Erc1 (ELKS/RAB6-interacting/CAST family member 1) - Rat Genome Database

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Gene: Erc1 (ELKS/RAB6-interacting/CAST family member 1) Rattus norvegicus
Analyze
Symbol: Erc1
Name: ELKS/RAB6-interacting/CAST family member 1
RGD ID: 628733
Description: Enables PDZ domain binding activity. Predicted to be involved in several processes, including chemical synaptic transmission; maintenance of presynaptic active zone structure; and regulation of calcium-dependent activation of synaptic vesicle fusion. Located in membrane; postsynaptic density; and synaptic vesicle. Is active in presynaptic active zone cytoplasmic component. Orthologous to human ERC1 (ELKS/RAB6-interacting/CAST family member 1); PARTICIPATES IN interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CAST; Cast2; CAZ-associated structural protein 2; Elks; ERC; ERC protein 1; ERC-1; ERC1b; Rab6 interacting protein 2; Rab6-interacting protein 2; Rab6ip2; RIM-Binding Protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24152,763,664 - 153,055,724 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4152,767,419 - 153,055,639 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4159,025,966 - 159,332,211 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04154,809,683 - 155,115,934 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04153,433,030 - 153,739,286 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04152,087,393 - 152,380,023 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4152,087,379 - 152,380,184 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04219,174,705 - 219,465,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44155,931,377 - 156,221,104 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14156,234,169 - 156,465,945 (-)NCBI
Celera4141,623,820 - 141,910,539 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Kaeser PS, etal., Cell. 2011 Jan 21;144(2):282-95. doi: 10.1016/j.cell.2010.12.029.
3. Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide. Lu J, etal., J Mol Biol. 2005 Sep 16;352(2):455-66.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. SAD-B Phosphorylation of CAST Controls Active Zone Vesicle Recycling for Synaptic Depression. Mochida S, etal., Cell Rep. 2016 Sep 13;16(11):2901-2913. doi: 10.1016/j.celrep.2016.08.020.
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones. Wang Y, etal., Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14464-9.
Additional References at PubMed
PMID:11929610   PMID:14723704   PMID:15218148   PMID:16716196   PMID:19515363   PMID:21700703   PMID:21712437   PMID:23791195   PMID:25209271   PMID:25468996   PMID:27224062   PMID:27253063  
PMID:27537483   PMID:28264913  


Genomics

Comparative Map Data
Erc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24152,763,664 - 153,055,724 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4152,767,419 - 153,055,639 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4159,025,966 - 159,332,211 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04154,809,683 - 155,115,934 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04153,433,030 - 153,739,286 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04152,087,393 - 152,380,023 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4152,087,379 - 152,380,184 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04219,174,705 - 219,465,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44155,931,377 - 156,221,104 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14156,234,169 - 156,465,945 (-)NCBI
Celera4141,623,820 - 141,910,539 (-)NCBICelera
Cytogenetic Map4q42NCBI
ERC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812989,959 - 1,495,933 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12990,509 - 1,495,933 (+)EnsemblGRCh38hg38GRCh38
GRCh37121,100,389 - 1,605,099 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612970,665 - 1,472,958 (+)NCBINCBI36Build 36hg18NCBI36
Celera122,707,077 - 3,211,656 (+)NCBICelera
Cytogenetic Map12p13.33NCBI
HuRef12952,225 - 1,457,980 (+)NCBIHuRef
CHM1_1121,099,408 - 1,604,090 (+)NCBICHM1_1
T2T-CHM13v2.012985,850 - 1,490,194 (+)NCBIT2T-CHM13v2.0
Erc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396119,547,757 - 119,830,985 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6119,547,757 - 119,825,128 (-)EnsemblGRCm39 Ensembl
GRCm386119,570,796 - 119,848,184 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6119,570,796 - 119,848,167 (-)EnsemblGRCm38mm10GRCm38
MGSCv376119,520,814 - 119,798,168 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366119,540,864 - 119,813,753 (-)NCBIMGSCv36mm8
Celera6121,405,104 - 121,685,429 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map656.86NCBI
Erc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554543,586,667 - 4,031,130 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554543,584,910 - 4,036,276 (+)NCBIChiLan1.0ChiLan1.0
ERC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1126,486,819 - 7,022,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,066,034 - 1,597,562 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1121,027,967 - 1,550,182 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,027,967 - 1,545,431 (+)Ensemblpanpan1.1panPan2
ERC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12743,004,243 - 43,544,260 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2743,038,544 - 43,678,843 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,140,420 - 3,679,170 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02743,365,560 - 43,911,683 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2743,365,538 - 43,911,649 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12743,303,937 - 43,842,830 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02743,275,814 - 43,815,242 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,498,548 - 3,038,339 (-)NCBIUU_Cfam_GSD_1.0
Erc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945107,470,207 - 107,982,754 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366061,201,657 - 1,708,551 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366061,201,420 - 1,713,894 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl568,223,729 - 68,608,703 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1568,223,722 - 68,608,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2570,490,274 - 70,873,482 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111989,376 - 1,530,470 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl111,030,294 - 1,524,817 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660636,812,077 - 7,356,786 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Erc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473511,400,159 - 11,841,920 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473511,398,603 - 11,907,553 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Erc1
1395 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:58
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000012397
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat

Markers in Region
D4Rat107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24152,925,326 - 152,925,562 (+)MAPPERmRatBN7.2
Rnor_6.04152,249,616 - 152,249,849NCBIRnor6.0
Rnor_5.04219,336,960 - 219,337,193UniSTSRnor5.0
RGSC_v3.44156,090,003 - 156,090,237RGDRGSC3.4
RGSC_v3.44156,090,004 - 156,090,237UniSTSRGSC3.4
RGSC_v3.14156,334,845 - 156,335,078RGD
Celera4141,780,453 - 141,780,686UniSTS
RH 3.4 Map4978.8RGD
RH 3.4 Map4978.8UniSTS
RH 2.0 Map4972.5RGD
SHRSP x BN Map477.0299RGD
Cytogenetic Map4q42UniSTS
BE108954  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24153,004,831 - 153,005,011 (+)MAPPERmRatBN7.2
Rnor_6.04152,329,598 - 152,329,777NCBIRnor6.0
Rnor_5.04219,416,860 - 219,417,039UniSTSRnor5.0
RGSC_v3.44156,170,532 - 156,170,711UniSTSRGSC3.4
Celera4141,859,984 - 141,860,163UniSTS
RH 3.4 Map4978.9UniSTS
Cytogenetic Map4q42UniSTS
BE095665  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24152,868,812 - 152,868,967 (+)MAPPERmRatBN7.2
Rnor_6.04152,193,101 - 152,193,255NCBIRnor6.0
Rnor_5.04219,280,713 - 219,280,867UniSTSRnor5.0
RGSC_v3.44156,032,819 - 156,032,973UniSTSRGSC3.4
Celera4141,724,043 - 141,724,197UniSTS
RH 3.4 Map4978.7UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 11 5 8 5 1 1 74 22 34 11 1
Low 3 15 46 36 11 36 7 10 13 7 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001394882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_172210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC106348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF541926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY174115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000012397   ⟹   ENSRNOP00000012397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4152,768,451 - 153,055,533 (-)Ensembl
Rnor_6.0 Ensembl4152,092,180 - 152,380,023 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091473   ⟹   ENSRNOP00000070778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4152,767,419 - 153,055,533 (-)Ensembl
Rnor_6.0 Ensembl4152,087,379 - 152,380,184 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102886   ⟹   ENSRNOP00000092904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4152,814,772 - 153,055,639 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109038   ⟹   ENSRNOP00000094050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4152,767,419 - 153,055,533 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115061   ⟹   ENSRNOP00000084657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4152,767,419 - 153,055,533 (-)Ensembl
RefSeq Acc Id: NM_001394882   ⟹   NP_001381811
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,763,664 - 153,055,724 (-)NCBI
RefSeq Acc Id: NM_001394883   ⟹   NP_001381812
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,763,664 - 153,055,724 (-)NCBI
RefSeq Acc Id: NM_001394884   ⟹   NP_001381813
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,763,664 - 153,055,724 (-)NCBI
RefSeq Acc Id: NR_172210
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,763,664 - 153,055,724 (-)NCBI
RefSeq Acc Id: XM_006237226   ⟹   XP_006237288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,763,664 - 153,055,704 (-)NCBI
Rnor_6.04152,087,393 - 152,380,021 (-)NCBI
Rnor_5.04219,174,705 - 219,465,108 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237230   ⟹   XP_006237292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,763,664 - 153,055,704 (-)NCBI
Rnor_6.04152,087,393 - 152,380,021 (-)NCBI
Rnor_5.04219,174,705 - 219,465,108 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592490   ⟹   XP_017447979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,788,247 - 153,055,704 (-)NCBI
Rnor_6.04152,112,020 - 152,380,021 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592491   ⟹   XP_017447980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,788,247 - 153,055,705 (-)NCBI
Rnor_6.04152,112,020 - 152,380,021 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107147   ⟹   XP_038963075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,763,664 - 153,055,705 (-)NCBI
RefSeq Acc Id: XM_039107148   ⟹   XP_038963076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,763,664 - 153,055,704 (-)NCBI
RefSeq Acc Id: XM_039107150   ⟹   XP_038963078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,763,664 - 153,055,706 (-)NCBI
RefSeq Acc Id: XM_039107151   ⟹   XP_038963079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,788,247 - 153,055,704 (-)NCBI
RefSeq Acc Id: XM_039107152   ⟹   XP_038963080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,788,247 - 153,055,705 (-)NCBI
RefSeq Acc Id: XM_039107154   ⟹   XP_038963082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24152,865,933 - 153,055,706 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_006237292   ⟸   XM_006237230
- Peptide Label: isoform X8
- UniProtKB: A6IL88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237288   ⟸   XM_006237226
- Peptide Label: isoform X5
- UniProtKB: F1LPE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447979   ⟸   XM_017592490
- Peptide Label: isoform X10
- UniProtKB: F1LPE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447980   ⟸   XM_017592491
- Peptide Label: isoform X12
- UniProtKB: A6IL89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012397   ⟸   ENSRNOT00000012397
RefSeq Acc Id: ENSRNOP00000070778   ⟸   ENSRNOT00000091473
RefSeq Acc Id: XP_038963078   ⟸   XM_039107150
- Peptide Label: isoform X7
- UniProtKB: A6IL89 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963075   ⟸   XM_039107147
- Peptide Label: isoform X1
- UniProtKB: F1LPE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963076   ⟸   XM_039107148
- Peptide Label: isoform X3
- UniProtKB: F1LPE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963080   ⟸   XM_039107152
- Peptide Label: isoform X11
- UniProtKB: A6IL89 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963079   ⟸   XM_039107151
- Peptide Label: isoform X9
- UniProtKB: F1LPE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963082   ⟸   XM_039107154
- Peptide Label: isoform X13
- UniProtKB: F1LPE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092904   ⟸   ENSRNOT00000102886
RefSeq Acc Id: ENSRNOP00000094050   ⟸   ENSRNOT00000109038
RefSeq Acc Id: ENSRNOP00000084657   ⟸   ENSRNOT00000115061
RefSeq Acc Id: NP_001381813   ⟸   NM_001394884
- Peptide Label: isoform 3
- UniProtKB: A0A8I6A0L5 (UniProtKB/TrEMBL),   A6IL87 (UniProtKB/TrEMBL),   F1LPE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001381812   ⟸   NM_001394883
- Peptide Label: isoform 2
- UniProtKB: A0A0G2JYT1 (UniProtKB/TrEMBL),   F1LPE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001381811   ⟸   NM_001394882
- Peptide Label: isoform 1
- UniProtKB: A0A8I6GKZ4 (UniProtKB/TrEMBL),   F1LPE9 (UniProtKB/TrEMBL)
Protein Domains
FIP-RBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q811U3-F1-model_v2 AlphaFold Q811U3 1-948 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628733 AgrOrtholog
BioCyc Gene G2FUF-43216 BioCyc
Ensembl Genes ENSRNOG00000009264 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012397 ENTREZGENE
  ENSRNOP00000012397.5 UniProtKB/TrEMBL
  ENSRNOP00000070778 ENTREZGENE
  ENSRNOP00000070778.2 UniProtKB/TrEMBL
  ENSRNOP00000084657 ENTREZGENE
  ENSRNOP00000084657.1 UniProtKB/TrEMBL
  ENSRNOP00000092904 ENTREZGENE
  ENSRNOP00000092904.1 UniProtKB/TrEMBL
  ENSRNOP00000094050 ENTREZGENE
  ENSRNOP00000094050.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012397 ENTREZGENE
  ENSRNOT00000012397.5 UniProtKB/TrEMBL
  ENSRNOT00000091473 ENTREZGENE
  ENSRNOT00000091473.2 UniProtKB/TrEMBL
  ENSRNOT00000102886 ENTREZGENE
  ENSRNOT00000102886.1 UniProtKB/TrEMBL
  ENSRNOT00000109038 ENTREZGENE
  ENSRNOT00000109038.1 UniProtKB/TrEMBL
  ENSRNOT00000115061 ENTREZGENE
  ENSRNOT00000115061.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.2440 UniProtKB/TrEMBL
  1.20.5.340 UniProtKB/TrEMBL
InterPro ELKS/CAST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIP-RBD_C_sf UniProtKB/TrEMBL
  Rab-bd_FIP-RBD UniProtKB/TrEMBL
KEGG Report rno:266806 UniProtKB/Swiss-Prot
NCBI Gene 266806 ENTREZGENE
PANTHER ELKS/RAB6-INTERACTING/CAST FAMILY MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ELKS/RAB6-INTERACTING/CAST PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cast UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD-FIP UniProtKB/TrEMBL
PhenoGen Erc1 PhenoGen
PROSITE FIP_RBD UniProtKB/TrEMBL
Superfamily-SCOP Myosin rod fragments UniProtKB/TrEMBL
  SSF144270 UniProtKB/TrEMBL
  Tropomyosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JYT1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0L5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIL7_RAT UniProtKB/TrEMBL
  A0A8I6GKZ4 ENTREZGENE, UniProtKB/TrEMBL
  A6IL87 ENTREZGENE, UniProtKB/TrEMBL
  A6IL88 ENTREZGENE, UniProtKB/TrEMBL
  A6IL89 ENTREZGENE, UniProtKB/TrEMBL
  F1LPE9 ENTREZGENE, UniProtKB/TrEMBL
  Q811U3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8CIY9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Erc1  ELKS/RAB6-interacting/CAST family member 1  Rab6ip2  Rab6 interacting protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rab6ip2  Rab6 interacting protein 2  Elks  ELKS protein  Symbol and Name updated 1299863 APPROVED
2003-02-27 Elks  ELKS protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_transcript has two alternative splicing variants; one variant generates a longer transcript that does not bind to RIMs 632516