Defa3 (defensin alpha 3) - Rat Genome Database

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Gene: Defa3 (defensin alpha 3) Rattus norvegicus
Analyze
Symbol: Defa3 (Ensembl: Defa11)
Name: defensin alpha 3 (Ensembl:defensin alpha 11)
RGD ID: 1587186
Description: Predicted to be involved in cellular response to lipopolysaccharide; defense response to other organism; and disruption of plasma membrane integrity in another organism. Predicted to be active in extracellular space. Orthologous to human DEFA5 (defensin alpha 5); INTERACTS WITH aflatoxin B1 (ortholog); all-trans-retinoic acid (ortholog); arsenous acid (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-defensin 11; Defa11; defensin alpha 11; neutrophil defensin 4
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,235,885 - 77,238,041 (-)NCBIGRCr8
mRatBN7.21670,533,436 - 70,535,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,533,436 - 70,535,604 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,810,363 - 75,811,194 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,255,833 - 79,256,664 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,505,274 - 74,506,105 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,517,421 - 75,519,605 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,517,505 - 75,518,336 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01675,118,070 - 75,120,254 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,324,009 - 75,324,840 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1668,395,242 - 68,396,073 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Defa3RatRecombinant Chromosome 8 Syndrome  ISODEFA3 (Homo sapiens)8554872ClinVar Annotator: match by term: Recombinant 8 syndromeClinVarPMID:31690835
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Defa3Ratacute promyelocytic leukemia  ISODEFA3 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:16019513

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Defa3Rataflatoxin B1 increases methylationISODEFA3 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of DEFA3 geneCTDPMID:27153756
Defa3Ratall-trans-retinoic acid increases expressionISODEFA3 (Homo sapiens)6480464Tretinoin results in increased expression of DEFA3 mRNA and Tretinoin results in increased expression of DEFA3 proteinCTDPMID:15894607 more ...
Defa3Ratall-trans-retinoic acid multiple interactionsISODEFA3 (Homo sapiens)6480464[Tretinoin co-treated with Arsenic Trioxide] results in increased expression of DEFA3 mRNACTDPMID:15894607
Defa3Ratarsenous acid multiple interactionsISODEFA3 (Homo sapiens)6480464[Tretinoin co-treated with Arsenic Trioxide] results in increased expression of DEFA3 mRNACTDPMID:15894607
Defa3Ratbenzo[a]pyrene affects methylationISODEFA3 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of DEFA3 promoterCTDPMID:27901495
Defa3Ratbeta-naphthoflavone increases expressionISODEFA3 (Homo sapiens)6480464beta-Naphthoflavone results in increased expression of DEFA3 mRNACTDPMID:19737606
Defa3Ratbis(2-ethylhexyl) phthalate increases expressionISODEFA3 (Homo sapiens)6480464Diethylhexyl Phthalate results in increased expression of DEFA3 mRNACTDPMID:28412506
Defa3Ratchlorothalonil multiple interactionsISODefa3 (Mus musculus)6480464[tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of DEFA3 mRNACTDPMID:33246813
Defa3Ratchromium(6+) affects expressionISODefa3 (Mus musculus)6480464chromium hexavalent ion affects the expression of DEFA3 mRNACTDPMID:28472532
Defa3Ratciguatoxin CTX1B affects expressionISODefa3 (Mus musculus)6480464Ciguatoxins affects the expression of DEFA3 mRNACTDPMID:18353800
Defa3Ratdiarsenic trioxide multiple interactionsISODEFA3 (Homo sapiens)6480464[Tretinoin co-treated with Arsenic Trioxide] results in increased expression of DEFA3 mRNACTDPMID:15894607
Defa3Ratdisodium selenite increases expressionISODEFA3 (Homo sapiens)6480464Sodium Selenite results in increased expression of DEFA3 mRNACTDPMID:18175754
Defa3Ratenilconazole decreases expressionISODefa3 (Mus musculus)6480464enilconazole results in decreased expression of DEFA3 mRNACTDPMID:32814239
Defa3Ratiron atom decreases expressionISODEFA3 (Homo sapiens)6480464Iron deficiency results in decreased expression of DEFA3 mRNACTDPMID:20368581
Defa3Ratiron(0) decreases expressionISODEFA3 (Homo sapiens)6480464Iron deficiency results in decreased expression of DEFA3 mRNACTDPMID:20368581
Defa3Ratmifepristone decreases expressionISODEFA3 (Homo sapiens)6480464Mifepristone results in decreased expression of DEFA3 proteinCTDPMID:17701593
Defa3Ratprocymidone increases expressionISODefa3 (Mus musculus)6480464procymidone results in increased expression of DEFA3 mRNACTDPMID:33246813
Defa3Ratprocymidone multiple interactionsISODefa3 (Mus musculus)6480464[tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of DEFA3 mRNACTDPMID:33246813
Defa3Ratprocymidone affects expressionISODefa3 (Mus musculus)6480464procymidone affects the expression of DEFA3 mRNACTDPMID:36764477
Defa3Ratprogesterone increases expressionISODEFA3 (Homo sapiens)6480464Progesterone results in increased expression of DEFA3 mRNA and Progesterone results in increased expression of DEFA3 proteinCTDPMID:17701593

