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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adcy9
Name: adenylate cyclase 9
Acc ID: CHEBI:6923
Term: miconazole
Definition: A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.
Chemical ID: MESH:D008825
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adcy9increases activityISOADCY9 (Homo sapiens)6480464CTDMiconazole results in increased activity of ADCY9 protein; Miconazole results in increased activity of ADCY9 protein alternative formPMID:30607468
Adcy9increases activityISOAdcy9 (Mus musculus)6480464CTDMiconazole results in increased activity of ADCY9 proteinPMID:30607468
Adcy9multiple interactionsISOADCY9 (Homo sapiens)6480464CTD[Isoproterenol co-treated with Miconazole] results in increased activity of ADCY9 protein alternative form; Calcium inhibits the reaction [Miconazole results in increased activity of ADCY9 protein]; Tacrolimus inhibits the reaction [Calcium inhibits the reaction [Miconazole results in increased activity of ADCY9 protein]]PMID:30607468
Adcy9multiple interactionsISOAdcy9 (Mus musculus)6480464CTD[Colforsin co-treated with Miconazole] results in increased activity of ADCY9 proteinPMID:30607468
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