Npr3 (natriuretic peptide receptor 3)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Npr3 (natriuretic peptide receptor 3) Rattus norvegicus

Analyze

Symbol:

Npr3

Name:

natriuretic peptide receptor 3

RGD ID:

3196

Description:

Enables identical protein binding activity; peptide hormone binding activity; and peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity; and positive regulation of nitric-oxide synthase activity. Located in membrane. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3); PARTICIPATES IN C-type natriuretic peptide signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ANP-C; ANP-CR; ANPR-C; ANPRC; atrial natriuretic peptide C-type receptor; atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide clearence receptor 3; atrial natriuretic peptide receptor 3; atrial natriuretic peptide receptor type C; natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); NPR-C; NPRC

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NPR3 (natriuretic peptide receptor 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Npr3 (natriuretic peptide receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Npr3 (natriuretic peptide receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NPR3 (natriuretic peptide receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NPR3 (natriuretic peptide receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Npr3 (natriuretic peptide receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NPR3 (natriuretic peptide receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NPR3 (natriuretic peptide receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Npr3 (natriuretic peptide receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Npr3 (natriuretic peptide receptor 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NPR3 (natriuretic peptide receptor 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	npr3 (natriuretic peptide receptor 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG14877	Alliance	DIOPT (OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	60,865,483 - 60,933,432 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	60,870,594 - 60,932,955 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	68,000,358 - 68,061,538 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	66,121,915 - 66,183,093 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	61,123,277 - 61,184,447 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	61,883,946 - 61,950,291 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	61,888,950 - 61,949,926 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	82,740,513 - 82,806,584 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	61,278,264 - 61,341,460 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	61,206,496 - 61,269,693 (-)	NCBI
Celera	2	57,760,666 - 57,821,249 (+)	NCBI		Celera
Cytogenetic Map	2	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

bone disease (ISS)

BOUDIN-MORTIER SYNDROME (ISO)

diabetic retinopathy (IEP)

genetic disease (ISO)

hypertension (ISO)

musculoskeletal system disease (ISO)

Myocardial Reperfusion Injury (IDA)

Neurodevelopmental Disorders (ISO)

Prostatic Neoplasms (ISO)

Weight Gain (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

acrolein (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

barium(0) (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

C60 fullerene (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

carvedilol (EXP)

chlormequat chloride (EXP)

chloroprene (ISO)

chromium atom (ISO)

chrysene (ISO)

cobalt atom (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (EXP)

dichloroacetic acid (ISO)

Didecyldimethylammonium (ISO)

dimethylselenide (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

flavonoids (EXP)

flusilazole (EXP)

folic acid (ISO)

fonofos (ISO)

fulvestrant (ISO)

furan (EXP)

geldanamycin (ISO)

genistein (ISO)

gentamycin (EXP)

Guanylin (ISO)

lead diacetate (EXP)

lipopolysaccharide (EXP,ISO)

methyl salicylate (ISO)

methylisothiazolinone (ISO)

N-ethyl-N-nitrosourea (ISO)

nickel atom (ISO)

nitrofen (EXP)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

parathion (ISO)

peroxynitrous acid (EXP)

phenformin (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

potassium atom (ISO)

potassium bromate (ISO)

potassium chromate (ISO)

progesterone (ISO)

quercetin (ISO)

reactive oxygen species (ISO)

rimonabant (ISO)

rotenone (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

S-nitroso-N-acetyl-D-penicillamine (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sotorasib (ISO)

sulforaphane (ISO)

sunitinib (ISO)

terbufos (ISO)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

titanium dioxide (EXP,ISO)

trametinib (ISO)

triadimefon (ISO)

trichostatin A (ISO)

troglitazone (ISO)

valproic acid (ISO)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (IMP)

angiogenesis (ISO)

blood vessel remodeling (ISO)

negative regulation of adenylate cyclase activity (IDA)

negative regulation of cold-induced thermogenesis (ISO,ISS)

negative regulation of smooth muscle cell proliferation (IMP)

osteoclast proliferation (ISO,ISS)

pancreatic juice secretion (IMP)

phosphatidylinositol-mediated signaling (IMP)

phospholipase C-activating G protein-coupled receptor signaling pathway (IMP)

positive regulation of nitric-oxide synthase activity (IDA)

positive regulation of urine volume (ISO,ISS)

regulation of blood pressure (IMP,ISO,ISS)

regulation of osteoblast proliferation (ISO,ISS)

response to ischemia (ISO)

signal transduction (IBA)

skeletal system development (ISO,ISS)

vasodilation (IMP)

Cellular Component

membrane (IDA)

membrane (IEA)

plasma membrane (IC)

protein-containing complex (ISO)

Molecular Function

chloride ion binding (ISO)

G protein-coupled peptide receptor activity (IDA)

hormone binding (ISO)

identical protein binding (IPI)

natriuretic peptide receptor activity (IBA,IDA,IMP,ISO,ISS)

peptide binding (ISO)

peptide hormone binding (IBA,IDA,ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

