Pla2g7 (phospholipase A2 group VII) - Rat Genome Database

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Gene: Pla2g7 (phospholipase A2 group VII) Rattus norvegicus
Analyze
Symbol: Pla2g7
Name: phospholipase A2 group VII
RGD ID: 1310734
Description: Predicted to enable 1-alkyl-2-acetylglycerophosphocholine esterase activity; calcium-independent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in several processes, including glycerophospholipid catabolic process; plasma lipoprotein particle remodeling; and positive regulation of monocyte chemotaxis. Located in cytoplasm and extracellular space. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); glomerulonephritis (multiple); hemolytic-uremic syndrome; proteinuria (multiple); and type 2 diabetes mellitus. Orthologous to human PLA2G7 (phospholipase A2 group VII); PARTICIPATES IN ether lipid metabolic pathway; ether lipid metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC301265; MGC95107; phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma); platelet-activating factor acetylhydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2917,362,214 - 17,404,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl917,362,225 - 17,404,476 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx925,952,093 - 25,994,494 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0931,026,641 - 31,069,054 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0929,315,869 - 29,358,274 (-)NCBIRnor_WKY
Rnor_6.0919,935,754 - 19,978,013 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl919,935,768 - 19,978,013 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0918,813,216 - 18,855,030 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4913,057,988 - 13,100,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1913,055,311 - 13,097,611 (-)NCBI
Celera915,085,734 - 15,127,419 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amphetamine  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
diclofenac  (ISO)
dimethylarsinic acid  (ISO)
dinitrogen oxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxycycline  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ezetimibe  (ISO)
fenofibrate  (ISO)
folic acid  (ISO)
fonofos  (ISO)
furan  (EXP)
genistein  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (EXP,ISO)
menadione  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotinic acid  (ISO)
nitrogen dioxide  (ISO)
orlistat  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (EXP)
raloxifene  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
sulfur dioxide  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Urine of patients with nephrotic syndrome contains the plasma type of PAF-acetylhydrolase associated with lipoproteins. Balafa OC, etal., Nephron Physiol. 2004;97(3):p45-52.
2. The association among lipoprotein-associated phospholipase A2 levels, total antioxidant capacity and arousal in male patients with OSA. Bekci TT, etal., Int J Med Sci. 2011;8(5):369-76. Epub 2011 Jun 10.
3. Phospholipase A2 in patients with noncardioembolic ischemic stroke and severe inflammatory reaction. Cojocaru IM, etal., Rom J Intern Med. 2009;47(1):61-5.
4. Association of serum lipoprotein-associated phospholipase A2 level with nonalcoholic fatty liver disease. Colak Y, etal., Metab Syndr Relat Disord. 2012 Apr;10(2):103-9. Epub 2011 Nov 23.
5. Decreased circulating lipoprotein-associated phospholipase A2 levels are associated with coronary plaque regression in patients with acute coronary syndrome. Dohi T, etal., Atherosclerosis. 2011 Dec;219(2):907-12. Epub 2011 Sep 17.
6. High-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2 stability before and after stroke and myocardial infarction. Elkind MS, etal., Stroke. 2009 Oct;40(10):3233-7. Epub 2009 Jul 30.
7. Translational studies of lipoprotein-associated phospholipase A in inflammation and atherosclerosis. Ferguson JF, etal., J Am Coll Cardiol. 2012 Feb 21;59(8):764-72.
8. The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats. Fevre C, etal., Biochim Biophys Acta. 2011 Jun;1811(6):409-17. Epub 2010 Dec 21.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Evidence Supporting a Key Role of Lp-PLA2-Generated Lysophosphatidylcholine in Human Atherosclerotic Plaque Inflammation. Goncalves I, etal., Arterioscler Thromb Vasc Biol. 2012 Apr 12.
12. The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats. Howard KM and Olson MS, J Biol Chem. 2000 Jun 30;275(26):19891-6.
13. The inhibition of lipoprotein-associated phospholipase A2 exerts beneficial effects against atherosclerosis in LDLR-deficient mice. Hu MM, etal., Acta Pharmacol Sin. 2011 Oct;32(10):1253-8. doi: 10.1038/aps.2011.127. Epub 2011 Aug 15.
14. Platelet-activating factor levels and PAF acetylhydrolase activities in patients with primary glomerulonephritis. Iatrou C, etal., Nephron. 1996;72(4):611-6.
15. Adenovirus-mediated gene transfer and lipoprotein-mediated protein delivery of plasma PAF-AH ameliorates proteinuria in rat model of glomerulosclerosis. Iso-O N, etal., Mol Ther. 2006 Jan;13(1):118-26. Epub 2005 Oct 5.
16. The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. Kruse S, etal., Am J Hum Genet. 2000 May;66(5):1522-30. Epub 2000 Mar 24.
17. Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low-density lipoprotein and exhibit decreased activity of the lipoprotein-associated phospholipase A2. Lourida ES, etal., Arthritis Res Ther. 2007;9(1):R19.
18. Lipoprotein-associated phospholipase A2 independently predicts the angiographic diagnosis of coronary artery disease and coronary death. May HT, etal., Am Heart J. 2006 Nov;152(5):997-1003.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Changes in glycerophospholipid profile in experimental nephrotic syndrome. Mimura K, etal., Metabolism. 1996 Jul;45(7):822-6.
21. Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) and Future Risk of Type 2 Diabetes: Results from the Cardiovascular Health Study. Nelson TL, etal., J Clin Endocrinol Metab. 2012 Mar 7.
22. Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease. Ninio E, etal., Hum Mol Genet. 2004 Jul 1;13(13):1341-51. Epub 2004 Apr 28.
23. Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam Study. Oei HH, etal., Circulation. 2005 Feb 8;111(5):570-5.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. PAF-acetylhydrolase activity in plasma of patients with chronic kidney disease. Effect of long-term therapy with erythropoietin. Papavasiliou EC, etal., Nephrol Dial Transplant. 2006 May;21(5):1270-7. Epub 2006 Jan 18.
26. Lp-PLA2 activity and mass are associated with increased incidence of ischemic stroke: a population-based cohort study from Malmo, Sweden. Persson M, etal., Atherosclerosis. 2008 Sep;200(1):191-8. Epub 2008 Feb 21.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Comprehensive gene review and curation RGD comprehensive gene curation
32. Circulating lipoprotein-associated phospholipase A2 in high-grade carotid stenosis: a new biomarker for predicting unstable plaque. Sarlon-Bartoli G, etal., Eur J Vasc Endovasc Surg. 2012 Feb;43(2):154-9. Epub 2011 Nov 9.
33. Lp-PLA2: Inflammatory Biomarker of Vascular Risk in Multiple Sclerosis. Sternberg Z, etal., J Clin Immunol. 2012 Jan 13.
34. Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy. Tanaka R, etal., Am J Kidney Dis. 1999 Aug;34(2):289-95.
35. Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese. Unno N, etal., Ann Surg. 2002 Feb;235(2):297-302.
36. Lipoprotein-associated phospholipase A2 is associated with risk of dementia. van Oijen M, etal., Ann Neurol. 2006 Jan;59(1):139-44.
37. Lipoprotein-associated phospholipase A2 activity and risk of heart failure: The Rotterdam study. van Vark LC, etal., Eur Heart J. 2006 Oct;27(19):2346-52. Epub 2006 Sep 4.
38. Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157-associated hemolytic uremic syndrome. Xu H, etal., Am J Kidney Dis. 2000 Jul;36(1):42-6.
39. Platelet-activating factor acetylhydrolase gene mutation in Japanese nephrotic children. Xu H, etal., Kidney Int. 1998 Dec;54(6):1867-71.
40. Association of plasma PAF acetylhydrolase gene polymorphism with IMT of carotid arteries in Japanese type 2 diabetic patients. Yamamoto I, etal., Diabetes Res Clin Pract. 2003 Mar;59(3):219-24.
41. Interdependent effect of angiotensin-converting enzyme and platelet-activating factor acetylhydrolase gene polymorphisms on the progression of immunoglobulin A nephropathy. Yoon HJ, etal., Clin Genet. 2002 Aug;62(2):128-34.
Additional References at PubMed
PMID:2040620   PMID:8624782   PMID:10066756   PMID:10504265   PMID:11590221   PMID:12477932   PMID:12821559  


Genomics

Comparative Map Data
Pla2g7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2917,362,214 - 17,404,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl917,362,225 - 17,404,476 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx925,952,093 - 25,994,494 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0931,026,641 - 31,069,054 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0929,315,869 - 29,358,274 (-)NCBIRnor_WKY
Rnor_6.0919,935,754 - 19,978,013 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl919,935,768 - 19,978,013 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0918,813,216 - 18,855,030 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4913,057,988 - 13,100,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1913,055,311 - 13,097,611 (-)NCBI
Celera915,085,734 - 15,127,419 (-)NCBICelera
Cytogenetic Map9q13NCBI
PLA2G7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38646,704,201 - 46,735,721 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl646,704,201 - 46,735,693 (-)EnsemblGRCh38hg38GRCh38
GRCh37646,671,938 - 46,703,458 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36646,780,237 - 46,811,061 (-)NCBINCBI36Build 36hg18NCBI36
Build 34646,780,236 - 46,811,055NCBI
Celera648,224,575 - 48,255,899 (-)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef646,395,325 - 46,426,641 (-)NCBIHuRef
CHM1_1646,675,466 - 46,706,812 (-)NCBICHM1_1
T2T-CHM13v2.0646,541,848 - 46,573,366 (-)NCBIT2T-CHM13v2.0
Pla2g7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391743,878,885 - 43,923,093 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1743,878,989 - 43,923,092 (+)EnsemblGRCm39 Ensembl
GRCm381743,567,994 - 43,612,202 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1743,568,098 - 43,612,201 (+)EnsemblGRCm38mm10GRCm38
MGSCv371743,705,400 - 43,749,150 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361743,031,500 - 43,075,242 (+)NCBIMGSCv36mm8
Celera1746,991,155 - 47,035,006 (+)NCBICelera
Cytogenetic Map17B3NCBI
Pla2g7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543711,534,173 - 11,555,996 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543711,534,251 - 11,577,942 (-)NCBIChiLan1.0ChiLan1.0
PLA2G7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1647,558,861 - 47,590,212 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl647,558,861 - 47,590,212 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0646,264,262 - 46,318,487 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PLA2G7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11214,866,229 - 14,908,230 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1214,866,229 - 14,908,114 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1214,897,517 - 14,938,972 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01215,366,067 - 15,408,199 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1215,366,063 - 15,408,686 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11214,881,621 - 14,922,982 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01214,970,576 - 15,012,067 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01215,117,009 - 15,158,322 (-)NCBIUU_Cfam_GSD_1.0
Pla2g7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494650,314,028 - 50,350,357 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647613,609,374 - 13,649,998 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647613,609,847 - 13,646,174 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl741,486,598 - 41,531,345 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1741,488,152 - 41,531,383 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2748,149,037 - 48,192,545 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11725,538,645 - 25,571,230 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1725,538,438 - 25,574,269 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604446,721,234 - 46,754,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475413,904,797 - 13,931,670 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475413,905,084 - 13,932,366 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pla2g7
436 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:16
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000038222
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 9 25 1 21 2
Low 43 46 34 10 34 8 10 37 34 20 9 8
Below cutoff 7 7 7 1 12

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000038222   ⟹   ENSRNOP00000031958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl917,362,225 - 17,404,476 (-)Ensembl
Rnor_6.0 Ensembl919,935,768 - 19,978,013 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108028   ⟹   ENSRNOP00000077842
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl917,362,225 - 17,381,155 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119925   ⟹   ENSRNOP00000085766
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl917,362,225 - 17,382,704 (-)Ensembl
RefSeq Acc Id: NM_001009353   ⟹   NP_001009353
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2917,362,214 - 17,404,476 (-)NCBI
Rnor_6.0919,935,754 - 19,978,013 (-)NCBI
Rnor_5.0918,813,216 - 18,855,030 (-)NCBI
RGSC_v3.4913,057,988 - 13,100,289 (-)RGD
Celera915,085,734 - 15,127,419 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244606   ⟹   XP_006244668
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2917,362,214 - 17,396,329 (-)NCBI
Rnor_6.0919,935,754 - 19,969,954 (-)NCBI
Rnor_5.0918,813,216 - 18,855,030 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001009353 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244668 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88457 (Get FASTA)   NCBI Sequence Viewer  
  EDM18696 (Get FASTA)   NCBI Sequence Viewer  
  EDM18697 (Get FASTA)   NCBI Sequence Viewer  
  EDM18698 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001009353   ⟸   NM_001009353
- Peptide Label: precursor
- UniProtKB: Q5M7T7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244668   ⟸   XM_006244606
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000031958   ⟸   ENSRNOT00000038222
RefSeq Acc Id: ENSRNOP00000085766   ⟸   ENSRNOT00000119925
RefSeq Acc Id: ENSRNOP00000077842   ⟸   ENSRNOT00000108028

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M7T7-F1-model_v2 AlphaFold Q5M7T7 1-440 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696556
Promoter ID:EPDNEW_R7080
Type:initiation region
Name:Pla2g7_1
Description:phospholipase A2 group VII
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0919,977,943 - 19,978,003EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310734 AgrOrtholog
BioCyc Gene G2FUF-28111 BioCyc
Ensembl Genes ENSRNOG00000025691 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000031958 ENTREZGENE
  ENSRNOP00000031958.3 UniProtKB/TrEMBL
  ENSRNOP00000077842.1 UniProtKB/TrEMBL
  ENSRNOP00000085766.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038222 ENTREZGENE
  ENSRNOT00000038222.5 UniProtKB/TrEMBL
  ENSRNOT00000108028.1 UniProtKB/TrEMBL
  ENSRNOT00000119925.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127300 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/TrEMBL
  Ac_Ohase_PAF UniProtKB/TrEMBL
  PAF_acetylhydro_II UniProtKB/TrEMBL
KEGG Report rno:301265 UniProtKB/TrEMBL
MGC_CLONE MGC:95107 IMAGE-MGC_LOAD
NCBI Gene 301265 ENTREZGENE
PANTHER PAF_acetylhydro_II UniProtKB/TrEMBL
  PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE UniProtKB/TrEMBL
Pfam PAF-AH_p_II UniProtKB/TrEMBL
PhenoGen Pla2g7 PhenoGen
PIRSF PAF_acetylhydrolase UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A8I5Y241_RAT UniProtKB/TrEMBL
  A0A8I6GE94_RAT UniProtKB/TrEMBL
  Q5M7T7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pla2g7  phospholipase A2 group VII  Pla2g7  phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Pla2g7  phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)  Pla2g7_predicted  phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Pla2g7_predicted  phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (predicted)      Symbol and Name status set to approved 70820 APPROVED