Kcnh1 (potassium voltage-gated channel subfamily H member 1) - Rat Genome Database

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Gene: Kcnh1 (potassium voltage-gated channel subfamily H member 1) Rattus norvegicus
Analyze
Symbol: Kcnh1
Name: potassium voltage-gated channel subfamily H member 1
RGD ID: 68398
Description: Enables several functions, including 14-3-3 protein binding activity; calmodulin binding activity; and delayed rectifier potassium channel activity. Involved in cellular response to calcium ion; potassium ion transmembrane transport; and startle response. Located in several cellular components, including axolemma; neuronal cell body; and nuclear inner membrane. Part of potassium channel complex. Is active in postsynaptic density membrane and presynaptic membrane. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human KCNH1 (potassium voltage-gated channel subfamily H member 1); INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EAG channel 1; EAG1; ether-a-go-go potassium channel 1; potassium channel, voltage gated eag related subfamily H, member 1; potassium voltage-gated channel, subfamily H (eag-related), member 1; r-eag; voltage-gated delayed rectifier potassium channel KCNH1; voltage-gated potassium channel subunit Kv10.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813106,253,101 - 106,555,712 (+)NCBIGRCr8
mRatBN7.213103,722,140 - 104,024,762 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13103,722,245 - 104,024,740 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13106,242,159 - 106,544,653 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013107,626,002 - 107,928,502 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013104,840,996 - 105,143,620 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013110,920,712 - 111,232,291 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,920,737 - 111,232,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013115,478,526 - 115,789,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413108,129,617 - 108,407,815 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113108,318,724 - 108,596,919 (+)NCBI
Celera13103,160,967 - 103,461,850 (+)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1H-benzimidazol-2-one  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
astemizole  (ISO)
atrazine  (EXP)
barium(0)  (ISO)
benzamides  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
D-glucose  (ISO)
desmethylastemizole  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
E-4031  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
Ginsenoside Rh4  (ISO)
glucose  (ISO)
herbicide  (ISO)
imipramine  (ISO)
ketoconazole  (EXP)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
ozone  (EXP)
perfluorooctanoic acid  (EXP)
phencyclidine  (ISO)
phenobarbital  (EXP)
piperidines  (ISO)
potassium dichromate  (ISO)
procyanidin B1  (ISO)
quinidine  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
sulpiride  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Regulation of an ERG K+ current by Src tyrosine kinase. Cayabyab FS and Schlichter LC, J Biol Chem 2002 Apr 19;277(16):13673-81.
2. Distal end of carboxyl terminus is not essential for the assembly of rat Eag1 potassium channels. Chen IH, etal., J Biol Chem. 2011 Aug 5;286(31):27183-96. doi: 10.1074/jbc.M111.233825. Epub 2011 Jun 6.
3. Functional K(v)10.1 channels localize to the inner nuclear membrane. Chen Y, etal., PLoS One. 2011 May 3;6(5):e19257. doi: 10.1371/journal.pone.0019257.
4. The punctate localization of rat Eag1 K+ channels is conferred by the proximal post-CNBHD region. Chuang CC, etal., BMC Neurosci. 2014 Feb 4;15:23. doi: 10.1186/1471-2202-15-23.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Characterization of Eag1 channel lateral mobility in rat hippocampal cultures by single-particle-tracking with quantum dots. Gomez-Varela D, etal., PLoS One. 2010 Jan 25;5(1):e8858. doi: 10.1371/journal.pone.0008858.
8. Overexpression of Eag1 potassium channels in clinical tumours. Hemmerlein B, etal., Mol Cancer. 2006 Oct 5;5:41.
9. KCR1, a membrane protein that facilitates functional expression of non-inactivating K+ currents associates with rat EAG voltage-dependent K+ channels. Hoshi N, etal., J Biol Chem 1998 Sep 4;273(36):23080-5.
