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Gene: Mdh1 (malate dehydrogenase 1) Rattus norvegicus
Symbol: Mdh1
Name: malate dehydrogenase 1
RGD ID: 3072
Description: Exhibits L-malate dehydrogenase activity and NAD binding activity. Involved in NAD metabolic process; NADH metabolic process; and dicarboxylic acid metabolic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy. Orthologous to human MDH1 (malate dehydrogenase 1); PARTICIPATES IN Leigh disease pathway; nicotinamide adenine dinucleotide metabolic pathway; primary hyperoxaluria type 2 pathway; INTERACTS WITH 1-benzylpiperazine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cytosolic malate dehydrogenase; malate dehydrogenase 1, NAD (soluble); malate dehydrogenase soluble; malate dehydrogenase, cytoplasmic; malate dehydrogenase, peroxisomal; malate dehydrogenase, soluble; Malate dehydrogenase-like enzyme; Mdhl; MDL1; Mor2
Homo sapiens (human) : MDH1 (malate dehydrogenase 1)  HGNC  Alliance
Mus musculus (house mouse) : Mdh1 (malate dehydrogenase 1, NAD (soluble))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mdh1 (malate dehydrogenase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MDH1 (malate dehydrogenase 1)
Canis lupus familiaris (dog) : MDH1 (malate dehydrogenase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mdh1 (malate dehydrogenase 1)
Sus scrofa (pig) : MDH1 (malate dehydrogenase 1)
Chlorocebus sabaeus (African green monkey) : MDH1 (malate dehydrogenase 1)
Heterocephalus glaber (naked mole-rat) : Mdh1 (malate dehydrogenase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.014106,378,349 - 106,393,642 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14106,378,942 - 106,393,670 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014106,449,337 - 106,463,995 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414102,259,130 - 102,273,788 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.114102,278,343 - 102,292,999 (-)NCBI
Celera1494,639,971 - 94,655,156 (-)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Mdh1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3072
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.