Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ireb2 (iron responsive element binding protein 2) Rattus norvegicus
Symbol: Ireb2
Name: iron responsive element binding protein 2
Description: Exhibits 4 iron, 4 sulfur cluster binding activity; iron-responsive element binding activity; and regulatory region RNA binding activity. Involved in several processes, including cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; and response to iron ion. Localizes to axon; cytosol; and neuronal cell body. Used to study anemia. Biomarker of anemia; hyperinsulinism; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
Also known as: IRE-BP 2; iron regulatory protein 2; iron-regulatory protein 2; iron-responsive element-binding protein 2; Irp2; MGC93423
Homo sapiens (human) : IREB2 (iron responsive element binding protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Ireb2 (iron responsive element binding protein 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ireb2 (iron responsive element binding protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IREB2 (iron responsive element binding protein 2)
Canis lupus familiaris (dog) : IREB2 (iron responsive element binding protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ireb2 (iron responsive element binding protein 2)
Sus scrofa (pig) : IREB2 (iron responsive element binding protein 2)
Chlorocebus sabaeus (African green monkey) : IREB2 (iron responsive element binding protein 2)
Heterocephalus glaber (naked mole-rat) : Ireb2 (iron responsive element binding protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0859,450,974 - 59,503,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,420,123 - 59,501,118 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,002,720 - 58,085,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,433,218 - 58,477,305 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1858,452,371 - 58,496,928 (+)NCBI
Celera854,752,036 - 54,796,112 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ireb2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621539
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.