Mmp14 (matrix metallopeptidase 14) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mmp14 (matrix metallopeptidase 14) Rattus norvegicus
Symbol: Mmp14
Name: matrix metallopeptidase 14
RGD ID: 620198
Description: Enables integrin binding activity. Involved in several processes, including gonad development; negative regulation of focal adhesion assembly; and response to odorant. Predicted to be located in several cellular components, including cytosol; intermediate filament cytoskeleton; and macropinosome. Predicted to be active in extracellular space and plasma membrane. Used to study ischemia. Biomarker of IgA glomerulonephritis; anti-basement membrane glomerulonephritis; artery disease (multiple); cerebrovascular disease (multiple); and congestive heart failure. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14); PARTICIPATES IN hypoxia inducible factor pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: matrix metallopeptidase 14 (membrane-inserted); matrix metalloproteinase 14 (membrane-inserted); matrix metalloproteinase 14 membrane-inserted; matrix metalloproteinase 14, membrane-inserted; matrix metalloproteinase-14; membrane type 1-matrix metalloproteinase; membrane-type matrix metalloproteinase 1; membrane-type-1 matrix metalloproteinase; MMP-14; MT-MMP 1; Mt1-mmp; MT1MMP; MTMMP1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81531,857,824 - 31,867,049 (+)NCBIGRCr8
mRatBN7.21527,887,795 - 27,897,020 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1527,887,727 - 27,899,864 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1529,727,071 - 29,736,290 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01530,874,288 - 30,883,507 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,124,651 - 29,133,873 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,074,441 - 33,083,666 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,074,441 - 33,083,655 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01536,960,282 - 36,969,507 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,493,852 - 32,503,077 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11532,509,551 - 32,518,777 (+)NCBI
Celera1527,470,861 - 27,480,086 (+)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-Nerolidylcatechol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ageladine A  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aminoguanidine  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (EXP)
beta-aminopropionitrile  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carvone  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
cumene  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cysteamine  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
demethoxycurcumin  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dihydroartemisinin  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
Geniposide pentaacetate  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidyl methacrylate  (ISO)
graphene oxide  (ISO)
heparin  (ISO)
hydrogen cyanide  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
inulin  (ISO)
Isoangustone A  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP)
melatonin  (EXP)
mercury dibromide  (ISO)
metformin  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperine  (ISO)
pirinixic acid  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trametinib  (ISO)
Trapidil  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
triticonazole  (EXP)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEP)
astrocyte cell migration  (IEP)
bone development  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
cell migration  (ISO)
chondrocyte proliferation  (ISO)
collagen catabolic process  (IBA,ISO)
craniofacial suture morphogenesis  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
endochondral ossification  (ISO)
endodermal cell differentiation  (ISO)
endothelial cell proliferation  (IEP)
extracellular matrix organization  (IBA)
head development  (ISO)
lung development  (ISO)
male gonad development  (IEP)
negative regulation of focal adhesion assembly  (IDA)
negative regulation of GDF15-GFRAL signaling pathway  (ISO)
negative regulation of Notch signaling pathway  (ISO,ISS)
ossification  (IEP,ISO)
ovarian follicle development  (IEP)
positive regulation of B cell differentiation  (ISO,ISS)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of macrophage migration  (ISO)
positive regulation of myotube differentiation  (ISO,ISS)
positive regulation of protein processing  (IMP)
protein catabolic process  (ISO)
proteolysis  (IEA,ISO)
regulation of protein localization to plasma membrane  (ISO)
response to estrogen  (IEP)
response to hormone  (IDA)
response to hypoxia  (IEP)
response to mechanical stimulus  (IEP)
response to odorant  (IEP)
response to organic cyclic compound  (IEP)
response to oxidative stress  (IEP)
skeletal system development  (IBA,ISO)
tissue remodeling  (IDA)
zymogen activation  (IBA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection. Akiyama M, etal., Virchows Arch. 2006 Jun;448(6):811-21. Epub 2006 Apr 12.
2. Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification. Alvarez J, etal., J Bone Miner Res. 2005 Jun;20(6):1011-21. Epub 2005 Feb 7.
3. Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms. Annabi B, etal., J Vasc Surg. 2002 Mar;35(3):539-46.
4. Upregulated expression and activation of membrane‚ÄĎassociated proteases in esophageal squamous cell carcinoma. Augoff K, etal., Oncol Rep. 2014 Jun;31(6):2820-6. doi: 10.3892/or.2014.3162. Epub 2014 Apr 29.
5. Vascular extracellular matrix remodeling in cerebral aneurysms. Bruno G, etal., J Neurosurg. 1998 Sep;89(3):431-40.
6. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
7. Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis. Choi EY, etal., Exp Mol Med. 2002 Dec 31;34(6):391-400.
8. Gubernaculum as icebreaker: do matrix metalloproteinases in rodent gubernaculum and inguinal fat pad permit testicular descent? Churchill JA, etal., J Pediatr Surg. 2011 Dec;46(12):2353-7. doi: 10.1016/j.jpedsurg.2011.09.025.
9. Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14). Covington MD, etal., Am J Physiol Renal Physiol. 2006 Jan;290(1):F43-51. Epub 2005 Aug 2.
10. Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin. Dahi S, etal., J Vasc Surg. 2005 Sep;42(3):539-45.
11. MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells. Filippov S, etal., J Exp Med. 2005 Sep 5;202(5):663-71.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis. Hayashi K, etal., J Am Soc Nephrol. 1998 Dec;9(12):2262-71.
15. Macrophage-derived MT1-MMP and increased MMP-2 activity are associated with glomerular damage in crescentic glomerulonephritis. Hayashi K, etal., J Pathol. 2000 Jul;191(3):299-305.
16. Induction of Matrix Metalloproteinase-2 Enhances Systemic Vasoconstriction after Hypoxia. He JZ, etal., Am J Physiol Heart Circ Physiol. 2006 Sep 15;.
17. Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. Hosomi N, etal., Neuroscience. 2005;134(1):225-31.
18. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
19. Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus. Irwin LN and Byers DM, Brain Res. 2012 Dec 13;1489:1-7. doi: 10.1016/j.brainres.2012.10.034. Epub 2012 Oct 26.
20. Membrane type 1-matrix metalloproteinase (MMP)-associated MMP-2 activation increases in the rat ovary in response to an ovulatory dose of human chorionic gonadotropin. Jo M, etal., Biol Reprod. 2004 Apr;70(4):1024-32. Epub 2003 Dec 10.
21. Matrix metalloproteinases are down-regulated in rat lenses exposed to oxidative stress. John M, etal., Exp Eye Res. 2004 Dec;79(6):839-46.
22. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Kassiri Z, etal., Circ Res. 2005 Aug 19;97(4):380-90. Epub 2005 Jul 21.
23. Expression of matrix metalloproteinases and their inhibitors by rat NK cells: inhibition of their expression by genistein. Kim MH, etal., In Vivo. 2000 Sep-Oct;14(5):557-64.
24. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human urothelial carcinomas. Kitagawa Y, etal., J Urol. 1998 Oct;160(4):1540-5.
25. Membrane-type matrix metalloproteinase-1 (MT1-MMP) is down-regulated in estrogen-deficient rat osteoblast in vivo. Liao EY, etal., J Endocrinol Invest. 2004 Jan;27(1):1-5.
26. Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution. Manase K, etal., Reprod Biol Endocrinol. 2006 Jun 2;4:32.
27. Role of MT1-MMP in the osteogenic differentiation. Manduca P, etal., Bone. 2009 Feb;44(2):251-65. Epub 2008 Nov 5.
28. Basal membrane remodeling during follicle histogenesis in the rat ovary: contribution of proteinases of the MMP and PA families. Mazaud S, etal., Dev Biol. 2005 Jan 15;277(2):403-16.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Decreased vascular matrix metalloproteinase abundance in diabetic patients with symptomatic macroangiopathy. Mondy JS, etal., Ethn Dis. 2002 Fall;12(4):S3-18-22.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures. Nezi L, etal., Biol Chem 2002 Jan;383(1):167-76.
33. Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers. Norgauer J, etal., Br J Dermatol. 2002 Dec;147(6):1180-6.
34. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Okada A, etal., Proc Natl Acad Sci U S A 1995 Mar 28;92(7):2730-4.
35. Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas. Orlandi A, etal., Am J Pathol. 2005 Jun;166(6):1619-28.
36. Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. Peterson JT, etal., Cardiovasc Res. 2000 May;46(2):307-15.
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
39. GOA pipeline RGD automated data pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction. Schmidt R, etal., Circulation. 2006 Feb 14;113(6):834-41. Epub 2006 Feb 6.
43. Cleavage of focal adhesion kinase in vascular smooth muscle cells overexpressing membrane-type matrix metalloproteinases. Shofuda T, etal., Arterioscler Thromb Vasc Biol. 2004 May;24(5):839-44. Epub 2004 Mar 25.
44. Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms. Sinha I, etal., Surgery. 2004 Aug;136(2):176-82.
45. Expression of matrix metalloproteases (MMP-2, MT1 -MMP) and their tissue inhibitor (TIMP-2) by rat sertoli cells in culture: implications for spermatogenesis. Slongo ML, etal., Biol Chem 2002 Jan;383(1):235-9.
46. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
47. Role of intracellular S100A4 for migration of rat astrocytes. Takenaga K and Kozlova EN, Glia. 2006 Feb;53(3):313-21.
48. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas. Ueno H, etal., Cancer Res. 1997 May 15;57(10):2055-60.
49. Impaired angiogenesis in SHR is associated with decreased KDR and MT1-MMP expression. Wang H, etal., Biochem Biophys Res Commun. 2004 Mar 5;315(2):363-8.
50. Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway. Wang TL, etal., J Mol Cell Cardiol. 2004 Sep;37(3):785-94.
51. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
Additional References at PubMed
PMID:12747454   PMID:12970340   PMID:14729674   PMID:15351710   PMID:15358140   PMID:15509661   PMID:15572153   PMID:15863497   PMID:16541018   PMID:17644578   PMID:17684756   PMID:18022611  
PMID:18286538   PMID:18436234   PMID:18562481   PMID:18668563   PMID:20666777   PMID:20683769   PMID:20857180   PMID:20945382   PMID:21385940   PMID:21414971   PMID:21423176   PMID:21572390  
PMID:21826658   PMID:21909755   PMID:22065321   PMID:22342460   PMID:22974613   PMID:23154389   PMID:23404084   PMID:23683405   PMID:24379181   PMID:24784232   PMID:24859005   PMID:24867951  
PMID:24970228   PMID:24990232   PMID:25028660   PMID:25031710   PMID:25759388   PMID:26234751   PMID:26598508   PMID:26620678   PMID:27640084   PMID:27712978   PMID:29853773   PMID:30035384  
PMID:30659604   PMID:33287916   PMID:34229297  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81531,857,824 - 31,867,049 (+)NCBIGRCr8
mRatBN7.21527,887,795 - 27,897,020 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1527,887,727 - 27,899,864 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1529,727,071 - 29,736,290 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01530,874,288 - 30,883,507 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,124,651 - 29,133,873 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,074,441 - 33,083,666 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,074,441 - 33,083,655 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01536,960,282 - 36,969,507 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,493,852 - 32,503,077 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11532,509,551 - 32,518,777 (+)NCBI
Celera1527,470,861 - 27,480,086 (+)NCBICelera
Cytogenetic Map15p13NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381422,836,585 - 22,847,758 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1422,836,560 - 22,849,041 (+)EnsemblGRCh38hg38GRCh38
GRCh371423,305,794 - 23,316,967 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,375,633 - 22,386,643 (+)NCBINCBI36Build 36hg18NCBI36
Build 341422,375,632 - 22,386,642NCBI
Celera143,168,679 - 3,179,688 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,422,922 - 3,433,986 (+)NCBIHuRef
CHM1_11423,304,418 - 23,315,462 (+)NCBICHM1_1
T2T-CHM13v2.01417,034,651 - 17,045,822 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391454,669,055 - 54,679,913 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1454,669,069 - 54,682,821 (+)EnsemblGRCm39 Ensembl
GRCm381454,431,598 - 54,442,456 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,431,612 - 54,445,364 (+)EnsemblGRCm38mm10GRCm38
MGSCv371455,050,441 - 55,060,095 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,385,824 - 53,395,458 (+)NCBIMGSCv36mm8
Celera1452,223,646 - 52,233,174 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1427.79NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540937,440,541 - 37,448,437 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540937,438,924 - 37,448,704 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21524,266,301 - 24,277,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11423,482,405 - 23,494,022 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0143,654,125 - 3,665,158 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11421,753,305 - 21,764,061 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1421,753,305 - 21,764,058 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.183,183,419 - 3,193,079 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,183,606 - 3,194,122 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,132,308 - 3,142,668 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,291,562 - 3,301,919 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,291,310 - 3,301,917 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.182,983,033 - 2,993,386 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,044,810 - 3,055,166 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,306,779 - 3,317,137 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440864034,931,359 - 34,941,231 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,447,335 - 1,457,611 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,447,189 - 1,457,632 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl776,172,971 - 76,185,928 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1776,174,502 - 76,185,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2781,413,927 - 81,424,899 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12923,201,425 - 23,212,408 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,201,112 - 23,212,679 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605923,209,848 - 23,220,925 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248209,667,262 - 9,677,774 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,667,371 - 9,677,488 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Mmp14
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:399
Count of miRNA genes:173
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000042938, ENSRNOT00000075610
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21527,896,772 - 27,896,928 (+)MAPPERmRatBN7.2
Rnor_6.01533,083,419 - 33,083,574NCBIRnor6.0
Rnor_5.01536,969,260 - 36,969,415UniSTSRnor5.0
RGSC_v3.41532,502,830 - 32,502,985UniSTSRGSC3.4
Celera1527,479,839 - 27,479,994UniSTS
Cytogenetic Map15p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21527,896,812 - 27,896,979 (+)MAPPERmRatBN7.2
Rnor_6.01533,083,459 - 33,083,625NCBIRnor6.0
Rnor_5.01536,969,300 - 36,969,466UniSTSRnor5.0
RGSC_v3.41532,502,870 - 32,503,036UniSTSRGSC3.4
Celera1527,479,879 - 27,480,045UniSTS
Cytogenetic Map15p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21527,896,211 - 27,896,319 (+)MAPPERmRatBN7.2
Rnor_6.01533,082,858 - 33,082,965NCBIRnor6.0
Rnor_5.01536,968,699 - 36,968,806UniSTSRnor5.0
RGSC_v3.41532,502,269 - 32,502,376UniSTSRGSC3.4
Celera1527,479,278 - 27,479,385UniSTS
Cytogenetic Map15p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.410103,730,181 - 103,730,256UniSTSRGSC3.4
RGSC_v3.41532,500,938 - 32,502,522UniSTSRGSC3.4
Celera1527,477,947 - 27,479,531UniSTS
Celera1097,735,660 - 97,735,735UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21527,895,200 - 27,896,218 (+)MAPPERmRatBN7.2
Rnor_6.01533,081,847 - 33,082,864NCBIRnor6.0
Rnor_5.01536,967,688 - 36,968,705UniSTSRnor5.0
RGSC_v3.41532,501,258 - 32,502,275UniSTSRGSC3.4
Celera1527,478,267 - 27,479,284UniSTS
Cytogenetic Map15p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01536,967,368 - 36,968,952UniSTSRnor5.0
RGSC_v3.41532,500,938 - 32,502,522UniSTSRGSC3.4
Celera1527,477,947 - 27,479,531UniSTS
Cytogenetic Map15p13UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 40 57 41 19 41 6 8 64 35 40 11 6
Low 3 2 3 10 1 2
Below cutoff


RefSeq Acc Id: ENSRNOT00000075610   ⟹   ENSRNOP00000065434
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1527,887,764 - 27,897,009 (+)Ensembl
Rnor_6.0 Ensembl1533,074,441 - 33,083,655 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096630   ⟹   ENSRNOP00000081148
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1527,890,846 - 27,897,009 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118043   ⟹   ENSRNOP00000086712
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1527,887,727 - 27,899,864 (+)Ensembl
RefSeq Acc Id: NM_031056   ⟹   NP_112318
Rat AssemblyChrPosition (strand)Source
GRCr81531,857,824 - 31,867,049 (+)NCBI
mRatBN7.21527,887,795 - 27,897,020 (+)NCBI
Rnor_6.01533,074,441 - 33,083,666 (+)NCBI
Rnor_5.01536,960,282 - 36,969,507 (+)NCBI
RGSC_v3.41532,493,852 - 32,503,077 (+)RGD
Celera1527,470,861 - 27,480,086 (+)RGD
RefSeq Acc Id: NP_112318   ⟸   NM_031056
- Peptide Label: precursor
- UniProtKB: Q6IN06 (UniProtKB/Swiss-Prot),   Q10739 (UniProtKB/Swiss-Prot),   A6KGU1 (UniProtKB/TrEMBL),   A0A8I5ZRB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065434   ⟸   ENSRNOT00000075610
RefSeq Acc Id: ENSRNOP00000086712   ⟸   ENSRNOT00000118043
RefSeq Acc Id: ENSRNOP00000081148   ⟸   ENSRNOT00000096630
Protein Domains
Peptidase metallopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q10739-F1-model_v2 AlphaFold Q10739 1-582 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699650
Promoter ID:EPDNEW_R10173
Type:initiation region
Description:matrix metallopeptidase 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01533,074,386 - 33,074,446EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620198 AgrOrtholog
BioCyc Gene G2FUF-13802 BioCyc
Ensembl Genes ENSRNOG00000010947 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055011907 UniProtKB/Swiss-Prot
  ENSRNOG00060027477 UniProtKB/Swiss-Prot
  ENSRNOG00065031768 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000075610 ENTREZGENE
  ENSRNOT00000075610.3 UniProtKB/Swiss-Prot
  ENSRNOT00000096630.1 UniProtKB/TrEMBL
  ENSRNOT00000118043.1 UniProtKB/TrEMBL
  ENSRNOT00055020294 UniProtKB/Swiss-Prot
  ENSRNOT00060047919 UniProtKB/Swiss-Prot
  ENSRNOT00065054795 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M10A_MMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A_metallopeptidase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBDSf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81707 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3377 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mmp14 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010947 RatGTEx
  ENSRNOG00055011907 RatGTEx
  ENSRNOG00060027477 RatGTEx
  ENSRNOG00065031768 RatGTEx
SMART SM00120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MMP14_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6IN06 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Mmp14  matrix metallopeptidase 14  Mmp14  matrix metallopeptidase 14 (membrane-inserted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Mmp14  matrix metallopeptidase 14 (membrane-inserted)    matrix metalloproteinase 14 (membrane-inserted)  Name updated 1299863 APPROVED
2004-09-10 Mmp14  matrix metalloproteinase 14 (membrane-inserted)    matrix metalloproteinase 14, membrane-inserted  Name updated 1299863 APPROVED
2002-08-07 Mmp14  matrix metalloproteinase 14, membrane-inserted      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process may have a critical role in tumor progression 729349