Acadm (acyl-CoA dehydrogenase medium chain) - Rat Genome Database

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Gene: Acadm (acyl-CoA dehydrogenase medium chain) Rattus norvegicus
Symbol: Acadm
Name: acyl-CoA dehydrogenase medium chain
RGD ID: 2012
Description: Enables several functions, including acyl-CoA dehydrogenase activity; identical protein binding activity; and nucleotide binding activity. Involved in several processes, including fatty acid catabolic process; response to copper ion; and response to glucocorticoid. Located in mitochondrial matrix and mitochondrial membrane. Biomarker of metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain); PARTICIPATES IN fatty acid beta degradation pathway; 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; INTERACTS WITH (+)-schisandrin B; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acetyl-Coenzyme A dehydrogenase, medium chain; acyl-CoA dehydrogenase, C-4 to C-12 straight chain; Acyl-Coenzyme A dehydrogenase C-4 to C-12 straight-chain; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain; Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight-chain; acyl-Coenzyme A dehydrogenase, medium chain; MCAD; MCAD, medium chain acyl-CoA dehydrogenase; medium-chain acyl-CoA dehydrogenase; medium-chain specific acyl-CoA dehydrogenase, mitochondrial
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82245,518,693 - 245,542,864 (-)NCBIGRCr8
mRatBN7.22242,858,865 - 242,883,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2242,858,865 - 242,883,147 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2250,681,651 - 250,705,889 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02248,575,474 - 248,599,714 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02243,474,041 - 243,498,277 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02260,124,418 - 260,148,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2260,124,418 - 260,148,589 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02278,788,485 - 278,812,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42251,866,645 - 251,890,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12251,881,251 - 251,905,336 (-)NCBI
Celera2234,791,302 - 234,815,446 (-)NCBICelera
RH 3.4 Map21631.1RGD
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
AICA ribonucleotide  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-hexachlorocyclohexane  (ISO)
bexarotene  (EXP)
bezafibrate  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroform  (EXP)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clenbuterol  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
Clofop  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dioscin  (EXP,ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
etoposide  (ISO)
farnesol  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
fructose  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 7647  (EXP,ISO)
hexadecanoic acid  (EXP)
homocysteine  (ISO)
indometacin  (EXP)
inulin  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
linoleic acid  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
melatonin  (EXP,ISO)
meldonium  (ISO)
methotrexate  (ISO)
microcystin-LR  (ISO)
miquelianin  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
NMN zwitterion  (ISO)
oleic acid  (EXP,ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phlorizin  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
quinidine  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
streptozocin  (EXP)
sucrose  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tectoridin  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA,ISO)
cytoplasm  (IBA)
mitochondrial matrix  (IDA,IEA,ISO)
mitochondrial membrane  (IDA,IEA,ISO)
mitochondrion  (IBA,ISO)

Molecular Function


References - curated
# Reference Title Reference Citation
1. Transcriptional regulation by glucocorticoids of mitochondrial oxidative enzyme genes in the developing rat kidney. Djouadi F, etal., Biochem J. 1996 Apr 15;315 ( Pt 2):555-62.
2. Tissue-specific regulation of medium-chain acyl-CoA dehydrogenase gene by thyroid hormones in the developing rat. Djouadi F, etal., Biochem J. 1997 May 15;324 ( Pt 1):289-94.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Acyl-CoA dehydrogenases. A mechanistic overview. Ghisla S and Thorpe C, Eur J Biochem. 2004 Feb;271(3):494-508.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Biosynthesis of four rat liver mitochondrial acyl-CoA dehydrogenases: in vitro synthesis, import into mitochondria, and processing of their precursors in a cell-free system and in cultured cells. Ikeda Y, etal., Arch Biochem Biophys. 1987 Feb 1;252(2):662-74.
7. Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme. Ikeda Y, etal., J Biol Chem. 1985 Jan 25;260(2):1311-25.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Selenium significantly inhibits adipocyte hypertrophy and abdominal fat accumulation in OLETF rats via induction of fatty acid beta-oxidation. Kim JE, etal., Biol Trace Elem Res. 2012 Dec;150(1-3):360-70. doi: 10.1007/s12011-012-9519-1. Epub 2012 Oct 18.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
12. Mitochondrial transcription factor A is increased but expression of ATP synthase beta subunit and medium-chain acyl-CoA dehydrogenase genes are decreased in hearts of copper-deficient rats. Mao S, etal., J Nutr. 2000 Sep;130(9):2143-50.
13. Molecular cloning and nucleotide sequence of cDNA encoding the entire precursor of rat liver medium chain acyl coenzyme A dehydrogenase. Matsubara Y, etal., J Biol Chem 1987 Jul 25;262(21):10104-8.
14. Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzyme A, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase family. Matsubara Y, etal., J Biol Chem 1989 Sep 25;264(27):16321-31.
15. A skeletal growth defect in the puma (Felis concolor). McMullin PF Vet Rec 1978 Oct 14;103(16):356-8.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Supplementation with alpha-linolenic acid-rich diacylglycerol suppresses fatty liver formation accompanied by an up-regulation of beta-oxidation in Zucker fatty rats. Murase T, etal., Biochim Biophys Acta. 2005 Apr 15;1733(2-3):224-31. Epub 2005 Jan 13.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Mechanisms of ketamine action on lipid metabolism in rats. Saranteas T, etal., Eur J Anaesthesiol. 2005 Mar;22(3):222-6.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Cloning of a cDNA for short/branched chain acyl-Coenzyme A dehydrogenase from rat and characterization of its tissue expression and substrate specificity. Willard J, etal., Arch Biochem Biophys 1996 Jul 1;331(1):127-33.
30. Intrinsic isomerase activity of medium-chain acyl-CoA dehydrogenase. Zeng J and Li D, Biochemistry. 2005 May 3;44(17):6715-22.
31. Expression and purification of His-tagged rat mitochondrial medium-chain acyl-CoA dehydrogenase wild-type and Arg256 mutant proteins. Zeng J and Li D, Protein Expr Purif 2004 Oct;37(2):472-8.
Additional References at PubMed
PMID:1902818   PMID:1970566   PMID:2029527   PMID:2393404   PMID:3597357   PMID:14651853   PMID:16020546   PMID:16121256   PMID:16972171   PMID:18061544   PMID:18459129   PMID:18614015  
PMID:19224950   PMID:19428797   PMID:19703432   PMID:21084676   PMID:21237683   PMID:21630459   PMID:23376485   PMID:25416781   PMID:26316108   PMID:26767982   PMID:32227582  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82245,518,693 - 245,542,864 (-)NCBIGRCr8
mRatBN7.22242,858,865 - 242,883,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2242,858,865 - 242,883,147 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2250,681,651 - 250,705,889 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02248,575,474 - 248,599,714 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02243,474,041 - 243,498,277 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02260,124,418 - 260,148,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2260,124,418 - 260,148,589 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02278,788,485 - 278,812,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42251,866,645 - 251,890,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12251,881,251 - 251,905,336 (-)NCBI
Celera2234,791,302 - 234,815,446 (-)NCBICelera
RH 3.4 Map21631.1RGD
Cytogenetic Map2q45NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38175,724,709 - 75,763,679 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,724,431 - 75,787,575 (+)EnsemblGRCh38hg38GRCh38
GRCh37176,190,394 - 76,229,364 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36175,962,870 - 76,001,771 (+)NCBINCBI36Build 36hg18NCBI36
Build 34175,902,302 - 75,941,204NCBI
Celera174,429,931 - 74,469,272 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef174,319,974 - 74,359,196 (+)NCBIHuRef
CHM1_1176,305,398 - 76,344,690 (+)NCBICHM1_1
T2T-CHM13v2.0175,561,369 - 75,600,339 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm393153,627,990 - 153,650,280 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3153,627,994 - 153,650,269 (-)EnsemblGRCm39 Ensembl
GRCm383153,922,353 - 153,944,643 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3153,922,357 - 153,944,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv373153,585,323 - 153,607,396 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363153,859,745 - 153,881,818 (-)NCBIMGSCv36mm8
Celera3160,386,018 - 160,408,092 (-)NCBICelera
Cytogenetic Map3H3NCBI
cM Map378.77NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542317,172,779 - 17,199,090 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542317,173,648 - 17,199,189 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21151,129,587 - 151,168,926 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11150,290,108 - 150,329,365 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,939,477 - 74,978,815 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1176,911,763 - 76,950,840 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl176,911,763 - 76,950,840 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1670,852,223 - 70,881,979 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl670,853,061 - 70,878,668 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha673,516,991 - 73,547,426 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0671,444,858 - 71,475,297 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl671,444,855 - 71,475,372 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1670,941,180 - 70,971,613 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0670,886,684 - 70,917,117 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0671,380,006 - 71,410,441 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505887,250,876 - 87,286,693 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365712,761,254 - 2,797,045 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl6137,541,381 - 137,595,108 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16137,541,481 - 137,575,544 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26127,513,877 - 127,547,942 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12057,428,863 - 57,468,422 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2057,428,472 - 57,468,359 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603360,040,155 - 60,081,642 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462474221,188,062 - 21,215,436 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Acadm
88 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:240
Count of miRNA genes:156
Interacting mature miRNAs:178
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22242,859,103 - 242,859,280 (+)MAPPERmRatBN7.2
Rnor_6.02260,124,657 - 260,124,833NCBIRnor6.0
Rnor_5.02278,788,724 - 278,788,900UniSTSRnor5.0
RGSC_v3.42251,866,882 - 251,867,058UniSTSRGSC3.4
Celera2234,791,541 - 234,791,717UniSTS
RH 3.4 Map21631.1UniSTS
Cytogenetic Map2q45UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22242,861,648 - 242,861,836 (+)MAPPERmRatBN7.2
Rnor_6.02260,127,202 - 260,127,389NCBIRnor6.0
Rnor_5.02278,791,269 - 278,791,456UniSTSRnor5.0
RGSC_v3.42251,869,427 - 251,869,614UniSTSRGSC3.4
Celera2234,794,086 - 234,794,273UniSTS
Cytogenetic Map2q45UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22242,879,862 - 242,880,059 (+)MAPPERmRatBN7.2
Rnor_6.02260,145,416 - 260,145,612NCBIRnor6.0
Rnor_5.02278,809,483 - 278,809,679UniSTSRnor5.0
RGSC_v3.42251,887,641 - 251,887,837UniSTSRGSC3.4
Celera2234,812,273 - 234,812,469UniSTS
RH 3.4 Map21639.8UniSTS
Cytogenetic Map2q45UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22242,874,262 - 242,874,390 (+)MAPPERmRatBN7.2
Rnor_6.02260,139,816 - 260,139,943NCBIRnor6.0
Rnor_5.02278,803,883 - 278,804,010UniSTSRnor5.0
RGSC_v3.42251,882,041 - 251,882,168UniSTSRGSC3.4
Celera2234,806,696 - 234,806,823UniSTS
RH 3.4 Map21630.2UniSTS
Cytogenetic Map2q45UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 35 11 8
Low 6
Below cutoff


RefSeq Acc Id: ENSRNOT00000013238   ⟹   ENSRNOP00000013238
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2242,858,869 - 242,883,147 (-)Ensembl
Rnor_6.0 Ensembl2260,124,418 - 260,148,589 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114224   ⟹   ENSRNOP00000079047
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2242,858,865 - 242,880,647 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116479   ⟹   ENSRNOP00000078034
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2242,858,865 - 242,880,770 (-)Ensembl
RefSeq Acc Id: NM_016986   ⟹   NP_058682
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr82245,518,693 - 245,542,864 (-)NCBI
