Pgp (phosphoglycolate phosphatase)

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Gene: Pgp (phosphoglycolate phosphatase) Rattus norvegicus

Analyze

Symbol:

Pgp

Name:

phosphoglycolate phosphatase

RGD ID:

1307773

Description:

Enables glycerol-3-phosphatase activity. Involved in glycerol biosynthetic process; glycerophospholipid metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PGP (phosphoglycolate phosphatase); PARTICIPATES IN glyoxylate and dicarboxylate metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

aspartate-based ubiquitous Mg(2+)-dependent phosphatase; AUM; G3PP; glycerol-3-phosphate phosphatase; LOC287115; RGD1307773; similar to RIKEN cDNA 1700012G19 gene

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PGP (phosphoglycolate phosphatase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Pgp (phosphoglycolate phosphatase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pgp (phosphoglycolate phosphatase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PGP (phosphoglycolate phosphatase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PGP (phosphoglycolate phosphatase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pgp (phosphoglycolate phosphatase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PGP (phosphoglycolate phosphatase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PGP (phosphoglycolate phosphatase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pgp (phosphoglycolate phosphatase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ATAD5 (ATPase family AAA domain containing 5)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Pgp (phosphoglycolate phosphatase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PGP (phosphoglycolate phosphatase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pgp (phosphoglycolate phosphatase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PHO13	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11291	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	C45E5.1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	C53A3.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F44E7.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	K09H11.7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5577	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG32487	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5567	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32488	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pgp	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	13,495,232 - 13,497,858 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	13,494,291 - 13,497,858 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	18,241,800 - 18,244,426 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	17,730,645 - 17,733,271 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	13,229,830 - 13,232,456 (+)	NCBI	Rnor_WKY
Rnor_6.0	10	13,836,105 - 13,838,731 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	13,836,128 - 13,838,765 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	13,653,091 - 13,655,717 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	13,722,365 - 13,724,991 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	13,722,431 - 13,724,292 (+)	NCBI
Celera	10	13,175,712 - 13,178,338 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant polycystic kidney disease (ISO)

developmental and epileptic encephalopathy 1 (ISO)

endometrial carcinoma (ISO)

epilepsy (ISO)

genetic disease (ISO)

idiopathic generalized epilepsy (ISO)

short-rib thoracic dysplasia 9 with or without polydactyly (ISO)

tuberous sclerosis 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-nitrophenyl phosphate (ISO)

acrylamide (ISO)

ADP (ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

ATP (ISO)

benzalkonium chloride (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

calcium atom (ISO)

calcium(0) (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

dextran sulfate (ISO)

dibutyl phthalate (EXP,ISO)

dioxygen (ISO)

doxorubicin (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

ethyl methanesulfonate (ISO)

ethylenediaminetetraacetic acid (ISO)

fluoranthene (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

GDP (ISO)

gentamycin (EXP)

GTP (ISO)

inulin (ISO)

ivermectin (ISO)

lipopolysaccharide (ISO)

methyl methanesulfonate (ISO)

miconazole (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

trifluoroberyllate(1-) (ISO)

triphenyl phosphate (EXP)

valproic acid (ISO)

vinclozolin (EXP)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glycerol biosynthetic process (IDA,IEA,ISO)

glycerophospholipid metabolic process (IEA,IMP,ISO)

negative regulation of gluconeogenesis (IEA,IMP,ISO)

Cellular Component

cytoplasm (IBA)

cytosol (TAS)

Molecular Function

ADP phosphatase activity (ISO)

glycerol-1-phosphatase activity (IEA)

glycerol-3-phosphatase activity (IBA,IEA,IMP,ISO)

magnesium ion binding (ISO)

phosphoglycolate phosphatase activity (IEA,ISO)

protein tyrosine phosphatase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

glyoxylate and dicarboxylate metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic beta-cells and hepatocytes.	Mugabo Y, etal., Proc Natl Acad Sci U S A. 2016 Jan 11. pii: 201514375.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:24338473

Genomics

Comparative Map Data

Pgp
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	13,495,232 - 13,497,858 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	13,494,291 - 13,497,858 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	18,241,800 - 18,244,426 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	17,730,645 - 17,733,271 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	13,229,830 - 13,232,456 (+)	NCBI	Rnor_WKY
Rnor_6.0	10	13,836,105 - 13,838,731 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	13,836,128 - 13,838,765 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	13,653,091 - 13,655,717 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	13,722,365 - 13,724,991 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	13,722,431 - 13,724,292 (+)	NCBI
Celera	10	13,175,712 - 13,178,338 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

PGP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	2,211,593 - 2,214,840 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	16	2,211,593 - 2,214,840 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	2,261,594 - 2,264,841 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	2,201,604 - 2,204,823 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	2,476,021 - 2,479,244 (-)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	2,187,781 - 2,191,004 (-)	NCBI		HuRef
CHM1_1	16	2,261,530 - 2,264,753 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	2,234,051 - 2,237,302 (-)	NCBI		T2T-CHM13v2.0

Pgp
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	24,689,400 - 24,692,084 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	24,689,366 - 24,692,084 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	24,470,426 - 24,473,110 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	24,470,392 - 24,473,110 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	24,607,418 - 24,608,547 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	24,198,073 - 24,199,202 (+)	NCBI		MGSCv36	mm8
Celera	17	24,986,247 - 24,987,376 (+)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI

Pgp
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	15,051,183 - 15,052,289 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	15,051,149 - 15,053,123 (+)	NCBI	ChiLan1.0	ChiLan1.0

PGP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	16	6,495,802 - 6,498,615 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	1,070,291 - 1,073,123 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	2,313,409 - 2,315,698 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

PGP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ROS_Cfam_1.0	6	39,064,885 - 39,067,721 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	39,064,879 - 39,066,030 (+)	Ensembl		ROS_Cfam_1.0 Ensembl

Pgp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	104,873,104 - 104,875,444 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936694	1,834,016 - 1,836,359 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PGP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	39,762,608 - 39,778,011 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	39,776,815 - 39,779,669 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	42,401,344 - 42,404,185 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PGP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	2,107,850 - 2,110,657 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	2,106,451 - 2,110,657 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	28,951,132 - 28,952,300 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pgp
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624913	45,499 - 49,060 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624913	45,439 - 48,259 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pgp
7 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	598
Count of miRNA genes:	259
Interacting mature miRNAs:	347
Transcripts:	ENSRNOT00000012720
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
1576304	Schws7	Schwannoma susceptibility QTL 7		0.0115	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	4765527	19816042	Rat
631828	Alc5	Alcohol consumption QTL 5	2.4		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	17245662	Rat
737820	Alc9	Alcohol consumption QTL 9	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	19233348	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6154182	15990232	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat

Markers in Region

AI481330

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	13,496,075 - 13,496,330 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	13,836,949 - 13,837,203	NCBI	Rnor6.0
Rnor_5.0	10	13,653,935 - 13,654,189	UniSTS	Rnor5.0
RGSC_v3.4	10	13,723,209 - 13,723,463	UniSTS	RGSC3.4
Celera	10	13,176,556 - 13,176,810	UniSTS
Cytogenetic Map	10	q12	UniSTS

RH98228

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	13,496,076 - 13,496,203 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	13,836,950 - 13,837,076	NCBI	Rnor6.0
Rnor_5.0	10	13,653,936 - 13,654,062	UniSTS	Rnor5.0
RGSC_v3.4	10	13,723,210 - 13,723,336	UniSTS	RGSC3.4
Celera	10	13,176,557 - 13,176,683	UniSTS
Cytogenetic Map	10	q12	UniSTS

RH127723

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	13,497,645 - 13,497,827 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	13,838,519 - 13,838,700	NCBI	Rnor6.0
Rnor_5.0	10	13,655,505 - 13,655,686	UniSTS	Rnor5.0
RGSC_v3.4	10	13,724,779 - 13,724,960	UniSTS	RGSC3.4
Celera	10	13,178,126 - 13,178,307	UniSTS
Cytogenetic Map	10	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	41	41	30	14	30	8	11	74	29	39	11	8
Low		2	16	11	5	11				6	2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001169152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC103090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000012720 ⟹ ENSRNOP00000012720

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	13,494,291 - 13,497,858 (+)	Ensembl
Rnor_6.0 Ensembl	10	13,836,128 - 13,838,765 (+)	Ensembl

RefSeq Acc Id:

NM_001169152 ⟹ NP_001162623

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	13,495,232 - 13,497,858 (+)	NCBI
Rnor_6.0	10	13,836,105 - 13,838,731 (+)	NCBI
Rnor_5.0	10	13,653,091 - 13,655,717 (+)	NCBI
RGSC_v3.4	10	13,722,365 - 13,724,991 (+)	RGD
Celera	10	13,175,712 - 13,178,338 (+)	RGD

Sequence:

show sequence

GCGGCGGCGGCGGGTGGCGGCAGCGGTCAGCGGTCGGCCATGGCGGAGGCGGAGGCCGGCGGCG
ACGAAGTCCGCTGCGTGCGGCTGAGCGCCGAGCGGGCCAAGTTGCTGCTGGCCGAAGTGGACAC
GCTGCTGTTCGACTGCGATGGCGTGCTGTGGCGCGGCGAGACGGCCGTGCCGGGCGCGCCGGAG
ACTCTGCGGGCGCTGCGGGCCCGCGGCAAGCGACTGGGCTTCATCACCAACAACAGCAGCAAGA
CTCGTACGGCCTACGCGGAGAAGCTCAGGCGCTTGGGTTTCGGTGGCCCGATGGGGCCCGAAGC
GGGCCTCGAGGTCTTCGGCACGGCCTACTGCAGCGCGCTCTATCTGCGCCAACGCCTGGCCGGC
GTGCCGGACCCCAAGGCCTACGTGCTGGGCAGCCCGGCCTTAGCCGCGGAGCTGGAGGCCGTGG
GTGTCACTAGCGTGGGCGTGGGCCCGGACGTGCTTCACGGCGATGGCCCAAGCGACTGGCTAGC
CGTGCCGCTCGAACCCGACGTGCGCGCGGTAGTGGTGGGCTTCGACCCACACTTCAGCTACATG
AAGCTTACCAAGGCCGTGCGGTACCTGCAGCAGCCCGACTGTCTGCTCGTGGGCACCAACATGG
ACAACCGGCTCCCGCTAGAGAACGGCCGTTTCATTGCGGGTACCGGCTGTCTGGTGCGAGCCGT
GGAGATGGCCGCCCAGCGCCAGGCGGACATCATCGGGAAGCCTAGCCGCTTCATCTTCGACTGC
GTGTCCCAGGAGTATGGTATCAACCCGGAGCGCACCGTCATGGTGGGAGACCGCCTGGACACAG
ACATCCTCCTGGGCTCCACCTGTAGCCTGAAGACTATCCTGACCCTCACCGGAGTCTCCAGTCT
TGAGGATGTGAAGAGCAATCAGGAAAGTGACTGCATGTTCAAGAAGAAAATGGTCCCTGACTTC
TATGTTGACAGCATAGCCGACCTCTTGCCTGCCCTTCAAGGTTAAAGATCTCGTGTCTTTAATC
TCTGGAATAAAAAAAAAAAAAAAAAGAAAAGAAAAAGAAAATCAGCTACCTAAATTAATAGGTG
GGGCTTAGGAATAGCTGAGTTAGGTGGCTGCAGGTTAACTGAAGTAAAGGCGGTAGTTAATCTT
GTAAGTAAGTGTTGGGGGGAGGTGTTGTTTACAGAGAATTATATTTTAAGATGCACTTTTAAGC
TTGGAAGGCATTATGAGGTGGGCATAGCACATGCCCAACGTTCAGGTAACCTCAGGCTCTGTTG
CTCCGACTGAAGTGGGTCAAGGGTTGTGTCTTGCTTTTTACTGAAGTGTAGTCAGGGATCAGGC
CCTAAGGTGGGCAGAGTAAAGAAAAGGGGCTCTGAAGTAACCAAACACTGGGGTTTCCCCTAAT
GTGATCATGCAGCAGAGGTGCCTGTTACTGTACCCCAGTTCCTCACCTTCGGGGTGGGAGCGCT
CTATTGTTGGGGTTTGGATGCTGCTCTTGACAACCTCCACTCACTCTGCTTCTTTGAAAACCAC
TTTGACATCACAGTTGTCTGTTCTGTTTCAGATGCCCAGCACTGCAGACCCCCATGCACAGTAA
CAGCAGCCCAGCTAAACTTTGGCTGTCTTGTGTGAATTTAACCCAGGTGTCATAGTGTGGCCTG
CTGAGCAGCCAATTGGGTCCGGAGGGCCTGCCCTGGGCTCCGTGCTGCTTTATGGGAGCTCAGA
ACAGTGCTTACTTCTTCAAACTAGTGAATGGCATTGTCAAGTGTGGAATTGGATCTTAAGTGTC
TGAATTAATAGCGCTGCTCTGTCTCAAGGGTAAACCCCACTGAAGAAATCTCATGCCCCAGTCA
GCAGCACAGCCAGTGTGCAAGTCAAGGATTGCCTTGTTTCCCAGAGTACCCTCTGGGTAGGAAG
GAATGAGGAGCCCAGAAGATAGTTAAGTCTCTAAGAAAGCATACAATTCCCCTTGTCCAGGTCA
CTTTCGGTTGTGCATGGGTTAAGTATCGGTGCTCCTTGATACCACCACCAATCTCGATCTTGGA
CTTCCTTGTTGGTAGCCAGCCATAAGGCCTACCAACCACTTGGCTTCTCAACATCTCTGGCCTT
TTCCTCTGCTCTTCAAGTCCCTGACCTTTAGCAATCTGCTGAGCAGACTGGGAAACATTCATGG
GGCATACCCGGGAAGTTGCTCCTTTTGGCCGACTCCTTTCTGGCACCTTGCCCTGTACCAAGTG
GCTACTCTCATGGTCACAGTACTTCACCTGTTCACCAAGTTCTCAGAGCAATAAAAGTCTGAAG
CTGCTCACAGGCCGGGTGGGAGTGGAATGGTGCCATAGATCAACATGATGGCAGTAGTGCCTGT
AACATTGGTGGTGCTGATCCCAAGTCTGAATAATGACCAGGCTTGGCAGATGTGCAGCCAGGGA
TGCCCTCTCTGGGCAGATGCTAGAGAACCTATGTGTGTTACATTTCCAGCTTGTCTTGCTGTGT
GACCTCAAATGCACATTAAACTCAAACCCACAATGATTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001162623	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D3ZDK7	(Get FASTA)	NCBI Sequence Viewer
	EDM03833	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001162623 ⟸ NM_001169152

- UniProtKB:

D3ZDK7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEAEAGGDEVRCVRLSAERAKLLLAEVDTLLFDCDGVLWRGETAVPGAPETLRALRARGKRLG
FITNNSSKTRTAYAEKLRRLGFGGPMGPEAGLEVFGTAYCSALYLRQRLAGVPDPKAYVLGSPA
LAAELEAVGVTSVGVGPDVLHGDGPSDWLAVPLEPDVRAVVVGFDPHFSYMKLTKAVRYLQQPD
CLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTV
MVGDRLDTDILLGSTCSLKTILTLTGVSSLEDVKSNQESDCMFKKKMVPDFYVDSIADLLPALQ
G

hide sequence

RefSeq Acc Id:

ENSRNOP00000012720 ⟸ ENSRNOT00000012720

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZDK7-F1-model_v2	AlphaFold	D3ZDK7	1-321	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697011

Promoter ID:

EPDNEW_R7535

Type:

initiation region

Name:

Pgp_1

Description:

phosphoglycolate phosphatase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	13,836,102 - 13,836,162	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307773	AgrOrtholog
BioCyc Gene	G2FUF-25857	BioCyc
Ensembl Genes	ENSRNOG00000009536	Ensembl, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000012720.6	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012720.8	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1000	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	HAD-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HAD-SF_hydro_IIA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HAD_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PGP_euk	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:287115	UniProtKB/Swiss-Prot
NCBI Gene	287115	ENTREZGENE
PANTHER	4-NITROPHENYLPHOSPHATASE-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GLYCEROL-3-PHOSPHATE PHOSPHATASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Hydrolase_6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Hydrolase_like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pgp	PhenoGen
PIRSF	PGP-type_phosphatase	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56784	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	HAD-SF-IIA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PGP_euk	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2Q5X6_RAT	UniProtKB/TrEMBL
	D3ZDK7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-09	Pgp	phosphoglycolate phosphatase	RGD1307773	similar to RIKEN cDNA 1700012G19 gene	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1307773	similar to RIKEN cDNA 1700012G19 gene	RGD1307773_predicted	similar to RIKEN cDNA 1700012G19 gene (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1307773_predicted	similar to RIKEN cDNA 1700012G19 gene (predicted)	LOC287115_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC287115_predicted	similar to RIKEN cDNA 1700012G19 gene (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)