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Biological Process
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Defa3Ratantibacterial humoral response involved_inIBAMGI:1915259 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Defa3Ratantimicrobial humoral immune response mediated by antimicrobial peptide involved_inISODEFA3 (Homo sapiens)1624291 PMID:12860195RGDPMID:12860195
Defa3Ratantimicrobial humoral immune response mediated by antimicrobial peptide involved_inIBAPANTHER:PTN002275316 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Defa3Ratcellular response to lipopolysaccharide acts_upstream_of_or_withinISODefa3 (Mus musculus)1624291MGI:94880 more ...RGDPMID:11248802
Defa3Ratcellular response to lipopolysaccharide involved_inIBAMGI:94880 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Defa3Ratdefense response involved_inIEAInterPro:IPR002366 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Defa3Ratdefense response involved_inIEAUniProtKB-KW:KW-02111600115GO_REF:0000043UniProtGO_REF:0000043
Defa3Ratdefense response involved_inIEAARBA:ARBA000263151600115GO_REF:0000117UniProtGO_REF:0000117
Defa3Ratdefense response to bacterium acts_upstream_of_or_withinISODefa3 (Mus musculus)1624291 PMID:7927786RGDPMID:7927786
Defa3Ratdefense response to bacterium involved_inIEAUniProtKB-KW:KW-00441600115GO_REF:0000043UniProtGO_REF:0000043
Defa3Ratdefense response to fungus involved_inIEAUniProtKB-KW:KW-02951600115GO_REF:0000043UniProtGO_REF:0000043
Defa3Ratdefense response to Gram-negative bacterium acts_upstream_of_or_withinISODefa3 (Mus musculus)1624291MGI:94880 more ...RGDPMID:11248802
Defa3Ratdefense response to Gram-negative bacterium involved_inIBAMGI:94880 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Defa3Ratdefense response to Gram-positive bacterium acts_upstream_of_or_withinISODefa3 (Mus musculus)1624291MGI:94880 more ...RGDPMID:11248802
Defa3Ratdefense response to Gram-positive bacterium involved_inIBAMGI:94880 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Defa3Ratdisruption of plasma membrane integrity in another organism involved_inIBAMGI:99584 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Defa3Ratestrogen receptor signaling pathway involved_inISODEFA3 (Homo sapiens)1624291 PMID:21861873RGDPMID:21861873
Defa3Ratinnate immune response in mucosa involved_inIBAPANTHER:PTN002275316 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Defa3Ratinnate immune response in mucosa involved_inISODEFA3 (Homo sapiens)1624291 PMID:12860195RGDPMID:12860195
Defa3Ratkilling of cells of another organism involved_inIEAUniProtKB-KW:KW-02951600115GO_REF:0000043UniProtGO_REF:0000043
1 to 20 of 21 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Defa3Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Defa3Ratextracellular region located_inIEAInterPro:IPR006080 and InterPro:IPR0060811600115GO_REF:0000002InterProGO_REF:0000002
Defa3Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Defa3Ratextracellular space located_inISODefa3 (Mus musculus)1624291 PMID:11248802RGDPMID:11248802
Defa3Ratextracellular space located_inISODEFA3 (Homo sapiens)1624291 PMID:12860195 and PMID:21861873RGDPMID:12860195 and PMID:21861873
Defa3Ratextracellular space located_inIEAInterPro:IPR0163271600115GO_REF:0000002InterProGO_REF:0000002
Defa3Ratextracellular space is_active_inIBAMGI:1915259 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Defa3Ratprotein homodimerization activity enablesISODEFA3 (Homo sapiens)1624291 PMID:2006422RGDPMID:2006422


