Eea1 (early endosome antigen 1) - Rat Genome Database

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Gene: Eea1 (early endosome antigen 1) Rattus norvegicus
Analyze
Symbol: Eea1
Name: early endosome antigen 1
RGD ID: 1310167
Description: Predicted to enable 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Predicted to be involved in chemical postsynaptic transmission; endocytosis; and vesicle fusion. Located in recycling endosome. Is active in presynaptic endosome. Orthologous to human EEA1 (early endosome antigen 1); PARTICIPATES IN endocytosis pathway; phagocytosis pathway; tuberculosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314764
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8732,441,281 - 32,608,808 (+)NCBIGRCr8
mRatBN7.2730,554,686 - 30,722,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl730,554,552 - 30,718,487 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0737,101,415 - 37,186,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl737,018,459 - 37,186,732 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0737,144,373 - 37,233,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4733,294,184 - 33,396,666 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1733,311,103 - 33,413,833 (+)NCBI
Celera727,696,956 - 27,782,232 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 97 rows

  
Object Symbol
Species
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Evidence
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Reference
Notes
Source
Original Reference(s)
Eea1Rat(-)-epigallocatechin 3-gallate multiple interactionsISORGD:13209116480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EEA1 mRNACTDPMID:22079256
Eea1Rat(1->4)-beta-D-glucan multiple interactionsISORGD:13209126480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of EEA1 mRNACTDPMID:36331819
Eea1Rat1,2-dimethylhydrazine decreases expressionISORGD:132091264804641,2-Dimethylhydrazine results in decreased expression of EEA1 mRNACTDPMID:22206623
Eea1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISORGD:132091164804642,2',4,4'-tetrabromodiphenyl ether results in decreased expression of EEA1 proteinCTDPMID:31675489
Eea1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of EEA1 mRNACTDPMID:33387578
Eea1Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642,3,7,8-tetrachlorodibenzofuran results in decreased expression of EEA1 mRNACTDPMID:32109520
Eea1Rat2,4,6-tribromophenol increases expressionISORGD:132091164804642,4,6-tribromophenol results in increased expression of EEA1 mRNACTDPMID:31675489
Eea1Rat2,6-dimethoxyphenol multiple interactionsISORGD:13209116480464[pyrogallol 1,3-dimethyl ether co-treated with Furaldehyde] results in decreased expression of and affects the localization more ...CTDPMID:38598786
Eea1Rat2,6-dinitrotoluene affects expressionEXP 64804642,6-dinitrotoluene affects the expression of EEA1 mRNACTDPMID:21346803
Eea1Rat2-bromohexadecanoic acid multiple interactionsISORGD:132091164804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ...CTDPMID:38195004
Eea1Rat3,3',5,5'-tetrabromobisphenol A increases expressionISORGD:13209126480464tetrabromobisphenol A results in increased expression of EEA1 mRNACTDPMID:25172293
Eea1Rat3,4-methylenedioxymethamphetamine decreases expressionISORGD:13209126480464N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of EEA1 mRNACTDPMID:26251327
Eea1Ratacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of EEA1 mRNACTDPMID:28959563
Eea1Rataflatoxin B1 increases expressionISORGD:13209126480464Aflatoxin B1 results in increased expression of EEA1 mRNACTDPMID:19770486
Eea1Rataristolochic acid A decreases expressionISORGD:13209116480464aristolochic acid I results in decreased expression of EEA1 mRNACTDPMID:33212167
Eea1Ratarsane affects methylationISORGD:13209116480464Arsenic affects the methylation of EEA1 geneCTDPMID:25304211
Eea1Ratarsenic atom affects methylationISORGD:13209116480464Arsenic affects the methylation of EEA1 geneCTDPMID:25304211
Eea1Ratarsenite(3-) multiple interactionsISORGD:13209116480464arsenite inhibits the reaction [G3BP1 protein binds to EEA1 mRNA]CTDPMID:32406909
Eea1Ratbenzo[a]pyrene diol epoxide I decreases expressionISORGD:132091164804647,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EEA1 mRNACTDPMID:19150397
Eea1Ratbis(2-ethylhexyl) phthalate decreases expressionISORGD:13209126480464Diethylhexyl Phthalate results in decreased expression of EEA1 mRNACTDPMID:33754040

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Biological Process

  
Object Symbol
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Original Reference(s)
Eea1Ratchemical synaptic transmission, postsynaptic involved_inISORGD:13209121624291 PMID:17113235RGDPMID:17113235
Eea1Ratchemical synaptic transmission, postsynaptic involved_inIEAUniProtKB:Q8BL66|ensembl:ENSMUSP000000614931600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Ratendocytosis involved_inISORGD:13209111624291 PMID:21081650RGDPMID:21081650
Eea1Ratendocytosis involved_inIEAUniProtKB:Q15075|ensembl:ENSP000003179551600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Ratendocytosis involved_inIBAPANTHER:PTN000570604|UniProtKB:Q15075|WB:WBGene000116961600115GO_REF:0000033GO_CentralGO_REF:0000033
Eea1Ratmodulation by host of viral process involved_inIEAUniProtKB:Q15075|ensembl:ENSP000003179551600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Ratvesicle fusion involved_inISORGD:13209111624291 PMID:9697774RGDPMID:9697774
Eea1Ratvesicle fusion involved_inIEAUniProtKB:Q15075|ensembl:ENSP000003179551600115GO_REF:0000107EnsemblGO_REF:0000107

Cellular Component
1 to 20 of 25 rows

  
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Original Reference(s)
Eea1Rataxonal spine located_inISORGD:13209121624291 PMID:23303939RGDPMID:23303939
Eea1Rataxonal spine located_inIEAUniProtKB:Q8BL66|ensembl:ENSMUSP000000614931600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Ratcytoplasmic vesicle located_inISORGD:13209121624291 PMID:23553667RGDPMID:23553667
Eea1Ratcytoplasmic vesicle located_inIEAUniProtKB:Q8BL66|ensembl:ENSMUSP000000614931600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Ratcytosol located_inISORGD:13209111624291 PMID:7768953RGDPMID:7768953
Eea1Ratcytosol located_inIEAUniProtKB:Q15075|ensembl:ENSP000003179551600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Ratearly endosome located_inISORGD:13209121624291 PMID:12746448, PMID:14668490, PMID:15078902, PMID:15588329, PMID:15975910, PMID:16204232, PMID:16399794, PMID:17003038, PMID:17620357, PMID:17716972, PMID:17765678, PMID:18838382, PMID:20943658, more ...RGDPMID:12746448|PMID:14668490|PMID:15078902|PMID:15588329|PMID:15975910|PMID:16204232|PMID:16399794|PMID:17003038|PMID:17620357|PMID:17716972|PMID:17765678|PMID:18838382|PMID:20943658|PMID:21502359|PMID:23918928|PMID:23926254|PMID:24029230|PMID:24334765|PMID:24760869|PMID:26965651
Eea1Ratearly endosome located_inIEAUniProtKB:Q15075|ensembl:ENSP000003179551600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Ratearly endosome is_active_inIBAFB:FBgn0034585|MGI:2442192|PANTHER:PTN000570604|UniProtKB:Q15075|WB:WBGene000116961600115GO_REF:0000033GO_CentralGO_REF:0000033
Eea1Ratearly endosome located_inIEAUniProtKB:Q8BL66|ensembl:ENSMUSP000000614931600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Ratearly endosome part_ofISORGD:13209111624291 PMID:16543144RGDPMID:16543144
Eea1Ratearly endosome located_inISORGD:13209111624291 PMID:11741531, PMID:12536145, PMID:15229288, PMID:15792797, PMID:15880641, PMID:16542649, PMID:18388320, PMID:18767904, PMID:19535332, PMID:22719997, PMID:22792322, PMID:25327288RGDPMID:11741531|PMID:12536145|PMID:15229288|PMID:15792797|PMID:15880641|PMID:16542649|PMID:18388320|PMID:18767904|PMID:19535332|PMID:22719997|PMID:22792322|PMID:25327288
Eea1Ratearly endosome membrane located_inISORGD:13209111624291 PMID:7768953RGDPMID:7768953
Eea1Ratearly endosome membrane located_inIEAUniProtKB:Q15075|ensembl:ENSP000003179551600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Ratendosome located_inISORGD:13209121624291 PMID:12890772, PMID:14718562, PMID:16923123, PMID:24239381, PMID:26582200RGDPMID:12890772|PMID:14718562|PMID:16923123|PMID:24239381|PMID:26582200
Eea1Ratendosome located_inIEAUniProtKB:Q8BL66|ensembl:ENSMUSP000000614931600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Ratglutamatergic synapse is_active_inISORGD:13209121624291 PMID:17113235RGDPMID:17113235
Eea1Ratglutamatergic synapse is_active_inIEAUniProtKB:Q8BL66|ensembl:ENSMUSP000000614931600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Ratpostsynaptic early endosome is_active_inISORGD:13209121624291 PMID:17113235, PMID:34564930RGDPMID:17113235|PMID:34564930
Eea1Ratpostsynaptic early endosome is_active_inIEAUniProtKB:Q8BL66|ensembl:ENSMUSP000000614931600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 20 of 25 rows

Molecular Function
1 to 13 of 13 rows

  
Object Symbol
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Original Reference(s)
Eea1Rat1-phosphatidylinositol binding enablesISORGD:13209111624291 PMID:11256955RGDPMID:11256955
Eea1Rat1-phosphatidylinositol binding enablesIEAUniProtKB:Q15075|ensembl:ENSP000003179551600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Rat1-phosphatidylinositol binding enablesIBAPANTHER:PTN000570604|UniProtKB:Q150751600115GO_REF:0000033GO_CentralGO_REF:0000033
Eea1RatGTP-dependent protein binding enablesISORGD:13209111624291 PMID:10491193RGDPMID:10491193
Eea1RatGTP-dependent protein binding enablesIEAUniProtKB:Q15075|ensembl:ENSP000003179551600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Ratmetal ion binding enablesIEAInterPro:IPR0003061600115GO_REF:0000002InterProGO_REF:0000002
Eea1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Eea1Ratprotein binding  IPIRGD:130485913504749 RGD 
Eea1Ratprotein binding enablesISORGD:13209121624291PR:P35278|PR:Q9CQD1 PMID:20534488RGDPMID:20534488
Eea1Ratprotein binding enablesISORGD:13209111624291UniProtKB:P04626|UniProtKB:P20339|UniProtKB:P51148|UniProtKB:P61020|UniProtKB:Q5K651|UniProtKB:Q63635|UniProtKB:Q69Z37|UniProtKB:Q7Z3T8|UniProtKB:Q8IVG5|UniProtKB:Q9UL26 PMID:10491193, PMID:10506127, PMID:11870209, PMID:14613930, PMID:16314522, PMID:16902405, PMID:24029230, PMID:25114243, PMID:25266290, PMID:29568061, PMID:9697774RGDPMID:10491193|PMID:10506127|PMID:11870209|PMID:14613930|PMID:16314522|PMID:16902405|PMID:24029230|PMID:25114243|PMID:25266290|PMID:29568061|PMID:9697774
Eea1Ratprotein homodimerization activity enablesISORGD:13209111624291 PMID:11741531RGDPMID:11741531
Eea1Ratprotein homodimerization activity enablesIEAUniProtKB:Q15075|ensembl:ENSP000003179551600115GO_REF:0000107EnsemblGO_REF:0000107
Eea1Ratzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043
1 to 13 of 13 rows

Imported Annotations - KEGG (archival)

Object Symbol
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Evidence
With
Reference
Notes
Source
Original Reference(s)
Eea1Ratendocytosis pathway  IEA 6907045 KEGGrno:04144
Eea1Ratphagocytosis pathway  IEA 6907045 KEGGrno:04145
Eea1Rattuberculosis pathway  IEA 6907045 KEGGrno:05152

1 to 11 of 11 rows
#
Reference Title
Reference Citation
1. Critical role for Piccolo in synaptic vesicle retrieval. Ackermann F, etal., Elife. 2019 May 10;8. pii: 46629. doi: 10.7554/eLife.46629.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions. Mao L, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19038-43. doi: 10.1073/pnas.1013494107. Epub 2010 Oct 18.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default. Verges M, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10146-51.
11. Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. Wan J, etal., J Neurosci. 2008 Sep 3;28(36):9002-12. doi: 10.1523/JNEUROSCI.0767-08.2008.
1 to 11 of 11 rows
PMID:7768953   PMID:9697774   PMID:10491193   PMID:11256955   PMID:11741531   PMID:12536145   PMID:12746448   PMID:12890772   PMID:14668490   PMID:14718562   PMID:15078902   PMID:15229288  
PMID:15588329   PMID:15792797   PMID:15880641   PMID:15975910   PMID:16204232   PMID:16399794   PMID:16542649   PMID:16923123   PMID:17003038   PMID:17620357   PMID:17716972   PMID:17728463  
PMID:17765678   PMID:18388320   PMID:18523162   PMID:18767904   PMID:18838382   PMID:19056867   PMID:19376974   PMID:19535332   PMID:20943658   PMID:21081650   PMID:21097843   PMID:21502359  
PMID:22719997   PMID:23303939   PMID:23553667   PMID:23918928   PMID:23926254   PMID:24029230   PMID:24239381   PMID:24334765   PMID:24760869   PMID:25327288   PMID:25662281   PMID:26582200  
PMID:26965651   PMID:28176461   PMID:31505169  



Eea1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8732,441,281 - 32,608,808 (+)NCBIGRCr8
mRatBN7.2730,554,686 - 30,722,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl730,554,552 - 30,718,487 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0737,101,415 - 37,186,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl737,018,459 - 37,186,732 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0737,144,373 - 37,233,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4733,294,184 - 33,396,666 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1733,311,103 - 33,413,833 (+)NCBI
Celera727,696,956 - 27,782,232 (+)NCBICelera
Cytogenetic Map7q13NCBI
EEA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381292,770,637 - 92,929,295 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1292,770,637 - 92,929,331 (-)EnsemblGRCh38hg38GRCh38
GRCh371293,164,413 - 93,323,071 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361291,690,416 - 91,847,238 (-)NCBINCBI36Build 36hg18NCBI36
Build 341291,671,790 - 91,825,475NCBI
Celera1292,837,376 - 92,994,185 (-)NCBICelera
Cytogenetic Map12q22NCBI
HuRef1290,233,695 - 90,352,959 (-)NCBIHuRef
CHM1_11293,130,989 - 93,288,076 (-)NCBICHM1_1
T2T-CHM13v2.01292,748,215 - 92,957,284 (-)NCBIT2T-CHM13v2.0
Eea1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391095,776,525 - 95,881,380 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1095,776,512 - 95,881,380 (+)EnsemblGRCm39 Ensembl
GRCm381095,940,663 - 96,045,518 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1095,940,650 - 96,045,518 (+)EnsemblGRCm38mm10GRCm38
MGSCv371095,403,297 - 95,508,152 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361095,370,351 - 95,474,820 (+)NCBIMGSCv36mm8
Celera1097,916,805 - 98,021,533 (+)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1049.59NCBI
Eea1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540529,760,332 - 29,868,755 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540529,760,332 - 29,959,553 (-)NCBIChiLan1.0ChiLan1.0
EEA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210100,799,346 - 100,957,036 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112100,795,736 - 100,953,409 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01290,299,582 - 90,457,109 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11293,611,628 - 93,767,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1293,611,628 - 93,767,583 (-)Ensemblpanpan1.1panPan2
EEA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11533,145,250 - 33,234,899 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1533,148,637 - 33,256,669 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1533,597,838 - 33,709,848 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01533,814,867 - 33,927,149 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1533,816,143 - 33,927,195 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11533,094,790 - 33,206,783 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01533,183,253 - 33,295,258 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01533,447,116 - 33,559,225 (-)NCBIUU_Cfam_GSD_1.0
Eea1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494526,769,728 - 26,903,979 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365079,331,455 - 9,424,835 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365079,331,572 - 9,465,708 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EEA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl590,168,242 - 90,257,241 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1590,131,707 - 90,257,014 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2594,369,958 - 94,492,342 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EEA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11188,164,064 - 88,318,305 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1188,167,550 - 88,318,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037156,846,305 - 157,001,660 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eea1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475013,848,833 - 13,968,552 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475013,773,127 - 13,969,438 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Eea1
1053 total Variants

Predicted Target Of
Summary Value
Count of predictions:316
Count of miRNA genes:195
Interacting mature miRNAs:242
Transcripts:ENSRNOT00000029764
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 32 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat

1 to 10 of 32 rows
RH130077  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2730,721,729 - 30,721,914 (+)MAPPERmRatBN7.2
Rnor_6.0737,189,851 - 37,190,035NCBIRnor6.0
Rnor_5.0737,233,180 - 37,233,364UniSTSRnor5.0
RGSC_v3.4733,396,564 - 33,396,748UniSTSRGSC3.4
Celera727,785,549 - 27,785,733UniSTS
RH 3.4 Map7241.5UniSTS
Cytogenetic Map7q13UniSTS
RH130537  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2730,637,818 - 30,638,031 (+)MAPPERmRatBN7.2
Rnor_6.0737,106,496 - 37,106,708NCBIRnor6.0
Rnor_5.0737,149,907 - 37,150,119UniSTSRnor5.0
RGSC_v3.4733,308,383 - 33,308,595UniSTSRGSC3.4
Celera727,702,030 - 27,702,242UniSTS
RH 3.4 Map7241.0UniSTS
Cytogenetic Map7q13UniSTS
BF389134  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2730,689,763 - 30,689,886 (+)MAPPERmRatBN7.2
Rnor_6.0737,158,417 - 37,158,539NCBIRnor6.0
Rnor_5.0737,201,405 - 37,201,527UniSTSRnor5.0
RGSC_v3.4733,363,397 - 33,363,519UniSTSRGSC3.4
Celera727,754,447 - 27,754,569UniSTS
RH 3.4 Map7241.5UniSTS
Cytogenetic Map7q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000029764   ⟹   ENSRNOP00000029575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl730,632,334 - 30,718,487 (+)Ensembl
Rnor_6.0 Ensembl737,101,391 - 37,186,534 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087297   ⟹   ENSRNOP00000071305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl730,554,552 - 30,718,487 (+)Ensembl
Rnor_6.0 Ensembl737,018,459 - 37,186,732 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095444   ⟹   ENSRNOP00000092690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl730,604,739 - 30,718,487 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103157   ⟹   ENSRNOP00000087995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl730,604,739 - 30,718,487 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107821   ⟹   ENSRNOP00000094814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl730,604,770 - 30,718,487 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117665   ⟹   ENSRNOP00000083105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl730,604,739 - 30,718,487 (+)Ensembl
RefSeq Acc Id: NM_001427400   ⟹   NP_001414329
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,491,558 - 32,608,476 (+)NCBI
RefSeq Acc Id: XM_039080104   ⟹   XP_038936032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,491,542 - 32,608,808 (+)NCBI
mRatBN7.2730,604,663 - 30,722,186 (+)NCBI
RefSeq Acc Id: XM_039080106   ⟹   XP_038936034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,441,490 - 32,608,808 (+)NCBI
mRatBN7.2730,554,686 - 30,722,186 (+)NCBI
RefSeq Acc Id: XM_039080107   ⟹   XP_038936035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,441,281 - 32,608,808 (+)NCBI
mRatBN7.2730,554,686 - 30,722,186 (+)NCBI
RefSeq Acc Id: XM_063263460   ⟹   XP_063119530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,491,542 - 32,608,808 (+)NCBI
RefSeq Acc Id: XM_063263461   ⟹   XP_063119531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,484,866 - 32,608,808 (+)NCBI
RefSeq Acc Id: XM_063263462   ⟹   XP_063119532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,519,538 - 32,608,808 (+)NCBI
RefSeq Acc Id: XM_063263463   ⟹   XP_063119533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,574,274 - 32,608,808 (+)NCBI
1 to 5 of 14 rows
1 to 5 of 14 rows
Ensembl Acc Id: ENSRNOP00000071305   ⟸   ENSRNOT00000087297
Ensembl Acc Id: ENSRNOP00000029575   ⟸   ENSRNOT00000029764
RefSeq Acc Id: XP_038936034   ⟸   XM_039080106
- Peptide Label: isoform X4
- UniProtKB: F1LUA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936035   ⟸   XM_039080107
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K051 (UniProtKB/TrEMBL),   F1LUA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936032   ⟸   XM_039080104
- Peptide Label: isoform X1
- UniProtKB: F1LUA1 (UniProtKB/TrEMBL),   A0A8I6AIN6 (UniProtKB/TrEMBL)
C2H2-type   FYVE-type

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K051-F1-model_v2 AlphaFold A0A0G2K051 1-1449 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 41 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-34314 BioCyc
Ensembl Genes ENSRNOG00000021681 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029764.6 UniProtKB/TrEMBL
  ENSRNOT00000087297 ENTREZGENE
  ENSRNOT00000087297.2 UniProtKB/TrEMBL
  ENSRNOT00000095444 ENTREZGENE
  ENSRNOT00000095444.1 UniProtKB/TrEMBL
  ENSRNOT00000103157 ENTREZGENE
  ENSRNOT00000103157.1 UniProtKB/TrEMBL
  ENSRNOT00000107821 ENTREZGENE
  ENSRNOT00000107821.1 UniProtKB/TrEMBL
  ENSRNOT00000117665 ENTREZGENE
  ENSRNOT00000117665.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
  L1 transposable element, trimerization domain UniProtKB/TrEMBL
InterPro Znf_C2H2_type UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene 314764 ENTREZGENE
PANTHER EARLY ENDOSOME ANTIGEN 1 UniProtKB/TrEMBL
  EARLY ENDOSOME ANTIGEN 1 UniProtKB/TrEMBL
Pfam FYVE UniProtKB/TrEMBL
PhenoGen Eea1 PhenoGen
PROSITE ZF_FYVE UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021681 RatGTEx
SMART FYVE UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
  Tropomyosin UniProtKB/TrEMBL
UniProt A0A0G2K051 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZV67 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8E0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIH5_RAT UniProtKB/TrEMBL
  A0A8I6AIN6 ENTREZGENE, UniProtKB/TrEMBL
  A6IG51 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Eea1  early endosome antigen 1   Eea1_predicted  early endosome antigen 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Eea1_predicted  early endosome antigen 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED