Lars2 (leucyl-tRNA synthetase 2, mitochondrial) - Rat Genome Database
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Gene: Lars2 (leucyl-tRNA synthetase 2, mitochondrial) Rattus norvegicus
Analyze
Symbol: Lars2
Name: leucyl-tRNA synthetase 2, mitochondrial
RGD ID: 1308429
Description: Predicted to have leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial); PARTICIPATES IN aminoacyl-tRNA biosynthetic pathway; valine, leucine and isoleucine biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; bisphenol A; flutamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: leucyl-tRNA synthetase 2; leucyl-tRNA synthetase, mitochondrial; LOC363172; probable leucine--tRNA ligase, mitochondrial; probable leucyl-tRNA synthetase, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28123,010,271 - 123,108,957 (+)NCBI
Rnor_6.0 Ensembl8132,441,285 - 132,536,369 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08132,441,277 - 132,537,176 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08131,593,987 - 131,689,876 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,136,948 - 128,232,441 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18128,156,801 - 128,252,130 (+)NCBI
Celera8122,121,425 - 122,216,021 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10684970   PMID:14651853   PMID:18614015   PMID:26537577  


Genomics

Comparative Map Data
Lars2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28123,010,271 - 123,108,957 (+)NCBI
Rnor_6.0 Ensembl8132,441,285 - 132,536,369 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08132,441,277 - 132,537,176 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08131,593,987 - 131,689,876 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,136,948 - 128,232,441 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18128,156,801 - 128,252,130 (+)NCBI
Celera8122,121,425 - 122,216,021 (+)NCBICelera
Cytogenetic Map8q32NCBI
LARS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl345,388,561 - 45,554,726 (+)EnsemblGRCh38hg38GRCh38
GRCh38345,388,564 - 45,549,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37345,430,068 - 45,590,899 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37345,430,053 - 45,590,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36345,405,079 - 45,565,332 (+)NCBINCBI36hg18NCBI36
Build 34345,405,078 - 45,565,332NCBI
Celera345,368,449 - 45,528,754 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef345,473,932 - 45,634,902 (+)NCBIHuRef
CHM1_1345,380,072 - 45,540,452 (+)NCBICHM1_1
Lars2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,195,992 - 123,291,740 (+)NCBIGRCm39mm39
GRCm389123,366,927 - 123,462,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9123,366,927 - 123,462,666 (+)EnsemblGRCm38mm10GRCm38
MGSCv379123,276,058 - 123,371,782 (+)NCBIGRCm37mm9NCBIm37
MGSCv369123,215,638 - 123,311,362 (+)NCBImm8
Celera9123,819,514 - 123,915,073 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map973.92NCBI
Lars2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542026,343,649 - 26,441,736 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542026,342,129 - 26,446,959 (-)NCBIChiLan1.0ChiLan1.0
LARS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1346,405,636 - 46,564,994 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl346,405,636 - 46,564,994 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0345,296,129 - 45,455,836 (+)NCBIMhudiblu_PPA_v0panPan3
LARS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2042,892,801 - 43,081,197 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12042,891,823 - 43,080,987 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lars2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936695353,965 - 492,014 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LARS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1328,524,813 - 28,692,327 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11328,524,778 - 28,692,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21331,530,356 - 31,641,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LARS2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,861,105 - 7,021,325 (+)NCBI
ChlSab1.1 Ensembl226,861,006 - 7,020,009 (+)Ensembl
Lars2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473075,228,638 - 75,335,045 (-)NCBI