C-type natriuretic peptide signaling pathway (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Cytoplasmic domain of natriuretic peptide receptor-C inhibits adenylyl cyclase. Involvement of a pertussis toxin-sensitive G protein.	Anand-Srivastava MB, etal., J Biol Chem. 1996 Aug 9;271(32):19324-9.
2.	Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes.	Bordicchia M, etal., J Clin Invest. 2012 Mar;122(3):1022-36. doi: 10.1172/JCI59701. Epub 2012 Feb 6.
3.	Modulation of ANP-C receptor signaling by endothelin-1 in A-10 smooth muscle cells.	Boumati M, etal., Arch Biochem Biophys 2002 May 15;401(2):178-86.
4.	A single residue determines the distinct pharmacology of rat and human natriuretic peptide receptor-C.	Engel AM, etal., J Biol Chem 1994 Jun 24;269(25):17005-8.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide.	Hobbs A, etal., Circulation. 2004 Sep 7;110(10):1231-5. Epub 2004 Aug 30.
8.	Three new allelic mouse mutations that cause skeletal overgrowth involve the natriuretic peptide receptor C gene (Npr3).	Jaubert J, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10278-83.
9.	Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide.	Khambata RS, etal., Br J Pharmacol. 2011 Sep;164(2b):584-97. doi: 10.1111/j.1476-5381.2011.01400.x.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Atrial natriuretic peptide-C receptor-induced attenuation of adenylyl cyclase signaling activates phosphatidylinositol turnover in A10 vascular smooth muscle cells.	Mouawad R, etal., Mol Pharmacol. 2004 Apr;65(4):917-24.
12.	G protein-dependent activation of smooth muscle eNOS via natriuretic peptide clearance receptor.	Murthy KS, etal., Am J Physiol. 1998 Dec;275(6 Pt 1):C1409-16.
13.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
14.	Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A.	Oliver PM, etal., Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14730-5.
15.	Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype.	Pitzalis MV, etal., J Hypertens. 2003 Aug;21(8):1491-6.
16.	GOA pipeline	RGD automated data pipeline
17.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
19.	Downregulation of the atrial natriuretic peptide/natriuretic peptide receptor-C system in the early stages of diabetic retinopathy in the rat.	Rollin R, etal., Mol Vis. 2005 Mar 18;11:216-24.
20.	Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPR-C receptors.	Sabbatini ME, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G929-37. Epub 2003 Jun 26.
21.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22.	Molecular characterisation and functional interrogation of a local natriuretic peptide system in rodent pituitaries, alphaT3-1 and LbetaT2 gonadotroph cells.	Thompson IR, etal., J Endocrinol. 2009 Nov;203(2):215-29. doi: 10.1677/JOE-09-0189. Epub 2009 Aug 7.
23.	Natriuretic peptides suppress protein kinase C activity to reduce evoked dopamine efflux from pheochromocytoma (PC12) cells.	Trachte GJ Endocrinology 2003 Jan;144(1):94-100.
24.	Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor.	Villar IC, etal., Cardiovasc Res. 2007 Jun 1;74(3):515-25. Epub 2007 Mar 3.
25.	Identification of the G protein-activating sequence of the single-transmembrane natriuretic peptide receptor C (NPR-C).	Zhou H and Murthy KS, Am J Physiol Cell Physiol. 2003 May;284(5):C1255-61.

Additional References at PubMed

PMID:1660465	PMID:7554122	PMID:10377427	PMID:14599710	PMID:15911073	PMID:16712979	PMID:16870210	PMID:17702953	PMID:17951249	PMID:18162186	PMID:18778744	PMID:19187227
PMID:19252090	PMID:19878700	PMID:19969282	PMID:20304036	PMID:20564198	PMID:21723350	PMID:22131352	PMID:23376485	PMID:23533145	PMID:24155894	PMID:24189506	PMID:25736855
PMID:27108789	PMID:27494651	PMID:29417337	PMID:33849828	PMID:36243172

Genomics

Comparative Map Data

Npr3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	60,865,483 - 60,933,432 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	60,870,594 - 60,932,955 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	68,000,358 - 68,061,538 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	66,121,915 - 66,183,093 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	61,123,277 - 61,184,447 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	61,883,946 - 61,950,291 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	61,888,950 - 61,949,926 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	82,740,513 - 82,806,584 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	61,278,264 - 61,341,460 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	61,206,496 - 61,269,693 (-)	NCBI
Celera	2	57,760,666 - 57,821,249 (+)	NCBI		Celera
Cytogenetic Map	2	q16	NCBI

NPR3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	32,690,872 - 32,791,720 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	5	32,689,070 - 32,791,724 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	32,690,978 - 32,791,826 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	32,747,422 - 32,823,013 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	32,747,421 - 32,823,009	NCBI
Celera	5	32,593,318 - 32,668,888 (+)	NCBI		Celera
Cytogenetic Map	5	p13.3	NCBI
HuRef	5	32,678,571 - 32,759,879 (+)	NCBI		HuRef
CHM1_1	5	32,712,833 - 32,793,931 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	32,804,528 - 32,905,709 (+)	NCBI		T2T-CHM13v2.0

Npr3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	11,839,982 - 11,907,923 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	11,839,982 - 11,907,373 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	11,839,896 - 11,907,837 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	11,839,896 - 11,907,287 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	11,769,651 - 11,835,429 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	11,784,621 - 11,850,399 (-)	NCBI		MGSCv36	mm8
Celera	15	11,624,844 - 11,690,388 (-)	NCBI		Celera
Cytogenetic Map	15	A1	NCBI
cM Map	15	5.83	NCBI

Npr3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955426	18,491,350 - 18,553,743 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955426	18,491,350 - 18,559,299 (+)	NCBI	ChiLan1.0	ChiLan1.0

NPR3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	5	82,921,035 - 83,004,964 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	82,926,409 - 83,004,964 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	5	77,542,200 - 77,621,983 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

NPR3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	74,794,553 - 74,863,344 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	74,799,857 - 74,862,969 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	74,429,055 - 74,497,877 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	75,311,739 - 75,380,568 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	75,311,746 - 75,380,475 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	75,049,009 - 75,118,047 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	75,177,562 - 75,246,355 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	75,708,336 - 75,777,195 (-)	NCBI		UU_Cfam_GSD_1.0

Npr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	223,211,508 - 223,281,564 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936518	8,093,561 - 8,158,868 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936518	8,093,111 - 8,158,862 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NPR3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	18,842,039 - 18,929,805 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	18,841,540 - 18,929,813 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

NPR3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	31,984,712 - 32,062,593 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	31,986,217 - 32,062,199 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	22,244,880 - 22,328,902 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Npr3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	21,829,336 - 21,904,405 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624759	21,826,271 - 21,904,928 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Npr3
272 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	80
Count of miRNA genes:	70
Interacting mature miRNAs:	74
Transcripts:	ENSRNOT00000025966
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	16491740	61491740	Rat
1357990	Ael1	Aortic elastin QTL 1	3.1	0.00091	aorta elastin amount (VT:0003905)	aortic elastin	2	19076825	64076825	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	20304672	65304672	Rat
2300168	Bmd47	Bone mineral density QTL 47	6.6	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	2	20662448	65662448	Rat
10402051	Gdil2	Gastrointestinal dilation QTL 2			enteric ganglion morphology trait (VT:0001045)	length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)	2	24903853	74786777	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	26917817	81754745	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	26917817	81754745	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	81754745	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	27157160	72157160	Rat
10755434	Coatc7	Coat color QTL 7		0.04794	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	30648065	75648065	Rat
10755436	Coatc8	Coat color QTL 8		0.02431	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	35023117	80023117	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	35134841	88029593	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	40067944	102785628	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	157142209	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
2293676	Bmd19	Bone mineral density QTL 19	10.7	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	43162366	111362592	Rat
2293682	Bmd24	Bone mineral density QTL 24	8.9	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	43162366	111362592	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43162366	148478373	Rat
631208	Bw1	Body weight QTL1	5.09		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	2	43171017	83575226	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1354592	Rf50	Renal function QTL 50	3.5		urine output (VT:0003620)	timed urine volume (CMO:0000260)	2	53822747	74786777	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
6480225	Gdil1	Gastrointestinal dilation QTL 1			enteric ganglion morphology trait (VT:0001045)	length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)	2	56660879	74786777	Rat
1582246	Cm60	Cardiac mass QTL 60	5.8		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	57605612	76539510	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	59134147	127460910	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	59324377	103795077	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	59324377	103795077	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	59324377	141596857	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	59324719	102755241	Rat
1578777	Stresp15	Stress response QTL 15	2	0.05	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	2	59846005	104846005	Rat

Markers in Region

PMC17879P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	60,931,634 - 60,932,217 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	61,949,650 - 61,950,232	NCBI	Rnor6.0
Rnor_5.0	2	82,740,551 - 82,741,133	UniSTS	Rnor5.0
RGSC_v3.4	2	61,341,404 - 61,341,986	UniSTS	RGSC3.4
Celera	2	57,760,140 - 57,760,722	UniSTS
Cytogenetic Map	2	q16	UniSTS

RH130055

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	60,889,134 - 60,889,352 (+)	MAPPER	mRatBN7.2
mRatBN7.2	16	10,074,951 - 10,075,169 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	11,108,549 - 11,108,766	NCBI	Rnor6.0
Rnor_6.0	2	61,907,585 - 61,907,802	NCBI	Rnor6.0
Rnor_5.0	16	9,434,028 - 9,434,245	UniSTS	Rnor5.0
Rnor_5.0	2	82,783,104 - 82,783,321	UniSTS	Rnor5.0
RGSC_v3.4	2	61,297,441 - 61,297,658	UniSTS	RGSC3.4
RGSC_v3.4	16	10,409,488 - 10,409,705	UniSTS	RGSC3.4
Celera	16	5,142,569 - 5,142,786	UniSTS
Celera	2	57,802,577 - 57,802,794	UniSTS
RH 3.4 Map	16	98.1	UniSTS
Cytogenetic Map	2	q16	UniSTS
Cytogenetic Map	16	p15	UniSTS

PMC22098P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	60,930,929 - 60,931,451 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	61,948,945 - 61,949,466	NCBI	Rnor6.0
Rnor_5.0	2	82,741,317 - 82,741,838	UniSTS	Rnor5.0
RGSC_v3.4	2	61,340,699 - 61,341,220	UniSTS	RGSC3.4
Celera	2	57,760,906 - 57,761,427	UniSTS
Cytogenetic Map	2	q16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		40	18	10	2	10	2	2	12	31	18	11	2
Low	3	3	38	30	14	30	6	9	62	4	23		6
Below cutoff			1	1	3	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L27339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X75605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X78595	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000025966 ⟹ ENSRNOP00000025966

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	60,870,594 - 60,931,691 (-)	Ensembl
Rnor_6.0 Ensembl	2	61,888,950 - 61,949,926 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000116101 ⟹ ENSRNOP00000079490

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	60,870,634 - 60,932,955 (-)	Ensembl

RefSeq Acc Id:

NM_012868 ⟹ NP_037000

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	60,870,594 - 60,931,691 (-)	NCBI
Rnor_6.0	2	61,889,053 - 61,949,706 (-)	NCBI
Rnor_5.0	2	82,740,513 - 82,806,584 (+)	NCBI
RGSC_v3.4	2	61,278,264 - 61,341,460 (-)	RGD
Celera	2	57,760,666 - 57,821,249 (+)	RGD

Sequence:

show sequence

GCTTGCTGGCAACAGGATGCGGTCCCTGCTGCTGTTCACTTTCTCGGCGTGCGTGCTGCTGGCC
CGGGCGCTGCTGGCTGGCGGTGCGAGTAGTGGCGGTGGGGACACCGGGCCAGGCAACAGGCGCC
GGGAGAGAGAGGCGCTGGCGGCTCAAAAGATCGAGGTGCTTGTGCTATTGCCCCGGGACGATTC
GTACTTGTTCTCGCTGGCCCGGGTGAGGCCGGCCATCGAGTACGCGCTGCGTAGCGTGGAGGGC
AATGGCACCGGCAGGAAGCTGCTGCCGCCCGGCACTCGCTTCCAGGTGGCCTATGAAGACTCTG
ACTGTGGCAACCGTGCGCTCTTCAGTTTGGTGGACCGCGTGGCGGCGGCGCGCGGCGCCAAGCC
GGACCTCATCCTGGGTCCGGTGTGCGAGTACGCTGCGGCGCCGGTGGCCCGGCTGGCGTCTCAC
TGGGACCTGCCGATGCTGTCCGCAGGAGCGCTGGCCGCGGGTTTCCAGCACAAGGACACGGAGT
ACTCGCACCTCACGCGCGTGGCGCCTGCCTACGCCAAGATGGGAGAGATGATGCTCGCTCTGTT
CCGCCACCACCACTGGAGCCGCGCTGCCCTGCTCTACAGCGACGACAAACTCGAGAGAAACTGC
TACTTCACTCTCGAGGGGGTCCACGAGGTTTTCCAGGAGGAGGGCTTGCACACGTCTGCCTACA
ATTTCGACGAGACCAAAGACTTGGACCTGGACGACATAGTGCGCTACATCCAGGGCAGTGAGCG
AGTGGTGATCATGTGTGCCAGTGGTGACACCATTCGGAGAATCATGTTGGCGGTGCACAGACAC
GGCATGACCAGTGGAGACTATGCTTTCTTCAACATTGAACTCTTCAACAGTTCTTCTTACGGAG
ATGGCTCGTGGAAGAGAGGGGACAAACACGACTTTGAAGCTAAGCAAGCTTACTCATCCCTCCA
AACAGTCACCCTGCTGAGGACCGCGAAGCCTGAGTTTGAGAAGTTTTCCATGGAGGTGAAAAGT
TCTGTTGAGAAACAAGGGCTCAATGAGGAGGATTACGTGAACATGTTCGTTGAAGGCTTCCATG
ATGCCATCCTCCTCTACGTTCTGGCTTTGCATGAAGTGCTCAGAGCTGGCTACAGCAAGAAGGA
TGGGGGGAAAATCATCCAGCAGACTTGGAACAGGACATTTGAAGGTATCGCCGGGCAGGTGTCC
ATAGATGCTAATGGGGATCGGTATGGAGACTTCTCTGTGGTTGCCATGACTGATACAGAAGCAG
GTACCCAGGAGGTCATTGGTGATTACTTTGGAAAAGAAGGCCGGTTCAAAATGCGATCCAATGT
CAAATATCCTTGGGGCTCTTTGAAATTGAGAATAGATGAAACCAGAATTGTGGAGCACACCAAC
AGCTCTCCTTGCAAATCATGTGGCCTAGAAGAATCAGCAGTGACAGGAATTGTTGTGGGGGCCC
TACTAGGTGCTGGTTTGCTAATGGCCTTCTACTTTTTCAGGAAGAAATACAGAATAACCATTGA
GAGGCGAAATCACCAAGAAGAAAGCAACATTGGGAAACATCGAGAGCTGCGGGAAGATTCCATC
AGATCACATTTTTCGGTGGCTTAAAAGAAATGCCCCCCTTGCTTTGTCTGCTTGAGATTCCTTA
AAGAGATAGTTGAAGGACAGACATCAATGGAACAGAAAGGGTGTTCTTGGAGAATT

hide sequence

RefSeq Acc Id:

XM_006232045 ⟹ XP_006232107

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	60,865,483 - 60,932,662 (-)	NCBI
Rnor_6.0	2	61,883,946 - 61,950,291 (-)	NCBI
Rnor_5.0	2	82,740,513 - 82,806,584 (+)	NCBI

Sequence:

show sequence

CCCCACCCGTTGCAGAGACAAGCCCGGCCTCGGCGCGCCATGTGTGGTAACGCGCTGCGCCGCT
GCCACGCTATTTAAACACCGGCTATGGATCCAGAAACCCGCGCGAATCAATGGGATCAAACGCG
AAGGAGGTGCACCGTCAATTACAAGCACTTGGACAAGTTTAACTTCTTTTTCTTTTACAAATAA
GGCCTTCAAACGCAACCTTAGCAACGCCCAAATAAGAAGCCACCTCTAAGCCAAATAGCCTATG
TGCAAAGGAAGGGAGAATATATATATATACATATATATATATATATATATATATATATATATAT
TTATAATAAGTCTATATGTATATTACAGACGCACAGGTTTACATTCTGTGAACTTTTTTCTTTT
TTCTTTCTTTGCTTTTTTTTTTTTTAAGCCTAGGGATATTGCAGAGGAGTCTTCCTCTCTATCT
TTTGGCGCGTTACTGAAGGGGGTATTCTGTTTTCTTGGAGCGCCTAAGGGGGCGCAGGGACAGA
GGAAAGAAAAGAGCAGGGAGGAAAGGGGCAGGGTGGGTGGGGGGCAGAGGGCGAGCCGGTGGCC
AGGGCGAGCGCTTGCTGGCAACAGGATGCGGTCCCTGCTGCTGTTCACTTTCTCGGCGTGCGTG
CTGCTGGCCCGGGCGCTGCTGGCTGGCGGTGCGAGTAGTGGCGGTGGGGACACCGGGCCAGGCA
ACAGGCGCCGGGAGAGAGAGGCGCTGGCGGCTCAAAAGATCGAGGTGCTTGTGCTATTGCCCCG
GGACGATTCGTACTTGTTCTCGCTGGCCCGGGTGAGGCCGGCCATCGAGTACGCGCTGCGTAGC
GTGGAGGGCAATGGCACCGGCAGGAAGCTGCTGCCGCCCGGCACTCGCTTCCAGGTGGCCTATG
AAGACTCTGACTGTGGCAACCGCGCGCTCTTCAGTTTGGTGGACCGCGTGGCGGCGGCGCGCGG
CGCCAAGCCGGACCTCATCCTGGGTCCGGTGTGCGAGTACGCTGCGGCGCCGGTGGCCCGGCTG
GCGTCTCACTGGGACCTGCCGATGCTGTCCGCAGGAGCGCTGGCCGCGGGTTTCCAGCACAAGG
ACACGGAGTACTCGCACCTCACGCGCGTGGCGCCTGCCTACGCCAAGATGGGAGAGATGATGCT
CGCTCTGTTCCGCCACCACCACTGGAGCCGCGCTGCCCTGCTCTACAGCGACGACAAACTCGAG
AGAAACTGCTACTTCACTCTCGAGGGGGTCCACGAGGTTTTCCAGGAGGAGGGCTTGCACACGT
CTGCCTACAATTTCGACGAGACCAAAGACTTGGACCTGGACGACATAGTGCGCTACATCCAGGG
CAGTGAGCGAGTGGTGATCATGTGTGCCAGTGGTGACACCATTCGGAGAATCATGTTGGCGGTG
CACAGACACGGCATGACCAGTGGAGACTACGCTTTCTTCAACATTGAACTCTTCAACAGTTCTT
CTTACGGAGATGGCTCGTGGAAGAGAGGGGACAAACACGACTTTGAAGCTAAGCAAGCTTACTC
ATCCCTCCAAACAGTCACCCTGCTGAGGACCGCGAAGCCTGAGTTTGAGAAGTTTTCCATGGAG
GTGAAAAGTTCTGTTGAGAAACAAGGGCTCAATGAGGAGGATTACGTGAACATGTTCGTTGAAG
GCTTCCATGATGCCATCCTCCTCTACGTTCTGGCTTTGCATGAAGTGCTCAGAGCTGGCTACAG
CAAGAAGGATGGGGGGAAAATCATCCAGCAGACTTGGAACAGGACATTTGAAGGTATCGCCGGG
CAGGTGTCCATAGATGCTAATGGGGATCGGTATGGAGACTTCTCTGTGGTTGCCATGACTGATA
CAGAAGCAGGTACCCAGGAGGTCATTGGTGATTACTTTGGAAAAGAAGGCCGGTTCAAAATGCG
ATCCAATGTCAAATATCCTTGGGGCTCTTTGAAATTGAGAATAGATGAAACCAGAATTGTGGAG
CACACCAACAGCTCTCCTTGCAAATCATCAGGTGGCCTAGAAGAATCAGCAGTGACAGGAATTG
TTGTGGGGGCCCTACTAGGTGCTGGTTTGCTAATGGCCTTCTACTTTTTCAGGAAGAAATACAG
AATAACCATTGAGAGGCGAAATCACCAAGAAGAAAGCAACATTGGGAAACATCGAGAGCTGCGG
GAAGATTCCATCAGATCACATTTTTCGGTGGCTTAAAAGAAATGCCCCCCTTGCTTTGTCTGCT
TGAGATTCCTTAAAGAGATAGTTGAAGGACAGACATCAATGGAACAGAAAGGGTGTTCTTGGAG
AATTCATTCTTTTAAGCAGTAGTCATTTCATTTTAAATTTTCTTTAGAAGCTCAGGAATGATTA
TTAATCACTATCTGCCTTCTGGTCTTTCATCTCATGGCAAACAGATATAATTATATAACGTAAT
CCTGTTAAGTGTTCTGGCTGTTGGAGGGGCATCGGAGTAGATTTATGTCTCGAAAGTCTGGAGT
CTCCATATCTTGATTGCTTTGGGGGTATTTCACACAAGGTTATAAAAATGTGGTTTTTCCAAAA
TGAAATGTTTTGTAGCTAGAATAAAACAATTTTTACAAGTAGAATATTCTTGGAAAGAATTTAA
CACCCAATAAGAGGACAAAGGAATGAGAGAAATCTCAAGGCTGGGAATGCATGCCCCTCTCTCT
GGAGTTGGGGAACAGGTTTGTGGTTGCCGAGGGCTTCGTCCAACGTCCACATTCAGGTCTGACT
TCATATCTCAAGAAAGGATCCTCCCTGTCTCTTTTAGTGTCTCATCAAAGCTACTCTGGAAATC
TGTAAATACTAGTGAGTTAGGTGGATTTATATAAAAAAATCAGTCTAAAATGTTTCTTTTATGA
TGTAAAAAAAAGCCCTACTTCATACTAACATTTTATTTTTAAGTATTTTAATCTTATATTTTGG
TATTAGAAATGTGTCTATTTTTTCATTTTGAAGATTAAATTTCACTTATATTTTAAGAGCATGG
AGGAGGCGTGTGACAAATCTGTGGTGAGGGAGGACTGGTTCTCTTTTTCTCTGCTGTTCTCTTT
CTTGGCTGTGGCTAATACTAACCTCGCTGCTCTGACTGAAGATGGGGAGAAGTCTGTTGAGCTT
ACAGTATCTGAAGCATTAGATTGATGTTAAGCTGTTGTTCATTTTCGACCGCTTTAAAATGTAT
GTTATTGGAGGGCTACATCCCTTCTGAACTATGGTCGAATGATGCACTTCAAAACCAGTAGACT
TCAGCAGAATCTATAAAGAAACACAACCCCTTTCCCTCCAGAACAAGCAGACAGTGAGAATTCG
ACAGCAAGATACAGTGATGATACATTTTAAAAAACTGCACACAATTTATCAAAATCTGAGGTGA
TGATTTTGATTAAAAAAGAGAACGTTGGTAGGTGCTGTGTCCCTTTAACCTCATAGAGTTTTAC
AGCCACCACAAATCACCCATAGCTTGGACAGTGATCTAGGACAGACAAGGGCAGCATGGCCAGG
ACTGAGAGCCAACCTTTGCTGGGTATCGGCTTTGCGCTCGGTTCTGTGTGCGGAGGTTTAAATT
TGGGTTCCTAGTTTATCATTCGAGGAGGGAACAAGGGGACAGTCTTGTAATTACGCTTCTCTTG
GTAACATTTTTGAGCATCTGAAACCCAGTTTGAAGGGGAGGAATTAAGTAACTCCTTGGATATC
CGTTCAGGTTAACTGTAGAGAAAGTCAGGCAAGCGCAGCAAGCTCTGAAAGCTAGCTCCCCGGG
GAAGGAGTGTGTCACACCTCATTCTCGGTTAAGTCAAAGTGAATGACCTGCCTCTGTGAGGGGT
GCATTTCTTTATGGCTCAGGAAATGGGATGCAAACCTCATGATAAAATGAATTAGCTCTTGAAC
CATGGAAGGAGGTACATTGTGGTTCTGCACGTGGGATATTGAGGGAAAAAAATGCTGACTTCCA
AAAGAGCAGAAAAAGTAGGCCAGAAAGGTAAACTTCAAAAATGCTAATCTAGGAGGAGAGCTTG
TGGAGCACAACTCAGGAAGGCTGCGGCTGATGGTCAGAGACGCACCTAATGGAGACAGATGAGC
GGACTGCAACCACCCCAGTCCTTAGAGCCAGAGGGCTGTTTGTTTCTCTCTTTTTCAACGACGT
TTTCCCCTGTGTTTCAGAGATACTCATTTTCTGATGTTTATTTTTTTTGAACCTGTGTGTTAAT
TACAGGAGGGTGGTGGTGGGGAAAGTTCTCTACCTGGCTATATTCCTTGGGTGTAGATATTTCT
AGTCCTTTCTTGAGTTTATATGGTGACCCATTAATGGCAGTGTTGTTACTACAAGTATCTTTTA
TTTTTGCTCTAGCTAGAGGAATTGTTCTAAGGTTAGTAGCATAGTCCCAGATTAGATGTTAAAG
ATGAGAAGGAAGCTAGCCTTTAAAAAAAAAAAGGCAGGGTTAATCATGAGGTCCCTGGAGTCCT
TTCTTACAATGTTAAAGCAATTCTAGTATTATTAAGGTTGATTGCTCATTTACATGTCTGCTGT
ATGGTTTGTCTTTCTTGAATGTCTTTACATGACTAGGCAAAGTGGCACATGTCTTCAATCCCAG
TACTTGGGAGGTGGAAGCAGGGGAATATCTATGAGTTCAGGGCCAGACTGGATTCCAGAGTGAG
TTTCAGGTCAGCTGTAGTTGCACAGTTAGTCCTTGTCTCGGAAAAATAAGTCTTCATATGAGTT
TCTAAAATGAAGTTCTGAAAACACCACTAAGTTGGGAAACCTTCGCTGAGGCTGTAGATGTTTG
TTCCGTGATGGCCCTGGGTTAAGCACTCTTGGTATTGTATTGTAGAACTCAAATTCCTCACTGC
AAAGCAACTACTTTGACAATTATTCATAATCTGTCAGTAGTCAATGTTATATAATAAACAAAAT
