Ireb2 (iron responsive element binding protein 2) - Rat Genome Database

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Gene: Ireb2 (iron responsive element binding protein 2) Rattus norvegicus
Symbol: Ireb2
Name: iron responsive element binding protein 2
RGD ID: 621539
Description: Enables 4 iron, 4 sulfur cluster binding activity; iron-responsive element binding activity; and regulatory region RNA binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; response to hypoxia; and response to iron ion. Located in axon and neuronal cell body. Used to study anemia. Biomarker of anemia; hyperinsulinism; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
Previously known as: IRE-BP 2; iron regulatory protein 2; iron-regulatory protein 2; iron-responsive element-binding protein 2; Irp2; MGC93423
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2855,228,080 - 55,311,613 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,228,085 - 55,311,611 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,806,571 - 60,850,679 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0859,085,567 - 59,129,675 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0856,949,805 - 56,993,913 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,450,974 - 59,503,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,420,123 - 59,501,118 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,002,720 - 58,085,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,433,218 - 58,477,305 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1858,452,371 - 58,496,928 (+)NCBI
Celera854,752,036 - 54,796,112 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4-hydroxy-TEMPO  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP)
desferrioxamine B  (EXP,ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
etoposide  (ISO)
ferric ammonium citrate  (EXP,ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (EXP)
graphene oxide  (ISO)
hemin  (EXP)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
L-ascorbic acid  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
methapyrilene  (EXP,ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
miconazole  (ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (ISO)
nefazodone  (EXP)
okadaic acid  (EXP)
oxidopamine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (EXP)
phosphane  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
Ro 41-5253  (EXP)
SB 431542  (ISO)
sunitinib  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichloroethene  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
cytoplasm  (ISO)
cytosol  (IBA,IEA,ISO)
membrane  (IEA)
mitochondrion  (IBA,IEA)
neuronal cell body  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Surgical trauma induces iron accumulation and oxidative stress in a rodent model of postoperative cognitive dysfunction. An LN, etal., Biol Trace Elem Res. 2013 Feb;151(2):277-83. doi: 10.1007/s12011-012-9564-9. Epub 2012 Dec 11.
2. Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1. Beck G, etal., PLoS One. 2015 Oct 27;10(10):e0141629. doi: 10.1371/journal.pone.0141629. eCollection 2015.
3. Long-term aerobic exercise increases redox-active iron through nitric oxide in rat hippocampus. Chen Q and Xiao DS, Nitric Oxide. 2014 Jan 30;36:1-10. doi: 10.1016/j.niox.2013.10.009. Epub 2013 Oct 31.
4. Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease. Coon KD, etal., J Alzheimers Dis. 2006 Aug;9(3):225-33.
5. Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. Crooks DR, etal., J Neurosci Res. 2007 Jun;85(8):1797-809.
6. Hypoxia inducible factor-2 a is translationally repressed in response to dietary iron deficiency in Sprague-Dawley rats. Davis MR, etal., J Nutr. 2011 Sep;141(9):1590-6. doi: 10.3945/jn.111.144105. Epub 2011 Jul 13.
7. Aging-related changes in the iron status of skeletal muscle. DeRuisseau KC, etal., Exp Gerontol. 2013 Nov;48(11):1294-302. doi: 10.1016/j.exger.2013.08.011. Epub 2013 Aug 29.
8. mRNA expression of proteins involved in iron homeostasis in brain regions is altered by age and by iron overloading in the neonatal period. Dornelles AS, etal., Neurochem Res. 2010 Apr;35(4):564-71. Epub 2009 Nov 27.
9. The role of iron in anthracycline cardiotoxicity. Gammella E, etal., Front Pharmacol. 2014 Feb 26;5:25. doi: 10.3389/fphar.2014.00025. eCollection 2014.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice. Ghosh MC, etal., Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12028-33. Epub 2008 Aug 6.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels. Guo B, etal., J Biol Chem 1995 Jul 14;270(28):16529-35.
14. Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity. Guo B, etal., J Biol Chem. 1994 Sep 30;269(39):24252-60.
15. Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome. Guo B, etal., J Biol Chem. 1995 Sep 15;270(37):21645-51.
16. Upregulation of iron regulatory proteins and divalent metal transporter-1 isoforms in the rat hippocampus after kainate induced neuronal injury. Huang E, etal., Exp Brain Res. 2006 Apr;170(3):376-86. Epub 2005 Nov 19.
17. Divergent modulation of iron regulatory proteins and ferritin biosynthesis by hypoxia/reoxygenation in neurones and glial cells. Irace C, etal., J Neurochem. 2005 Dec;95(5):1321-31. Epub 2005 Aug 31.
18. Vitamin A deficiency aggravates iron deficiency by upregulating the expression of iron regulatory protein-2. Jiang S, etal., Nutrition. 2012 Mar;28(3):281-7. doi: 10.1016/j.nut.2011.08.015. Epub 2011 Dec 9.
19. Hyperinsulinemia induces hepatic iron overload by increasing liver TFR1 via the PI3K/IRP2 pathway. Jiang X, etal., J Mol Endocrinol. 2014 Dec;53(3):381-92. doi: 10.1530/JME-14-0122.
20. Temporal responses in the disruption of iron regulation by manganese. Kwik-Uribe C and Smith DR, J Neurosci Res. 2006 Jun;83(8):1601-10.
21. [Effect of all-trans retinoic acid deficiency on iron metabolism in rat primary hepatocyte]. Lan L, etal., Wei Sheng Yan Jiu. 2009 Sep;38(5):603-6.
22. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
23. Hypobaric Hypoxia Regulates Brain Iron Homeostasis in Rats. Li Y, etal., J Cell Biochem. 2017 Jun;118(6):1596-1605. doi: 10.1002/jcb.25822. Epub 2016 Dec 20.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Iron and iron regulatory proteins in amoeboid microglial cells are linked to oligodendrocyte death in hypoxic neonatal rat periventricular white matter through production of proinflammatory cytokines and reactive oxygen/nitrogen species. Rathnasamy G, etal., J Neurosci. 2011 Dec 7;31(49):17982-95.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorption. Schümann K, etal., Eur J Biochem. 1999 Mar;260(2):362-72.
31. Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain. Siddappa AJ, etal., J Neurosci Res. 2002 Jun 15;68(6):761-75.
32. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
33. Thyrotropin-releasing hormone and epidermal growth factor regulate iron-regulatory protein binding in pituitary cells via protein kinase C-dependent and -independent signaling pathways. Thomson AM, etal., J Biol Chem. 2000 Oct 13;275(41):31609-15.
34. Insights into the role of iron in immature rat model of hypoxic-ischemic brain injury. Wang ZW, etal., Exp Ther Med. 2016 Sep;12(3):1723-1731. Epub 2016 Jul 26.
35. [Effects of copper deficiency on iron metabolism in rats]. Xiao F, etal., Wei Sheng Yan Jiu. 2013 Jul;42(4):652-5.
36. Molecular pharmacology of the interaction of anthracyclines with iron. Xu X, etal., Mol Pharmacol. 2005 Aug;68(2):261-71. Epub 2005 May 9.
37. [Effects of different zinc nutritional status on iron metabolism in rats]. Yang L, etal., Wei Sheng Yan Jiu. 2013 Jul;42(4):647-51.
38. Effects of ferrous carbamoyl glycine on iron state and absorption in an iron-deficient rat model. Zhang Y, etal., Genes Nutr. 2015 Nov;10(6):54. doi: 10.1007/s12263-015-0504-0. Epub 2015 Nov 19.
39. [Expression of iron regulatory protein-2 and ferritins in intestinal mucosa of rats with iron deficiency]. Zuo WL, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Jun;16(3):565-8.
Additional References at PubMed
PMID:7983023   PMID:8262972   PMID:11175792   PMID:14726953   PMID:15489334   PMID:15831703   PMID:16144863   PMID:18177727   PMID:18574241   PMID:18614015   PMID:19252502   PMID:21907140  
PMID:23891004   PMID:30915432   PMID:35720183  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2855,228,080 - 55,311,613 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,228,085 - 55,311,611 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,806,571 - 60,850,679 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0859,085,567 - 59,129,675 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0856,949,805 - 56,993,913 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,450,974 - 59,503,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,420,123 - 59,501,118 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,002,720 - 58,085,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,433,218 - 58,477,305 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1858,452,371 - 58,496,928 (+)NCBI
Celera854,752,036 - 54,796,112 (+)NCBICelera
Cytogenetic Map8q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381578,437,431 - 78,501,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,437,431 - 78,501,453 (+)EnsemblGRCh38hg38GRCh38
GRCh371578,729,773 - 78,793,795 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,517,573 - 76,580,853 (+)NCBINCBI36Build 36hg18NCBI36
Build 341576,517,680 - 76,578,522NCBI
Celera1555,667,049 - 55,730,320 (+)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,487,914 - 55,551,183 (+)NCBIHuRef
CHM1_11578,849,070 - 78,912,332 (+)NCBICHM1_1
T2T-CHM13v2.01576,300,098 - 76,364,103 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39954,769,942 - 54,819,812 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,771,073 - 54,819,814 (+)EnsemblGRCm39 Ensembl
GRCm38954,862,658 - 54,912,534 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,863,789 - 54,912,530 (+)EnsemblGRCm38mm10GRCm38
MGSCv37954,711,562 - 54,760,341 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,661,926 - 54,708,169 (+)NCBIMGSCv36mm8
Celera952,108,353 - 52,158,699 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map929.81NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955450852,554 - 900,011 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955450852,554 - 898,908 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11571,817,336 - 71,880,436 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,367,314 - 57,430,322 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,331,610 - 76,394,476 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,331,610 - 76,394,476 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11338,398,445 - 38,441,128 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,400,591 - 38,441,015 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,376,325 - 38,418,383 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,889,612 - 38,931,847 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,889,614 - 38,931,872 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,580,619 - 38,622,667 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,690,365 - 38,732,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,165,328 - 39,207,352 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640118,699,487 - 118,752,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647136,547,500 - 36,600,636 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647136,547,552 - 36,601,327 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl747,478,706 - 47,529,242 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1747,481,539 - 47,529,199 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,974,224 - 53,021,936 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1264,842,328 - 4,905,941 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,842,122 - 4,905,964 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048136,891,175 - 136,954,571 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248942,445,704 - 2,499,009 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248942,446,014 - 2,498,650 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ireb2
539 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:31
Interacting mature miRNAs:37
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300150Cm3Cardiac mass QTL 33.97heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)85423781455523877Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2855,308,838 - 55,309,027 (+)MAPPERmRatBN7.2
Rnor_6.0859,500,860 - 59,501,048NCBIRnor6.0
Rnor_5.0858,083,019 - 58,083,207UniSTSRnor5.0
RGSC_v3.4858,477,047 - 58,477,235UniSTSRGSC3.4
Celera854,795,854 - 54,796,042UniSTS
RH 3.4 Map8611.7UniSTS
Cytogenetic Map8q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2855,274,884 - 55,275,092 (+)MAPPERmRatBN7.2
Rnor_6.0859,466,916 - 59,467,123NCBIRnor6.0
Rnor_5.0858,049,073 - 58,049,280UniSTSRnor5.0
RGSC_v3.4858,443,116 - 58,443,323UniSTSRGSC3.4
Celera854,761,934 - 54,762,141UniSTS
Cytogenetic Map8q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2855,298,815 - 55,299,302 (+)MAPPERmRatBN7.2
Rnor_6.0859,490,846 - 59,491,332NCBIRnor6.0
Rnor_5.0858,073,003 - 58,073,489UniSTSRnor5.0
RGSC_v3.4858,467,033 - 58,467,519UniSTSRGSC3.4
Celera854,785,836 - 54,786,322UniSTS
Cytogenetic Map8q24UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 34 57 41 19 41 6 7 74 35 39 11 6
Low 9 2 4 2 2
Below cutoff


RefSeq Acc Id: ENSRNOT00000017900   ⟹   ENSRNOP00000017900
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl855,264,984 - 55,311,611 (+)Ensembl
Rnor_6.0 Ensembl859,457,018 - 59,501,118 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077922   ⟹   ENSRNOP00000070223
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl855,228,085 - 55,311,611 (+)Ensembl
Rnor_6.0 Ensembl859,420,123 - 59,501,054 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098096   ⟹   ENSRNOP00000084367
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl855,256,704 - 55,311,611 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108716   ⟹   ENSRNOP00000080151
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl855,266,317 - 55,311,611 (+)Ensembl
RefSeq Acc Id: NM_022863   ⟹   NP_074054
Rat AssemblyChrPosition (strand)Source
mRatBN7.2855,264,986 - 55,309,097 (+)NCBI
Rnor_6.0859,457,018 - 59,501,118 (+)NCBI
Rnor_5.0858,002,720 - 58,085,793 (+)NCBI
RGSC_v3.4858,433,218 - 58,477,305 (+)RGD
Celera854,752,036 - 54,796,112 (+)RGD
RefSeq Acc Id: XM_039082090   ⟹   XP_038938018
Rat AssemblyChrPosition (strand)Source
mRatBN7.2855,228,108 - 55,311,613 (+)NCBI
RefSeq Acc Id: XM_039082091   ⟹   XP_038938019
Rat AssemblyChrPosition (strand)Source
mRatBN7.2855,228,104 - 55,311,613 (+)NCBI
RefSeq Acc Id: XM_039082092   ⟹   XP_038938020
Rat AssemblyChrPosition (strand)Source
mRatBN7.2855,228,080 - 55,305,419 (+)NCBI
RefSeq Acc Id: NP_074054   ⟸   NM_022863
- UniProtKB: Q66HL4 (UniProtKB/Swiss-Prot),   Q62751 (UniProtKB/Swiss-Prot),   A6J4M8 (UniProtKB/TrEMBL),   A0A8I5ZQ27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070223   ⟸   ENSRNOT00000077922
RefSeq Acc Id: ENSRNOP00000017900   ⟸   ENSRNOT00000017900
RefSeq Acc Id: XP_038938020   ⟸   XM_039082092
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038938019   ⟸   XM_039082091
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQ27 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938018   ⟸   XM_039082090
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JXC9 (UniProtKB/TrEMBL),   A0A8I5ZQ27 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000084367   ⟸   ENSRNOT00000098096
RefSeq Acc Id: ENSRNOP00000080151   ⟸   ENSRNOT00000108716
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62751-F1-model_v2 AlphaFold Q62751 1-963 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695986
Promoter ID:EPDNEW_R6511
Type:initiation region
Description:iron responsive element binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_R6510  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0859,457,012 - 59,457,072EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621539 AgrOrtholog
BioCyc Gene G2FUF-30389 BioCyc
Ensembl Genes ENSRNOG00000013271 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055031180 UniProtKB/Swiss-Prot
  ENSRNOG00060014254 UniProtKB/Swiss-Prot
  ENSRNOG00065018777 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017900 ENTREZGENE
  ENSRNOT00000017900.5 UniProtKB/Swiss-Prot
  ENSRNOT00000077922.2 UniProtKB/TrEMBL
  ENSRNOT00000098096.1 UniProtKB/TrEMBL
  ENSRNOT00000108716.1 UniProtKB/TrEMBL
  ENSRNOT00055054067 UniProtKB/Swiss-Prot
  ENSRNOT00060024400 UniProtKB/Swiss-Prot
  ENSRNOT00065031535 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.499.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AcnA_IRP_Swivel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acnase/IPM_dHydase_lsu_aba_1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acoase/IPM_deHydtase_lsu_aba UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase/3IPM_dehydase_swvl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase/IRP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_4Fe-4S_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_4Fe-4S_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AconitaseA/IPMdHydase_ssu_swvl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64831 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11670 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11670:SF31 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aconitase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ireb2 PhenoGen
  ACONITASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013271 RatGTEx
  ENSRNOG00055031180 RatGTEx
  ENSRNOG00060014254 RatGTEx
  ENSRNOG00065018777 RatGTEx
Superfamily-SCOP LeuD/IlvD-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53732 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q66HL4 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Ireb2  iron responsive element binding protein 2    iron-regulatory protein 2  Name updated 1299863 APPROVED
2002-08-07 Ireb2  iron-regulatory protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_transcript 3'-untranslated region contains multiple polyadenylation signals 729000