10. 14-3-3theta is a binding partner of rat Eag1 potassium channels. Hsu PH, etal., PLoS One. 2012;7(7):e41203. doi: 10.1371/journal.pone.0041203. Epub 2012 Jul 20.
11. Hippocampal ether-a-go-go1 potassium channels blockade: effects in the startle reflex and prepulse inhibition. Issy AC, etal., Neurosci Lett. 2014 Jan 24;559:13-7. doi: 10.1016/j.neulet.2013.11.026. Epub 2013 Nov 24.
12. The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains. Lin TF, etal., J Biol Chem. 2014 Aug 15;289(33):22815-34. doi: 10.1074/jbc.M114.574814. Epub 2014 Jul 9.
13. Functional expression of a rat homologue of the voltage gated either a go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart. Ludwig J, etal., EMBO J 1994 Oct 3;13(19):4451-8.
14. Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain. Martin S, etal., Neuroscience. 2008 Aug 26;155(3):833-44. doi: 10.1016/j.neuroscience.2008.05.019. Epub 2008 Jul 22.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. KV 10.1 opposes activity-dependent increase in Ca²¿ influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse. Mortensen LS, etal., J Physiol. 2015 Jan 1;593(1):181-96. doi: 10.1113/jphysiol.2014.281600. Epub 2014 Nov 25.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Physical and functional interaction of KV10.1 with Rabaptin-5 impacts ion channel trafficking. Ninkovic M, etal., FEBS Lett. 2012 Sep 21;586(19):3077-84. doi: 10.1016/j.febslet.2012.07.055. Epub 2012 Jul 25.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Expression of voltage-gated potassium channels in human and mouse colonic carcinoma. Ousingsawat J, etal., Clin Cancer Res. 2007 Feb 1;13(3):824-31.
21. Purification of an EH domain-binding protein from rat brain that modulates the gating of the rat ether-a-go-go channel. Piros ET, etal., J Biol Chem. 1999 Nov 19;274(47):33677-83.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Elevation of intracellular calcium by muscarinic receptor activation induces a block of voltage-activated rat ether-a-go-go channels in a stably transfected cell line. Stansfeld CE, etal., Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9910-4.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Differential expression of potassium ion channels in human renal cell carcinoma. Wadhwa S, etal., Int Urol Nephrol. 2009;41(2):251-7. doi: 10.1007/s11255-008-9459-z. Epub 2008 Sep 8.
28. Regulation of Eag1 gating by its intracellular domains. Whicher JR and MacKinnon R, Elife. 2019 Sep 6;8:e49188. doi: 10.7554/eLife.49188.
29. Structure of the voltage-gated K(+) channel Eag1 reveals an alternative voltage sensing mechanism. Whicher JR and MacKinnon R, Science. 2016 Aug 12;353(6300):664-9. doi: 10.1126/science.aaf8070.
Additional References at PubMed
PMID:9400421   PMID:10718922   PMID:15706225   PMID:18063306   PMID:19671703   PMID:20662937   PMID:22048886   PMID:22732247   PMID:23881642   PMID:27005320   PMID:27325704   PMID:33647316  
PMID:36717938  


Genomics

Comparative Map Data
Kcnh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813106,253,101 - 106,555,712 (+)NCBIGRCr8
mRatBN7.213103,722,140 - 104,024,762 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13103,722,245 - 104,024,740 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13106,242,159 - 106,544,653 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013107,626,002 - 107,928,502 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013104,840,996 - 105,143,620 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013110,920,712 - 111,232,291 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,920,737 - 111,232,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013115,478,526 - 115,789,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413108,129,617 - 108,407,815 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113108,318,724 - 108,596,919 (+)NCBI
Celera13103,160,967 - 103,461,850 (+)NCBICelera
Cytogenetic Map13q27NCBI
KCNH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,678,314 - 211,134,148 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,676,823 - 211,134,165 (-)EnsemblGRCh38hg38GRCh38
GRCh371210,851,656 - 211,307,490 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361208,923,178 - 209,374,080 (-)NCBINCBI36Build 36hg18NCBI36
Build 341207,244,949 - 207,695,852NCBI
Celera1184,078,007 - 184,534,030 (-)NCBICelera
Cytogenetic Map1q32.2NCBI
HuRef1181,528,354 - 181,984,466 (-)NCBIHuRef
CHM1_11212,124,419 - 212,580,029 (-)NCBICHM1_1
T2T-CHM13v2.01209,920,145 - 210,379,828 (-)NCBIT2T-CHM13v2.0
Kcnh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391191,871,759 - 192,192,467 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1191,873,082 - 192,192,467 (+)EnsemblGRCm39 Ensembl
GRCm381192,189,144 - 192,510,159 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1192,190,774 - 192,510,159 (+)EnsemblGRCm38mm10GRCm38
MGSCv371194,014,754 - 194,334,040 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361193,891,596 - 194,210,882 (+)NCBIMGSCv36mm8
Celera1199,081,917 - 199,396,846 (+)NCBICelera
Cytogenetic Map1H6NCBI
cM Map197.33NCBI
Kcnh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554891,179,053 - 1,545,355 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554891,176,615 - 1,549,880 (+)NCBIChiLan1.0ChiLan1.0
KCNH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2138,274,955 - 38,737,394 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1138,239,979 - 38,703,633 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01186,233,881 - 186,696,509 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11191,102,299 - 191,561,879 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1191,107,256 - 191,562,766 (-)Ensemblpanpan1.1panPan2
KCNH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.179,317,804 - 9,631,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl79,252,488 - 9,631,150 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha78,829,600 - 9,206,958 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.078,949,600 - 9,333,811 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl78,954,637 - 9,334,074 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.178,881,430 - 9,257,585 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.078,973,450 - 9,359,036 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.079,110,853 - 9,483,089 (-)NCBIUU_Cfam_GSD_1.0
Kcnh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934464,893,289 - 65,249,587 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365572,133,564 - 2,493,155 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365572,133,596 - 2,493,170 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9131,960,480 - 132,334,953 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19131,960,566 - 132,336,029 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29145,245,936 - 145,368,735 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12518,353,356 - 18,788,472 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2518,353,482 - 18,783,592 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605518,890,057 - 19,338,331 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248071,056,313 - 1,388,491 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248071,019,347 - 1,392,433 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnh1
2226 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:576
Count of miRNA genes:249
Interacting mature miRNAs:318
Transcripts:ENSRNOT00000005209
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
D13Rat90  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.013110,987,474 - 110,987,854NCBIRnor6.0
Rnor_5.013115,544,837 - 115,545,217UniSTSRnor5.0
RGSC_v3.413108,161,587 - 108,161,830RGDRGSC3.4
RGSC_v3.413108,161,588 - 108,161,830UniSTSRGSC3.4
RGSC_v3.113108,350,605 - 108,350,962RGD
Celera13103,218,254 - 103,218,496UniSTS
FHH x ACI Map1359.9799UniSTS
FHH x ACI Map1359.9799RGD
Cytogenetic Map13q27UniSTS
RH133640  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr813106,555,328 - 106,555,528 (+)Marker Load Pipeline
mRatBN7.213104,024,378 - 104,024,578 (+)MAPPERmRatBN7.2
Rnor_6.013111,231,908 - 111,232,107NCBIRnor6.0
Rnor_5.013115,789,322 - 115,789,521UniSTSRnor5.0
RGSC_v3.413108,407,454 - 108,407,653UniSTSRGSC3.4
Celera13103,461,489 - 103,461,688UniSTS
Cytogenetic Map13q27UniSTS
BF387220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213103,953,993 - 103,954,181 (+)MAPPERmRatBN7.2
Rnor_6.013111,161,533 - 111,161,720NCBIRnor6.0
Rnor_5.013115,718,896 - 115,719,083UniSTSRnor5.0
RGSC_v3.413108,337,021 - 108,337,208UniSTSRGSC3.4
Celera13103,391,977 - 103,392,164UniSTS
RH 3.4 Map13750.8UniSTS
Cytogenetic Map13q27UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 42 113 80 79 48 25 48 6 200 90 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000005209   ⟹   ENSRNOP00000005209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13103,722,245 - 104,024,740 (+)Ensembl
Rnor_6.0 Ensembl13110,920,737 - 111,232,269 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076362   ⟹   ENSRNOP00000068448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13110,920,830 - 111,228,836 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077014   ⟹   ENSRNOP00000068394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13110,920,830 - 111,228,836 (+)Ensembl
RefSeq Acc Id: NM_031742   ⟹   NP_113930
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813106,253,216 - 106,555,712 (+)NCBI
mRatBN7.213103,722,248 - 104,024,762 (+)NCBI
Rnor_6.013110,920,737 - 111,232,269 (+)NCBI
Rnor_5.013115,478,526 - 115,789,705 (+)NCBI
RGSC_v3.413108,129,617 - 108,407,815 (+)RGD
Celera13103,160,967 - 103,461,850 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598933   ⟹   XP_017454422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813106,253,101 - 106,555,712 (+)NCBI
mRatBN7.213103,722,140 - 104,024,762 (+)NCBI
Rnor_6.013110,920,712 - 111,232,291 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091086   ⟹   XP_038947014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813106,392,198 - 106,555,712 (+)NCBI
mRatBN7.213103,877,572 - 104,024,762 (+)NCBI
RefSeq Acc Id: XM_063272592   ⟹   XP_063128662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813106,305,469 - 106,555,712 (+)NCBI
RefSeq Acc Id: XM_063272593   ⟹   XP_063128663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813106,322,768 - 106,555,712 (+)NCBI
RefSeq Acc Id: NP_113930   ⟸   NM_031742
- UniProtKB: Q63472 (UniProtKB/Swiss-Prot),   A6JH11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454422   ⟸   XM_017598933
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q1G4 (UniProtKB/TrEMBL),   A6JH10 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068394   ⟸   ENSRNOT00000077014
Ensembl Acc Id: ENSRNOP00000005209   ⟸   ENSRNOT00000005209
Ensembl Acc Id: ENSRNOP00000068448   ⟸   ENSRNOT00000076362
RefSeq Acc Id: XP_038947014   ⟸   XM_039091086
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063128662   ⟸   XM_063272592
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128663   ⟸   XM_063272593
- Peptide Label: isoform X2
Protein Domains
Cyclic nucleotide-binding   PAC   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63472-F1-model_v2 AlphaFold Q63472 1-962 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68398 AgrOrtholog
BioCyc Gene G2FUF-16807 BioCyc
Ensembl Genes ENSRNOG00000003841 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005209 ENTREZGENE
  ENSRNOT00000005209.6 UniProtKB/TrEMBL
  ENSRNOT00000147245 ENTREZGENE
Gene3D-CATH 1.10.1200.260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom_sf UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNH_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-assoc_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65198 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 65198 ENTREZGENE
PANTHER PTHR10217:SF530 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnh1 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EAGCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003841 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218785
UniProt A0A8L2Q1G4 ENTREZGENE, UniProtKB/TrEMBL
  A6JH10 ENTREZGENE, UniProtKB/TrEMBL
  A6JH11 ENTREZGENE, UniProtKB/TrEMBL
  KCNH1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Kcnh1  potassium voltage-gated channel subfamily H member 1  Kcnh1  potassium channel, voltage gated eag related subfamily H, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnh1  potassium channel, voltage gated eag related subfamily H, member 1  Kcnh1  potassium voltage-gated channel, subfamily H (eag-related), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnh1  potassium voltage-gated channel, subfamily H (eag-related), member 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the central nervous system 68271