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Defa3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,235,885 - 77,238,041 (-)NCBIGRCr8
mRatBN7.21670,533,436 - 70,535,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,533,436 - 70,535,604 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,810,363 - 75,811,194 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,255,833 - 79,256,664 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,505,274 - 74,506,105 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,517,421 - 75,519,605 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,517,505 - 75,518,336 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01675,118,070 - 75,120,254 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,324,009 - 75,324,840 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1668,395,242 - 68,396,073 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
DEFA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3887,015,869 - 7,018,297 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl87,015,869 - 7,018,297 (-)EnsemblGRCh38hg38GRCh38
GRCh3786,873,391 - 6,875,819 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3686,860,805 - 6,863,226 (-)NCBINCBI36Build 36hg18NCBI36
Build 3486,860,804 - 6,863,226NCBI
Cytogenetic Map8p23.1NCBI
HuRef86,614,645 - 6,617,074 (-)NCBIHuRef
CHM1_186,961,928 - 6,964,357 (-)NCBICHM1_1
T2T-CHM13v2.086,770,536 - 6,772,968 (-)NCBIT2T-CHM13v2.0
Defa3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39821,777,425 - 21,778,393 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl821,777,425 - 21,778,393 (+)EnsemblGRCm39 Ensembl
GRCm38821,287,409 - 21,288,377 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl821,287,409 - 21,288,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv37822,427,088 - 22,428,056 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36822,782,195 - 22,783,035 (+)NCBIMGSCv36mm8
Celera820,702,827 - 20,703,795 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map810.35NCBI

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Variants in Defa3
29 total Variants

Predicted Target Of
Summary Value
Count of predictions:12
Count of miRNA genes:12
Interacting mature miRNAs:12
Transcripts:ENSRNOT00000058037
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 12 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat

1 to 10 of 12 rows



alimentary part of gastrointestinal system
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
renal system
reproductive system
respiratory system
1 37 37 30 23 30 64 23 10 17 7



Ensembl Acc Id: ENSRNOT00000058037   ⟹   ENSRNOP00000054846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1670,533,436 - 70,535,604 (-)Ensembl
Rnor_6.0 Ensembl1675,517,505 - 75,518,336 (-)Ensembl
RefSeq Acc Id: NM_001033078   ⟹   NP_001028250
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,235,885 - 77,238,041 (-)NCBI
mRatBN7.21670,533,436 - 70,535,592 (-)NCBI
Rnor_6.01675,517,505 - 75,518,336 (-)NCBI
Rnor_5.01675,118,070 - 75,120,254 (-)NCBI
RGSC_v3.41675,324,009 - 75,324,840 (-)RGD
Celera1668,395,242 - 68,396,073 (-)RGD
Sequence:
Protein RefSeqs NP_001028250 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT68754 (Get FASTA)   NCBI Sequence Viewer  
  AAT68762 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054846
  ENSRNOP00000054846.1
RefSeq Acc Id: NP_001028250   ⟸   NM_001033078
- Peptide Label: precursor
- UniProtKB: Q4JEI3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054846   ⟸   ENSRNOT00000058037
Mammalian defensins

Name Modeler Protein Id AA Range Protein Structure
AF-Q4JEI3-F1-model_v2 AlphaFold Q4JEI3 1-104 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-10826 BioCyc
Ensembl Genes ENSRNOG00000038133 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058037 ENTREZGENE
  ENSRNOT00000058037.2 UniProtKB/TrEMBL
InterPro Alpha-defensin UniProtKB/TrEMBL
  Defensin_alpha UniProtKB/TrEMBL
  Defensin_mammal UniProtKB/TrEMBL
  Defensin_propep UniProtKB/TrEMBL
KEGG Report rno:613225 UniProtKB/TrEMBL
NCBI Gene 613225 ENTREZGENE
PANTHER DEFENSIN ALPHA 10-RELATED UniProtKB/TrEMBL
  PTHR11876 UniProtKB/TrEMBL
Pfam Defensin_1 UniProtKB/TrEMBL
  Defensin_propep UniProtKB/TrEMBL
PhenoGen Defa3 PhenoGen
PIRSF Alpha-defensin UniProtKB/TrEMBL
PROSITE DEFENSIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038133 RatGTEx
SMART Defensin_propep UniProtKB/TrEMBL
  DEFSN UniProtKB/TrEMBL
Superfamily-SCOP Defensin-like UniProtKB/TrEMBL
UniProt Q4JEI3 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-07-09 Defa3  defensin alpha 3  Defa11  defensin alpha 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 Defa11  defensin alpha 11      Symbol and Name status set to provisional 70820 PROVISIONAL