Zfp703 (zinc finger protein 703) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Zfp703 (zinc finger protein 703) Rattus norvegicus
Analyze
Symbol: Zfp703
Name: zinc finger protein 703
RGD ID: 1588249
Description: Predicted to enable DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including cellular response to estradiol stimulus; positive regulation of mammary gland epithelial cell proliferation; and regulation of signal transduction. Predicted to be located in cytoplasm and nuclear matrix. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human ZNF703 (zinc finger protein 703); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC680717; similar to zinc finger protein 703; Znf703
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21665,076,507 - 65,080,677 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1665,076,507 - 65,080,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1670,359,975 - 70,364,169 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01673,766,303 - 73,770,497 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01669,011,894 - 69,016,064 (-)NCBIRnor_WKY
Rnor_6.01669,237,857 - 69,242,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1669,237,857 - 69,242,028 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01668,911,230 - 68,915,401 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41669,405,004 - 69,409,137 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1662,995,876 - 63,000,045 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
afimoxifene  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clofibrate  (ISO)
coumestrol  (ISO)
diazinon  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
Ethylenethiourea  (EXP)
fenarimol  (EXP)
flusilazole  (EXP)
genistein  (ISO)
gentamycin  (EXP)
leflunomide  (ISO)
Licochalcone B  (ISO)
manganese(II) chloride  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
propiconazole  (EXP)
prothioconazole  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
thioacetamide  (EXP)
triadimefon  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21317240   PMID:21328542   PMID:21337521  


Genomics

Comparative Map Data
Zfp703
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21665,076,507 - 65,080,677 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1665,076,507 - 65,080,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1670,359,975 - 70,364,169 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01673,766,303 - 73,770,497 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01669,011,894 - 69,016,064 (-)NCBIRnor_WKY
Rnor_6.01669,237,857 - 69,242,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1669,237,857 - 69,242,028 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01668,911,230 - 68,915,401 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41669,405,004 - 69,409,137 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1662,995,876 - 63,000,045 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
ZNF703
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38837,695,782 - 37,700,019 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl837,695,782 - 37,700,019 (+)EnsemblGRCh38hg38GRCh38
GRCh37837,553,300 - 37,557,537 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36837,672,459 - 37,675,554 (+)NCBINCBI36Build 36hg18NCBI36
Celera836,506,270 - 36,509,365 (+)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,088,055 - 36,091,097 (+)NCBIHuRef
CHM1_1837,754,737 - 37,757,832 (+)NCBICHM1_1
T2T-CHM13v2.0837,972,157 - 37,976,394 (+)NCBIT2T-CHM13v2.0
Zfp703
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39827,467,364 - 27,471,490 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl827,467,353 - 27,471,489 (+)EnsemblGRCm39 Ensembl
GRCm38826,977,336 - 26,981,462 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl826,977,325 - 26,981,461 (+)EnsemblGRCm38mm10GRCm38
MGSCv37828,087,808 - 28,091,934 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36828,441,489 - 28,447,402 (+)NCBIMGSCv36mm8
Celera828,466,249 - 28,470,375 (+)NCBICelera
Cytogenetic Map8A2NCBI
Znf703
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546313,407,491 - 13,411,562 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546313,407,491 - 13,411,562 (+)NCBIChiLan1.0ChiLan1.0
ZNF703
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1831,971,881 - 31,976,120 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0836,994,222 - 36,998,462 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,172,354 - 34,185,140 (+)NCBIpanpan1.1PanPan1.1panPan2
ZNF703
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,669,506 - 27,673,732 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,670,897 - 27,673,803 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1628,186,221 - 28,190,501 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01629,568,710 - 29,572,990 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1629,568,721 - 29,588,889 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,790,090 - 27,794,370 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01628,367,780 - 28,372,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01628,406,977 - 28,411,257 (-)NCBIUU_Cfam_GSD_1.0
Znf703
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494350,302,241 - 50,306,207 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,155,006 - 1,158,974 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049367101,155,007 - 1,158,972 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF703
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,692,320 - 48,696,644 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,692,316 - 48,696,639 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,809,369 - 55,813,713 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF703
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1835,730,678 - 35,735,015 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl835,730,736 - 35,737,788 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660526,270,025 - 6,274,311 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf703
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247805,895,998 - 5,900,367 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247805,896,424 - 5,900,425 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp703
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:272
Count of miRNA genes:170
Interacting mature miRNAs:201
Transcripts:ENSRNOT00000019002
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 4 1 4 2 64 20 28 3
Low 43 50 34 18 34 8 9 10 15 13 8 8
Below cutoff 3 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019002   ⟹   ENSRNOP00000019001
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1665,076,507 - 65,080,677 (-)Ensembl
Rnor_6.0 Ensembl1669,237,857 - 69,242,028 (-)Ensembl
RefSeq Acc Id: NM_001109425   ⟹   NP_001102895
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21665,076,507 - 65,080,677 (-)NCBI
Rnor_6.01669,237,857 - 69,242,028 (-)NCBI
Rnor_5.01668,911,230 - 68,915,401 (-)NCBI
RGSC_v3.41669,405,004 - 69,409,137 (-)RGD
Celera1662,995,876 - 63,000,045 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102895 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09087 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001102895   ⟸   NM_001109425
- UniProtKB: D4ABF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019001   ⟸   ENSRNOT00000019002
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ABF5-F1-model_v2 AlphaFold D4ABF5 1-593 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700158
Promoter ID:EPDNEW_R10681
Type:single initiation site
Name:Zfp703_1
Description:zinc finger protein 703
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01669,241,957 - 69,242,017EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588249 AgrOrtholog
BioCyc Gene G2FUF-11027 BioCyc
Ensembl Genes ENSRNOG00000014199 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019001 ENTREZGENE
  ENSRNOP00000019001.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019002 ENTREZGENE
  ENSRNOT00000019002.7 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Tscrpt_rep_NocA-like UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
KEGG Report rno:680717 UniProtKB/TrEMBL
NCBI Gene 680717 ENTREZGENE
PANTHER ZINC FINGER PROTEIN 703 UniProtKB/TrEMBL
  ZINC-FINGER PROTEIN NOLZ1-RELATED UniProtKB/TrEMBL
Pfam nlz1 UniProtKB/TrEMBL
PhenoGen Zfp703 PhenoGen
PROSITE ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
UniProt D4ABF5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-19 Zfp703  zinc finger protein 703  Znf703  zinc finger protein 703  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Znf703  zinc finger protein 703  Zfp703  zinc finger protein 703  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-17 Zfp703  zinc finger protein 703  LOC684528  similar to zinc finger protein 703  Data Merged 1643240 APPROVED
2008-03-05 Zfp703  zinc finger protein 703  LOC680717  similar to zinc finger protein 703  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC680717  similar to zinc finger protein 703      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684528  similar to zinc finger protein 703      Symbol and Name status set to provisional 70820 PROVISIONAL