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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:econazole
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Accession:CHEBI:4754 term browser browse the term
Definition:A racemate composed of equimolar amounts of (R)- and (S)-econazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections.
Synonyms:exact_synonym: rac-1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
 related_synonym: (RS)-econazole;   1-(2,4-Dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole;   Formula=C18H15Cl3N2O;   rac-econazole
 xref: CAS:27220-47-9;   DrugBank:DB01127;   HMDB:HMDB0015259;   KEGG:C08068;   KEGG:D03936
 xref_mesh: MESH:D004464
 xref: PMID:11065186;   PMID:15094063;   PMID:24374794;   PMID:24530389;   Reaxys:964150;   Wikipedia:Econazole


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econazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy9 adenylate cyclase 9 increases activity ISO Econazole results in increased activity of ADCY9 protein CTD PMID:30607468 NCBI chr10:11,645,373...11,768,462
Ensembl chr10:11,139,446...11,262,066 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases expression 		ISO Econazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; Econazole promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]
Econazole results in decreased activity of CYP3A4 protein
Econazole results in increased expression of CYP3A4 mRNA 		CTD PMID:15135088 PMID:17998298 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases response to substance ISO CYP51A1 gene results in decreased susceptibility to Econazole CTD PMID:18694951 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Econazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 multiple interactions
decreases activity 		ISO [Econazole results in decreased activity of KCNA3 protein] which results in decreased import of Thallium CTD PMID:21362439 NCBI chr 2:194,632,106...194,634,059
Ensembl chr 2:194,632,196...194,650,138 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions 		ISO Econazole results in decreased activity of KCNH2 protein
[Econazole results in decreased activity of KCNH2 protein] which results in decreased import of Thallium 		CTD PMID:21362439 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Econazole promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:17998298 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Econazole binds to and results in increased activity of NR1I2 protein; Econazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Econazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA] CTD PMID:17998298 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO [tebuconazole co-treated with Econazole] results in increased phosphorylation of PRKAA1 protein CTD PMID:30698772 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO [tebuconazole co-treated with Econazole] results in increased phosphorylation of PRKAA2 protein CTD PMID:30698772 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Econazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions ISO [Econazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium] CTD PMID:22036725 NCBI chr20:10,703,190...10,752,795
Ensembl chr20:10,707,014...10,753,181 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions ISO [tebuconazole co-treated with Econazole] results in increased phosphorylation of ULK1 protein; dorsomorphin inhibits the reaction [[tebuconazole co-treated with Econazole] results in increased phosphorylation of ULK1 protein] CTD PMID:30698772 NCBI chr12:51,511,492...51,537,746
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    chemical entity 20854
      chemical substance 14582
        mixture 13899
          racemate 12288
            econazole 13
              econazole nitrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            organic molecule 20649
                              organic cyclic compound 20400
                                organic heterocyclic compound 19383
                                  heteroarene 17452
                                    monocyclic heteroarene 15191
                                      azole 14622
                                        diazole 10862
                                          imidazoles 10301
                                            1-\{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl\}imidazole 13
                                              (S)-econazole 13
                                                econazole 13
                                                  econazole nitrate 0
paths to the root