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Gene: Ireb2 (iron responsive element binding protein 2) Rattus norvegicus
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Symbol: Ireb2
Name: iron responsive element binding protein 2
Description: Exhibits 4 iron, 4 sulfur cluster binding activity; iron-responsive element binding activity; and regulatory region RNA binding activity. Involved in several processes, including aging; cellular response to decreased oxygen levels; and response to iron ion. Localizes to the axon; cytosol; and neuronal cell body. Used to study anemia. Biomarker of anemia; hyperinsulinism; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IRE-BP 2; iron regulatory protein 2; iron-regulatory protein 2; iron-responsive element-binding protein 2; Irp2; MGC93423
Orthologs:
Homo sapiens (human) : IREB2 (iron responsive element binding protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Ireb2 (iron responsive element binding protein 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ireb2 (iron responsive element binding protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IREB2 (iron responsive element binding protein 2)
Canis lupus familiaris (dog) : IREB2 (iron responsive element binding protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ireb2 (iron responsive element binding protein 2)
Sus scrofa (pig) : IREB2 (iron responsive element binding protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0859,450,974 - 59,503,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0858,002,720 - 58,085,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,433,218 - 58,477,305 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1858,452,371 - 58,496,928 (+)NCBI
Celera854,752,036 - 54,796,112 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ireb2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621539
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.