mRatBN7.22242,858,865 - 242,883,036 (-)NCBI
Rnor_6.02260,124,418 - 260,148,589 (-)NCBI
Rnor_5.02278,788,485 - 278,812,656 (-)NCBI
RGSC_v3.42251,866,645 - 251,890,729 (-)RGD
Celera2234,791,302 - 234,815,446 (-)NCBI
Protein Sequences
Protein RefSeqs NP_058682 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40670 (Get FASTA)   NCBI Sequence Viewer  
  EDL82532 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013238
GenBank Protein P08503 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058682   ⟸   NM_016986
- Peptide Label: precursor
- UniProtKB: P08503 (UniProtKB/Swiss-Prot),   G3V796 (UniProtKB/TrEMBL),   A6HWP6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013238   ⟸   ENSRNOT00000013238
RefSeq Acc Id: ENSRNOP00000078034   ⟸   ENSRNOT00000116479
RefSeq Acc Id: ENSRNOP00000079047   ⟸   ENSRNOT00000114224
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08503-F1-model_v2 AlphaFold P08503 1-421 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691832
Promoter ID:EPDNEW_R2356
Type:initiation region
Description:acyl-CoA dehydrogenase medium chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.02260,148,504 - 260,148,564EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2012 AgrOrtholog
BioCyc Gene G2FUF-50767 BioCyc
Ensembl Genes ENSRNOG00000009845 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055028387 UniProtKB/Swiss-Prot
  ENSRNOG00060001604 UniProtKB/Swiss-Prot
  ENSRNOG00065012684 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013238 ENTREZGENE
  ENSRNOT00000013238.4 UniProtKB/TrEMBL
  ENSRNOT00000114224.1 UniProtKB/TrEMBL
  ENSRNOT00000116479.1 UniProtKB/TrEMBL
  ENSRNOT00055049201 UniProtKB/Swiss-Prot
  ENSRNOT00060002450 UniProtKB/Swiss-Prot
  ENSRNOT00065020681 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.540.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyryl-CoA Dehydrogenase, subunit A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Acyl-CoA_DH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_cen-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_mid-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCo_DH-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCo_DH/oxidase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/ox_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/ox_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/oxidase_NM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24158 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Acyl-CoA_dh_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_dh_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_dh_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acadm PhenoGen
  ACYL_COA_DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009845 RatGTEx
  ENSRNOG00055028387 RatGTEx
  ENSRNOG00060001604 RatGTEx
  ENSRNOG00065012684 RatGTEx
Superfamily-SCOP SSF47203 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56645 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216640
UniProt A0A8I5Y8D9_RAT UniProtKB/TrEMBL
  ACADM_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-09 Acadm  acyl-CoA dehydrogenase medium chain  Acadm  acyl-CoA dehydrogenase, C-4 to C-12 straight chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-28 Acadm  acyl-CoA dehydrogenase, C-4 to C-12 straight chain  Acadm  acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Acadm  acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain  Acadm  acyl-Coenzyme A dehydrogenase, medium chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-14 Acadm  acyl-Coenzyme A dehydrogenase, medium chain  Acadm  acetyl-Coenzyme A dehydrogenase, medium chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Acadm  acetyl-coenzyme A dehydrogenase, medium chain    Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight-chain  Name updated 625702 APPROVED
2002-06-10 Acadm  Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight-chain      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 631724
gene_function catalyzes the alpha,beta-dehydrogenation of acyl-CoA esters 631739
gene_homology has high similarity to acyl-CoA dehydrogenase family members short chain acyl-CoA (SCAD), long chain acyl-CoA dehydrogenase (LCAD), and isovaleryl-CoA dehydrogenase (IVD) 631718
gene_process plays a role in fatty acid metabolism 631739
gene_product member of the acyl-CoA dehydrogenase family 631724