Myl12a (myosin light chain 12A) - Rat Genome Database
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Gene: Myl12a (myosin light chain 12A) Rattus norvegicus
Analyze
Symbol: Myl12a
Name: myosin light chain 12A
RGD ID: 1309537
Description: Predicted to have glutamate receptor binding activity. Predicted to be involved in platelet aggregation; protein localization to plasma membrane; and regulation of cell shape. Localizes to protein-containing complex. Orthologous to human MYL12A (myosin light chain 12A); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC363299; myosin regulatory light chain 2-A, smooth muscle isoform; myosin regulatory light chain RLC-A; myosin RLC-A; myosin, light chain 12A, regulatory, non-sarcomeric; RGD1309537; Rlc-a; similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A)
RGD Orthologs
Human
Mouse
Dog
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.29110,891,970 - 110,899,655 (-)NCBI
Rnor_6.0 Ensembl9119,325,283 - 119,332,967 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.09119,325,282 - 119,333,012 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.09118,779,616 - 118,787,326 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49110,190,030 - 110,197,715 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.19110,399,541 - 110,420,043 (-)NCBI
Celera9108,022,176 - 108,029,861 (-)NCBICelera
Cytogenetic Map9q38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1649372   PMID:2391362   PMID:3584239   PMID:8034049   PMID:8889548   PMID:18945678   PMID:20458337   PMID:21126233   PMID:23376485   PMID:23382103   PMID:23870127   PMID:27233767  
PMID:29476059  


Genomics

Comparative Map Data
Myl12a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.29110,891,970 - 110,899,655 (-)NCBI
Rnor_6.0 Ensembl9119,325,283 - 119,332,967 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.09119,325,282 - 119,333,012 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.09118,779,616 - 118,787,326 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49110,190,030 - 110,197,715 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.19110,399,541 - 110,420,043 (-)NCBI
Celera9108,022,176 - 108,029,861 (-)NCBICelera
Cytogenetic Map9q38NCBI
MYL12A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl183,247,481 - 3,256,236 (+)EnsemblGRCh38hg38GRCh38
GRCh38183,247,482 - 3,256,237 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37183,247,480 - 3,256,235 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37183,247,472 - 3,256,234 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36183,237,528 - 3,246,234 (+)NCBINCBI36hg18NCBI36
Celera183,127,027 - 3,135,734 (+)NCBI
Cytogenetic Map18p11.31NCBI
HuRef183,211,956 - 3,220,663 (+)NCBIHuRef
CHM1_1183,246,864 - 3,255,620 (+)NCBICHM1_1
Myl12a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391771,300,788 - 71,309,528 (-)NCBIGRCm39mm39
GRCm381770,993,793 - 71,002,533 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1770,993,656 - 71,002,878 (-)EnsemblGRCm38mm10GRCm38
MGSCv371771,343,133 - 71,351,873 (-)NCBIGRCm37mm9NCBIm37
MGSCv361770,898,650 - 70,907,390 (-)NCBImm8
Celera1775,264,345 - 75,272,999 (-)NCBICelera
Cytogenetic Map17E1.3NCBI
LOC607207
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1769,860,472 - 69,871,878 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC103222703
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11862,496,372 - 62,504,835 (+)NCBI
ChlSab1.1 Ensembl1862,501,879 - 62,505,937 (+)Ensembl

Position Markers
RH128359  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.09119,325,433 - 119,325,618NCBIRnor6.0
Rnor_5.09118,779,767 - 118,779,952UniSTSRnor5.0
RGSC_v3.49110,190,181 - 110,190,366UniSTSRGSC3.4
Celera9108,022,327 - 108,022,512UniSTS
Cytogenetic Map9q38UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)929075079122095297Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)981411073119983851Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)990024661119983851Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:39
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000021048
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 3 43 57 41 19 41 8 11 74 35 41 9 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001135017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BQ207032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV767772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000021048   ⟹   ENSRNOP00000021048
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl9119,325,283 - 119,332,967 (-)Ensembl
RefSeq Acc Id: NM_001135017   ⟹   NP_001128489
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29110,891,970 - 110,899,655 (-)NCBI
Rnor_6.09119,325,282 - 119,332,967 (-)NCBI
Rnor_5.09118,779,616 - 118,787,326 (-)NCBI
RGSC_v3.49110,190,030 - 110,197,715 (-)RGD
Celera9108,022,176 - 108,029,861 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245667   ⟹   XP_006245729
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29110,891,974 - 110,896,118 (-)NCBI
Rnor_6.09119,325,286 - 119,329,442 (-)NCBI
Rnor_5.09118,779,616 - 118,787,326 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245668   ⟹   XP_006245730
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29110,891,974 - 110,899,628 (-)NCBI
Rnor_6.09119,325,286 - 119,333,012 (-)NCBI
Rnor_5.09118,779,616 - 118,787,326 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001128489   ⟸   NM_001135017
- UniProtKB: P13832 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245730   ⟸   XM_006245668
- Peptide Label: isoform X2
- UniProtKB: P13832 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245729   ⟸   XM_006245667
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000021048   ⟸   ENSRNOT00000021048
Protein Domains
EF-hand

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696911
Promoter ID:EPDNEW_R7436
Type:initiation region
Name:Myl12a_1
Description:myosin light chain 12A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09119,332,893 - 119,332,953EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309537 AgrOrtholog
Ensembl Genes ENSRNOG00000015278 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000021048 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021048 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
KEGG Report rno:501203 UniProtKB/Swiss-Prot
NCBI Gene 501203 ENTREZGENE
Pfam EF-hand_6 UniProtKB/Swiss-Prot
  EF-hand_8 UniProtKB/Swiss-Prot
PhenoGen Myl12a PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt MRLCA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Myl12a  myosin light chain 12A  Myl12a  myosin, light chain 12A, regulatory, non-sarcomeric  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Myl12a  myosin, light chain 12A, regulatory, non-sarcomeric  RGD1309537  similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1309537  similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A)   RGD1309537_predicted  similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1309537_predicted  similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A) (predicted)  LOC363299_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC363299_predicted  similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL