Srp54a (signal recognition particle 54A) - Rat Genome Database
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Gene: Srp54a (signal recognition particle 54A) Rattus norvegicus
Analyze
Symbol: Srp54a
Name: signal recognition particle 54A
RGD ID: 621390
Description: Predicted to have several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and purine ribonucleoside binding activity. Predicted to be involved in several processes, including SRP-dependent cotranslational protein targeting to membrane; exocrine pancreas development; and neutrophil chemotaxis. Predicted to localize to cytosol; nucleus; and signal recognition particle, endoplasmic reticulum targeting. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54); INTERACTS WITH 2,6-dinitrotoluene; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: signal recognition particle 54; signal recognition particle 54 kDa; signal recognition particle 54kDa; Srp54
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2672,587,582 - 72,645,154 (+)NCBI
Rnor_6.0 Ensembl675,996,643 - 76,034,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0675,996,629 - 76,035,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0685,532,350 - 85,572,100 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,446,838 - 75,494,001 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1675,474,626 - 75,478,796 (+)NCBI
Celera671,428,873 - 71,466,500 (+)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8247130   PMID:8521805   PMID:8622769   PMID:9511762   PMID:10618370   PMID:12477932   PMID:15489334   PMID:16469117   PMID:18089836   PMID:22658674   PMID:28972538   PMID:31505169  


Genomics

Comparative Map Data
Srp54a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2672,587,582 - 72,645,154 (+)NCBI
Rnor_6.0 Ensembl675,996,643 - 76,034,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0675,996,629 - 76,035,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0685,532,350 - 85,572,100 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,446,838 - 75,494,001 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1675,474,626 - 75,478,796 (+)NCBI
Celera671,428,873 - 71,466,500 (+)NCBICelera
Cytogenetic Map6q23NCBI
SRP54
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1434,981,957 - 35,029,686 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1434,981,957 - 35,029,567 (+)EnsemblGRCh38hg38GRCh38
GRCh381434,982,981 - 35,029,567 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371435,452,198 - 35,498,773 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361434,521,982 - 34,568,519 (+)NCBINCBI36hg18NCBI36
Build 341434,521,981 - 34,568,517NCBI
Celera1415,315,912 - 15,362,600 (+)NCBI
Cytogenetic Map14q13.2NCBI
HuRef1415,564,659 - 15,611,702 (+)NCBIHuRef
CHM1_11435,450,690 - 35,497,725 (+)NCBICHM1_1
Srp54a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,127,261 - 55,162,152 (+)NCBIGRCm39mm39
GRCm39 Ensembl1255,127,047 - 55,162,152 (+)Ensembl
GRCm381255,080,476 - 55,115,367 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,080,262 - 55,115,367 (+)EnsemblGRCm38mm10GRCm38
MGSCv371256,181,483 - 56,216,354 (+)NCBIGRCm37mm9NCBIm37
MGSCv361255,998,696 - 56,031,814 (+)NCBImm8
Celera1256,371,141 - 56,408,843 (+)NCBICelera
Cytogenetic Map12C1NCBI
Srp54
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540925,977,226 - 26,016,351 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540925,977,226 - 26,016,351 (-)NCBIChiLan1.0ChiLan1.0
SRP54
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11433,920,330 - 33,966,023 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1433,920,287 - 34,017,151 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01415,733,446 - 15,779,987 (+)NCBIMhudiblu_PPA_v0panPan3
SRP54
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl813,677,760 - 13,837,722 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1813,800,275 - 13,837,799 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Srp54
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364949,183,620 - 9,220,510 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRP54
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl764,828,874 - 64,877,193 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1764,829,625 - 64,877,574 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2769,658,033 - 69,706,782 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SRP54
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12411,802,671 - 11,846,534 (+)NCBI
ChlSab1.1 Ensembl2411,812,672 - 11,846,675 (+)Ensembl
Srp54
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248381,697,863 - 1,747,115 (-)NCBI

Position Markers
D6Rat22  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0676,002,643 - 76,002,731NCBIRnor6.0
Rnor_5.0685,538,356 - 85,538,444UniSTSRnor5.0
RGSC_v3.4675,462,022 - 75,462,111RGDRGSC3.4
RGSC_v3.4675,462,023 - 75,462,111UniSTSRGSC3.4
RGSC_v3.1675,465,149 - 75,465,237RGD
Celera671,434,873 - 71,434,961UniSTS
RH 2.0 Map6698.7RGD
SHRSP x BN Map647.8099RGD
FHH x ACI Map656.9999RGD
Cytogenetic Map6q23UniSTS
D6Got311  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0676,013,618 - 76,013,845NCBIRnor6.0
Rnor_5.0685,549,608 - 85,549,835UniSTSRnor5.0
RGSC_v3.4675,473,358 - 75,473,585UniSTSRGSC3.4
Celera671,445,833 - 71,446,060UniSTS
Cytogenetic Map6q23UniSTS
RH128735  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0676,033,858 - 76,034,039NCBIRnor6.0
Rnor_5.0685,570,203 - 85,570,384UniSTSRnor5.0
RGSC_v3.4675,493,773 - 75,493,954UniSTSRGSC3.4
Celera671,466,272 - 71,466,453UniSTS
Cytogenetic Map6q23UniSTS
RH144431  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0676,035,441 - 76,035,695NCBIRnor6.0
Rnor_5.0685,571,786 - 85,572,040UniSTSRnor5.0
RGSC_v3.4675,495,356 - 75,495,610UniSTSRGSC3.4
Celera671,467,855 - 71,468,109UniSTS
Cytogenetic Map6q23UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)6616172276002731Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6616172276002731Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)67009971115379601Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63436743680490628Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63626028884763275Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63810630883106308Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64167904686679046Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)648432758108268790Rat
4889848Pur25Proteinuria QTL 25140.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65980306594001333Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)660606431108154445Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)660606431108154445Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)662263348107263348Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)666129520111129520Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)671206251116206251Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)675449871120449871Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)675623277120276465Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)675623277120623277Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)675623277136143011Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)675623277136426962Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)67562339384763275Rat
1581550Pur8Proteinuria QTL 8total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)675623393136142742Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)675623393136142742Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:786
Count of miRNA genes:310
Interacting mature miRNAs:397
Transcripts:ENSRNOT00000052076
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 41 11 8
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000052076   ⟹   ENSRNOP00000048945
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl675,996,643 - 76,034,083 (+)Ensembl
RefSeq Acc Id: NM_053871   ⟹   NP_446323
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2672,587,597 - 72,625,196 (+)NCBI
Rnor_6.0675,996,643 - 76,034,086 (+)NCBI
Rnor_5.0685,532,350 - 85,572,100 (+)NCBI
RGSC_v3.4675,446,838 - 75,494,001 (+)RGD
Celera671,428,873 - 71,466,500 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240097   ⟹   XP_006240159
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2672,587,622 - 72,625,196 (+)NCBI
Rnor_6.0675,996,629 - 76,035,768 (+)NCBI
Rnor_5.0685,532,350 - 85,572,100 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039111664   ⟹   XP_038967592
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2672,587,584 - 72,626,878 (+)NCBI
RefSeq Acc Id: XM_039111666   ⟹   XP_038967594
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2672,587,582 - 72,645,154 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_446323   ⟸   NM_053871
- UniProtKB: Q6AYB5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006240159   ⟸   XM_006240097
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000048945   ⟸   ENSRNOT00000052076
RefSeq Acc Id: XP_038967594   ⟸   XM_039111666
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038967592   ⟸   XM_039111664
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694602
Promoter ID:EPDNEW_R5126
Type:initiation region
Name:Srp54a_1
Description:signal recognition particle 54A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0675,996,654 - 75,996,714EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621390 AgrOrtholog
Ensembl Genes ENSRNOG00000032776 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000048945 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000052076 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.260.30 UniProtKB/Swiss-Prot
  1.20.120.140 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7126297 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Signal_recog_part_SRP54_M_sf UniProtKB/Swiss-Prot
  Signal_recog_particl_SRP54_hlx UniProtKB/Swiss-Prot
  Signal_recog_particle_SRP54_M UniProtKB/Swiss-Prot
  SRP54 UniProtKB/Swiss-Prot
  SRP54_euk UniProtKB/Swiss-Prot
  SRP54_GTPase_dom UniProtKB/Swiss-Prot
  SRP54_N_sf UniProtKB/Swiss-Prot
KEGG Report rno:116650 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94117 IMAGE-MGC_LOAD
NCBI Gene 116650 ENTREZGENE
PANTHER PTHR11564 UniProtKB/Swiss-Prot
Pfam SRP54 UniProtKB/Swiss-Prot
  SRP54_N UniProtKB/Swiss-Prot
  SRP_SPB UniProtKB/Swiss-Prot
PhenoGen Srp54a PhenoGen
PROSITE SRP54 UniProtKB/Swiss-Prot
SMART AAA UniProtKB/Swiss-Prot
  SRP54 UniProtKB/Swiss-Prot
  SRP54_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47446 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
TIGRFAMs SRP54_euk UniProtKB/Swiss-Prot
UniProt Q6AYB5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-19 Srp54a  signal recognition particle 54A  Srp54a  signal recognition particle 54kDa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-11 Srp54a  signal recognition particle 54kDa  Srp54  signal recognition particle 54A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-03 Srp54  signal recognition particle 54A  Srp54a  signal recognition particle 54a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Srp54a  signal recognition particle 54a  Srp54  signal recognition particle 54  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Srp54  signal recognition particle 54    signal recognition particle 54 kDa  Name updated 1299863 APPROVED
2002-08-07 Srp54  signal recognition particle 54 kDa      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression increases in preosteoblastic cells subcultured on collagen compared with subculture on plastic only 634092