Position Markers
D8Rat192  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.08132,478,292 - 132,478,460NCBIRnor6.0
Rnor_5.08131,630,992 - 131,631,160UniSTSRnor5.0
RGSC_v3.48128,174,399 - 128,174,568RGDRGSC3.4
RGSC_v3.48128,174,400 - 128,174,568UniSTSRGSC3.4
RGSC_v3.18128,194,136 - 128,194,305RGD
Celera8122,157,980 - 122,158,148UniSTS
Cytogenetic Map8q32UniSTS
BE110407  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.08132,536,684 - 132,536,800NCBIRnor6.0
Rnor_5.08131,689,384 - 131,689,500UniSTSRnor5.0
RGSC_v3.48128,232,792 - 128,232,908UniSTSRGSC3.4
Celera8122,216,372 - 122,216,488UniSTS
RH 3.4 Map81277.79UniSTS
Cytogenetic Map8q32UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102051964133307652Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8104682575133307652Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)8104682575133307652Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:140
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000068233
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 38 43 27 18 27 6 9 70 34 34 9 6
Low 2 5 14 14 1 14 2 2 4 1 7 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000068233   ⟹   ENSRNOP00000058878
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8132,441,314 - 132,536,333 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087488   ⟹   ENSRNOP00000074967
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8132,441,285 - 132,536,369 (+)Ensembl
RefSeq Acc Id: NM_001108787   ⟹   NP_001102257
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28123,010,301 - 123,105,558 (+)NCBI
Rnor_6.08132,441,314 - 132,536,333 (+)NCBI
Rnor_5.08131,593,987 - 131,689,876 (+)NCBI
RGSC_v3.48128,136,948 - 128,232,441 (+)RGD
Celera8122,121,425 - 122,216,021 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244201   ⟹   XP_006244263
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28123,010,271 - 123,108,957 (+)NCBI
Rnor_6.08132,441,278 - 132,537,176 (+)NCBI
Rnor_5.08131,593,987 - 131,689,876 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008766727   ⟹   XP_008764949
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28123,010,271 - 123,105,558 (+)NCBI
Rnor_6.08132,441,277 - 132,536,333 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001102257 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244263 (Get FASTA)   NCBI Sequence Viewer  
  XP_008764949 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL76761 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001102257   ⟸   NM_001108787
- UniProtKB: D3Z9N3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244263   ⟸   XM_006244201
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K9E5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764949   ⟸   XM_008766727
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000074967   ⟸   ENSRNOT00000087488
RefSeq Acc Id: ENSRNOP00000058878   ⟸   ENSRNOT00000068233
Protein Domains
Anticodon_1   tRNA-synt_1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696408
Promoter ID:EPDNEW_R6933
Type:multiple initiation site
Name:Lars2_1
Description:leucyl-tRNA synthetase 2, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08132,441,315 - 132,441,375EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308429 AgrOrtholog
Ensembl Genes ENSRNOG00000004760 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000058878 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000074967 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068233 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000087488 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.620 UniProtKB/TrEMBL
  3.90.740.10 UniProtKB/TrEMBL
InterPro aa-tRNA-synth_I_CS UniProtKB/TrEMBL
  aa-tRNA-synth_Ia UniProtKB/TrEMBL
  Leu-tRNA-synth_Ia_bac/mito UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/TrEMBL
  tRNAsynth_1a_anticodon-bd UniProtKB/TrEMBL
  V/L/I-tRNA-synth_anticodon-bd UniProtKB/TrEMBL
  Val/Leu/Ile-tRNA-synth_Ia_edit UniProtKB/TrEMBL
KEGG Report rno:363172 UniProtKB/TrEMBL
NCBI Gene 363172 ENTREZGENE
PANTHER PTHR43740 UniProtKB/TrEMBL
Pfam Anticodon_1 UniProtKB/TrEMBL
  tRNA-synt_1 UniProtKB/TrEMBL
PhenoGen Lars2 PhenoGen
PRINTS TRNASYNTHLEU UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_I UniProtKB/TrEMBL
Superfamily-SCOP tRNAsyn_1a_bind UniProtKB/TrEMBL
  ValRS_IleRS_edit UniProtKB/TrEMBL
TIGRFAMs leuS_bact UniProtKB/TrEMBL
UniProt A0A0G2K9E5 ENTREZGENE, UniProtKB/TrEMBL
  D3Z9N3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-27 Lars2  leucyl-tRNA synthetase 2, mitochondrial  Lars2  leucyl-tRNA synthetase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-23 Lars2  leucyl-tRNA synthetase 2  Lars2  leucyl-tRNA synthetase 2, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Lars2  leucyl-tRNA synthetase 2, mitochondrial  Lars2  leucyl-tRNA synthetase, mitochondrial   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Lars2  leucyl-tRNA synthetase, mitochondrial   Lars2_predicted  leucyl-tRNA synthetase, mitochondrial (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lars2_predicted  leucyl-tRNA synthetase, mitochondrial (predicted)      Symbol and Name status set to approved 70820 APPROVED