Chmp4b (charged multivesicular body protein 4B)

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Gene: Chmp4b (charged multivesicular body protein 4B) Rattus norvegicus

Analyze

Symbol:

Chmp4b

Name:

charged multivesicular body protein 4B

RGD ID:

1309846

Description:

Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including mitotic nuclear division; proteolysis involved in protein catabolic process; and regulation of organelle assembly. Predicted to be located in several cellular components, including bounding membrane of organelle; kinetochore microtubule; and midbody. Predicted to be part of ESCRT III complex; membrane coat; and nuclear pore. Human ortholog(s) of this gene implicated in cataract 31 multiple types. Orthologous to several human genes including CHMP4B (charged multivesicular body protein 4B); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 2-methoxyethanol; 4,4'-sulfonyldiphenol; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

chromatin modifying protein 4B; LOC100359642; LOC312254; rCG27912; rCG37275-like; RGD1309846; RGD1565889; similar to RIKEN cDNA 2010012F05

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	143,170,822 - 143,211,376 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	143,170,902 - 143,210,844 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	147,038,366 - 147,078,867 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	155,655,650 - 155,696,272 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	153,395,185 - 153,435,681 (+)	NCBI	Rnor_WKY
Rnor_6.0	3	150,188,275 - 150,227,453 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	150,188,455 - 150,227,405 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	156,559,302 - 156,597,243 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	145,138,905 - 145,176,471 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	141,903,054 - 141,940,133 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cataract 31 multiple types (ISO)

genetic disease (ISO)

long QT syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-methoxyethanol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bezafibrate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium dichloride (ISO)

carbon nanotube (ISO)

choline (ISO)

ciguatoxin CTX1B (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

folic acid (ISO)

fulvestrant (ISO)

indometacin (ISO)

ivermectin (ISO)

L-methionine (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

miconazole (ISO)

paracetamol (ISO)

pentachlorophenol (ISO)

perfluorooctanoic acid (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

titanium dioxide (ISO)

triptonide (ISO)

valproic acid (ISO)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagosome maturation (ISO)

autophagy (ISO)

exit from mitosis (ISO)

late endosome to lysosome transport (ISO)

late endosome to vacuole transport via multivesicular body sorting pathway (IBA)

maintenance of lens transparency (ISO)

membrane fission (ISO)

midbody abscission (ISO)

mitotic cytokinesis (ISO)

mitotic metaphase plate congression (ISO)

multivesicular body sorting pathway (ISO)

negative regulation of autophagosome assembly (ISO)

negative regulation of cell death (ISO)

negative regulation of neuron death (ISO)

nervous system process (ISO)

nuclear membrane reassembly (ISO)

nucleus organization (ISO)

plasma membrane repair (ISO)

post-translational protein targeting to endoplasmic reticulum membrane (ISO)

protein polymerization (ISO)

regulation of autophagy (ISO)

regulation of centrosome duplication (ISO)

regulation of mitotic spindle assembly (ISO)

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (ISO)

ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway (ISO)

vesicle budding from membrane (IBA)

viral budding (ISO)

viral budding from plasma membrane (ISO)

viral budding via host ESCRT complex (ISO)

Cellular Component

amphisome membrane (ISO)

autophagosome membrane (ISO)

cytoplasm (ISO)

cytoplasmic side of plasma membrane (IBA,ISO)

cytosol (ISO)

endosome (ISO)

ESCRT III complex (IBA,ISO)

kinetochore (ISO)

kinetochore microtubule (ISO)

lysosomal membrane (ISO)

membrane (ISO)

membrane coat (ISO)

midbody (ISO)

multivesicular body (IBA)

multivesicular body membrane (ISO)

nuclear envelope (ISO)

nuclear pore (ISO)

nucleus (ISO)

plasma membrane (ISO)

vesicle (ISO)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endocytosis pathway (IEA)

External Pathway Database Links

KEGG Pathway

Endocytosis

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:14505570	PMID:14519844	PMID:16730941	PMID:17683935	PMID:17701905	PMID:18209100	PMID:19056867	PMID:19523902	PMID:20458337	PMID:20616062	PMID:21310966	PMID:21975012
PMID:22547407	PMID:22724069	PMID:23376485	PMID:23533145	PMID:24095276	PMID:24107264	PMID:24878737	PMID:25002582	PMID:25468996	PMID:25478783	PMID:26040712

Genomics

Comparative Map Data

Chmp4b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	143,170,822 - 143,211,376 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	143,170,902 - 143,210,844 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	147,038,366 - 147,078,867 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	155,655,650 - 155,696,272 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	153,395,185 - 153,435,681 (+)	NCBI	Rnor_WKY
Rnor_6.0	3	150,188,275 - 150,227,453 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	150,188,455 - 150,227,405 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	156,559,302 - 156,597,243 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	145,138,905 - 145,176,471 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	141,903,054 - 141,940,133 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

CHMP4B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	33,811,348 - 33,854,366 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	20	33,811,348 - 33,854,366 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	32,399,154 - 32,442,172 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	31,862,780 - 31,905,831 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	31,862,779 - 31,905,830	NCBI
Celera	20	29,151,820 - 29,194,895 (+)	NCBI		Celera
Cytogenetic Map	20	q11.22	NCBI
HuRef	20	29,183,904 - 29,227,019 (+)	NCBI		HuRef
CHM1_1	20	32,300,438 - 32,343,523 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	35,537,705 - 35,580,724 (+)	NCBI		T2T-CHM13v2.0

