Srpk2 (SRSF protein kinase 2) - Rat Genome Database

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Gene: Srpk2 (SRSF protein kinase 2) Rattus norvegicus
Analyze
Symbol: Srpk2
Name: SRSF protein kinase 2
RGD ID: 1305107
Description: Predicted to have several functions, including 14-3-3 protein binding activity; ATP binding activity; and magnesium ion binding activity. Predicted to be involved in several processes, including nuclear speck organization; nucleic acid metabolic process; and regulation of viral genome replication. Predicted to localize to chromatin; cytosol; and nuclear lumen. Orthologous to human SRPK2 (SRSF protein kinase 2); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC296753; serine/arginine-rich protein specific kinase 2; serine/threonine-protein kinase SRPK2; SFRS protein kinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2411,464,684 - 11,655,993 (+)NCBI
Rnor_6.0 Ensembl48,066,737 - 8,185,935 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.047,994,025 - 8,187,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.048,001,928 - 8,193,168 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,918,521 - 7,039,871 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.146,918,542 - 7,039,871 (+)NCBI
Celera47,148,433 - 7,267,472 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9446799   PMID:9472028   PMID:12417631   PMID:12477932   PMID:18559500   PMID:19592491   PMID:19906640   PMID:20498328   PMID:22658674   PMID:22681889   PMID:26167880   PMID:28076779  


Genomics

Comparative Map Data
Srpk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2411,464,684 - 11,655,993 (+)NCBI
Rnor_6.0 Ensembl48,066,737 - 8,185,935 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.047,994,025 - 8,187,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.048,001,928 - 8,193,168 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,918,521 - 7,039,871 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.146,918,542 - 7,039,871 (+)NCBI
Celera47,148,433 - 7,267,472 (+)NCBICelera
Cytogenetic Map4q11NCBI
SRPK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7105,110,704 - 105,399,308 (-)EnsemblGRCh38hg38GRCh38
GRCh387105,110,708 - 105,399,363 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377104,756,821 - 105,029,838 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367104,544,059 - 104,816,577 (-)NCBINCBI36hg18NCBI36
Build 347104,350,774 - 104,623,292NCBI
Celera799,562,462 - 99,834,859 (-)NCBI
Cytogenetic Map7q22.3NCBI
HuRef799,117,123 - 99,299,796 (-)NCBIHuRef
CHM1_17104,690,144 - 104,962,686 (-)NCBICHM1_1
CRA_TCAGchr7v27104,117,494 - 104,389,934 (-)NCBI
Srpk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39523,708,354 - 23,889,639 (-)NCBIGRCm39mm39
GRCm39 Ensembl523,708,262 - 23,889,615 (-)Ensembl
GRCm38523,503,356 - 23,684,642 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl523,503,264 - 23,684,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv37523,009,174 - 23,122,389 (-)NCBIGRCm37mm9NCBIm37
MGSCv36523,015,180 - 23,128,395 (-)NCBImm8
Celera520,441,421 - 20,555,098 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map510.36NCBI
Srpk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554109,811,584 - 9,942,323 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554109,807,936 - 10,034,760 (-)NCBIChiLan1.0ChiLan1.0
SRPK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17109,834,478 - 110,119,558 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7109,834,478 - 109,989,050 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0797,102,226 - 97,378,773 (-)NCBIMhudiblu_PPA_v0panPan3
SRPK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11814,991,187 - 15,243,124 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1814,999,422 - 15,236,393 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1814,642,234 - 14,889,552 (+)NCBI
ROS_Cfam_1.01815,295,582 - 15,546,667 (+)NCBI
UMICH_Zoey_3.11815,079,634 - 15,328,371 (+)NCBI
UNSW_CanFamBas_1.01815,002,645 - 15,251,931 (+)NCBI
UU_Cfam_GSD_1.01815,282,883 - 15,531,664 (+)NCBI
Srpk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511857,405,767 - 57,550,172 (+)NCBI
SpeTri2.0NW_00493647918,541,167 - 18,675,039 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRPK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9105,006,986 - 105,265,595 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19105,009,550 - 105,264,689 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29115,729,526 - 115,831,344 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SRPK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12174,032,668 - 74,312,887 (-)NCBI
ChlSab1.1 Ensembl2174,034,136 - 74,201,243 (-)Ensembl
Vero_WHO_p1.0NW_02366604229,604,750 - 29,946,732 (+)NCBI
Srpk2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473924,127,562 - 24,369,217 (+)NCBI

Position Markers
RH130578  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2411,655,707 - 11,655,889 (+)MAPPER
Rnor_6.048,185,648 - 8,185,829NCBIRnor6.0
Rnor_5.048,191,361 - 8,191,542UniSTSRnor5.0
RGSC_v3.447,039,586 - 7,039,767UniSTSRGSC3.4
Celera47,267,187 - 7,267,368UniSTS
RH 3.4 Map423.1UniSTS
Cytogenetic Map4q11UniSTS
RH129727  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2411,654,861 - 11,655,049 (+)MAPPER
Rnor_6.048,184,802 - 8,184,989NCBIRnor6.0
Rnor_5.048,190,515 - 8,190,702UniSTSRnor5.0
RGSC_v3.447,038,740 - 7,038,927UniSTSRGSC3.4
Celera47,266,341 - 7,266,528UniSTS
RH 3.4 Map414.0UniSTS
Cytogenetic Map4q11UniSTS
BF395851  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2411,570,610 - 11,570,841 (+)MAPPER
Rnor_6.048,099,781 - 8,100,011NCBIRnor6.0
Rnor_5.048,106,574 - 8,106,804UniSTSRnor5.0
RGSC_v3.446,951,744 - 6,951,974UniSTSRGSC3.4
Celera47,182,592 - 7,182,822UniSTS
RH 3.4 Map40.0UniSTS
Cytogenetic Map4q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4125545519Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4125545519Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4125545519Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4126654881Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4126803291Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4128352196Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4128352196Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4128352196Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4128352196Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4129778604Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4129778604Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4131554484Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)4142118977Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4304323179575658Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)43043231145254791Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304401755791834Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304401764915903Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4304411426753655Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304780755324857Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4646769343414792Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4657293937703537Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)4734240492484039Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4805218953052189Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)4805218953052189Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)4805218953052189Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4805218953052189Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4805218953052189Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)4805218953052189Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:105
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000063994
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 36 20 19 20 3 5 74 35 41 11 3
Low 6 21 21 21 5 6 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF102149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000063994   ⟹   ENSRNOP00000059855
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl48,066,737 - 8,185,935 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076429   ⟹   ENSRNOP00000068064
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl48,166,082 - 8,184,587 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080811   ⟹   ENSRNOP00000070149
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl48,066,907 - 8,184,681 (+)Ensembl
RefSeq Acc Id: NM_001106575   ⟹   NP_001100045
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,537,385 - 11,655,993 (+)NCBI
Rnor_6.048,066,737 - 8,185,933 (+)NCBI
Rnor_5.048,001,928 - 8,193,168 (+)NCBI
RGSC_v3.446,918,521 - 7,039,871 (+)RGD
Celera47,148,433 - 7,267,472 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235903   ⟹   XP_006235965
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,538,163 - 11,654,614 (+)NCBI
Rnor_6.048,064,325 - 8,187,455 (+)NCBI
Rnor_5.048,001,928 - 8,193,168 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762635   ⟹   XP_008760857
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.048,064,325 - 8,187,455 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592513   ⟹   XP_017448002
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,464,684 - 11,654,614 (+)NCBI
Rnor_6.047,994,025 - 8,187,455 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592514   ⟹   XP_017448003
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.047,994,025 - 8,187,455 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592515   ⟹   XP_017448004
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.047,994,026 - 8,187,455 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107226   ⟹   XP_038963154
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,475,526 - 11,655,991 (+)NCBI
RefSeq Acc Id: XM_039107227   ⟹   XP_038963155
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,475,258 - 11,655,991 (+)NCBI
RefSeq Acc Id: XM_039107228   ⟹   XP_038963156
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,475,268 - 11,655,991 (+)NCBI
RefSeq Acc Id: XM_039107229   ⟹   XP_038963157
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,475,526 - 11,655,991 (+)NCBI
RefSeq Acc Id: XM_039107230   ⟹   XP_038963158
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,475,938 - 11,654,614 (+)NCBI
RefSeq Acc Id: XM_039107231   ⟹   XP_038963159
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,475,277 - 11,654,614 (+)NCBI
RefSeq Acc Id: XM_039107232   ⟹   XP_038963160
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,464,684 - 11,654,614 (+)NCBI
RefSeq Acc Id: XM_039107233   ⟹   XP_038963161
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,475,282 - 11,655,991 (+)NCBI
RefSeq Acc Id: XM_039107234   ⟹   XP_038963162
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,475,991 - 11,654,614 (+)NCBI
RefSeq Acc Id: XM_039107235   ⟹   XP_038963163
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,553,965 - 11,655,991 (+)NCBI
RefSeq Acc Id: XM_039107236   ⟹   XP_038963164
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,548,844 - 11,655,991 (+)NCBI
RefSeq Acc Id: XM_039107237   ⟹   XP_038963165
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,494,577 - 11,655,991 (+)NCBI
RefSeq Acc Id: XM_039107238   ⟹   XP_038963166
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2411,476,122 - 11,655,991 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001100045   ⟸   NM_001106575
- UniProtKB: B1WBT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235965   ⟸   XM_006235903
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008760857   ⟸   XM_008762635
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017448002   ⟸   XM_017592513
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017448003   ⟸   XM_017592514
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017448004   ⟸   XM_017592515
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000070149   ⟸   ENSRNOT00000080811
RefSeq Acc Id: ENSRNOP00000059855   ⟸   ENSRNOT00000063994
RefSeq Acc Id: ENSRNOP00000068064   ⟸   ENSRNOT00000076429
RefSeq Acc Id: XP_038963160   ⟸   XM_039107232
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038963155   ⟸   XM_039107227
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038963156   ⟸   XM_039107228
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038963159   ⟸   XM_039107231
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038963161   ⟸   XM_039107233
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038963154   ⟸   XM_039107226
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038963157   ⟸   XM_039107229
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038963158   ⟸   XM_039107230
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038963162   ⟸   XM_039107234
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038963166   ⟸   XM_039107238
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038963165   ⟸   XM_039107237
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038963164   ⟸   XM_039107236
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038963163   ⟸   XM_039107235
- Peptide Label: isoform X10
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692800
Promoter ID:EPDNEW_R3324
Type:multiple initiation site
Name:Srpk2_1
Description:SRSF protein kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.048,066,724 - 8,066,784EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 8190154 8190155 C G snv SR/JrHsd (MCW), FHH/EurMcwi (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 7038379 7038380 C G snv SR/JrHsd (MCW), FHH/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305107 AgrOrtholog
Ensembl Genes ENSRNOG00000010601 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059855 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000068064 UniProtKB/TrEMBL
  ENSRNOP00000070149 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000063994 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000076429 UniProtKB/TrEMBL
  ENSRNOT00000080811 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125533 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:296753 UniProtKB/TrEMBL
MGC_CLONE MGC:187443 IMAGE-MGC_LOAD
NCBI Gene 296753 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Srpk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A096MJB4_RAT UniProtKB/TrEMBL
  A0A0G2JX62_RAT UniProtKB/TrEMBL
  B1WBT4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Srpk2  SRSF protein kinase 2  Srpk2  SFRS protein kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-22 Srpk2  SFRS protein kinase 2  Srpk2  Srsf protein kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-13 Srpk2  Srsf protein kinase 2  Srpk2  SFRS protein kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Srpk2  SFRS protein kinase 2  Srpk2  serine/arginine-rich protein specific kinase 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Srpk2  serine/arginine-rich protein specific kinase 2   Srpk2_predicted  serine/arginine-rich protein specific kinase 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Srpk2_predicted  serine/arginine-rich protein specific kinase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED