Npr3 (natriuretic peptide receptor 3) - Rat Genome Database

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Gene: Npr3 (natriuretic peptide receptor 3) Rattus norvegicus
Analyze
Symbol: Npr3
Name: natriuretic peptide receptor 3
RGD ID: 3196
Description: Enables identical protein binding activity; peptide hormone binding activity; and peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of smooth muscle cell proliferation; and positive regulation of pancreatic juice secretion. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3); PARTICIPATES IN C-type natriuretic peptide signaling pathway; natriuretic peptide signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ANP-C; ANP-CR; ANPR-C; ANPRC; atrial natriuretic peptide C-type receptor; atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide clearence receptor 3; atrial natriuretic peptide receptor 3; atrial natriuretic peptide receptor type C; natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); NPR-C; NPRC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8262,592,557 - 62,660,497 (-)NCBIGRCr8
mRatBN7.2260,865,483 - 60,933,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl260,870,594 - 60,932,955 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx268,000,358 - 68,061,538 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0266,121,915 - 66,183,093 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0261,123,277 - 61,184,447 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0261,883,946 - 61,950,291 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl261,888,950 - 61,949,926 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0282,740,513 - 82,806,584 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4261,278,264 - 61,341,460 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1261,206,496 - 61,269,693 (-)NCBI
Celera257,760,666 - 57,821,249 (+)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
barium(0)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
chlormequat chloride  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium atom  (ISO)
chrysene  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dichloroacetic acid  (ISO)
Didecyldimethylammonium  (ISO)
diethylstilbestrol  (EXP)
dimethylselenide  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethylparaben  (ISO)
flavonoids  (EXP)
flusilazole  (EXP)
folic acid  (ISO)
fonofos  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Guanylin  (ISO)
ketoconazole  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
methyl salicylate  (ISO)
methylisothiazolinone  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
peroxynitrous acid  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium atom  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
titanium dioxide  (EXP,ISO)
trametinib  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cytoplasmic domain of natriuretic peptide receptor-C inhibits adenylyl cyclase. Involvement of a pertussis toxin-sensitive G protein. Anand-Srivastava MB, etal., J Biol Chem. 1996 Aug 9;271(32):19324-9.
2. Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. Bordicchia M, etal., J Clin Invest. 2012 Mar;122(3):1022-36. doi: 10.1172/JCI59701. Epub 2012 Feb 6.
3. Modulation of ANP-C receptor signaling by endothelin-1 in A-10 smooth muscle cells. Boumati M, etal., Arch Biochem Biophys 2002 May 15;401(2):178-86.
4. A single residue determines the distinct pharmacology of rat and human natriuretic peptide receptor-C. Engel AM, etal., J Biol Chem 1994 Jun 24;269(25):17005-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Hobbs A, etal., Circulation. 2004 Sep 7;110(10):1231-5. Epub 2004 Aug 30.
8. Three new allelic mouse mutations that cause skeletal overgrowth involve the natriuretic peptide receptor C gene (Npr3). Jaubert J, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10278-83.
9. Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide. Khambata RS, etal., Br J Pharmacol. 2011 Sep;164(2b):584-97. doi: 10.1111/j.1476-5381.2011.01400.x.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Atrial natriuretic peptide-C receptor-induced attenuation of adenylyl cyclase signaling activates phosphatidylinositol turnover in A10 vascular smooth muscle cells. Mouawad R, etal., Mol Pharmacol. 2004 Apr;65(4):917-24.
12. G protein-dependent activation of smooth muscle eNOS via natriuretic peptide clearance receptor. Murthy KS, etal., Am J Physiol. 1998 Dec;275(6 Pt 1):C1409-16.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Oliver PM, etal., Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14730-5.
15. Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype. Pitzalis MV, etal., J Hypertens. 2003 Aug;21(8):1491-6.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Downregulation of the atrial natriuretic peptide/natriuretic peptide receptor-C system in the early stages of diabetic retinopathy in the rat. Rollin R, etal., Mol Vis. 2005 Mar 18;11:216-24.
20. Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPR-C receptors. Sabbatini ME, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G929-37. Epub 2003 Jun 26.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Molecular characterisation and functional interrogation of a local natriuretic peptide system in rodent pituitaries, alphaT3-1 and LbetaT2 gonadotroph cells. Thompson IR, etal., J Endocrinol. 2009 Nov;203(2):215-29. doi: 10.1677/JOE-09-0189. Epub 2009 Aug 7.
23. Natriuretic peptides suppress protein kinase C activity to reduce evoked dopamine efflux from pheochromocytoma (PC12) cells. Trachte GJ Endocrinology 2003 Jan;144(1):94-100.
24. Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor. Villar IC, etal., Cardiovasc Res. 2007 Jun 1;74(3):515-25. Epub 2007 Mar 3.
25. Identification of the G protein-activating sequence of the single-transmembrane natriuretic peptide receptor C (NPR-C). Zhou H and Murthy KS, Am J Physiol Cell Physiol. 2003 May;284(5):C1255-61.
Additional References at PubMed
PMID:1660465   PMID:7554122   PMID:10377427   PMID:14599710   PMID:15911073   PMID:16712979   PMID:16870210   PMID:17702953   PMID:17951249   PMID:18162186   PMID:18778744   PMID:19187227  
PMID:19252090   PMID:19878700   PMID:19969282   PMID:20304036   PMID:20564198   PMID:21723350   PMID:22131352   PMID:23376485   PMID:23533145   PMID:24155894   PMID:24189506   PMID:25736855  
PMID:27108789   PMID:27494651   PMID:29417337   PMID:33849828   PMID:36243172  


Genomics

Comparative Map Data
Npr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8262,592,557 - 62,660,497 (-)NCBIGRCr8
mRatBN7.2260,865,483 - 60,933,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl260,870,594 - 60,932,955 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx268,000,358 - 68,061,538 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0266,121,915 - 66,183,093 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0261,123,277 - 61,184,447 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0261,883,946 - 61,950,291 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl261,888,950 - 61,949,926 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0282,740,513 - 82,806,584 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4261,278,264 - 61,341,460 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1261,206,496 - 61,269,693 (-)NCBI
Celera257,760,666 - 57,821,249 (+)NCBICelera
Cytogenetic Map2q16NCBI
NPR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38532,690,872 - 32,791,720 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl532,689,070 - 32,791,724 (+)EnsemblGRCh38hg38GRCh38
GRCh37532,690,978 - 32,791,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36532,747,422 - 32,823,013 (+)NCBINCBI36Build 36hg18NCBI36
Build 34532,747,421 - 32,823,009NCBI
Celera532,593,318 - 32,668,888 (+)NCBICelera
Cytogenetic Map5p13.3NCBI
HuRef532,678,571 - 32,759,879 (+)NCBIHuRef
CHM1_1532,712,833 - 32,793,931 (+)NCBICHM1_1
T2T-CHM13v2.0532,804,528 - 32,905,709 (+)NCBIT2T-CHM13v2.0
Npr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391511,839,982 - 11,907,287 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1511,839,982 - 11,907,373 (-)EnsemblGRCm39 Ensembl
GRCm381511,839,896 - 11,907,837 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1511,839,896 - 11,907,287 (-)EnsemblGRCm38mm10GRCm38
MGSCv371511,769,651 - 11,835,429 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361511,784,621 - 11,850,399 (-)NCBIMGSCv36mm8
Celera1511,624,844 - 11,690,388 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map155.83NCBI
Npr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542618,491,350 - 18,553,743 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542618,491,350 - 18,559,299 (+)NCBIChiLan1.0ChiLan1.0
NPR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2477,504,441 - 77,588,838 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1575,658,072 - 75,742,227 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0577,542,200 - 77,621,983 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1582,921,035 - 83,004,964 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl582,926,409 - 83,004,964 (-)Ensemblpanpan1.1panPan2
NPR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1474,794,553 - 74,863,344 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl474,799,857 - 74,862,969 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha474,429,055 - 74,497,877 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0475,311,739 - 75,380,568 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl475,311,746 - 75,380,475 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1475,049,009 - 75,118,047 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0475,177,562 - 75,246,355 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0475,708,336 - 75,777,195 (-)NCBIUU_Cfam_GSD_1.0
Npr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213223,211,508 - 223,281,564 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365188,093,561 - 8,158,868 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365188,093,111 - 8,158,862 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1618,842,039 - 18,929,805 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11618,841,540 - 18,929,813 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NPR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1431,984,712 - 32,062,593 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl431,986,217 - 32,062,199 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607122,244,880 - 22,328,902 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475921,829,336 - 21,904,405 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475921,826,271 - 21,904,928 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Npr3
272 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:70
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000025966
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25666087974786777Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)25760561276539510Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat

Markers in Region
PMC17879P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2260,931,634 - 60,932,217 (+)MAPPERmRatBN7.2
Rnor_6.0261,949,650 - 61,950,232NCBIRnor6.0
Rnor_5.0282,740,551 - 82,741,133UniSTSRnor5.0
RGSC_v3.4261,341,404 - 61,341,986UniSTSRGSC3.4
Celera257,760,140 - 57,760,722UniSTS
Cytogenetic Map2q16UniSTS
RH130055  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2260,889,134 - 60,889,352 (+)MAPPERmRatBN7.2
mRatBN7.21610,074,951 - 10,075,169 (+)MAPPERmRatBN7.2
Rnor_6.01611,108,549 - 11,108,766NCBIRnor6.0
Rnor_6.0261,907,585 - 61,907,802NCBIRnor6.0
Rnor_5.0169,434,028 - 9,434,245UniSTSRnor5.0
Rnor_5.0282,783,104 - 82,783,321UniSTSRnor5.0
RGSC_v3.4261,297,441 - 61,297,658UniSTSRGSC3.4
RGSC_v3.41610,409,488 - 10,409,705UniSTSRGSC3.4
Celera165,142,569 - 5,142,786UniSTS
Celera257,802,577 - 57,802,794UniSTS
RH 3.4 Map1698.1UniSTS
Cytogenetic Map2q16UniSTS
Cytogenetic Map16p15UniSTS
PMC22098P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2260,930,929 - 60,931,451 (+)MAPPERmRatBN7.2
Rnor_6.0261,948,945 - 61,949,466NCBIRnor6.0
Rnor_5.0282,741,317 - 82,741,838UniSTSRnor5.0
RGSC_v3.4261,340,699 - 61,341,220UniSTSRGSC3.4
Celera257,760,906 - 57,761,427UniSTS
Cytogenetic Map2q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 40 18 10 2 10 2 2 12 31 18 11 2
Low 3 3 38 30 14 30 6 9 62 4 23 6
Below cutoff 1 1 3 1

Sequence


RefSeq Acc Id: ENSRNOT00000025966   ⟹   ENSRNOP00000025966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl260,870,594 - 60,931,691 (-)Ensembl
Rnor_6.0 Ensembl261,888,950 - 61,949,926 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116101   ⟹   ENSRNOP00000079490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl260,870,634 - 60,932,955 (-)Ensembl
RefSeq Acc Id: NM_012868   ⟹   NP_037000
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,597,668 - 62,658,765 (-)NCBI
mRatBN7.2260,870,594 - 60,931,691 (-)NCBI
Rnor_6.0261,889,053 - 61,949,706 (-)NCBI
Rnor_5.0282,740,513 - 82,806,584 (+)NCBI
RGSC_v3.4261,278,264 - 61,341,460 (-)RGD
Celera257,760,666 - 57,821,249 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232045   ⟹   XP_006232107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,592,557 - 62,659,732 (-)NCBI
mRatBN7.2260,865,483 - 60,932,662 (-)NCBI
Rnor_6.0261,883,946 - 61,950,291 (-)NCBI
Rnor_5.0282,740,513 - 82,806,584 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101782   ⟹   XP_038957710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,592,557 - 62,660,497 (-)NCBI
mRatBN7.2260,865,483 - 60,933,432 (-)NCBI
RefSeq Acc Id: NP_037000   ⟸   NM_012868
- Peptide Label: precursor
- UniProtKB: Q64156 (UniProtKB/Swiss-Prot),   P41740 (UniProtKB/Swiss-Prot),   A6KJR1 (UniProtKB/TrEMBL),   A0A8L2QFC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232107   ⟸   XM_006232045
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000025966   ⟸   ENSRNOT00000025966
RefSeq Acc Id: XP_038957710   ⟸   XM_039101782
- Peptide Label: isoform X2
- UniProtKB: A6KJR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079490   ⟸   ENSRNOT00000116101
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41740-F1-model_v2 AlphaFold P41740 1-535 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691192
Promoter ID:EPDNEW_R1716
Type:single initiation site
Name:Npr3_1
Description:natriuretic peptide receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0261,949,881 - 61,949,941EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3196 AgrOrtholog
BioCyc Gene G2FUF-54054 BioCyc
Ensembl Genes ENSRNOG00000019184 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025966.6 UniProtKB/TrEMBL
  ENSRNOT00000116101.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANPR/GUC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25339 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25339 ENTREZGENE
PANTHER ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NATRIURETIC PEPTIDE RECEPTOR 3-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Npr3 PhenoGen
PRINTS NATPEPTIDER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANF_RECEPTORS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019184 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC232480
UniProt A0A8I6G3D8_RAT UniProtKB/TrEMBL
  A0A8L2QFC4 ENTREZGENE, UniProtKB/TrEMBL
  A6KJR1 ENTREZGENE, UniProtKB/TrEMBL
  A6KJR2_RAT UniProtKB/TrEMBL
  A6KJR3 ENTREZGENE, UniProtKB/TrEMBL
  ANPRC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64156 ENTREZGENE
UniProt Secondary Q64156 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-07 Npr3  natriuretic peptide receptor 3  Npr3  natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-10 Npr3  natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)  Npr3  natriuretic peptide receptor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-23 Npr3  natriuretic peptide receptor 3      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process mediates the attenuation of protein kinase C activity 727487
gene_regulation downregulated by endothelin-1 in A-10 smooth muscle cells 729225