GGAACTTTAGTTCTTAAGCCATTCTATAATTTTTTACTCTTAAGTCCAATGATCAAGGTTTCAA
AGGGTGAGTATTTTATTAGCATTTTTCATATTTGGTCAAATATAAGTTCATATGCACGCTAAAA
TAAGCATATACTTGTGGTGATGGAAATAAACACGAATTTTACAGCCAATGTTATTGTCTTAGAT
TTGAGAGAGAAGCTGAACTCAGAAATAGAACTTTCTGGGTAGAGTCATATCTATTCCCAGCACA
GAGGTTTCACATGGACTCCGTCAACATGCATTGTTTTGAGGAGCCATCTGCGTGTCTTTTCCTG
AACCACGGACAGAACTCCACATGTCTTGAAATGGTTGTTTACATTTCAGAACTCATGGAGGAGA
GGGGAATCCTATGGAATGAGAGCAGATGCCCCACCCCCACTTCCTCTTTCTCTTGAAGAAAAAG
CTTTTGGAATGACAAGTCACTTCCCCCTGCTTACAGGCACCCTGCCCCTTTGCTGAAGGCACAT
CTGCCTGTGTCCCTAACTTGCCTCTTTTCCTCTGGTTGGGACTGATTGGAGGAGTCTAAGACAG
GCAGTGGGAAGTGAAAAGGGAGGCCTTGTATATCTCGGACAGACACAGAGCGGGTTCAGAAGCT
GTTTCCAGTGGAGCCATTGCTTCTTGAAGCAGAGTTACTTGGGCAGGTTCTTTTAGATGTGTAT
GCGTGCGCGCATGCATGCATATTTAAGAAAAAGAGACCGAAGGAACAGTGTTCATAAATTGGAA
AATACTAGGGCCTAAGTTTCTTGAGACACAAAGAACTCAGATCCCTAGTGGGTGCAACTATGAA
GGTAAATGCCTATTGACATTTGGCTCTAAACCTACATGGCATGTTTTATTTGTTACACCCCATG
GTTCAGGACTTCAGAAGACAGCTGCTAATGAGCTGAATTTCTTAGTCAGTGGGAAAAAATGGAA
ACTGTCTAGAAACACAGGATGCTTTAGGGGCAGCATAGAAGTAGGGAGAATGAGCCAGCCCCAC
TGGAGGGTTCCATCTCTGAAGTTGGTCTTTAGAATGGAAGAATAAGGAACAGTTTAGACCTTCT
TCAATAGCCAGTCTCCACAAGAAGTGCTGGACATGCCTGAGAGAAGAACCAGGAGCTTATGCCT
CCGAGGTGACAGGGGAGGTGACAGGGAGAAGAAGTTTGAAGCGGACACAGGCTCTACTGTTCTT
CCCGGAGTCCCACCTGCCATCCATCGCATTTCTATGGAGGTGTCAGCAGCTTTCCCATGCAGGT
CGGAACTTGTGAGGAGGCCTCCGCACTTACTCAGAGACACAGACAAAACAGCACCACTGTGAGG
AGGTAGCTGACAGTATCTTGGCCATGCATGCTCTCAGACAGTTCACATCTGTGATTTTCATGTA
AACCAGGGAGCTGGACTTTGTTCTCAGCCTACGGGTTTTTCAGACGTCTCCCGCAGGCCTATGG
GATGAACAGAATCCTCAAAAGGCACTGAATTGGAGGTTGTTCAAATCTCTCATTAACCACTAAT
GTTCATTCATCCCAAACTCAGAGCATTCTGAGCCAGCAGATGCAGGCATTTCTGTTTTAAGTCA
CTTCAAACATAATTGAAAGGATTTCACTGAGAGCAGACTCTCAGAGGTAAAAATAAATATGTCA
CAAAAACTCTTTGGTATATGAGGTATCCTATGATTCCTGGTGGAAAGATTTGAACAAGTAGACT
TTCGAGTTAATAAAACATGTTCCATTTCTTTGATTCATATTTAAAGACATAAATTTATATGCAC
AGGGATAAAGAGTCCATTTGCCAAGTGTGAATCATAACAGGCCACCAAGTTCATTTTTATTTTC
TAGAACAAAAGTGTCACTTATTATTGGGTAGAGAAAGAGTTATTTCTGCAGAGAAAGAAGAAAA
CGTGGATTTTGACATGGACCATCTTATCCATTATTCAATGCCTGTGCCTGAACATGTTCAGTGT
GGTGTAGCCTATAAGTCAGCAAGGAAGTGCCCTCGAACTGTAGAGAATCAGAGCTTTGTTCCCT
GGGCAGAGCTCAAACACCAGGGGGTCATGAGCTAGGCACTGCAGGTCAGCCCCACAGCCTGTGT
CTTTTGAGCCATTTTGTTCATGGATAATTTAAATATAGGACCACCAAACAATAAAAACTTACCA
TGAATCTGGCAGAAAACTCAAGGCCACACTAGCTACATATAGTTTACTATTCTGATGTAAGTAG
AACTATCTGCATATAATGTGATTTAATTTATTGTTGTTCTGTGTAGAAAGCAAGGATTAATGAT
TGTGGATATAACCCTGTTTTGTATAATATATTTGATTTCTGGTGCAAAATTGGTCATTTAAGCA
ATCTACTTCATTTGGTGTTTGGATATAAATGTGTATGTGTTCTTGTAAAGGTTCATATTCAGCA
AGAATATCACATAGCTAAGTATAACAATATGTTCTCATTAAAAGTATAAGTTACA

hide sequence

RefSeq Acc Id:

XM_039101782 ⟹ XP_038957710

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	60,865,483 - 60,933,432 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_037000	(Get FASTA)	NCBI Sequence Viewer
	XP_006232107	(Get FASTA)	NCBI Sequence Viewer
	XP_038957710	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41721	(Get FASTA)	NCBI Sequence Viewer
	CAA55330	(Get FASTA)	NCBI Sequence Viewer
	EDL82971	(Get FASTA)	NCBI Sequence Viewer
	EDL82972	(Get FASTA)	NCBI Sequence Viewer
	EDL82973	(Get FASTA)	NCBI Sequence Viewer
	P41740	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_037000 ⟸ NM_012868
- Peptide Label:	precursor
- UniProtKB:	Q64156 (UniProtKB/Swiss-Prot), P41740 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MRSLLLFTFSACVLLARALLAGGASSGGGDTGPGNRRREREALAAQKIEVLVLLPRDDSYLFSL ARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILG PVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHW SRAALLYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMC ASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLL RTAKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKII QQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFKMRSNVKYPWG SLKLRIDETRIVEHTNSSPCKSCGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNHQ EESNIGKHRELREDSIRSHFSVA hide sequence

RefSeq Acc Id:

XP_006232107 ⟸ XM_006232045

- Peptide Label:

isoform X1

- Sequence:

show sequence

MCKGRENIYIYIYIYIYIYIYIFIISLYVYYRRTGLHSVNFFLFSFFAFFFFKPRDIAEESSSL
SFGALLKGVFCFLGAPKGAQGQRKEKSREERGRVGGGQRASRWPGRALAGNRMRSLLLFTFSAC
VLLARALLAGGASSGGGDTGPGNRRREREALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALR
SVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVAR
LASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALLYSDDKL
ERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLA
VHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTAKPEFEKFSM
EVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIA
GQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFKMRSNVKYPWGSLKLRIDETRIV
EHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNHQEESNIGKHREL
REDSIRSHFSVA

hide sequence

RefSeq Acc Id:

ENSRNOP00000025966 ⟸ ENSRNOT00000025966

RefSeq Acc Id:	XP_038957710 ⟸ XM_039101782
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000079490 ⟸ ENSRNOT00000116101

Protein Domains

Receptor ligand binding region

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P41740-F1-model_v2	AlphaFold	P41740	1-535	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691192

Promoter ID:

EPDNEW_R1716

Type:

single initiation site

Name:

Npr3_1

Description:

natriuretic peptide receptor 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	61,949,881 - 61,949,941	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3196	AgrOrtholog
BioCyc Gene	G2FUF-54054	BioCyc
Ensembl Genes	ENSRNOG00000019184	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000025966	ENTREZGENE
	ENSRNOP00000025966.5	UniProtKB/TrEMBL
	ENSRNOP00000079490.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025966	ENTREZGENE
	ENSRNOT00000025966.6	UniProtKB/TrEMBL
	ENSRNOT00000116101.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.2300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	ANF_lig-bd_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ANPR/GUC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peripla_BP_I	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25339	UniProtKB/Swiss-Prot
NCBI Gene	25339	ENTREZGENE
PANTHER	ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NATRIURETIC PEPTIDE RECEPTOR 3-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ANF_receptor	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Npr3	PhenoGen
PRINTS	NATPEPTIDER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ANF_RECEPTORS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF53822	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC232480
UniProt	A0A8I6G3D8_RAT	UniProtKB/TrEMBL
	A0A8L2QFC4_RAT	UniProtKB/TrEMBL
	ANPRC_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q64156	ENTREZGENE
UniProt Secondary	Q64156	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-03-07	Npr3	natriuretic peptide receptor 3	Npr3	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-10	Npr3	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	Npr3	natriuretic peptide receptor 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2001-10-23	Npr3	natriuretic peptide receptor 3			Name updated to reflect Human and Mouse nomenclature	68913	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_process	mediates the attenuation of protein kinase C activity	727487
gene_regulation	downregulated by endothelin-1 in A-10 smooth muscle cells	729225

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations