Npw (neuropeptide W) - Rat Genome Database

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Gene: Npw (neuropeptide W) Rattus norvegicus
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Symbol: Npw
Name: neuropeptide W
RGD ID: 727858
Description: Enables G protein-coupled receptor binding activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in extracellular region. Orthologous to human NPW (neuropeptide W); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC259224; PPL8; prepro-Neuropeptide W polypeptide; preproprotein L8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Foco17
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21013,680,275 - 13,681,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,680,321 - 13,681,586 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,427,057 - 18,428,322 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01017,915,907 - 17,917,172 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01013,415,102 - 13,416,367 (-)NCBIRnor_WKY
Rnor_6.01014,021,187 - 14,022,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,021,187 - 14,022,452 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,838,167 - 13,839,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,908,150 - 13,909,415 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,908,149 - 13,909,415 (-)NCBI
Celera1013,360,353 - 13,361,618 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. Shimomura Y, etal., J Biol Chem 2002 Sep 27;277(39):35826-32. Epub 2002 Jul 18.
Additional References at PubMed
PMID:12401809   PMID:12810535   PMID:12959997   PMID:15345475   PMID:16736466   PMID:17273787   PMID:17868932   PMID:17870191   PMID:17884195   PMID:17959264   PMID:18285680   PMID:19686447  
PMID:19885618   PMID:19948359   PMID:20189998   PMID:20624436   PMID:22484289   PMID:23510017   PMID:24028220   PMID:28249734   PMID:33105700  


Genomics

Comparative Map Data
Npw
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21013,680,275 - 13,681,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,680,321 - 13,681,586 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,427,057 - 18,428,322 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01017,915,907 - 17,917,172 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01013,415,102 - 13,416,367 (-)NCBIRnor_WKY
Rnor_6.01014,021,187 - 14,022,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,021,187 - 14,022,452 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,838,167 - 13,839,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,908,150 - 13,909,415 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,908,149 - 13,909,415 (-)NCBI
Celera1013,360,353 - 13,361,618 (-)NCBICelera
Cytogenetic Map10q12NCBI
NPW
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,019,785 - 2,020,755 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl162,009,926 - 2,020,755 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,069,786 - 2,070,756 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,009,522 - 2,010,757 (+)NCBINCBI36Build 36hg18NCBI36
Celera162,281,696 - 2,282,931 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,993,757 - 1,994,993 (+)NCBIHuRef
CHM1_1162,069,500 - 2,070,735 (+)NCBICHM1_1
T2T-CHM13v2.0162,039,738 - 2,040,709 (+)NCBIT2T-CHM13v2.0
Npw
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,876,303 - 24,877,526 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,876,304 - 24,877,431 (-)EnsemblGRCm39 Ensembl
GRCm381724,657,329 - 24,658,552 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,657,330 - 24,658,457 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,794,275 - 24,795,370 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,384,930 - 24,392,489 (-)NCBIMGSCv36mm8
Celera1725,179,629 - 25,180,733 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
Npw
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,241,231 - 15,242,064 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,241,140 - 15,244,387 (-)NCBIChiLan1.0ChiLan1.0
NPW
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v016682,746 - 684,569 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC100683802
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,919,968 - 38,922,087 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,159,835 - 40,161,835 (-)NCBIDog10K_Boxer_Tasha
Npw
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,690,802 - 104,692,423 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366942,017,040 - 2,019,583 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPW
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,957,042 - 39,957,792 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,957,042 - 39,957,792 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,223,887 - 42,224,637 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPW
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,916,677 - 1,918,468 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606829,147,414 - 29,149,326 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npw
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913226,418 - 227,190 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913226,325 - 227,938 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Npw
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:32
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000016554
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat

Markers in Region
RH138336  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,680,396 - 13,681,189 (+)MAPPERmRatBN7.2
Rnor_6.01014,021,263 - 14,022,055NCBIRnor6.0
Rnor_5.01013,838,243 - 13,839,035UniSTSRnor5.0
RGSC_v3.41013,908,226 - 13,909,018UniSTSRGSC3.4
Celera1013,360,429 - 13,361,221UniSTS
RH 3.4 Map10170.2UniSTS
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11
Low 3 19 20 20 3 20 2 3 12 23 34 2
Below cutoff 23 30 18 10 18 6 6 52 12 7 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016554   ⟹   ENSRNOP00000016554
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,680,321 - 13,681,586 (-)Ensembl
Rnor_6.0 Ensembl1014,021,187 - 14,022,452 (-)Ensembl
RefSeq Acc Id: NM_153294   ⟹   NP_695206
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21013,680,321 - 13,681,586 (-)NCBI
Rnor_6.01014,021,187 - 14,022,452 (-)NCBI
Rnor_5.01013,838,167 - 13,839,432 (-)NCBI
RGSC_v3.41013,908,150 - 13,909,415 (-)RGD
Celera1013,360,353 - 13,361,618 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085300   ⟹   XP_038941228
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21013,680,275 - 13,681,618 (-)NCBI
Protein Sequences
Protein RefSeqs NP_695206 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941228 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC07174 (Get FASTA)   NCBI Sequence Viewer  
  EDM03853 (Get FASTA)   NCBI Sequence Viewer  
  EDM03854 (Get FASTA)   NCBI Sequence Viewer  
  Q8K1M5 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_695206   ⟸   NM_153294
- Peptide Label: precursor
- UniProtKB: Q8K1M5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016554   ⟸   ENSRNOT00000016554
RefSeq Acc Id: XP_038941228   ⟸   XM_039085300
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K1M5-F1-model_v2 AlphaFold Q8K1M5 1-185 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697019
Promoter ID:EPDNEW_R7544
Type:single initiation site
Name:Npw_1
Description:neuropeptide W
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,022,422 - 14,022,482EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727858 AgrOrtholog
BioCyc Gene G2FUF-25840 BioCyc
Ensembl Genes ENSRNOG00000012390 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000016554 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016554 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Neuropept_BW_pre UniProtKB/Swiss-Prot
  Neuropept_W_pre UniProtKB/Swiss-Prot
KEGG Report rno:259224 UniProtKB/Swiss-Prot
NCBI Gene 259224 ENTREZGENE
PANTHER PTHR28553 UniProtKB/Swiss-Prot
Pfam NPBW UniProtKB/Swiss-Prot
PhenoGen Npw PhenoGen
PRINTS NROPEPTIDEBW UniProtKB/Swiss-Prot
  PPNRPEPTIDEW UniProtKB/Swiss-Prot
UniProt NPW_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Npw  neuropeptide W  LOC259224  prepro-Neuropeptide W polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 LOC259224        Symbol and Name status set to provisional 70820 PROVISIONAL