaliplatin results in increased expression of NR2F1 mRNA CTD PMID:17762391 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of NR2F1 mRNA CTD PMID:18636392 p-chloromercuribenzoic acid decreases expression ISO RGD:732429 6480464 p-Chloromercuribenzoic Acid results in decreased expression of NR2F1 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:732429 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2F1 mRNA CTD PMID:27188386 panobinostat multiple interactions ISO RGD:732429 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NR2F1 mRNA CTD PMID:27188386 panobinostat increases expression ISO RGD:732429 6480464 panobinostat results in increased expression of NR2F1 mRNA CTD PMID:26272509 paracetamol affects expression ISO RGD:1317579 6480464 Acetaminophen affects the expression of NR2F1 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:732429 6480464 Acetaminophen results in increased expression of NR2F1 mRNA CTD PMID:21420995 paraquat increases expression EXP 6480464 Paraquat results in increased expression of NR2F1 mRNA CTD PMID:18198484 phenylmercury acetate increases expression ISO RGD:732429 6480464 Phenylmercuric Acetate results in increased expression of NR2F1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:732429 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NR2F1 mRNA CTD PMID:27188386 phenytoin increases expression EXP 6480464 Phenytoin results in increased expression of NR2F1 mRNA CTD PMID:20345932 pirinixic acid multiple interactions ISO RGD:1317579 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NR2F1 mRNA CTD PMID:19710929 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of NR2F1 mRNA CTD PMID:12832660 SB 431542 multiple interactions ISO RGD:732429 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silver atom decreases expression ISO RGD:1317579 6480464 Silver results in decreased expression of NR2F1 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:1317579 6480464 Silver results in decreased expression of NR2F1 mRNA CTD PMID:27131904 sodium arsenite decreases expression ISO RGD:1317579 6480464 sodium arsenite results in decreased expression of NR2F1 mRNA CTD PMID:16014739 tamoxifen decreases activity ISO RGD:1317579 6480464 Tamoxifen results in decreased activity of NR2F1 protein CTD PMID:20937368 tamoxifen decreases expression ISO RGD:1317579 6480464 Tamoxifen results in decreased expression of NR2F1 mRNA CTD PMID:29974145 temozolomide affects response to substance ISO RGD:732429 6480464 NR2F1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 testosterone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of NR2F1 mRNA] CTD PMID:20032058 thapsigargin decreases expression ISO RGD:732429 6480464 Thapsigargin results in decreased expression of NR2F1 mRNA CTD PMID:29453283 triacsin C decreases expression ISO RGD:732429 6480464 triacsin C results in decreased expression of NR2F1 mRNA CTD PMID:16704987 trichostatin A increases expression ISO RGD:732429 6480464 trichostatin A results in increased expression of NR2F1 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:732429 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NR2F1 mRNA CTD PMID:27188386 triclosan decreases expression ISO RGD:732429 6480464 Triclosan results in decreased expression of NR2F1 mRNA CTD PMID:30510588 urethane increases expression ISO RGD:732429 6480464 Urethane results in increased expression of NR2F1 mRNA CTD PMID:28818685 valproic acid increases methylation ISO RGD:732429 6480464 Valproic Acid results in increased methylation of NR2F1 gene CTD PMID:29154799 valproic acid multiple interactions ISO RGD:732429 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NR2F1 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:732429 6480464 Valproic Acid results in increased expression of NR2F1 mRNA CTD PMID:23179753 more ... valproic acid affects expression ISO RGD:732429 6480464 Valproic Acid affects the expression of NR2F1 mRNA CTD PMID:25979313 vitamin E increases expression ISO RGD:732429 6480464 Vitamin E results in increased expression of NR2F1 mRNA CTD PMID:19244175
Gene-Chemical Interaction Annotations