Chmp4b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	154,498,946 - 154,536,703 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	154,493,625 - 154,536,705 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	154,657,026 - 154,694,783 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	154,651,705 - 154,694,785 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	154,482,762 - 154,520,519 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	154,348,505 - 154,386,224 (+)	NCBI		MGSCv36	mm8
Celera	2	160,576,332 - 160,622,337 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI

Chmp4b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	27,478,698 - 27,526,575 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	27,482,239 - 27,526,798 (-)	NCBI	ChiLan1.0	ChiLan1.0

CHMP4B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	20	31,237,881 - 31,286,065 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	31,236,778 - 31,285,264 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	20	30,098,796 - 30,146,347 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

CHMP4B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	22,995,677 - 23,050,084 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	22,995,672 - 23,049,287 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	22,640,928 - 22,694,729 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	23,682,594 - 23,736,450 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	23,682,589 - 23,736,528 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	22,975,014 - 23,028,808 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	23,068,398 - 23,122,183 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	23,505,889 - 23,559,706 (+)	NCBI		UU_Cfam_GSD_1.0

Chmp4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	171,950,653 - 171,993,189 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	6,756,307 - 6,799,290 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936561	6,756,360 - 6,798,964 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHMP4B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	37,285,442 - 37,334,101 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	37,285,422 - 37,334,103 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	42,214,644 - 42,263,471 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CHMP4B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	38,093,909 - 38,139,932 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	38,093,829 - 38,140,367 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	88,741,182 - 88,785,653 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chmp4b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624842	5,450,900 - 5,505,418 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624842	5,454,616 - 5,505,454 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Chmp4b
59 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	46
Count of miRNA genes:	45
Interacting mature miRNAs:	46
Transcripts:	ENSRNOT00000072917
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	121056165	145956249	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	140069424	146976080	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141339013	162184794	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141339236	155617360	Rat

Markers in Region

RH128471

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	143,211,168 - 143,211,350 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	150,227,976 - 150,228,157	NCBI	Rnor6.0
Rnor_5.0	3	156,598,901 - 156,599,082	UniSTS	Rnor5.0
RGSC_v3.4	3	145,179,643 - 145,179,824	UniSTS	RGSC3.4
Celera	3	141,942,265 - 141,942,446	UniSTS
RH 3.4 Map	3	1328.6	UniSTS
Cytogenetic Map	3	q41	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	40	49	33	19	33	7	10	74	35	41	11	7
Low		3	8	8		8	1	1					1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001399657	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006224717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106697	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000072917 ⟹ ENSRNOP00000067294

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	143,170,902 - 143,209,107 (+)	Ensembl
Rnor_6.0 Ensembl	3	150,188,455 - 150,227,405 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000100710 ⟹ ENSRNOP00000079776

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	143,170,902 - 143,210,844 (+)	Ensembl

RefSeq Acc Id:

XM_039106697 ⟹ XP_038962625

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	143,170,822 - 143,211,376 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001386586	(Get FASTA)	NCBI Sequence Viewer
	XP_038962625	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000067294 ⟸ ENSRNOT00000072917

RefSeq Acc Id:

XP_038962625 ⟸ XM_039106697

RefSeq Acc Id:

ENSRNOP00000079776 ⟸ ENSRNOT00000100710

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0RCH6-F1-model_v2	AlphaFold	M0RCH6	1-222	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309846	AgrOrtholog
BioCyc Gene	G2FUF-47163	BioCyc
Ensembl Genes	ENSRNOG00000046585	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000067294.3	UniProtKB/TrEMBL
	ENSRNOP00000079776	ENTREZGENE
	ENSRNOP00000079776.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000072917.3	UniProtKB/TrEMBL
	ENSRNOT00000100710	ENTREZGENE
	ENSRNOT00000100710.1	UniProtKB/TrEMBL
Gene3D-CATH	6.10.250.1710	UniProtKB/TrEMBL
	ESAT-6-like	UniProtKB/TrEMBL
InterPro	Snf7_fam	UniProtKB/TrEMBL
NCBI Gene	100359642	ENTREZGENE
PANTHER	CHARGED MULTIVESICULAR BODY PROTEIN 4B	UniProtKB/TrEMBL
	PTHR22761	UniProtKB/TrEMBL
Pfam	Snf7	UniProtKB/TrEMBL
PhenoGen	Chmp4b	PhenoGen
UniProt	A0A8I5ZP83	ENTREZGENE, UniProtKB/TrEMBL
	M0RCH6_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-03-19	Chmp4b	charged multivesicular body protein 4B	LOC100359642	rCG37275-like	Data Merged	737654	APPROVED
2013-01-14	Chmp4b	charged multivesicular body protein 4B	Chmp4b	chromatin modifying protein 4B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-20	LOC100359642	rCG37275-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-10-01	Chmp4b	chromatin modifying protein 4B	RGD1309846	similar to RIKEN cDNA 2010012F05	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1309846	similar to RIKEN cDNA 2010012F05	RGD1309846_predicted	similar to RIKEN cDNA 2010012F05 (predicted)	'predicted' is removed	2292626	APPROVED
2008-01-09	RGD1309846_predicted	similar to RIKEN cDNA 2010012F05 (predicted)	LOC683288	similar to Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b)	Data Merged	1643240	APPROVED
2006-11-19	LOC683288	similar to Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b)			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-20	RGD1309846_predicted	similar to RIKEN cDNA 2010012F05 (predicted)	LOC312254_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC312254_predicted	similar to RIKEN cDNA 2010012F05 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

External Pathway Database Links

External Pathway Database Links

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

External Pathway Database Links

External Pathway Database Links