Amh (anti-Mullerian hormone) - Rat Genome Database

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Gene: Amh (anti-Mullerian hormone) Rattus norvegicus
Analyze
Symbol: Amh
Name: anti-Mullerian hormone
RGD ID: 2108
Description: Exhibits transforming growth factor beta receptor binding activity. Involved in several processes, including negative regulation of ovarian follicle development; positive regulation of NF-kappaB transcription factor activity; and preantral ovarian follicle growth. Localizes to extracellular space. Human ortholog(s) of this gene implicated in disorder of sexual development; ovarian carcinoma; and persistent Mullerian duct syndrome. Orthologous to human AMH (anti-Mullerian hormone); PARTICIPATES IN cytokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: anti - Mullerian hormone; Anti - Mullerian hormone (Mulerian inhibiting substance); anti-Muellerian hormone; MIS; muellerian-inhibiting factor; muellerian-inhibiting substance
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,906,776 - 8,909,184 (-)NCBI
Rnor_6.0 Ensembl711,775,155 - 11,777,503 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0711,775,155 - 11,777,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0711,942,870 - 11,945,218 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,417,325 - 10,419,673 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,417,324 - 10,419,673 (-)NCBI
Celera77,089,574 - 7,091,922 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
extracellular space  (IBA,IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Bayrak A, etal., Fertil Steril. 2007 Jan 12;.
2. Bedecarrats GY, etal., Proc Natl Acad Sci U S A 2003 Aug 5;100(16):9348-53. Epub 2003 Jul 23.
3. Carlsson IB, etal., Hum Reprod. 2006 Sep;21(9):2223-7. Epub 2006 May 23.
4. Carre-Eusebe D, etal., Hum Genet. 1992 Dec;90(4):389-94.
5. Chang HL, etal., Gynecol Oncol. 2009 Jul;114(1):57-60. Epub 2009 Apr 8.
6. Dorgan JF, etal., J Natl Cancer Inst. 2009 Nov 4;101(21):1501-9. Epub 2009 Oct 9.
7. Freeman EW, etal., Fertil Steril. 2007 Jan;87(1):101-6. Epub 2006 Nov 15.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. GOA data from the GO Consortium
10. Haqq C, etal., Genomics 1992 Apr;12(4):665-9.
11. Ikeda Y, etal., Endocrinology 2002 Jan;143(1):304-12.
12. McGee EA, etal., Biol Reprod. 2001 Jan;64(1):293-8.
13. MGD data from the GO Consortium
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline
16. Pieretti-Vanmarcke R, etal., Clin Cancer Res. 2006 Mar 1;12(5):1593-8.
17. Pipeline to import KEGG annotations from KEGG into RGD
18. RGD automated data pipeline
19. RGD automated import pipeline for gene-chemical interactions
20. Segev DL, etal., J Biol Chem 2001 Jul 20;276(29):26799-806.
21. Song JY, etal., Int J Oncol. 2009 Jun;34(6):1583-91.
22. Tian XY, etal., Reproduction. 2001 Jun;121(6):873-80.
23. Uzumcu M, etal., J Endocrinol. 2006 Dec;191(3):549-58.
24. Visser JA, etal., Mol Endocrinol. 2001 Jun;15(6):936-45.
25. Yeh J, etal., Biochem Biophys Res Commun. 2006 Sep 22;348(2):337-44. Epub 2006 Jul 13.
26. Yeh J, etal., Fertil Steril. 2007 May;87(5):1227-30. Epub 2007 Jan 12.
Additional References at PubMed
PMID:14585814   PMID:14695376   PMID:14750901   PMID:15789443   PMID:16207837   PMID:20816688   PMID:21637711   PMID:25667201   PMID:26753790   PMID:27030385  


Genomics

Comparative Map Data
Amh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,906,776 - 8,909,184 (-)NCBI
Rnor_6.0 Ensembl711,775,155 - 11,777,503 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0711,775,155 - 11,777,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0711,942,870 - 11,945,218 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,417,325 - 10,419,673 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,417,324 - 10,419,673 (-)NCBI
Celera77,089,574 - 7,091,922 (-)NCBICelera
Cytogenetic Map7q11NCBI
AMH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl192,249,309 - 2,252,073 (+)EnsemblGRCh38hg38GRCh38
GRCh38192,249,323 - 2,252,073 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37192,249,322 - 2,252,072 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,200,113 - 2,203,072 (+)NCBINCBI36hg18NCBI36
Build 34192,200,121 - 2,203,071NCBI
Celera192,183,289 - 2,186,248 (+)NCBI
Cytogenetic Map19p13.3NCBI
HuRef192,020,229 - 2,023,188 (+)NCBIHuRef
CHM1_1192,248,616 - 2,251,575 (+)NCBICHM1_1
Amh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,641,074 - 80,643,513 (+)NCBIGRCm39mm39
GRCm39 Ensembl1080,641,077 - 80,643,482 (+)Ensembl
GRCm381080,805,240 - 80,807,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,805,243 - 80,807,648 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,267,993 - 80,270,393 (+)NCBIGRCm37mm9NCBIm37
MGSCv361080,208,377 - 80,210,777 (+)NCBImm8
Celera1081,823,618 - 81,826,018 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Amh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,893,446 - 5,895,912 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,893,375 - 5,896,152 (-)NCBIChiLan1.0ChiLan1.0
AMH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1192,231,984 - 2,236,130 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0191,260,219 - 1,263,395 (+)NCBIMhudiblu_PPA_v0panPan3
AMH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,785,960 - 56,788,815 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,581,099 - 56,583,889 (-)NCBI
ROS_Cfam_1.02057,518,896 - 57,521,686 (-)NCBI
UMICH_Zoey_3.12056,570,917 - 56,573,707 (-)NCBI
UNSW_CanFamBas_1.02057,056,052 - 57,058,835 (-)NCBI
UU_Cfam_GSD_1.02057,256,543 - 57,259,332 (-)NCBI
Amh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,489,037 - 216,492,075 (-)NCBI
SpeTri2.0NW_0049365881,342,791 - 1,345,746 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,405,253 - 76,418,312 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,415,564 - 76,418,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,982,764 - 76,983,243 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q14-q21NCBI
AMH
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,047,756 - 2,051,073 (+)NCBI
ChlSab1.1 Ensembl62,048,319 - 2,050,958 (+)Ensembl
Amh
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248286,635,192 - 6,638,104 (-)NCBI

Position Markers
PMC203309P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0711,775,948 - 11,776,135NCBIRnor6.0
Rnor_5.0711,943,663 - 11,943,850UniSTSRnor5.0
RGSC_v3.4710,418,118 - 10,418,305UniSTSRGSC3.4
Celera77,090,367 - 7,090,554UniSTS
Cytogenetic Map7q11UniSTS
UniSTS:547550  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0711,776,353 - 11,776,750NCBIRnor6.0
Rnor_5.0711,944,068 - 11,944,465UniSTSRnor5.0
Celera77,090,772 - 7,091,169UniSTS
Cytogenetic Map7q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7265313832258115Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7591147750911477Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7595196950951969Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7975804554758045Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)71164710256647102Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:40
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000026220
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 16
Low 7 17 7 7 28 15 5 7
Below cutoff 3 42 40 31 2 31 1 4 45 30 9 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026220   ⟹   ENSRNOP00000026220
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl711,775,155 - 11,777,503 (-)Ensembl
RefSeq Acc Id: NM_012902   ⟹   NP_037034
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,906,836 - 8,909,184 (-)NCBI
Rnor_6.0711,775,155 - 11,777,503 (-)NCBI
Rnor_5.0711,942,870 - 11,945,218 (-)NCBI
RGSC_v3.4710,417,325 - 10,419,673 (-)RGD
Celera77,089,574 - 7,091,922 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078464   ⟹   XP_038934392
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,906,776 - 8,908,923 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037034 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934392 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB22104 (Get FASTA)   NCBI Sequence Viewer  
  EDL89230 (Get FASTA)   NCBI Sequence Viewer  
  P49000 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037034   ⟸   NM_012902
- Peptide Label: precursor
- UniProtKB: P49000 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026220   ⟸   ENSRNOT00000026220
RefSeq Acc Id: XP_038934392   ⟸   XM_039078464
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695003
Promoter ID:EPDNEW_R5528
Type:single initiation site
Name:Amh_1
Description:anti-Mullerian hormone
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,777,488 - 11,777,548EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 10419432 10419433 A T snv SS/JrHsdMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2108 AgrOrtholog
Ensembl Genes ENSRNOG00000019377 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000026220 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026220 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro AMH_N UniProtKB/Swiss-Prot
  Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Muellerian-inhibiting_factor UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report rno:25378 UniProtKB/Swiss-Prot
NCBI Gene 25378 ENTREZGENE
PANTHER PTHR15009 UniProtKB/Swiss-Prot
Pfam AMH_N UniProtKB/Swiss-Prot
  TGF_beta UniProtKB/Swiss-Prot
PhenoGen Amh PhenoGen
PIRSF Muellerian-inhibiting_factor UniProtKB/Swiss-Prot
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt MIS_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Amh  anti-Mullerian hormone    anti-mullerian hormone  Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Amh  anti-mullerian hormone      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease inhibits human breast cancer cell growth in vitro through interference with cell cycle progression and induction of apoptosis 70295
gene_disease inhibits human breast cancer cell growth in vitro through interference with cell cycle progression and induction of apoptosis 70576
gene_expression produced by Sertoli cells of the testis (males); in females, synthesized by granulosa cells of the ovary and persists until menopause 70295
gene_expression produced by Sertoli cells of the testis (males); in females, synthesized by granulosa cells of the ovary and persists until menopause 70576
gene_expression expressed in the granulosa small growing follicles in the ovary 70295
gene_expression expressed in the granulosa small growing follicles in the ovary 70576
gene_expression expression is high in the 1-day-postnatal testis and decreases to a low level in the adult testis 1298546
gene_function testicular glycoprotein ligand for MIS receptor II that causes regression of Mullerian duct, the fallopian tubes and part of the vagina 1298546
gene_process responsible for the regression of Mullerian duct in male embryos 70295
gene_process responsible for the regression of Mullerian duct in male embryos 70576
gene_process plays a key role in male sexual development and differentiation 1298546
gene_process regulates such hypothalamic/pituitary/gonadal axis processes as steroidogenesis, breast and prostate growth, and ovarian follicle recruitment 1298576
gene_process enhances the effect of gonadotropin-releasing hormone (GnRH) agonist on the FSHbeta gene promoter and synergizes with the GnRH agonist to stimulate LHbeta gene promoter activity 1298576
gene_process regulates follicular growth 70576
gene_process contributes to ovarian development 70576
gene_process impedes cell cycle progression and apoptosis induction and thus breast cancer cell growth 70295
gene_process induces NFkappaB to bind to its cognate DNA sequence 70295
gene_process enhances IEX-1S mRNA expression in breast tissue 70295
gene_process increases apoptosis in the mouse mammary ductal epithelium 70295
gene_process potential endogenous hormonal regulator of NFkappaB signaling and growth in breast tissue 70295
gene_product member of the transforming growth factor b family  
gene_regulation mRNA and protein expression in ovary increased by E2 benzoate; reduction is correlated with the inhibotory effect of EB on the follicular stratification 70295
gene_regulation mRNA and protein expression in ovary increased by E2 benzoate; reduction is correlated with the inhibotory effect of EB on the follicular stratification 70576
gene_regulation transcription is estrogen responsive 70576
gene_regulation activated by steroidogenic factor 1 70576