 Gene-Chemical Interaction Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations |
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Analyze GeneStrainQTL List |
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Gene Annotator (Annotation Comparison) |
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MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology AnnotationsBiological Process
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Cellular Component
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Molecular Function
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Molecular Pathway AnnotationsReferences - curated| 1. | Kaeser PS, etal., Cell. 2011 Jan 21;144(2):282-95. doi: 10.1016/j.cell.2010.12.029. |
| 2. | Lu J, etal., J Mol Biol. 2005 Sep 16;352(2):455-66. |
| 3. | MGD data from the GO Consortium |
| 4. | Mochida S, etal., Cell Rep. 2016 Sep 13;16(11):2901-2913. doi: 10.1016/j.celrep.2016.08.020. |
| 5. | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 6. | RGD automated data pipeline |
| 7. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 8. | RGD automated import pipeline for gene-chemical interactions |
| 9. | Wang Y, etal., Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14464-9. |
References - uncurated| PubMed | 11929610 14723704 15218148 16716196 19515363 21700703 21712437 23791195 25209271 25468996 27224062 27253063 27537483 28264913 |
Genomics
Comparative Map Data| Erc1 (Rattus norvegicus - Norway rat) |
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| ERC1 (Homo sapiens - human) |
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| Erc1 (Mus musculus - house mouse) |
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| Erc1 (Chinchilla lanigera - long-tailed chinchilla) |
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| ERC1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| ERC1 (Canis lupus familiaris - dog) |
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| Erc1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| ERC1 (Sus scrofa - pig) |
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| ERC1 (Chlorocebus sabaeus - African green monkey) |
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| Erc1 (Heterocephalus glaber - naked mole-rat) |
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Position Markers| D4Rat107 |
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| BE108954 |
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| BE095665 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
| High | |||||||||||||
| Medium | 28 | 11 | 5 | 8 | 5 | 1 | 1 | 74 | 22 | 34 | 11 | 1 | |
| Low | 3 | 15 | 46 | 36 | 11 | 36 | 7 | 10 | 13 | 7 | 7 | ||
| Below cutoff |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_170788 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006237224 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006237225 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006237226 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006237227 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006237228 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006237229 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006237230 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006237231 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017592490 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017592491 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR07061903 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AABR07073067 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01032610 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01032611 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01032612 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01032613 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01032614 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01032615 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01032616 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AC106348 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF541926 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AY174115 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473964 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | ENSRNOT00000012397 ⟹ ENSRNOP00000012397 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | ENSRNOT00000091473 ⟹ ENSRNOP00000070778 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | NM_170788 ⟹ NP_740769 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
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| Sequence: |
GGCATTTGTCGTTTCCGACCGGGCTCTGCGCTCCCGGCCCTGGCTGGGCAGGGCAGAGTGCCCChide sequence |
| RefSeq Acc Id: | XM_006237224 ⟹ XP_006237286 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
CATTTGTCGTTTCCGACCGGGCTCTGCGCTCCCGGCCCTGGCTGGGCAGGGCAGAGTGCCCCTGhide sequence |
| RefSeq Acc Id: | XM_006237225 ⟹ XP_006237287 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
CATTTGTCGTTTCCGACCGGGCTCTGCGCTCCCGGCCCTGGCTGGGCAGGGCAGAGTGCCCCTGhide sequence |
| RefSeq Acc Id: | XM_006237226 ⟹ XP_006237288 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
CATTTGTCGTTTCCGACCGGGCTCTGCGCTCCCGGCCCTGGCTGGGCAGGGCAGAGTGCCCCTGhide sequence |
| RefSeq Acc Id: | XM_006237227 ⟹ XP_006237289 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
CATTTGTCGTTTCCGACCGGGCTCTGCGCTCCCGGCCCTGGCTGGGCAGGGCAGAGTGCCCCTGhide sequence |
| RefSeq Acc Id: | XM_006237228 ⟹ XP_006237290 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
CATTTGTCGTTTCCGACCGGGCTCTGCGCTCCCGGCCCTGGCTGGGCAGGGCAGAGTGCCCCTGhide sequence |
| RefSeq Acc Id: | XM_006237229 ⟹ XP_006237291 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
CATTTGTCGTTTCCGACCGGGCTCTGCGCTCCCGGCCCTGGCTGGGCAGGGCAGAGTGCCCCTGhide sequence |
| RefSeq Acc Id: | XM_006237230 ⟹ XP_006237292 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
CATTTGTCGTTTCCGACCGGGCTCTGCGCTCCCGGCCCTGGCTGGGCAGGGCAGAGTGCCCCTGhide sequence |
| RefSeq Acc Id: | XM_006237231 ⟹ XP_006237293 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
CATTTGTCGTTTCCGACCGGGCTCTGCGCTCCCGGCCCTGGCTGGGCAGGGCAGAGTGCCCCTGhide sequence |
| RefSeq Acc Id: | XM_017592490 ⟹ XP_017447979 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
CATTTGTCGTTTCCGACCGGGCTCTGCGCTCCCGGCCCTGGCTGGGCAGGGCAGAGTGCCCCTGhide sequence |
| RefSeq Acc Id: | XM_017592491 ⟹ XP_017447980 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
CATTTGTCGTTTCCGACCGGGCTCTGCGCTCCCGGCCCTGGCTGGGCAGGGCAGAGTGCCCCTGhide sequence |
Protein Sequences| Protein RefSeqs | NP_740769 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006237286 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006237287 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006237288 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006237289 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006237290 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006237291 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006237292 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006237293 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017447979 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017447980 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | AAN39293 | (Get FASTA) | NCBI Sequence Viewer |
| AAO25554 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM02050 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM02051 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM02052 | (Get FASTA) | NCBI Sequence Viewer | |
| Q811U3 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_740769 ⟸ NM_170788 |
| - UniProtKB: | Q811U3 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAhide sequence |
| RefSeq Acc Id: | XP_006237292 ⟸ XM_006237230 |
| - Peptide Label: | isoform X7 |
| - Sequence: |
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAhide sequence |
| RefSeq Acc Id: | XP_006237289 ⟸ XM_006237227 |
| - Peptide Label: | isoform X4 |
| - Sequence: |
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAhide sequence |
| RefSeq Acc Id: | XP_006237291 ⟸ XM_006237229 |
| - Peptide Label: | isoform X6 |
| - Sequence: |
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAhide sequence |
| RefSeq Acc Id: | XP_006237288 ⟸ XM_006237226 |
| - Peptide Label: | isoform X3 |
| - Sequence: |
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAhide sequence |
| RefSeq Acc Id: | XP_006237287 ⟸ XM_006237225 |
| - Peptide Label: | isoform X2 |
| - Sequence: |
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAhide sequence |
| RefSeq Acc Id: | XP_006237290 ⟸ XM_006237228 |
| - Peptide Label: | isoform X5 |
| - Sequence: |
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAhide sequence |
| RefSeq Acc Id: | XP_006237286 ⟸ XM_006237224 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | A0A0G2JYT1 (UniProtKB/TrEMBL) |
| - Sequence: |
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAhide sequence |
| RefSeq Acc Id: | XP_006237293 ⟸ XM_006237231 |
| - Peptide Label: | isoform X8 |
| - Sequence: |
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAhide sequence |
| RefSeq Acc Id: | XP_017447979 ⟸ XM_017592490 |
| - Peptide Label: | isoform X9 |
| - Sequence: |
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAhide sequence |
| RefSeq Acc Id: | XP_017447980 ⟸ XM_017592491 |
| - Peptide Label: | isoform X10 |
| - Sequence: |
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAhide sequence |
| RefSeq Acc Id: | ENSRNOP00000012397 ⟸ ENSRNOT00000012397 |
| RefSeq Acc Id: | ENSRNOP00000070778 ⟸ ENSRNOT00000091473 |
Protein Domains
FIP-RBD
TranscriptomePromoters| RGD ID: | 13693353 | ||||||||
| Promoter ID: | EPDNEW_R3875 | ||||||||
| Type: | multiple initiation site | ||||||||
| Name: | Erc1_1 | ||||||||
| Description: | ELKS/RAB6-interacting/CAST family member 1 | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
| Experiment Methods: | Single-end sequencing. | ||||||||
| Position: |
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Strain Variation
Strain Sequence Variants (Rnor 6.0)
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Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:628733 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000009264 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000012397 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000070778 | ENTREZGENE, UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000012397 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000091473 | ENTREZGENE, UniProtKB/TrEMBL | |
| InterPro | ELKS/CAST | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| FIP-RBD_C_sf | UniProtKB/TrEMBL | |
| Rab-bd_FIP-RBD | UniProtKB/TrEMBL | |
| KEGG Report | rno:266806 | UniProtKB/Swiss-Prot |
| NCBI Gene | 266806 | ENTREZGENE |
| Pfam | Cast | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| RBD-FIP | UniProtKB/TrEMBL | |
| PhenoGen | Erc1 | PhenoGen |
| PROSITE | FIP_RBD | UniProtKB/TrEMBL |
| Superfamily-SCOP | SSF144270 | UniProtKB/TrEMBL |
| UniGene | Rn.207836 | ENTREZGENE |
| UniProt | A0A0G2JYT1 | ENTREZGENE, UniProtKB/TrEMBL |
| F1LPE9_RAT | UniProtKB/TrEMBL | |
| Q811U3 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| UniProt Secondary | Q8CIY9 | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-02-25 | Erc1 | ELKS/RAB6-interacting/CAST family member 1 | Rab6ip2 | Rab6 interacting protein 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2004-09-10 | Rab6ip2 | Rab6 interacting protein 2 | Elks | ELKS protein | Symbol and Name updated | 1299863 | APPROVED |
| 2003-02-27 | Elks | ELKS protein | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_transcript | has two alternative splicing variants; one variant generates a longer transcript that does not bind to RIMs | 632516 |
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| More on Erc1 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 628733 |
| Created: | 2003-02-27 |
| Species: | Rattus norvegicus |
| Last Modified: | 2020-08-20 |
| Status: | ACTIVE |
