Dgka (diacylglycerol kinase, alpha) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Dgka (diacylglycerol kinase, alpha) Rattus norvegicus
Analyze
Symbol: Dgka
Name: diacylglycerol kinase, alpha
RGD ID: 70904
Description: Predicted to enable ATP-dependent diacylglycerol kinase activity and phospholipid binding activity. Predicted to be involved in glycerolipid metabolic process; intracellular signal transduction; and lipid phosphorylation. Located in cytosol. Orthologous to human DGKA (diacylglycerol kinase alpha); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 80 kDa diacylglycerol kinase; DAG kinase alpha; Dagk1; DGK-alpha; diacylglycerol kinase alpha; diacylglycerol kinase alpha (80kD); diacylglycerol kinase, alpha (80 kDa); diglyceride kinase alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,733,247 - 1,761,181 (-)NCBIGRCr8
mRatBN7.271,148,734 - 1,175,324 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,148,735 - 1,175,110 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,911,780 - 3,938,121 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,787,449 - 5,813,789 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,084,371 - 6,110,717 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,143,826 - 3,170,764 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,143,827 - 3,170,146 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,116,474 - 3,142,227 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,018,858 - 2,045,336 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.172,018,858 - 2,045,336 (-)NCBI
Celera71,019,006 - 1,045,924 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
Bisphenol B  (ISO)
bisphenol F  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
D-mannitol  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
Diisodecyl phthalate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
gentamycin  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ketoconazole  (EXP)
lead diacetate  (EXP)
metformin  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
tungsten  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IDA,IEA,ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases. Gellett AM, etal., Biochem Biophys Res Commun. 2012 Jun 15;422(4):758-63. doi: 10.1016/j.bbrc.2012.05.077. Epub 2012 May 22.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Gene cloning, sequence, expression and in situ localization of 80 kDa diacylglycerol kinase specific to oligodendrocyte of rat brain. Goto K, etal., Brain Res Mol Brain Res 1992 Nov;16(1-2):75-87.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2175712   PMID:12832407   PMID:15544348   PMID:18004883   PMID:19946888   PMID:23467923   PMID:23949095   PMID:34312706  


Genomics

Comparative Map Data
Dgka
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,733,247 - 1,761,181 (-)NCBIGRCr8
mRatBN7.271,148,734 - 1,175,324 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,148,735 - 1,175,110 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,911,780 - 3,938,121 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,787,449 - 5,813,789 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,084,371 - 6,110,717 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,143,826 - 3,170,764 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,143,827 - 3,170,146 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,116,474 - 3,142,227 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,018,858 - 2,045,336 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.172,018,858 - 2,045,336 (-)NCBI
Celera71,019,006 - 1,045,924 (-)NCBICelera
Cytogenetic Map7q11NCBI
DGKA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,927,316 - 55,954,023 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,927,319 - 55,954,027 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,321,100 - 56,347,807 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,611,213 - 54,634,074 (+)NCBINCBI36Build 36hg18NCBI36
Build 341254,612,078 - 54,634,072NCBI
Celera1255,977,545 - 56,000,461 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,363,942 - 53,386,835 (+)NCBIHuRef
CHM1_11256,292,082 - 56,314,941 (+)NCBICHM1_1
T2T-CHM13v2.01255,894,378 - 55,921,085 (+)NCBIT2T-CHM13v2.0
Dgka
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,556,000 - 128,581,002 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,556,003 - 128,580,724 (-)EnsemblGRCm39 Ensembl
GRCm3810128,720,131 - 128,745,084 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,720,134 - 128,744,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,157,190 - 128,181,112 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610128,123,083 - 128,147,005 (-)NCBIMGSCv36mm8
Celera10131,112,292 - 131,136,154 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.14NCBI
Dgka
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,524,542 - 3,544,374 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,517,519 - 3,544,651 (+)NCBIChiLan1.0ChiLan1.0
DGKA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,374,964 - 38,397,829 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,371,661 - 38,394,595 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,958,287 - 32,981,164 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,207,692 - 33,707,346 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,207,947 - 33,701,912 (-)Ensemblpanpan1.1panPan2
DGKA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110269,819 - 292,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10270,998 - 292,352 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10332,016 - 354,466 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010276,898 - 299,341 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10276,785 - 304,392 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110254,787 - 277,147 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010497,503 - 519,931 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010621,826 - 644,195 (+)NCBIUU_Cfam_GSD_1.0
Dgka
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,502,250 - 58,519,709 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646351,414 - 369,971 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646351,589 - 367,985 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DGKA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,331,473 - 21,355,534 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,331,473 - 21,355,614 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2522,811,847 - 22,835,786 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DGKA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11151,871,566 - 51,901,593 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1151,871,563 - 51,892,637 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037194,095,095 - 194,118,282 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dgka
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480212,093,196 - 12,110,227 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480212,092,949 - 12,115,472 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dgka
122 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000036373
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
D7Mgh11  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr871,740,957 - 1,741,094 (+)Marker Load Pipeline
mRatBN7.271,156,446 - 1,156,583 (+)MAPPERmRatBN7.2
Rnor_6.073,151,537 - 3,151,673NCBIRnor6.0
Rnor_5.073,124,185 - 3,124,321UniSTSRnor5.0
RGSC_v3.472,026,568 - 2,026,705RGDRGSC3.4
RGSC_v3.472,026,569 - 2,026,705UniSTSRGSC3.4
RGSC_v3.1289,737,808 - 89,738,090RGD
Celera71,026,718 - 1,026,854UniSTS
Cytogenetic Map7q11UniSTS
RH127677  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,148,886 - 1,149,093 (+)MAPPERmRatBN7.2
Rnor_6.073,143,979 - 3,144,185NCBIRnor6.0
Rnor_5.073,116,627 - 3,116,833UniSTSRnor5.0
RGSC_v3.472,019,011 - 2,019,217UniSTSRGSC3.4
Celera71,019,159 - 1,019,365UniSTS
Cytogenetic Map7q11UniSTS
RH131702  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,176,405 - 1,176,587 (+)MAPPERmRatBN7.2
Rnor_6.073,171,492 - 3,171,673NCBIRnor6.0
Rnor_5.073,143,573 - 3,143,754UniSTSRnor5.0
RGSC_v3.472,046,682 - 2,046,863UniSTSRGSC3.4
Celera71,047,269 - 1,047,450UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S49760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000036373   ⟹   ENSRNOP00000038628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl71,148,750 - 1,175,110 (-)Ensembl
Rnor_6.0 Ensembl73,143,827 - 3,170,146 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102609   ⟹   ENSRNOP00000080029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl71,148,735 - 1,167,877 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103403   ⟹   ENSRNOP00000076755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl71,148,739 - 1,174,844 (-)Ensembl
RefSeq Acc Id: NM_080787   ⟹   NP_542965
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,733,247 - 1,759,569 (-)NCBI
mRatBN7.271,148,734 - 1,175,060 (-)NCBI
Rnor_6.073,143,826 - 3,170,146 (-)NCBI
Rnor_5.073,116,474 - 3,142,227 (-)NCBI
RGSC_v3.472,018,858 - 2,045,336 (-)RGD
Celera71,019,006 - 1,045,924 (-)RGD
Sequence:
RefSeq Acc Id: XM_008765012   ⟹   XP_008763234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,733,247 - 1,753,519 (-)NCBI
mRatBN7.271,148,734 - 1,168,797 (-)NCBI
Rnor_6.073,143,913 - 3,164,125 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765013   ⟹   XP_008763235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,733,247 - 1,753,519 (-)NCBI
mRatBN7.271,148,819 - 1,168,797 (-)NCBI
Rnor_6.073,143,828 - 3,164,124 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765014   ⟹   XP_008763236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,733,247 - 1,753,519 (-)NCBI
mRatBN7.271,148,737 - 1,168,797 (-)NCBI
Rnor_6.073,143,913 - 3,164,124 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765015   ⟹   XP_008763237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,733,247 - 1,761,181 (-)NCBI
mRatBN7.271,148,734 - 1,175,324 (-)NCBI
Rnor_6.073,143,913 - 3,170,764 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765017   ⟹   XP_008763239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,733,247 - 1,753,519 (-)NCBI
mRatBN7.271,148,737 - 1,168,797 (-)NCBI
Rnor_6.073,143,913 - 3,164,124 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765018   ⟹   XP_008763240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,733,247 - 1,753,519 (-)NCBI
mRatBN7.271,148,821 - 1,168,797 (-)NCBI
Rnor_6.073,143,913 - 3,164,124 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765019   ⟹   XP_008763241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,733,247 - 1,753,519 (-)NCBI
mRatBN7.271,148,819 - 1,168,797 (-)NCBI
Rnor_6.073,143,828 - 3,164,122 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765020   ⟹   XP_008763242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,733,247 - 1,759,300 (-)NCBI
mRatBN7.271,148,821 - 1,175,312 (-)NCBI
Rnor_6.073,143,828 - 3,170,763 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594633   ⟹   XP_017450122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,733,247 - 1,753,519 (-)NCBI
mRatBN7.271,148,734 - 1,168,797 (-)NCBI
Rnor_6.073,143,913 - 3,162,921 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078319   ⟹   XP_038934247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,736,517 - 1,753,519 (-)NCBI
mRatBN7.271,154,238 - 1,168,797 (-)NCBI
RefSeq Acc Id: XM_039078320   ⟹   XP_038934248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,733,247 - 1,748,591 (-)NCBI
mRatBN7.271,148,737 - 1,164,083 (-)NCBI
RefSeq Acc Id: XM_063262930   ⟹   XP_063119000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,733,247 - 1,753,519 (-)NCBI
RefSeq Acc Id: XM_063262932   ⟹   XP_063119002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,733,247 - 1,753,519 (-)NCBI
RefSeq Acc Id: XM_063262933   ⟹   XP_063119003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,734,353 - 1,753,519 (-)NCBI
RefSeq Acc Id: XR_005486541
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,744,462 - 1,753,519 (-)NCBI
mRatBN7.271,159,943 - 1,168,797 (-)NCBI
RefSeq Acc Id: NP_542965   ⟸   NM_080787
- UniProtKB: P51556 (UniProtKB/Swiss-Prot),   A0A8I5ZK54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763242   ⟸   XM_008765020
- Peptide Label: isoform X11
- UniProtKB: A0A8L2QJB9 (UniProtKB/TrEMBL),   A0A8I5ZK54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763235   ⟸   XM_008765013
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008763241   ⟸   XM_008765019
- Peptide Label: isoform X8
- UniProtKB: A0A8I6G415 (UniProtKB/TrEMBL),   A0A8I5ZK54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763237   ⟸   XM_008765015
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZK54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763240   ⟸   XM_008765018
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZK54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763236   ⟸   XM_008765014
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008763239   ⟸   XM_008765017
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZK54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763234   ⟸   XM_008765012
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017450122   ⟸   XM_017594633
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZK54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038628   ⟸   ENSRNOT00000036373
RefSeq Acc Id: XP_038934248   ⟸   XM_039078320
- Peptide Label: isoform X13
- UniProtKB: A6KSH7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934247   ⟸   XM_039078319
- Peptide Label: isoform X12
Ensembl Acc Id: ENSRNOP00000080029   ⟸   ENSRNOT00000102609
Ensembl Acc Id: ENSRNOP00000076755   ⟸   ENSRNOT00000103403
RefSeq Acc Id: XP_063119002   ⟸   XM_063262932
- Peptide Label: isoform X9
- UniProtKB: P51556 (UniProtKB/Swiss-Prot),   A0A8I5ZK54 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119000   ⟸   XM_063262930
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZK54 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119003   ⟸   XM_063262933
- Peptide Label: isoform X10
- UniProtKB: A0A8I5ZK54 (UniProtKB/TrEMBL)
Protein Domains
DAGKc   EF-hand   Phorbol-ester/DAG-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51556-F1-model_v2 AlphaFold P51556 1-727 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694949
Promoter ID:EPDNEW_R5474
Type:multiple initiation site
Name:Dgka_1
Description:diacylglycerol kinase, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.073,169,949 - 3,170,009EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70904 AgrOrtholog
BioCyc Gene G2FUF-35335 BioCyc
Ensembl Genes ENSRNOG00000022943 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055014353 UniProtKB/Swiss-Prot
  ENSRNOG00060027146 UniProtKB/Swiss-Prot
  ENSRNOG00065012992 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000036373.6 UniProtKB/TrEMBL
  ENSRNOT00000102609.1 UniProtKB/TrEMBL
  ENSRNOT00000103403.1 UniProtKB/TrEMBL
  ENSRNOT00055024643 UniProtKB/Swiss-Prot
  ENSRNOT00060047150 UniProtKB/Swiss-Prot
  ENSRNOT00065021274 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.238.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.200.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATP-NAD_kinase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1_DGKalpha_rpt2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG_kinase_typeI_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DGK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DGK_typeI_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Diacylglycerol_kin_accessory UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD/diacylglycerol_kinase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140866 UniProtKB/Swiss-Prot
NCBI Gene 140866 ENTREZGENE
PANTHER DIACYLGLYCEROL KINASE ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11255 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG_kinase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAGK_acc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAGK_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dgka PhenoGen
PROSITE DAGK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022943 RatGTEx
  ENSRNOG00055014353 RatGTEx
  ENSRNOG00060027146 RatGTEx
  ENSRNOG00065012992 RatGTEx
SMART DAGKa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAGKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZK54 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G415 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QJB9 ENTREZGENE, UniProtKB/TrEMBL
  A6KSH7 ENTREZGENE, UniProtKB/TrEMBL
  DGKA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Dgka  diacylglycerol kinase, alpha    diacylglycerol kinase, alpha (80 kDa)  Name updated 1299863 APPROVED
2002-07-09 Dgka  diacylglycerol kinase, alpha (80 kDa)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains zinc finger-like sequences, E-F hand motifs, and ATP-binding sites 70714