Gene: Acot8 (acyl-CoA thioesterase 8) Rattus norvegicus
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Symbol: Acot8
Name: acyl-CoA thioesterase 8
Description: ENCODES a protein that exhibits acyl-CoA hydrolase activity; choloyl-CoA hydrolase activity; medium-chain acyl-CoA hydrolase activity (ortholog); INVOLVED IN acyl-CoA metabolic process; dicarboxylic acid catabolic process (ortholog); negative regulation of CD4 biosynthetic process (ortholog); FOUND IN peroxisome; peroxisomal matrix (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; ammonium chloride; bisphenol A
AGR Description: Predicted to have medium-chain acyl-CoA hydrolase activity, palmitoyl-CoA hydrolase activity, and signaling receptor binding activity; predicted to be involved in several processes, including acyl-CoA metabolic process, carboxylic acid metabolic process, and negative regulation of CD4 biosynthetic process; predicted to localize to the peroxisomal matrix; orthologous to human ACOT8 (acyl-CoA thioesterase 8).
Merged Description: Predicted to have medium-chain acyl-CoA hydrolase activity, palmitoyl-CoA hydrolase activity, and signaling receptor binding activity; predicted to be involved in several processes, including acyl-CoA metabolic process, carboxylic acid metabolic process, and negative regulation of CD4 biosynthetic process; predicted to localize to the peroxisomal matrix; orthologous to human ACOT8 (acyl-CoA thioesterase 8); INTERACTS WITH 17alpha-ethynylestradiol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4,8-dimethylnonanoyl-CoA thioesterase; 48-dimethylnonanoyl-CoA thioesterase; acyl-coenzyme A thioesterase 8; choloyl-coenzyme A thioesterase; peroxisomal acyl-CoA thioesterase 1; peroxisomal acyl-CoA thioesterase 2; peroxisomal acyl-coenzyme A thioester hydrolase 1; peroxisomal long-chain acyl-CoA thioesterase 1; peroxisomalacyl-CoAthioesterase1; PTE-1; PTE-2; Pte1
Orthologs:
Homo sapiens (human) : ACOT8 (acyl-CoA thioesterase 8)  HGNC  Alliance
Mus musculus (house mouse) : Acot8 (acyl-CoA thioesterase 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acot8 (acyl-CoA thioesterase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : ACOT8 (acyl-CoA thioesterase 8)
Canis lupus familiaris (dog) : ACOT8 (acyl-CoA thioesterase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acot8 (acyl-CoA thioesterase 8)
Sus scrofa (pig) : ACOT8 (acyl-CoA thioesterase 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03161,260,837 - 161,272,495 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03167,446,048 - 167,457,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,828,209 - 155,839,862 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13155,734,245 - 155,745,898 (-)NCBI
Celera3152,138,819 - 152,150,462 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Acot8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70368
Created: 2002-03-20
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.