Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Npr3 (natriuretic peptide receptor 3) Rattus norvegicus
Symbol: Npr3
Name: natriuretic peptide receptor 3
Description: Exhibits identical protein binding activity; peptide hormone binding activity; and peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; phosphatidylinositol-mediated signaling; and positive regulation of nitric-oxide synthase activity. Localizes to membrane. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3); PARTICIPATES IN C-type natriuretic peptide signaling pathway; INTERACTS WITH 17beta-estradiol; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Also known as: ANP-C; ANP-CR; ANPR-C; ANPRC; atrial natriuretic peptide C-type receptor; atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide clearence receptor 3; atrial natriuretic peptide receptor 3; atrial natriuretic peptide receptor type C; natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); NPR-C; NPRC
Homo sapiens (human) : NPR3 (natriuretic peptide receptor 3)  HGNC  Alliance
Mus musculus (house mouse) : Npr3 (natriuretic peptide receptor 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npr3 (natriuretic peptide receptor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NPR3 (natriuretic peptide receptor 3)
Canis lupus familiaris (dog) : NPR3 (natriuretic peptide receptor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npr3 (natriuretic peptide receptor 3)
Sus scrofa (pig) : NPR3 (natriuretic peptide receptor 3)
Chlorocebus sabaeus (African green monkey) : NPR3 (natriuretic peptide receptor 3)
Heterocephalus glaber (naked mole-rat) : Npr3 (natriuretic peptide receptor 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0261,883,946 - 61,950,291 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl261,888,950 - 61,949,926 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0282,740,513 - 82,806,584 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4261,278,264 - 61,341,460 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1261,206,496 - 61,269,693 (-)NCBI
Celera257,760,666 - 57,821,249 (+)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Npr3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3196
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.