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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:econazole
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Accession:CHEBI:4754 term browser browse the term
Definition:A racemate composed of equimolar amounts of (R)- and (S)-econazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections.
Synonyms:exact_synonym: rac-1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
 related_synonym: (RS)-econazole;   1-(2,4-Dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole;   Formula=C18H15Cl3N2O;   rac-econazole
 xref: CAS:27220-47-9;   DrugBank:DB01127;   HMDB:HMDB0015259;   KEGG:C08068;   KEGG:D03936
 xref_mesh: MESH:D004464
 xref: PMID:11065186;   PMID:15094063;   PMID:24374794;   PMID:24530389;   Reaxys:964150;   Wikipedia:Econazole



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econazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy9 adenylate cyclase 9 increases activity ISO Econazole results in increased activity of ADCY9 protein CTD PMID:30607468 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
decreases activity
ISO Econazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; Econazole promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]
Econazole results in increased expression of CYP3A4 mRNA
Econazole results in decreased activity of CYP3A4 protein
CTD PMID:15135088 PMID:17998298 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases response to substance ISO CYP51A1 gene results in decreased susceptibility to Econazole CTD PMID:18694951 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Econazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 multiple interactions
decreases activity
ISO [Econazole results in decreased activity of KCNA3 protein] which results in decreased import of Thallium CTD PMID:21362439 NCBI chr 2:194,632,360...194,633,937
Ensembl chr 2:194,632,196...194,650,138
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
ISO Econazole results in decreased activity of KCNH2 protein
[Econazole results in decreased activity of KCNH2 protein] which results in decreased import of Thallium
CTD PMID:21362439 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Econazole promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:17998298 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Econazole binds to and results in increased activity of NR1I2 protein; Econazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Econazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA] CTD PMID:17998298 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO [tebuconazole co-treated with Econazole] results in increased phosphorylation of PRKAA1 protein CTD PMID:30698772 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO [tebuconazole co-treated with Econazole] results in increased phosphorylation of PRKAA2 protein CTD PMID:30698772 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Econazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions ISO [Econazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium] CTD PMID:22036725 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions ISO [tebuconazole co-treated with Econazole] results in increased phosphorylation of ULK1 protein; dorsomorphin inhibits the reaction [[tebuconazole co-treated with Econazole] results in increased phosphorylation of ULK1 protein] CTD PMID:30698772 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      chemical substance 13190
        mixture 12396
          racemate 10478
            econazole 13
              econazole nitrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  heteroarene 16542
                                    monocyclic heteroarene 13505
                                      azole 12710
                                        diazole 8598
                                          imidazoles 7695
                                            1-\{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl\}imidazole 13
                                              (S)-econazole 13
                                                econazole 13
                                                  econazole nitrate 0
paths to the root